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1. 发明申请

WO1992006963A1 ARYLPYRIDAZINONES 审中-公开
公开(公告)号：WO1992006963A1
公开(公告)日：1992-04-30
申请号：PCT/EP1991001942
申请日：1991-10-12
申请人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , AMSCHLER, Hermann
发明人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , FIGALA, Volker , FLOCKERZI, Dieter , ULRICH, Wolf-Rüdiger , BEUME, Rolf , HÄFNER, Dietrich , HANAUER, Guido , ELTZE, Manfrid , SCHUDT, Christian , KILIAN, Ulrich
IPC分类号： C07D237/14
CPC分类号： C07D237/14
摘要： Disclosed are new compounds of general formula (I), in which one of the substituents R1 and R2 is a methoxy, difluoromethoxy or ethoxy group and the other is a C4-C7 cycloalkoxy or C3-C7 cycloalkylmethoxy group, as well as the salts formed by these compounds with bases. The compounds are suitable for use as active ingredients in bronchospasmolytics.
摘要翻译：公开了通式（I）的新化合物，其中取代基R 1和R 2中的一个是甲氧基，二氟甲氧基或乙氧基，另一个是C 4 -C 7环烷氧基或C 3 -C 7环烷基甲氧基，以及形成的盐通过这些化合物与碱。该化合物适用于支气管解痉药中的活性成分。

2. 发明申请

WO1997043288A1 NOVEL IMIDAZOPYRIDINES 审中-公开
标题翻译：新型咪唑啉
公开(公告)号：WO1997043288A1
公开(公告)日：1997-11-20
申请号：PCT/EP1997002310
申请日：1997-05-06
申请人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , AMSCHLER, Hermann
发明人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , BÄR, Thomas , FLOCKERZI, Dieter , GUTTERER, Beate , MARTIN, Thomas , ULRICH, Wolf-Rüdiger , HATZELMANN, Armin , BOSS, Hildegard , HÄFNER, Dietrich , BEUME, Rolf , KLEY, Hans-Peter
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Compounds of formula (I) in which A, B and Ar have the meanings indicated in the description, are novel effective bronchial therapeutics.
摘要翻译：其中A，B和Ar具有说明书中所示含义的式（I）化合物是新型有效的支气管治疗剂。

3. 发明申请

WO1984004302A1 SUBSTITUTED PICOLINIC ACIDS, PROCESSES FOR THEIR PREPARATION, THEIR USE AND MEDICAMENTS CONTAINING THEM 审中-公开
标题翻译：取代的皮质类药物，其制备方法，其使用和药物含有它们
公开(公告)号：WO1984004302A1
公开(公告)日：1984-11-08
申请号：PCT/EP1983000115
申请日：1983-04-27
申请人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT ... , AMSCHLER, Hermann , SANDERS, Karl , ULRICH, Wolf-Rüdiger
发明人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT ...
IPC分类号： C07D213/79
CPC分类号： C07D213/79 , C07D213/81
摘要： Substituted picolinic acids of the general formula (I), wherein R denotes alkyl with 1 to 7 carbon atoms - but not butyl if R and R denote alkyl and X denotes NH -, cycloalkylalkyl with 3 to 7 carbon atoms in the cycloalkyl part and 1 to 4 carbon atoms in the alkylene part, phenyl or substituted phenyl with up to three substituents from the group comprising halogen, hydroxyl, alkyl with 1 to 4 carbon atoms and alkoxy with 1 to 4 carbon atoms, R denotes alkyl with 1 to 4 carbon atoms or alkenyl with 3 to 5 carbon atoms and R denotes alkyl with 1 to 4 carbon atoms or alkenyl with 3 to 5 carbon atoms, or R and R together, and including the nitrogen atom to which they are bonded, denote pyrrolidino, morpholino, piperidino, hexahydroazepino, or 1-piperazinyl which is substituted in the 4-position by R , R denotes hydrogen, alkyl with 1 to 4 carbon atoms, phenyl, benzyl or substituted phenyl with up to three substituents from the group comprising halogen, hydroxyl, alkyl with 1 to 4 carbon atoms and alkoxy with 1 to 4 carbon atoms, A denotes straight-chain or branched alkylene with 1 to 5 carbon atoms and X denotes O (oxygen) or NH, and the acid addition salts of these compounds, R , R and R not simultaneously denoting alkyl if X represents O (oxygen) and A represents ethylene, are new compounds with a hypotensive activity. Processes for the preparation of these compounds are described.
摘要翻译：通式（I）的取代的吡啶甲酸，其中R 1表示具有1至7个碳原子的烷基，但不是丁基，如果R 2和R 3表示烷基，X表示NH - ，环烷基烷基，具有3至环烷基部分中的7个碳原子和亚烷基部分中的1至4个碳原子，苯基或取代苯基与最多三个来自卤素，羟基，具有1至4个碳原子的烷基和具有1至4个碳原子的烷氧基的取代基组成 R 2表示具有1至4个碳原子的烷基或具有3至5个碳原子的烯基，R 3表示具有1至4个碳原子的烷基或具有3至5个碳原子的链烯基，或R 2和R 包括与它们键合的氮原子表示吡咯烷子基，吗啉代，哌啶子基，六氢吖庚因或在4-位被R 4取代的1-哌嗪基，R 4表示氢，具有1至4个碳原子的烷基，苯基，苄基或取代的苯基，其中最多三个取代基包括卤素，羟基，具有1至4个碳原子的烷基和具有1至4个碳原子的烷氧基，A表示具有1至5个碳原子的直链或支链亚烷基，X表示O（氧）或NH，并且这些化合物的酸加成盐，R 如果X表示O（氧），A表示乙烯，则R 2和R 3不同时表示烷基，是具有降血压活性的新化合物。描述了这些化合物的制备方法。

