专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2016203267A2 DIAGNOSIS AND TREATMENT OF INFECTIOUS DISEASE 审中-公开
标题翻译：诊断和治疗感染性疾病
公开(公告)号：WO2016203267A2
公开(公告)日：2016-12-22
申请号：PCT/GB2016/051831
申请日：2016-06-17
申请人： CAMBRIDGE ENTERPRISE LIMITED
发明人： LEE, Helen , POWELL, Michael
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/689 , C12Q2600/106
摘要： Methods are described for determining whether a subject suffering from, or suspected of suffering from, an infectious disease caused by a microbe is infected with a strain of the microbe that is susceptible to an antimicrobial agent, where there exist different strains of the microbe that are resistant to the antimicrobial agent. The methods comprise determining whether nucleic acid of the strain of the microbe infecting the subject comprises wild-type nucleotide sequence at a conserved nucleotide position at which mutation is associated with resistance to the antimicrobial agent in nucleic acid of the different resistant strains. The methods are particularly applicable for determining whether a subject suffering from, or suspected of suffering from, Gonorrhoea is infected with a strain of Neisseria gonorrhoeae that is susceptible to an antimicrobial agent. Kits for use in the methods are described, as well as methods for treatment of infectious disease. Methods for reducing the prevalence of resistance of microbes causing infectious disease to antimicrobial agents are also described.
摘要翻译：描述了用于确定患有或怀疑患有由微生物引起的感染性疾病的受试者是否感染易受抗微生物剂影响的微生物菌株的方法，其中存在微生物的不同菌株抗菌剂。所述方法包括确定感染受试者的微生物菌株的核酸是否包含在不同抗性菌株的核酸中与抗微生物剂的抗性相关的保守核苷酸位置处的野生型核苷酸序列。该方法特别适用于确定患有或怀疑患有淋病的受试者是否感染易感于抗微生物剂的淋病奈瑟氏球菌菌株。描述了用于该方法的试剂盒，以及用于治疗感染性疾病的方法。还描述了将引起感染性疾病的微生物的抗性流行率降低到抗微生物剂的方法。

2. 发明申请

WO2016124926A9 ANTIMICROBIAL FIBERS AND COMPOSITIONS 审中-公开
公开(公告)号：WO2016124926A9
公开(公告)日：2016-08-11
申请号：PCT/GB2016/050253
申请日：2016-02-03
申请人： MATOKE HOLDINGS LIMITED
发明人： PATTON, Thomas , BRENNAN, James , STAPLES, Ian , ELDER, Iain , CALLAGHAN, Annette , DRYDEN, Matthew , BARRETT, John, Reginald , KERSHAW, David , SALIB, Rami
IPC分类号： A61L15/24 , A61L15/26 , A61L15/40 , A61L15/42 , A61L15/46
摘要： Fibers for generating antimicrobial activity are described. The fibers comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and an unrefined natural substance that includes a substrate for the enzyme, wherein the enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the unrefined natural substance. In the presence of sufficient free water, the enzyme converts the substrate to release hydrogen peroxide, which is effective against a wide range of microbes. Wound dressings and compositions comprising the fibers are also described, as is use of the fibers, wound dressings and compositions, particularly for wound healing.

3. 发明申请

WO2007015107A2 THERAPEUTIC AGENT 审中-公开
标题翻译：治疗剂
公开(公告)号：WO2007015107A2
公开(公告)日：2007-02-08
申请号：PCT/GB2006/002934
申请日：2006-08-04
申请人： HAEMOSTATIX LIMITED , GOODALL, Alison, Helena , TAYLOR, Sarah, Margaret , WALKER, Greg, Francis
发明人： GOODALL, Alison, Helena , TAYLOR, Sarah, Margaret , WALKER, Greg, Francis
IPC分类号： A61K47/48
CPC分类号： A61K47/6927 , A61K47/643 , A61K47/65
摘要： Therapeutic agents suitable for use as artificial platelets are described. The agents comprise a fibrinogen binding precursor bound to an insoluble carrier, wherein the fibrinogen binding precursor can be converted by a wound site specific agent, such as thrombin, to a fibrinogen binding component bound to the carrier. The fibrinogen binding component has increased ability to bind fibrinogen compared to the fibrinogen binding precursor. The agents may be used to treat patients with deficiencies in their own platelets, such as hereditary or acquired defects of platelet numbers (thrombocytopenia) or function (thrombasthenia).
摘要翻译：描述适合用作人造血小板的治疗剂。这些试剂包含与不溶性载体结合的纤维蛋白原结合前体，其中纤维蛋白原结合前体可以被伤口部位特异性试剂如凝血酶转化成与载体结合的纤维蛋白原结合成分。与纤维蛋白原结合前体相比，纤维蛋白原结合组分具有增加的结合纤维蛋白原的能力。这些药物可用于治疗患有自身血小板缺乏症的患者，例如血小板数目（血小板减少症）或功能障碍（血小板减少症）的遗传性或获得性缺陷。

