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1. 发明申请

WO2005120235A3 PROPELLANT FORMULATIONS 审中-公开
标题翻译： PROPELLANT公式
公开(公告)号：WO2005120235A3
公开(公告)日：2006-02-02
申请号：PCT/US2005013841
申请日：2005-04-22
申请人： MIDWEST RES INST INC , ALBURTY DAVID S , BROWN KELLY L , PAGE ANDREW E , FISCHER MICHAEL F
发明人： ALBURTY DAVID S , BROWN KELLY L , PAGE ANDREW E , FISCHER MICHAEL F
IPC分类号： A01N25/06 , A01N63/00 , A61L9/04 , A61K9/12 , A61K9/14 , A62D3/00 , C12M1/34
CPC分类号： A01N25/06 , A01N63/00 , A01N25/26 , A01N2300/00
摘要： The present invention provides propellant formulations for non-pharmaceutical use in dispersing insoluble particles having biological activity, such as bacterial spores and/or biological analogues, using a dispersion device such as a metered-dose inhaler. It is preferred that the propellant formulations of the present invention are chemically compatible with the biological analogues with which they are to be used, have substantially the same specific gravity as the biological analogues, and have sufficient vapor pressure to prevent agglomeration of the biological analogues. Methods of dispersing said biological analogues in accordance with the present invention are also provided.
摘要翻译：本发明提供了使用分散装置如计量吸入器分散非药物用于分散具有生物活性的不溶性颗粒的推进剂制剂，例如细菌孢子和/或生物类似物。优选本发明的推进剂制剂与其使用的生物类似物化学相容，具有与生物类似物基本相同的比重，并且具有足够的蒸气压以防止生物类似物的附聚。还提供了分散根据本发明的生物类似物的方法。

2. 发明申请

WO2005120235A2 PROPELLANT FORMULATIONS 审中-公开
标题翻译： PROPELLANT公式
公开(公告)号：WO2005120235A2
公开(公告)日：2005-12-22
申请号：PCT/US2005/013841
申请日：2005-04-22
申请人： MIDWEST RESEARCH INSTITUTE, INC. , ALBURTY, David, S. , BROWN, Kelly, L. , PAGE, Andrew, E. , FISCHER, Michael, F.
发明人： ALBURTY, David, S. , BROWN, Kelly, L. , PAGE, Andrew, E. , FISCHER, Michael, F.
IPC分类号： A01N63/00
CPC分类号： A01N25/06 , A01N63/00 , A01N25/26 , A01N2300/00
摘要： The present invention provides propellant formulations for non-pharmaceutical use in dispersing insoluble particles having biological activity, such as bacterial spores and/or biological analogues, using a dispersion device such as a metered-dose inhaler. It is preferred that the propellant formulations of the present invention are chemically compatible with the biological analogues with which they are to be used, have substantially the same specific gravity as the biological analogues, and have sufficient vapor pressure to prevent agglomeration of the biological analogues. Methods of dispersing said biological analogues in accordance with the present invention are also provided.
摘要翻译：本发明提供了使用分散装置如计量吸入器分散非药物用于分散具有生物活性的不溶性颗粒的推进剂制剂，例如细菌孢子和/或生物类似物。优选本发明的推进剂制剂与其使用的生物类似物化学相容，具有与生物类似物基本相同的比重，并且具有足够的蒸气压以防止生物类似物的附聚。还提供了分散根据本发明的生物类似物的方法。

3. 发明申请

WO2008151093A1 LIQUID TO LIQUID BIOLOGICAL PARTICLE CONCENTRATOR 审中-公开
标题翻译：液体生物颗粒浓缩液
公开(公告)号：WO2008151093A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/065439
申请日：2008-05-30
申请人： ALBURTYLAB, INC. , ALBURTY, David, S. , PAGE, Andrew, E. , PACKINGHAM, Zachary, A. , MARSKE, Daniel, B.
发明人： ALBURTY, David, S. , PAGE, Andrew, E. , PACKINGHAM, Zachary, A. , MARSKE, Daniel, B.
IPC分类号： C12M1/12 , C12M3/06
CPC分类号： C12Q1/24 , C12Q1/04 , G01N1/4005 , G01N1/4077 , G01N2001/4088
摘要： A rapid one-pass liquid filtration system efficiently concentrates biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. Additional concentration stages may be added in "cascade" fashion, in order to concentrate particles below the size cut of each preceding stage remaining in the separated fluid in a concentrated sample suspension. This process can also be used to create a "band¬ pass" concentration for concentration of a particular target size particle within a narrow range.
摘要翻译：快速单程液体过滤系统有效地将悬浮在液体中的生物颗粒从稀释的进料悬浮液中浓缩。保留样品浓缩物或滞留物悬浮液，同时在单独的流动流中消除分离的流体。悬浮的生物颗粒包括尺寸范围为约0.001微米至20微米直径的蛋白质/毒素，病毒，DNA和/或细菌等材料。这些颗粒的浓度对于在稀释悬浮液中检测目标颗粒是有利的，因为将它们浓缩成小体积使得它们更易于检测。可以以“级联”方式添加额外的浓缩级，以便使浓缩样品悬浮液中残留在分离的流体中的每个先前阶段的尺寸切割下方的颗粒浓缩。该方法也可用于产生在窄范围内浓缩特定目标粒度的“带通”浓度。