4. 发明申请

WO9807715A9 NOVEL BENZOFURAN-4-CARBOXAMIDES 审中-公开
标题翻译：新型苯并呋喃-4-羧酰胺
公开(公告)号：WO9807715A9
公开(公告)日：1999-04-29
申请号：PCT/EP9704398
申请日：1997-08-13
申请人： BYK GULDEN LOMBERG CHEM FAB , AMSCHLER HERMANN
发明人： ULRICH WOLF-RUEDIGER , FLOCKERZI DIETER , GUTTERER BEATE , THIBAUT ULRICH , HATZELMANN ARMIN , SCHUDT CHRISTIAN , BEUME ROLF , HAEFNER DIETRICH , KLEY HANS-PETER , AMSCHLER HERMANN
IPC分类号： A61K31/343 , A61K31/443 , A61P11/06 , A61P29/00 , A61P43/00 , C07D307/79 , C07D405/12 , C07D405/14 , A61K31/34 , A61K31/44
CPC分类号： C07D307/79 , C07D405/12
摘要： Compounds of formula (I) in which R1 is 1-2C-alkoxy or 1-2C-alkoxy which is completely or mainly substituted by fluorine, R2 is 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, Ar is phenyl, pyridyl, phenyl which is substituted by R3, R4 and R5 or pyridyl which is substituted by R6, R7, R8 and R9, where R3 is hydroxyl, halogen, cyano, carboxyl, trifluoromethyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyl, 1-4C-alkylcarbonyloxy, amino, mono- or di-1-4C-alkylamino or 1-4C-alkylcarbonylamino, R4 is hydrogen, hydroxyl, halogen, amino, trifluoromethyl, 1-4C-alkyl or 1-4C-alkoxy, R5 is hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy, R6 is hydroxyl, halogen, cyano, carboxyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl or amino, R7 is hydrogen, halogen, amino or 1-4C-alkyl, R8 is hydrogen or halogen and R9 is hydrogen or halogen, the salts of this compound, and the N-oxides of the pyridines and their salts are active bronchial therapeutics.
摘要翻译： R1为1-2C-烷氧基或完全或主要被氟取代的1-2C-烷氧基的式（Ⅰ）化合物，R2为1-7C-烷基，3-7C-环烷基或3-7C-环烷基甲基， Ar是苯基，吡啶基，被R3，R4和R5取代的苯基或被R6，R7，R8和R9取代的吡啶基，其中R3是羟基，卤素，氰基，羧基，三氟甲基，1-4C-烷基， 1-4C-烷氧基，1-4C-烷氧基羰基，1-4C-烷基羰基，1-4C-烷基羰基氧基，氨基，单或二1-4C-烷基氨基或1-4C-烷基羰基氨基，R4是氢，羟基，卤素，氨基，三氟甲基，1-4C-烷基或1-4C-烷氧基，R5是氢，卤素，1-4C-烷基或1-4C-烷氧基，R6是羟基，卤素，氰基，羧基，1-4C-烷基， 1-4C-烷氧基，1-4C-烷氧基羰基或氨基，R7是氢，卤素，氨基或1-4C-烷基，R8是氢或卤素，R9是氢或卤素，该化合物的盐和N- 吡啶及其盐的氧化物是活性支气管理。

