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1. 发明申请

WO2013165600A1 NON-CEMENTITIOUS COMPOSITIONS COMPRISING VATERITE AND METHODS THEREOF 审中-公开
标题翻译：含有VATERITE的非化学组合物及其方法
公开(公告)号：WO2013165600A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/031770
申请日：2013-03-14
申请人： CALERA CORPORATION , DEVENNEY, Martin , FERNANDEZ, Miguel , MORGAN, Samuel, O.
发明人： DEVENNEY, Martin , FERNANDEZ, Miguel , MORGAN, Samuel, O.
IPC分类号： C01F11/18 , C04B2/02 , D21H19/64
CPC分类号： C01F11/18 , C01P2004/61 , C01P2004/62 , C01P2006/88 , C04B30/02 , D21H17/675 , D21H19/64 , Y02W30/97 , C04B14/28 , C04B18/24 , C04B22/08 , C04B16/06
摘要： Non-cementitious compositions, products, methods of making, and using include a carbonate additive comprising vaterite such as reactive vaterite. The carbonate additive has a carbon isotopic fractionation value (delta 13C) of less than -12%. In some embodiments of the foregoing aspect and embodiments, the carbonate additive comprises between 50-99% w/w reactive vaterite. In some embodiments of the foregoing aspect and embodiments, the non-cementitious additive is more than 20% w/w cellulosic or polymeric fiber. In some embodiments of the foregoing aspect and embodiments, the composition comprises between 5-50% w/w carbonate additive. The composition is for a paper product; polymeric product; lubricant; adhesive; rubber; chalk; asphalt product; paint; abrasive for paint removal; personal care product; cosmetic; cleaning product; personal hygiene product; ingestible product; agricultural product; environmental remediation product; or combinations thereof.
摘要翻译：非水泥组合物，产品，制造方法和使用方法包括碳酸酯添加剂，其包括诸如反应性球霰石的球霰石。碳酸盐添加剂具有小于-12％的碳同位素分馏值（δ13C）。在前述方面和实施方案的一些实施方案中，碳酸酯添加剂包含50-99％w / w的反应性球霰石。在前述方面和实施方案的一些实施方案中，非胶结添加剂是大于20％w / w的纤维素或聚合物纤维。在前述方面和实施方案的一些实施方案中，组合物包含5-50％w / w碳酸酯添加剂。组合物用于纸制品; 聚合物; 润滑剂; 胶粘剂; 橡胶; 粉笔; 沥青产品; 涂料; 磨料用于除漆; 个人护理产品; 化妆品; 清洁用品; 个人卫生用品; 可摄入产品; 农产品; 环保整治产品; 或其组合。

2. 发明申请

WO2013119511A1 COMPOSITION, METHOD, AND DEVICES FOR REDUCTION OF CELLS IN A VOLUME OF MATTER 审中-公开
标题翻译：用于减少细胞数量的组合物，方法和装置
公开(公告)号：WO2013119511A1
公开(公告)日：2013-08-15
申请号：PCT/US2013/024661
申请日：2013-02-04
申请人： ELMEDTECH, LLC , RUBINSKY, Boris , RUBINSKY, Liel
发明人： RUBINSKY, Boris , RUBINSKY, Liel
IPC分类号： C12N13/00
CPC分类号： A61L2/03 , A23L3/32
摘要： The present disclosure provides devices, systems, and methods for affecting cells using low voltage high electric fields (LVHEF). In one embodiment, the present disclosure provides for reduction of microbial contamination using low voltage high electric fields. The devices of the disclosure are generally capable of affecting cells in a portion of a volume of matter of interest using one or more arrangements of electrodes configured to generate high electric fields powered by low voltages (L VHEF). In one embodiment, the present disclosure provides for exposure of cells to a low voltage high electric field such that at least a portion of the cells in a portion of the volume of interest are killed.
摘要翻译：本公开提供了使用低电压高电场（LVHEF）来影响细胞的装置，系统和方法。在一个实施方案中，本公开提供了使用低电压高电场来减少微生物污染。本公开的装置通常能够使用被配置为产生由低电压（L VHEF）供电的高电场的电极的一个或多个布置来影响感兴趣的体积体积的一部分中的细胞。在一个实施例中，本公开提供了将细胞暴露于低电压高电场，使得感兴趣体积的一部分中的至少一部分细胞被杀死。