4. 发明申请

WO2005026393A3 BIOLOGICAL PARTICULATE MATTER ANALOGUE 审中-公开
标题翻译：生物粒子物理模拟
公开(公告)号：WO2005026393A3
公开(公告)日：2005-06-02
申请号：PCT/US2004003699
申请日：2004-02-09
申请人： MIDWEST RES INST INC , PAGE ANDREW E , BROWN KELLY L , ALBURTY DAVID S , HUEBNER ROBERT C
发明人： PAGE ANDREW E , BROWN KELLY L , ALBURTY DAVID S , HUEBNER ROBERT C
IPC分类号： C12Q1/04 , C12Q1/68 , G01N33/543
CPC分类号： G01N33/543 , C12Q1/04 , C12Q1/6813 , C12Q1/6851 , C12Q2545/113 , C12Q2563/155
摘要： The present invention provides a biological particle analogue, or biological analogue, that simulates a chosen biological organism or compound. The biological analogue includes a first portion that is not, in and of itself, recognized by the biological detection system, and a second portion, which provides the properties necessary for recognition by the detection system, carried by the first portion. The biological analogue is constructed in such a way as to include some important characteristics of the chosen biological organism or compound, while excluding other undesirable characteristics of the chosen biological organism or compound. The present invention is useful in testing a variety of biological detection systems.
摘要翻译：本发明提供了模拟所选生物体或化合物的生物颗粒类似物或生物类似物。该生物学模拟物包括本身不被生物检测系统识别的第一部分和提供由第一部分携带的由检测系统识别所必需的性质的第二部分。构建生物类似物以包括选择的生物体或化合物的一些重要特征，同时排除选择的生物体或化合物的其它不良特征。本发明可用于测试各种生物检测系统。

5. 发明申请

WO2005026393A2 BIOLOGICAL PARTICULATE MATTER ANALOGUE 审中-公开
标题翻译：生物微粒物质模拟
公开(公告)号：WO2005026393A2
公开(公告)日：2005-03-24
申请号：PCT/US2004/003699
申请日：2004-02-09
申请人： MIDWEST RESEARCH INSTITUTE, INC. , PAGE, Andrew, E. , BROWN, Kelly, L. , ALBURTY, David, S. , HUEBNER, Robert, C.
发明人： PAGE, Andrew, E. , BROWN, Kelly, L. , ALBURTY, David, S. , HUEBNER, Robert, C.
IPC分类号： C12Q1/68
CPC分类号： G01N33/543 , C12Q1/04 , C12Q1/6813 , C12Q1/6851 , C12Q2545/113 , C12Q2563/155
摘要： The present invention provides a biological particle analogue, or biological analogue, that simulates a chosen biological organism or compound. The biological analogue includes a first portion that is not, in and of itself, recognized by the biological detection system, and a second portion, which provides the properties necessary for recognition by the detection system, carried by the first portion. The biological analogue is constructed in such a way as to include some important characteristics of the chosen biological organism or compound, while excluding other undesirable characteristics of the chosen biological organism or compound. The present invention is useful in testing a variety of biological detection systems.
摘要翻译：本发明提供了模拟所选择的生物有机体或化合物的生物颗粒类似物或生物类似物。生物类似物包括第一部分和第二部分，第一部分本身不被生物检测系统识别，第二部分提供由检测系统识别所必需的特性，第一部分携带第二部分。生物类似物以这样的方式构建，即包括所选生物有机体或化合物的一些重要特征，同时排除所选生物有机体或化合物的其他不良特征。本发明可用于测试各种生物检测系统。

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