5. 发明申请

WO1995001338A1 FLUOROALKOXY-SUBSTITUTED BENZAMIDES AND THEIR USE AS CYCLIC NUCLEOTIDE PHOSPHODIESTERASE INHIBITORS 审中-公开
标题翻译：氟烷氧基取代的苯甲酰胺及其作为环核苷酸磷酸二酯酶抑制剂的用途
公开(公告)号：WO1995001338A1
公开(公告)日：1995-01-12
申请号：PCT/EP1994002169
申请日：1994-07-02
申请人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , AMSCHLER, Hermann
发明人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , FLOCKERZI, Dieter , GUTTERER, Beate , HATZELMANN, Armin , SCHUDT, Christian , BEUME, Rolf , KILIAN, Ulrich , WOLF, Horst, P., O.
IPC分类号： C07D213/75
CPC分类号： C07D213/75 , C07C235/56
摘要： Compounds of formula (I), in which one of the substituents R1 or R2 stands for hydrogen, 1-6C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, benzyloxy or totally or partially fluorine-substituted 1-4C-alkoxy, and the other stands for totally or partially fluorine-substituted 1-4C-alkoxy, and R3 stands for phenyl, pyridyl, R31, R32 and R33- substituted phenyl or R34, R35, R36 and R37- substituted pyridyl, in which R31 stands for hydroxy, halogen, cyano, carboxyl, trifluoromethyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyl, 1-4C-alkylcarbonyloxy, amino, mono- or di-1-4C-alkylamino or 1-4C-alkylcarbonylamino; R32 stands for hydrogen, hydroxy, halogen, amino, trifluoromethyl, 1-4C-alkyl or 1-4C-alkoxy; R33 stands for hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy; R34 stands for hydroxy, halogen, cyano, carboxyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl or amino; R35 stands for hydrogen, halogen, amino or 1-4C-alkyl; R36 stands for hydrogen or halogen; and R37 stands for hydrogen or halogen. These compounds constitute new effective bronchotherapeutic drugs.
摘要翻译：式（I）的化合物，其中取代基R1和R2是氢，1-6C-烷氧基，3-7C-环，3-7C-环cycloalkylmethoxy，苄氧基或完全或部分氟取代的1-4C-烷氧基之一，并且完全或部分氟取代的1-4C-烷氧基，和R 3是苯基，吡啶基等手段，由R31，R32和R33表示取代的苯基或R34，R35，R36和R37取代的吡啶基，其中R31是羟基，卤素，氰基，羧基甲基，三氟甲基，1-4C-烷基，1-4C-烷氧基，1-4C-烷氧基羰基，1-4C-烷基羰基，1-4C-烷基羰基氧基，氨基，单或二C 1-4 - 烷基氨基或1-4C- 烷基羰基氨基，R32是氢，羟基，卤素，氨基，三氟甲基，1-4C-烷基或1-4C-烷氧基，R33是氢，卤素，1-4C-烷基或1-4C-烷氧基，R34羟基，卤素，氰基，羧基，1-4C-烷基，1-4C-烷氧基，1-4C-烷氧基羰基或氨基，R35是氢，卤素，氨基或1-4C-烷基，R36是氢或卤素和R 37是氢或卤素床 eutet是新的有效治疗支气管。