3. 发明申请

WO2012129450A1 MICROBIAL PRODUCTION OF CHEMICAL PRODUCTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS 审中-公开
标题翻译：化学产品的微生物生产及相关成分，方法和系统
公开(公告)号：WO2012129450A1
公开(公告)日：2012-09-27
申请号：PCT/US2012/030209
申请日：2012-03-22
申请人： OPX BIOTECHNOLOGIES, INC. , LYNCH, Michael, D. , LIPSCOMB, Tanya, E.w. , TRAHAN, Ashley, D. , SINGH, Amar , WOLTER, Travis
发明人： LYNCH, Michael, D. , LIPSCOMB, Tanya, E.w. , TRAHAN, Ashley, D. , SINGH, Amar , WOLTER, Travis
IPC分类号： C12P1/00
CPC分类号： C12P7/6409 , C07C53/126 , C12N9/001 , C12N9/1029 , C12N15/70 , C12P7/00 , C12P7/22 , C12P7/42 , C12P7/52 , C12P7/625 , C12P13/14 , C12Y103/01 , C12Y203/01041
摘要： Metabolically engineered microorganism strains are disclosed, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product. Such chemical products include polyketides, 3-hydroxypropionic acid, and various other chemical products described herein. Methods of production also may be applied to further downstream products, such as consumer products. In various embodiments, modifications to a microorganism and/or culture system divert, at least transiently, usage of malonyl-coA from the fatty acid biosynthesis pathway and thereby provides for usage of the malonyl-coA for a chemical product other than a fatty acid. In various embodiments, the fatty acid biosynthesis pathway is modulated to produce specific fatty acids or combinations of fatty acids.
摘要翻译：公开了代谢工程的微生物菌株，例如细菌菌株，其中丙二酰辅酶A用于生产化学产品的利用率增加。这些化学产品包括聚酮化合物，3-羟基丙酸和本文所述的各种其它化学产品。生产方法也可用于进一步的下游产品，如消费品。在各种实施方案中，对微生物和/或培养系统的修饰至少瞬时转移来自脂肪酸生物合成途径的丙二酰辅酶A的使用，从而提供除了脂肪酸以外的化学产品的丙二酰辅酶A的用途。在各种实施方案中，调节脂肪酸生物合成途径以产生特定脂肪酸或脂肪酸的组合。

