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1. 发明申请

WO1992019602A1 NOVEL PYRIDAZINES 审中-公开
标题翻译：新颖的紫薇
公开(公告)号：WO1992019602A1
公开(公告)日：1992-11-12
申请号：PCT/EP1992000872
申请日：1992-04-21
申请人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , AMSCHLER, Hermann , SCHUDT, Christian
发明人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , FIGALA, Volker , FLOCKERZI, Dieter , KILIAN, Ulrich , BEUME, Rolf , RIEDEL, Richard , ELTZE, Manfrid , HANAUER, Guido
IPC分类号： C07D237/20
CPC分类号： C07D237/20
摘要： Compounds of formula (I), in which R1, R2 and X have the meanings given in the specification, and their salts and N oxides are new agents for the treatment of bronchial conditions and dermatitis.

2. 发明申请

WO1997043288A1 NOVEL IMIDAZOPYRIDINES 审中-公开
标题翻译：新型咪唑啉
公开(公告)号：WO1997043288A1
公开(公告)日：1997-11-20
申请号：PCT/EP1997002310
申请日：1997-05-06
申请人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , AMSCHLER, Hermann
发明人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , BÄR, Thomas , FLOCKERZI, Dieter , GUTTERER, Beate , MARTIN, Thomas , ULRICH, Wolf-Rüdiger , HATZELMANN, Armin , BOSS, Hildegard , HÄFNER, Dietrich , BEUME, Rolf , KLEY, Hans-Peter
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Compounds of formula (I) in which A, B and Ar have the meanings indicated in the description, are novel effective bronchial therapeutics.
摘要翻译：其中A，B和Ar具有说明书中所示含义的式（I）化合物是新型有效的支气管治疗剂。

3. 发明申请

WO1992006963A1 ARYLPYRIDAZINONES 审中-公开
公开(公告)号：WO1992006963A1
公开(公告)日：1992-04-30
申请号：PCT/EP1991001942
申请日：1991-10-12
申请人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , AMSCHLER, Hermann
发明人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , FIGALA, Volker , FLOCKERZI, Dieter , ULRICH, Wolf-Rüdiger , BEUME, Rolf , HÄFNER, Dietrich , HANAUER, Guido , ELTZE, Manfrid , SCHUDT, Christian , KILIAN, Ulrich
IPC分类号： C07D237/14
CPC分类号： C07D237/14
摘要： Disclosed are new compounds of general formula (I), in which one of the substituents R1 and R2 is a methoxy, difluoromethoxy or ethoxy group and the other is a C4-C7 cycloalkoxy or C3-C7 cycloalkylmethoxy group, as well as the salts formed by these compounds with bases. The compounds are suitable for use as active ingredients in bronchospasmolytics.
摘要翻译：公开了通式（I）的新化合物，其中取代基R 1和R 2中的一个是甲氧基，二氟甲氧基或乙氧基，另一个是C 4 -C 7环烷氧基或C 3 -C 7环烷基甲氧基，以及形成的盐通过这些化合物与碱。该化合物适用于支气管解痉药中的活性成分。

4. 发明申请

WO1998007715A1 NOVEL BENZOFURAN-4-CARBOXAMIDES 审中-公开
标题翻译：新型苯并呋喃-4-羧酰胺
公开(公告)号：WO1998007715A1
公开(公告)日：1998-02-26
申请号：PCT/EP1997004398
申请日：1997-08-13
申请人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , AMSCHLER, Hermann
发明人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , ULRICH, Wolf-Rüdiger , FLOCKERZI, Dieter , GUTTERER, Beate , THIBAUT, Ulrich , HATZELMANN, Armin , SCHUDT, Christian , BEUME, Rolf , HÄFNER, Dietrich , KLEY, Hans-Peter
IPC分类号： C07D307/79
CPC分类号： C07D307/79 , C07D405/12
摘要： Compounds of formula (I) in which R1 is 1-2C-alkoxy or 1-2C-alkoxy which is completely or mainly substituted by fluorine, R2 is 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, Ar is phenyl, pyridyl, phenyl which is substituted by R3, R4 and R5 or pyridyl which is substituted by R6, R7, R8 and R9, where R3 is hydroxyl, halogen, cyano, carboxyl, trifluoromethyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyl, 1-4C-alkylcarbonyloxy, amino, mono- or di-1-4C-alkylamino or 1-4C-alkylcarbonylamino, R4 is hydrogen, hydroxyl, halogen, amino, trifluoromethyl, 1-4C-alkyl or 1-4C-alkoxy, R5 is hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy, R6 is hydroxyl, halogen, cyano, carboxyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl or amino, R7 is hydrogen, halogen, amino or 1-4C-alkyl, R8 is hydrogen or halogen and R9 is hydrogen or halogen, the salts of this compound, and the N-oxides of the pyridines and their salts are active bronchial therapeutics.
摘要翻译： R1为1-2C-烷氧基或完全或主要被氟取代的1-2C-烷氧基的式（Ⅰ）化合物，R2为1-7C-烷基，3-7C-环烷基或3-7C-环烷基甲基， Ar是苯基，吡啶基，被R3，R4和R5取代的苯基或被R6，R7，R8和R9取代的吡啶基，其中R3是羟基，卤素，氰基，羧基，三氟甲基，1-4C-烷基， 1-4C-烷氧基，1-4C-烷氧基羰基，1-4C-烷基羰基，1-4C-烷基羰基氧基，氨基，单或二1-4C-烷基氨基或1-4C-烷基羰基氨基，R4是氢，羟基，卤素，氨基，三氟甲基，1-4C-烷基或1-4C-烷氧基，R5是氢，卤素，1-4C-烷基或1-4C-烷氧基，R6是羟基，卤素，氰基，羧基，1-4C-烷基， 1-4C-烷氧基，1-4C-烷氧基羰基或氨基，R7是氢，卤素，氨基或1-4C-烷基，R8是氢或卤素，R9是氢或卤素，该化合物的盐和N- 吡啶及其盐的氧化物是活性支气管炎。

