会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 7. 发明申请
    • ISOINDOLINE DERIVATIVES COMPRISING A CYANO GROUP AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS
    • 包含CYANO集团的ISOINDOLINE衍生物及其在治疗疼痛症状中的应用
    • WO2009145719A1
    • 2009-12-03
    • PCT/SE2009/050616
    • 2009-05-29
    • ASTRAZENECA ABÅHLIN, KristoferARVIDSSON, Per IBESIDSKI, YevgeniNILSSON, Linda I
    • ÅHLIN, KristoferARVIDSSON, Per IBESIDSKI, YevgeniNILSSON, Linda I
    • C07D209/46A61K31/4035A61P25/04
    • C07D209/46
    • Compounds of formula I are claimed, wherein R 1 is hydrogen, C 1_3 alkyl, C 1_3 alkoxy, cyano, hydroxy or halo; and wherein said C 1-3 alkyl is optionally substituted by one or more substituents independently selected from hydroxy, C 1_3 alkoxy andfluoro; and said C 1_3 alkoxy is optionally substituted by one or more fluoro; m is 1, 2 or 3; R 2 and R 3 is each and independently selected from hydrogen, C 1-4 haloalkyl, C 1-4 haloalkoxy, halo, C 1-4 alkoxy, C 1-4 alkyl and C 3_7 Cycloalkyloxy; wherein said C 3_7 cycloalkyloxy is optionally substituted by one or more fluoro; and R 2 and R 3 may not both be hydrogen; L 1 is C 1-4 alkylene, pentylene, or C 3-6 cycloalkylene, wherein said C 1-4 alkylene, pentylene or C 3-6 cycloalkylene may be optionally substituted by one or more X 4 ; X 4 is fluoro, C 1_3 alkyl, C 3_7 Cycloalkyl, C 1_3 alkylOCi_3alkyl, C 1_3 alkoxy, cyano, hydroxy, R 4 O(C=O)-, R 4 NR 5 (C=O)-, R 4 O(C=O)NR 5 -, R 4 NR 5 (C=O)NR 5 -, R 4 (C=O)O-, R 4 (C=O)NR5-, R 4 NR 5 (C=O)O-, R 4 NR 5( C=O)NR 5 -, C 5-6 heteroaryl(C=O), or C 5-6 heteroaryl; R 4 is C 1-4 alkylOC 1-4 alkyl, C 5-6 cycloalkyl, aryl, or aryl-C 1-2 alkyl; R 5 is H or methyl; and wherein said C 1-3 alkylOC 1-3 alkyl, C 1-3 alkoxy and C 1-4 alkylsulfonyl is optionally substituted by one or more fluoro; L 2 is C 1-3 alkylene, optionally substituted by one or more X 4 ; as well as pharmaceutically acceptable salt, or isomer thereof, or a salt of said isomer. Compounds of the invention are useful in therapy, such as pain therapy.
    • 要求的式I化合物,其中R 1是氢,C 1-3烷基,C 1-3烷氧基,氰基,羟基或卤素; 并且其中所述C 1-3烷基任选被一个或多个独立地选自羟基,C 1-3烷氧基和氟的取代基取代; 并且所述C 1-3烷氧基任选被一个或多个氟取代; m为1,2或3; R 2和R 3各自独立地选自氢,C 1-4卤代烷基,C 1-4卤代烷氧基,卤素,C 1-4烷氧基,C 1-4烷基和C 3-8环烷氧基; 其中所述C 3-7环烷氧基任选被一个或多个氟取代; R2和R3不能都是氢; L 1是C 1-4亚烷基,亚戊基或C 3-6亚环烷基,其中所述C 1-4亚烷基,亚戊基或C 3-6亚环烷基可任选被一个或多个X 4取代; X 4是氟,C 1-3烷基,C 3-8环烷基,C 1-3烷基C 1-3烷基,C 1-3烷氧基,氰基,羟基,R 4 O(C = O) - ,R 4 NR 5(C = O) - ,R 40(C = O)NR 5 - ,R 4 NR 5(C = O)NR 5 - R4(C = O)O-,R4(C = O)NR5-,R4NR5(C = O)O-,R4NR5(C = O)NR5-,C5-6杂芳基(C = O) 杂; R 4是C 1-4烷基OC 1-4烷基,C 5-6环烷基,芳基或芳基-C 1-2烷基; R5是H或甲基; 并且其中所述C 1-3烷基OC 1-3烷基,C 1-3烷氧基和C 1-4烷基磺酰基任选被一个或多个氟取代; L2是任选被一个或多个X 4取代的C 1-3亚烷基; 以及其药学上可接受的盐或其异构体,或所述异构体的盐。 本发明的化合物可用于治疗,例如疼痛疗法。