4. 发明申请

WO2012048247A2 LOCALIZATION OF A BRAIN NETWORK ASSOCIATED WITH SUSTAINED CHRONIC PAIN 审中-公开
标题翻译：与持续慢性疼痛相关的脑网络的本地化
公开(公告)号：WO2012048247A2
公开(公告)日：2012-04-12
申请号：PCT/US2011/055408
申请日：2011-10-07
申请人： DECHARMS, Christopher, R.
发明人： DECHARMS, Christopher, R.
IPC分类号： G06Q50/24
CPC分类号： G06F19/322 , A61B5/055 , A61B5/4824 , G01R33/4806 , G16H10/60
摘要： Despite research progress identifying brain mechanisms mediating the experience of pain, our understanding of chronic pain lags behind experimentally-induced pain, largely because paradigms for studying the mechanisms of chronic pain have been limited. Here, we present a novel paradigm in which patients increase their own chronic pain experience by tensing the muscles surrounding their pain site, producing pain similar to that experienced during everyday muscle use. A broad sample of chronic pain patients report increased pain severity while tensing their pain site, and their pain remains elevated following tensing when the patients are no longer performing an overt task, mimicking sustained pain in their everyday experience. When patients perform this task during fMRI scanning, increased activation is observed throughout the 'pain matrix' including the thalamus and regions of insular, somatosensory, cingulate, prefrontal and orbitofrontal cortices. Following the termination of muscle tensing, pain remains elevated as reported using continuous quantitative pain ratings, and fMRI activation similarly remains elevated in anterior insular, cingulate, and somatosensory cortices. Activation in dorsal anterior cingulate cortex is linearly correlated with patients' pain ratings during the tensing period. Only the right anterior insula shows a correlation between activation and pain ratings during sustained pain. The activation pattern observed is similar when subjects repeat the task without providing continuous pain ratings. These results delineate brain regions mediating the perception of chronic pain, rather than acute experimental pain and provide a new approach to examining brain mechanisms of this disease.
摘要翻译：尽管研究进展确定脑机制介导疼痛的经验，但我们对慢性疼痛的理解落后于实验诱导的疼痛，主要是因为研究慢性疼痛机制的范式受到限制。在这里，我们提出了一个新颖的范例，患者通过张开其疼痛部位周围的肌肉来增加自己的慢性疼痛体验，产生类似于日常肌肉使用过程中的疼痛。慢性疼痛患者的广泛样本报告疼痛严重程度增加，同时张紧其疼痛部位，并且当患者不再执行明显的任务，模仿他们日常生活中的持续疼痛时，它们的疼痛在紧张后仍然升高。当患者在fMRI扫描期间执行此任务时，在整个“疼痛矩阵”中观察到增加的活化，包括丘脑和岛状，躯体感觉，扣带，前额叶和眶额叶皮质的区域。在肌肉紧张终止后，如使用连续定量疼痛评分所报道的，疼痛保持升高，并且在前岛，扣带和躯体感觉皮层中，fMRI激活同样保持升高。背侧前扣带皮质的激活与张力期患者的疼痛评分呈线性关系。只有正确的前额叶在持续疼痛期间显示活化和疼痛评分之间的相关性。当受试者重复任务而不提供持续的疼痛评分时，观察到的激活模式是相似的。这些结果描绘了大脑区域介导慢性疼痛的感觉，而不是急性实验性疼痛，并提供了一种检查这种疾病的脑机制的新方法。

5. 发明申请

WO2013148279A1 METHODS AND SYSTEMS FOR UTILIZING CARBIDE LIME 审中-公开
标题翻译：利用碳化物极限的方法和系统
公开(公告)号：WO2013148279A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/031670
申请日：2013-03-14
申请人： CALERA CORPORATION , DEVENNEY, Martin , FERNANDEZ, Miguel , CHEN, Irvin , CALAS, Guillaume
发明人： DEVENNEY, Martin , FERNANDEZ, Miguel , CHEN, Irvin , CALAS, Guillaume
IPC分类号： C08B3/26 , C04B11/28 , C01D7/38
CPC分类号： C04B7/345 , C01F11/182 , C01F11/183 , C01F11/185 , C01P2004/61 , C01P2006/80 , C04B2/005 , C04B7/36 , C04B28/10 , C04B2111/00758 , Y02P40/18
摘要： Methods and systems are provided for producing a carbonate precipitation material comprising stable or reactive vaterite from carbide lime that provides both a source of divalent cations (Ca divalent cations, Mg divalent cations, etc.) and a source of proton removing agent. A method of forming drywall, comprising a) contacting an aqueous solution comprising carbide lime with carbon dioxide from an industrial process; b) producing a precipitation material comprising reactive vaterite; c) setting and hardening the precipitation material by transforming the reactive vaterite to aragonite, and d) forming the drywall.
摘要翻译：提供了用于生产碳酸盐沉淀材料的方法和系统，该碳酸盐沉淀材料包含来自碳酸钙的稳定或反应性的球霰石，其提供二价阳离子源（Ca二价阳离子，Mg二价阳离子等）和质子去除剂源。一种形成干式墙体的方法，包括：a）将来自工业方法的包含碳化石灰的水溶液与二氧化碳接触; b）制备包含反应性球霰石的沉淀物; c）通过将反应性球霰石转化为文石来沉淀和硬化沉淀物质，以及d）形成干墙。