6. 发明申请

WO1992019602A1 NOVEL PYRIDAZINES 审中-公开
标题翻译：新颖的紫薇
公开(公告)号：WO1992019602A1
公开(公告)日：1992-11-12
申请号：PCT/EP1992000872
申请日：1992-04-21
申请人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , AMSCHLER, Hermann , SCHUDT, Christian
发明人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , FIGALA, Volker , FLOCKERZI, Dieter , KILIAN, Ulrich , BEUME, Rolf , RIEDEL, Richard , ELTZE, Manfrid , HANAUER, Guido
IPC分类号： C07D237/20
CPC分类号： C07D237/20
摘要： Compounds of formula (I), in which R1, R2 and X have the meanings given in the specification, and their salts and N oxides are new agents for the treatment of bronchial conditions and dermatitis.

7. 发明申请

WO1990012789A1 NOVEL ARYLPYRIDAZINES, THEIR MANUFACTURE, USE AND MEDICAMENTS CONTAINING THEM 审中-公开
标题翻译：新亚油酸，其制造，使用和药物含有它们
公开(公告)号：WO1990012789A1
公开(公告)日：1990-11-01
申请号：PCT/EP1990000578
申请日：1990-04-11
申请人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , AMSCHLER, Hermann , ULRICH, Wolf-Rüdiger
发明人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , BEUME, Rolf , EISTETTER, Klaus , ELTZE, Manfrid , FLOCKERZI, Dieter , KILIAN, Ulrich , SCHUDT, Christian
IPC分类号： C07D237/20
CPC分类号： C07D237/20
摘要： Compounds of the general formula (I), in which one of the substituents R1 and R2 is methoxy, difluoromethoxy or ethoxy and the other C1-C5-alkoxy, C4-C7-cycloalcoxy, C3-C7-cycloalkylmethoxy, C3-C5-alkenyloxy or C1-C4-polyfluoroalkoxy and X is cyanamino, and their pharmacologically tolerable salts with bases are novel and suitable as bronchospasmolytic agents.
摘要翻译：其中一个取代基R 1和R 2为甲氧基，二氟甲氧基或乙氧基，另一个C 1 -C 5 - 烷氧基，C 4 -C 7 - 环烷氧基，C 3 -C 7 - 环烷基甲氧基，C 3 -C 5 - 烯氧基或C1-C4-多氟烷氧基，X是氰氨基，其与碱的药理学上可耐受的盐是新颖的，适用作支气管痉挛剂。

8. 发明申请

WO1984004522A1 PYRIDAZINONE, PREPARATION PROCESS THEREOF AND UTILISATION THEREOF, DRUGS CONTAINING PYRIDAZINONE 审中-公开
标题翻译：吡咯烷酮，其制备方法及其利用方法，含有吡咯烷酮的药物
公开(公告)号：WO1984004522A1
公开(公告)日：1984-11-22
申请号：PCT/EP1984000140
申请日：1984-05-10
申请人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT ... , AMSCHLER, Hermann , ULRICH, Wolf-Rüdiger
发明人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT ... , ELTZE, Manfrid
IPC分类号： C07D237/14
CPC分类号： C07D237/14 , A61K31/50 , C07D237/18
摘要： 6-aryl-3 AD2H BD pyridazinone having the formula (I), wherein one of the substituents R1 or R2 represents a hydrogen and the other one (C1-C5)alcoxy, (C3-C5)alkenyloxy, (C3-C5)alkinyloxy or CF3, and wherein X is oxygen or sulfur, and pharmaceutically acceptable salts thereof with bases, are appropriate to be used as bronchospasmolytic agent. Method for the preparation of said compounds and corresponding drugs.