5. 发明申请

WO1995001338A1 FLUOROALKOXY-SUBSTITUTED BENZAMIDES AND THEIR USE AS CYCLIC NUCLEOTIDE PHOSPHODIESTERASE INHIBITORS 审中-公开
标题翻译：氟烷氧基取代的苯甲酰胺及其作为环核苷酸磷酸二酯酶抑制剂的用途
公开(公告)号：WO1995001338A1
公开(公告)日：1995-01-12
申请号：PCT/EP1994002169
申请日：1994-07-02
申请人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , AMSCHLER, Hermann
发明人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , FLOCKERZI, Dieter , GUTTERER, Beate , HATZELMANN, Armin , SCHUDT, Christian , BEUME, Rolf , KILIAN, Ulrich , WOLF, Horst, P., O.
IPC分类号： C07D213/75
CPC分类号： C07D213/75 , C07C235/56
摘要： Compounds of formula (I), in which one of the substituents R1 or R2 stands for hydrogen, 1-6C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, benzyloxy or totally or partially fluorine-substituted 1-4C-alkoxy, and the other stands for totally or partially fluorine-substituted 1-4C-alkoxy, and R3 stands for phenyl, pyridyl, R31, R32 and R33- substituted phenyl or R34, R35, R36 and R37- substituted pyridyl, in which R31 stands for hydroxy, halogen, cyano, carboxyl, trifluoromethyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyl, 1-4C-alkylcarbonyloxy, amino, mono- or di-1-4C-alkylamino or 1-4C-alkylcarbonylamino; R32 stands for hydrogen, hydroxy, halogen, amino, trifluoromethyl, 1-4C-alkyl or 1-4C-alkoxy; R33 stands for hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy; R34 stands for hydroxy, halogen, cyano, carboxyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl or amino; R35 stands for hydrogen, halogen, amino or 1-4C-alkyl; R36 stands for hydrogen or halogen; and R37 stands for hydrogen or halogen. These compounds constitute new effective bronchotherapeutic drugs.
摘要翻译：式（I）的化合物，其中取代基R1和R2是氢，1-6C-烷氧基，3-7C-环，3-7C-环cycloalkylmethoxy，苄氧基或完全或部分氟取代的1-4C-烷氧基之一，并且完全或部分氟取代的1-4C-烷氧基，和R 3是苯基，吡啶基等手段，由R31，R32和R33表示取代的苯基或R34，R35，R36和R37取代的吡啶基，其中R31是羟基，卤素，氰基，羧基甲基，三氟甲基，1-4C-烷基，1-4C-烷氧基，1-4C-烷氧基羰基，1-4C-烷基羰基，1-4C-烷基羰基氧基，氨基，单或二C 1-4 - 烷基氨基或1-4C- 烷基羰基氨基，R32是氢，羟基，卤素，氨基，三氟甲基，1-4C-烷基或1-4C-烷氧基，R33是氢，卤素，1-4C-烷基或1-4C-烷氧基，R34羟基，卤素，氰基，羧基，1-4C-烷基，1-4C-烷氧基，1-4C-烷氧基羰基或氨基，R35是氢，卤素，氨基或1-4C-烷基，R36是氢或卤素和R 37是氢或卤素床 eutet是新的有效治疗支气管。