6. 发明申请

WO2012159079A1 ASSAY TO DETERMINE LRRK2 ACTIVITY IN PARKINSON'S DISEASE 审中-公开
标题翻译：测定PARKINSON疾病中的LRRK2活性
公开(公告)号：WO2012159079A1
公开(公告)日：2012-11-22
申请号：PCT/US2012/038696
申请日：2012-05-18
申请人： THE PARKINSON'S INSTITUTE , NICHOLS, Jeremy , SCHUELE, Birgitt
发明人： NICHOLS, Jeremy , SCHUELE, Birgitt
IPC分类号： C07K16/40 , G01N33/53
CPC分类号： C12N9/12 , A61K35/30 , A61K35/545 , C07K16/40 , C07K16/44 , C12N5/0623 , C12N5/0696 , C12N2510/00 , C12Y207/11001 , G01N33/573 , G01N33/577 , G01N33/6896 , G01N2333/912 , G01N2333/91205 , G01N2440/14 , G01N2800/2835 , G01N2800/52
摘要： Disclosed are novel phosphorylation sites identified in LRRK2 and associated with Parkinson's Disease, antibodies that specifically bind to said novel phosphorylation sites, and laboratory and clinical uses thereof.
摘要翻译：公开了在LRRK2中鉴定并与帕金森病相关的新型磷酸化位点，特异性结合所述新型磷酸化位点的抗体及其实验室和临床应用。

7. 发明申请

WO2011149937A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：杂环化合物及其用途
公开(公告)号：WO2011149937A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/037742
申请日：2011-05-24
申请人： INTELLIKINE, INC. , REN, Pingda , LIU, Yi , LI, Liansheng , CHAN, Katrina , WILSON, Troy, Edward , CAMPBELL, Simon, Fraser
发明人： REN, Pingda , LIU, Yi , LI, Liansheng , CHAN, Katrina , WILSON, Troy, Edward , CAMPBELL, Simon, Fraser
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： C07D471/04
摘要： Heterocyclic entities that modulate PI3 kinase activity, pharmaceutical compositions containing the heterocyclic entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein.
摘要翻译：本文描述了调节PI3激酶活性的杂环实体，含有所述杂环实体的药物组合物以及使用这些化学实体治疗与PI3激酶活性相关的疾病和病症的方法。

8. 发明申请

WO2011038364A1 METHOD FOR PRODUCING 3-HYDROXYPROPIONIC ACID AND OTHER PRODUCTS 审中-公开
标题翻译：生产3-羟基丙酸及其他产品的方法
公开(公告)号：WO2011038364A1
公开(公告)日：2011-03-31
申请号：PCT/US2010/050436
申请日：2010-09-27
申请人： OPX BIOTECHNOLOGIES, INC. , THE REGENTS OF THE UNIVERSITY OF COLORADO , LYNCH, Michael, D. , GILL, Ryan, T. , WARNECKE-LIPSCOMB, Tanya
发明人： LYNCH, Michael, D. , GILL, Ryan, T. , WARNECKE-LIPSCOMB, Tanya
IPC分类号： C12N15/74 , C12P7/18 , C12N1/20
CPC分类号： C12P11/00 , A61L15/24 , C12M47/12 , C12N9/0008 , C12N9/12 , C12N9/16 , C12N15/63 , C12P7/40 , C12P7/42 , C12P7/52 , C12P7/62 , C12Y102/04001 , C12Y207/00 , C12Y301/02 , Y02P20/52 , C08L33/08
摘要： This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes 3- hydroxypropionic acid.
摘要翻译：本发明涉及代谢工程化的微生物菌株，例如细菌菌株，其中丙二酰辅酶A用于生产化学产品（其包括3-羟基丙酸）的利用率增加。

