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1. 发明申请

WO2010000819A1 CELLULAR COPD DIAGNOSIS 审中-公开
标题翻译：细胞性COPD诊断
公开(公告)号：WO2010000819A1
公开(公告)日：2010-01-07
申请号：PCT/EP2009/058354
申请日：2009-07-02
申请人： APOSCIENCE AG , ANKERSMIT, Jan, Hendrik
发明人： ANKERSMIT, Jan, Hendrik
IPC分类号： G01N33/569
CPC分类号： G01N33/56972 , G01N2333/70514 , G01N2333/70521 , G01N2800/122 , G01N2800/50 , G01N2800/56
摘要： Method for diagnosing the risk of a human subject to develop chronic obstructive pulmonary disease (COPD) comprising the steps of: - providing a sample from a human subject, - determining the amount of CD4+CD28null T-cells in said sample, - diagnosing the risk to develop COPD when the amount of CD4+CD28null T-cells is reduced compared to the amount of CD4+CD28null T-cells in healthy human subjects.
摘要翻译：用于诊断人受试者发展为慢性阻塞性肺病（COPD）的风险的方法，包括以下步骤： - 提供来自人受试者的样品， - 测定所述样品中CD4 + CD28null T细胞的量， - 诊断当CD4 + CD28null T细胞的量与健康人受试者中CD4 + CD28null T细胞的量相比减少时，发展为COPD的风险。

2. 发明申请

WO2010000820A2 COPD DIAGNOSIS 审中-公开
标题翻译： COPD诊断
公开(公告)号：WO2010000820A2
公开(公告)日：2010-01-07
申请号：PCT/EP2009058357
申请日：2009-07-02
申请人： APOSCIENCE AG , ANKERSMIT JAN HENDRIK
发明人： ANKERSMIT JAN HENDRIK
IPC分类号： G01N33/68
CPC分类号： G01N33/6869 , G01N33/6875 , G01N2800/122 , G01N2800/50 , G01N2800/56
摘要： The present invention relates to a method for diagnosing chronic obstructive pulmonary disease (COPD) in a human subject or the risk of a human subject to develop COPD comprising the steps of : - providing a sample from a human subject, - determining the amount of caspase-cleaved cytokeratin-18 (ccCK-18), histones, heat shock protein 27 (HSP27), heat shock protein 70 (HSP70) and/or heat shock protein 90 alpha (HSP90 alpha) in said sample, - diagnosing COPD when the amount of ccCK-18, histones, HSP27, HSP70 and/or HSP90 alpha is increased compared to the amount of ccCK-18, histones, HSP27, HSP70 and/or HSP90 alpha in healthy human subjects, or - diagnosing the risk to develop COPD when the amount of ccCK-18, histones and/or HSP70 is reduced compared to the amount of ccCK-18, histones and/or HSP70 in healthy human subjects.
摘要翻译：本发明涉及用于诊断人受试者的慢性阻塞性肺病（COPD）或人受试者发展COPD的风险的方法，其包括以下步骤： - 提供来自人受试者的样品， - 测定半胱天冬酶 - 在所述样品中切割的细胞角蛋白-18（ccCK-18），组蛋白，热休克蛋白27（HSP27），热休克蛋白70（HSP70）和/或热休克蛋白90α（HSP90α）与健康人受试者中ccCK-18，组蛋白，HSP27，HSP70和/或HSP90α的量相比，ccCK-18，组蛋白，HSP27，HSP70和/或HSP90α的量增加，或者 - 当与健康人受试者中ccCK-18，组蛋白和/或HSP70的量相比，ccCK-18，组蛋白和/或HSP70的量减少。

3. 发明申请

WO2010000820A3 COPD DIAGNOSIS 审中-公开
公开(公告)号：WO2010000820A3
公开(公告)日：2010-01-07
申请号：PCT/EP2009/058357
申请日：2009-07-02
申请人： APOSCIENCE AG , ANKERSMIT, Jan, Hendrik
发明人： ANKERSMIT, Jan, Hendrik
IPC分类号： G01N33/68
摘要： The present invention relates to a method for diagnosing chronic obstructive pulmonary disease (COPD) in a human subject or the risk of a human subject to develop COPD comprising the steps of : - providing a sample from a human subject, - determining the amount of caspase-cleaved cytokeratin-18 (ccCK-18), histones, heat shock protein 27 (HSP27), heat shock protein 70 (HSP70) and/or heat shock protein 90 alpha (HSP90 alpha) in said sample, - diagnosing COPD when the amount of ccCK-18, histones, HSP27, HSP70 and/or HSP90 alpha is increased compared to the amount of ccCK-18, histones, HSP27, HSP70 and/or HSP90 alpha in healthy human subjects, or - diagnosing the risk to develop COPD when the amount of ccCK-18, histones and/or HSP70 is reduced compared to the amount of ccCK-18, histones and/or HSP70 in healthy human subjects.

4. 发明申请

WO1992007392A1 PROCESS AND INSTALLATION FOR THE COMBINED GENERATION OF ELECTRICAL AND MECHANICAL ENERGY 审中-公开
标题翻译：电力和机械能源的组合生成的过程和安装
公开(公告)号：WO1992007392A1
公开(公告)日：1992-04-30
申请号：PCT/DE1991000781
申请日：1991-09-30
申请人： MANNESMANN AG , K.T.I. Group B.V. , ASA B.V. , ANKERSMIT, Jan, Hendrik , HENDRIKS, Rudolf , BLOMEN, Leo, Jozef, Maria, Johannes
发明人： MANNESMANN AG , K.T.I. Group B.V. , ASA B.V.
IPC分类号： H01M08/06
CPC分类号： F02C6/18 , C01B3/34 , C01B2203/0233 , C01B2203/0405 , C01B2203/066 , C01B2203/0811 , C01B2203/0827 , C01B2203/0883 , C01B2203/141 , C01B2203/84 , F01K23/067 , H01M8/0612 , Y02E20/14 , Y02E20/18 , Y02P20/129
摘要： The invention relates to a process for the combined generation of electrical and mechanical energy from the oxidation of fuel, whereby a gas containing hydrogen is generated by the endothermal reaction of hydrocarbon compounds, a part of said gas is burned to provide a combustion gas, a gas containing oxygen is compressed and introduced into the burning stage and the energy from the expansion of the hot combustion gas is generated in at least one gas turbine. In addition, the combustion gas produced is used to heat the endothermal reaction indirectly. According to the invention, at least part of the hydrogen-containing gas produced to generate electrical energy is taken as the anode gas via a fuel cell system and the anode exhaust gas is used to generate the combustion gas.

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