9. 发明申请

WO1998007715A1 NOVEL BENZOFURAN-4-CARBOXAMIDES 审中-公开
标题翻译：新型苯并呋喃-4-羧酰胺
公开(公告)号：WO1998007715A1
公开(公告)日：1998-02-26
申请号：PCT/EP1997004398
申请日：1997-08-13
申请人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , AMSCHLER, Hermann
发明人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , ULRICH, Wolf-Rüdiger , FLOCKERZI, Dieter , GUTTERER, Beate , THIBAUT, Ulrich , HATZELMANN, Armin , SCHUDT, Christian , BEUME, Rolf , HÄFNER, Dietrich , KLEY, Hans-Peter
IPC分类号： C07D307/79
CPC分类号： C07D307/79 , C07D405/12
摘要： Compounds of formula (I) in which R1 is 1-2C-alkoxy or 1-2C-alkoxy which is completely or mainly substituted by fluorine, R2 is 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, Ar is phenyl, pyridyl, phenyl which is substituted by R3, R4 and R5 or pyridyl which is substituted by R6, R7, R8 and R9, where R3 is hydroxyl, halogen, cyano, carboxyl, trifluoromethyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyl, 1-4C-alkylcarbonyloxy, amino, mono- or di-1-4C-alkylamino or 1-4C-alkylcarbonylamino, R4 is hydrogen, hydroxyl, halogen, amino, trifluoromethyl, 1-4C-alkyl or 1-4C-alkoxy, R5 is hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy, R6 is hydroxyl, halogen, cyano, carboxyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl or amino, R7 is hydrogen, halogen, amino or 1-4C-alkyl, R8 is hydrogen or halogen and R9 is hydrogen or halogen, the salts of this compound, and the N-oxides of the pyridines and their salts are active bronchial therapeutics.
摘要翻译： R1为1-2C-烷氧基或完全或主要被氟取代的1-2C-烷氧基的式（Ⅰ）化合物，R2为1-7C-烷基，3-7C-环烷基或3-7C-环烷基甲基， Ar是苯基，吡啶基，被R3，R4和R5取代的苯基或被R6，R7，R8和R9取代的吡啶基，其中R3是羟基，卤素，氰基，羧基，三氟甲基，1-4C-烷基， 1-4C-烷氧基，1-4C-烷氧基羰基，1-4C-烷基羰基，1-4C-烷基羰基氧基，氨基，单或二1-4C-烷基氨基或1-4C-烷基羰基氨基，R4是氢，羟基，卤素，氨基，三氟甲基，1-4C-烷基或1-4C-烷氧基，R5是氢，卤素，1-4C-烷基或1-4C-烷氧基，R6是羟基，卤素，氰基，羧基，1-4C-烷基， 1-4C-烷氧基，1-4C-烷氧基羰基或氨基，R7是氢，卤素，氨基或1-4C-烷基，R8是氢或卤素，R9是氢或卤素，该化合物的盐和N- 吡啶及其盐的氧化物是活性支气管炎。

10. 发明申请

WO1984004521A1 PYRIDAZINONES, THEIR PREPARATION AND USE, AND MEDICAMENTS CONTAINING PYRIDAZINONES 审中-公开
标题翻译：吡咯烷酮，他们的制备和使用以及含有吡咯烷酮的药物
公开(公告)号：WO1984004521A1
公开(公告)日：1984-11-22
申请号：PCT/EP1984000139
申请日：1984-05-10
申请人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT ... , AMSCHLER, Hermann , ULRICH, Wolf-Rüdiger
发明人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT ... , ELTZE, Manfrid , KILIAN, Ulrich , SANDERS, Karl , KOLASSA, Norbert
IPC分类号： C07D237/14
CPC分类号： A61K31/50 , C07D237/14 , C07D237/18
摘要： 6-Aryl-3[2H]pyridazinones of formula (I), wherein one of the substituents R1 or R2 denotes methoxy and the other denotes (C2-C5)alkoxy or (C3-C5)alkenyloxy and X denotes oxygen or sulfur, and their pharmaco logically acceptable salts with bases, are suitable for use as a bronchospasmolytic or cardiotonic agent. Processes for the preparation of the compounds and appropriate medicaments are described.
摘要翻译：式（I）的6-芳基-3 [2H]哒嗪酮，其中一个取代基R 1或R 2表示甲氧基，另一个表示（C 2 -C 5）烷氧基或（C 3 -C 5）烯氧基，X表示氧或硫，它们与碱的药理学上可接受的盐适合用作支气管扩张剂或强心剂。描述了制备化合物和适当药物的方法。

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