9. 发明申请

WO2013148216A1 ELECTROCHEMICAL HYDROXIDE SYSTEMS AND METHODS USING METAL OXIDATION 审中-公开
标题翻译：电化学氢氧化物系统和使用金属氧化的方法
公开(公告)号：WO2013148216A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/031064
申请日：2013-03-13
申请人： CALERA CORPORATION , GILLIAM, Ryan, J. , BOGGS, Bryan , SELF, Kyle , LECLERC, Margarete, K. , GORER, Alexander , WEISS, Michael, Joseph , MILLER, John, Hunter , MOHANTA, Samaresh
发明人： GILLIAM, Ryan, J. , BOGGS, Bryan , SELF, Kyle , LECLERC, Margarete, K. , GORER, Alexander , WEISS, Michael, Joseph , MILLER, John, Hunter , MOHANTA, Samaresh
IPC分类号： C25B15/08 , C25B9/00
CPC分类号： C25B9/00 , C25B11/02 , C25B15/08
摘要： There are provided methods and systems for an electrochemical cell including an anode and a cathode where the anode is contacted with a metal ion that converts the metal ion from a lower oxidation state to a higher oxidation state. The metal ion in the higher oxidation state is reacted with hydrogen gas, an unsaturated hydrocarbon, and/or a saturated hydrocarbon to form products.
摘要翻译：提供了包括阳极和阴极的电化学电池的方法和系统，其中阳极与将金属离子从较低氧化态转化为较高氧化态的金属离子接触。较高氧化态的金属离子与氢气，不饱和烃和/或饱和烃反应形成产物。

10. 发明申请

WO2013090469A1 DETECTION AND MEASUREMENT OF TISSUE-INFILTRATING LYMPHOCYTES 审中-公开
标题翻译：组织浸润淋巴细胞的检测和测量
公开(公告)号：WO2013090469A1
公开(公告)日：2013-06-20
申请号：PCT/US2012/069310
申请日：2012-12-12
申请人： SEQUENTA, INC. , FAHAM, Malek , KLINGER, Mark
发明人： FAHAM, Malek , KLINGER, Mark
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/06 , G01N33/5091 , G01N33/5094
摘要： The present invention is drawn to methods for measuring numbers, levels, and/or ratios of cells, such as lymphocytes, infiltrated into a solid tissue, such as a tumor or a tissue affected by an autoimmune disease, and to methods for making patient prognoses based on such measurements. In one aspect, methods of the invention comprise sorting lymphocytes from an accessible tissue, such as peripheral blood, into functional subsets, such as cytotoxic T cells and regulatory T cells, and generating clonotype profiles of each subset. An inaccessible disease- affected tissue is sampled and one or more clonotype profiles are generated. From the latter clonotype profiles, levels lymphocytes in each of the functional subsets are determined in the disease-affected tissue by their clonotypes, which are identified from lymphocytes sorted into subsets from the accessible tissue.
摘要翻译：本发明涉及用于测量浸润到固体组织例如肿瘤或受自身免疫性疾病影响的组织的细胞例如淋巴细胞的数量，水平和/或比率的方法，以及用于产生患者预后的方法基于这样的测量。在一个方面，本发明的方法包括将淋巴细胞从诸如外周血的可及组织分选成功能性亚类，例如细胞毒性T细胞和调节性T细胞，以及产生每个子集的克隆型谱。对不能接近的疾病影响的组织进行采样，并产生一个或多个克隆型谱。从后一种克隆型谱中，通过其克隆型在疾病影响组织中测定每个功能亚类中的淋巴细胞水平，所述克隆型从从可及组织分类为亚群的淋巴细胞中鉴定。

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