6. 发明申请

WO1990012789A1 NOVEL ARYLPYRIDAZINES, THEIR MANUFACTURE, USE AND MEDICAMENTS CONTAINING THEM 审中-公开
标题翻译：新亚油酸，其制造，使用和药物含有它们
公开(公告)号：WO1990012789A1
公开(公告)日：1990-11-01
申请号：PCT/EP1990000578
申请日：1990-04-11
申请人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , AMSCHLER, Hermann , ULRICH, Wolf-Rüdiger
发明人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , BEUME, Rolf , EISTETTER, Klaus , ELTZE, Manfrid , FLOCKERZI, Dieter , KILIAN, Ulrich , SCHUDT, Christian
IPC分类号： C07D237/20
CPC分类号： C07D237/20
摘要： Compounds of the general formula (I), in which one of the substituents R1 and R2 is methoxy, difluoromethoxy or ethoxy and the other C1-C5-alkoxy, C4-C7-cycloalcoxy, C3-C7-cycloalkylmethoxy, C3-C5-alkenyloxy or C1-C4-polyfluoroalkoxy and X is cyanamino, and their pharmacologically tolerable salts with bases are novel and suitable as bronchospasmolytic agents.
摘要翻译：其中一个取代基R 1和R 2为甲氧基，二氟甲氧基或乙氧基，另一个C 1 -C 5 - 烷氧基，C 4 -C 7 - 环烷氧基，C 3 -C 7 - 环烷基甲氧基，C 3 -C 5 - 烯氧基或C1-C4-多氟烷氧基，X是氰氨基，其与碱的药理学上可耐受的盐是新颖的，适用作支气管痉挛剂。

7. 发明申请

WO1993000903A1 USE OF SUBSTITUTED PYRIDAZINES AGAINST DERMATOSIS 审中-公开
标题翻译：使用取代的吡啶类抗真菌剂
公开(公告)号：WO1993000903A1
公开(公告)日：1993-01-21
申请号：PCT/EP1992001520
申请日：1992-07-06
申请人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , SCHUDT, Christian
发明人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , AMSCHLER, Hermann , FLOCKERZI, Dieter , BEUME, Rolf , RIEDEL, Richard
IPC分类号： A61K31/50
CPC分类号： A61K31/50
摘要： The invention concerns the use, for the preparation of drugs for use in the treatment of dermatosis, of compounds of the formula (I), in which one of the substituents R1 and R2 is hydrogen, C1-5-alkoxy or difluoromethoxy and the other is C1-5-alkoxy, C4-7-cycloalkoxy, C3-7-cycloalkylmethoxy, C3-5-alkenyloxy or C1-4-polyfluoroalkoxy and X is hydroxy or cyanamino, as well as their pharmacologically tolerated salts with bases.

8. 发明申请

WO1993009780A1 USE OF SULPHONYL COMPOUNDS 审中-公开
标题翻译：磺酰化合物的使用
公开(公告)号：WO1993009780A1
公开(公告)日：1993-05-27
申请号：PCT/EP1992002583
申请日：1992-11-11
申请人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , FLOCKERZI, Dieter , SCHUDT, Christian
发明人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , AMSCHLER, Hermann , BEUME, Rolf , RIEDEL, Richard
IPC分类号： A61K31/47
CPC分类号： A61K31/47
摘要： Compounds having the formula (I), in which the substituents have the meanings given in the description, and their pharmacologically tolerable salts, are used for preparing medicaments useful for treating dermatoses.
摘要翻译：具有式（I）的化合物，其中取代基具有本说明书中给出的含义及其药理学上可耐受的盐，用于制备用于治疗皮肤病的药物。

9. 发明申请

WO1998021208A1 BENZONAPHTHYRIDINES AS BRONCHIAL THERAPEUTICS 审中-公开
标题翻译：苯并噻嗪类作为BRONCHIAL THERAPEUTICS
公开(公告)号：WO1998021208A1
公开(公告)日：1998-05-22
申请号：PCT/EP1997006096
申请日：1997-11-05
申请人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , FLOCKERZI, Dieter
发明人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , GUTTERER, Beate , AMSCHLER, Hermann , ULRICH, Wolf-Rüdiger , MARTIN, Thomas , BÄR, Thomas , HATZELMANN, Armin , SANDERS, Karl , BEUME, Rolf , BOSS, Hildegard , HÄFNER, Dietrich , KLEY, Hans-Peter , GOEBEL, Karl-Josef
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Compounds of formula (I) in which R1, R2, R3 and R4 have the meanings indicated in the description, are novel active bronchial therapeutics.
摘要翻译：其中R1，R2，R3和R4具有说明书中所示含义的式（I）化合物是新型活性支气管理剂。

10. 发明申请

WO1997031638A1 USE OF 'alpha'1-ADRENOCEPTOR ANTAGONISTS 审中-公开
标题翻译：阿尔法1 - 肾上腺素受体拮抗剂的应用
公开(公告)号：WO1997031638A1
公开(公告)日：1997-09-04
申请号：PCT/EP1997000861
申请日：1997-02-22
申请人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , GREGORINI, Luigia, Ventura
发明人： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH , KOLASSA, Norbert , SANDERS, Karl
IPC分类号： A61K31/505
CPC分类号： A61K31/517 , A61K31/00 , A61K31/403 , A61K31/495 , A61K31/506
摘要： The invention concerns the use of alpha 1-adrenoceptor antagonists and their pharmacologically tolerable salts in the production of drugs for the prevention and treatment of conditions related to myocardial contractile dysfunction caused by ischaemia.
摘要翻译：本发明涉及使用阿尔法1 - 肾上腺素能受体拮抗剂，以及它们的药理学上可接受的盐的药物用于基于心肌收缩功能障碍，由于缺血疾病状态的预防和治疗中的用途。

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