4. 发明申请

WO2006043095A2 MONITORING ENZYME-SUBSTRATE REACTIONS 审中-公开
标题翻译：监测酶 - 底物反应
公开(公告)号：WO2006043095A2
公开(公告)日：2006-04-27
申请号：PCT/GB2005/004089
申请日：2005-10-21
申请人： E2V TECHNOLOGIES (UK) LIMITED , GILBERT, Richard
发明人： GILBERT, Richard
IPC分类号： C12Q1/37 , C12Q1/42 , C12Q1/48
CPC分类号： C12Q1/485 , C12Q1/37 , C12Q1/42
摘要： Methods of electrochemically monitoring enzyme-substrate reactions are described. The substrate is tagged with a redox-active group. Modification of the substrate by an enzyme can then be monitored electrochemically by means of the redox-active group. Such methods can be used in particular to monitor non-redox enzyme reactions, such as kinase, phosphatase, or protease reactions, although redox enzyme reactions can also be monitored by such methods. Screening assays to identify modulators of enzyme activity or new enzyme substrates are also described.
摘要翻译：描述了电化学监测酶底物反应的方法。底物标有氧化还原活性基团。然后可以借助氧化还原活性基团电化学监测通过酶修饰底物。这些方法可以特别用于监测非氧化还原酶反应，例如激酶，磷酸酶或蛋白酶反应，尽管还可以通过这些方法监测氧化还原酶反应。还描述了鉴定酶活性调节剂或新酶底物的筛选试验。

5. 发明申请

WO2006005940A2 MONOCLONAL ANTIBODY 审中-公开
标题翻译：单克隆抗体
公开(公告)号：WO2006005940A2
公开(公告)日：2006-01-19
申请号：PCT/GB2005/002727
申请日：2005-07-13
申请人： RIVERSIDE BIOSCIENCES LIMITED , COLLINS, Peter , ROBERSTON, Archie
发明人： COLLINS, Peter , ROBERSTON, Archie
IPC分类号： C07K16/00
CPC分类号： G01N33/689 , C07K16/28
摘要： A monoclonal antibody that recognises glucose transporter 2 (GLUT2) is described, as well as a hybridoma that produces the antibody. The antibody may be used to identify or isolate embryonic or fetal cells, for example in an in vitro method of prenatal diagnosis.
摘要翻译：描述识别葡萄糖转运蛋白2（GLUT2）的单克隆抗体，以及产生抗体的杂交瘤。抗体可用于鉴定或分离胚胎或胎儿细胞，例如在体外产前诊断方法中。

6. 发明申请

WO2005056571A1 IMPROVED SYNTHESIS OF 2-SUBSTITUTED ADENOSINES 审中-公开
标题翻译：改进的2-取代腺苷的合成
公开(公告)号：WO2005056571A1
公开(公告)日：2005-06-23
申请号：PCT/GB2004/005090
申请日：2004-12-03
申请人： CAMBRIDGE BIOTECHNOLOGY LIMITED , BROWN, Giles, Albert , SAVORY, Edward, Daniel , OUZMAN, Jacqueline, Valerie, Anne , STODDART, Alison, Margaret
发明人： BROWN, Giles, Albert , SAVORY, Edward, Daniel , OUZMAN, Jacqueline, Valerie, Anne , STODDART, Alison, Margaret
IPC分类号： C07H1/00
CPC分类号： C07H1/00 , C07H19/16
摘要： Synthesis of 2-substituted adenosines of formula (I) using 2-nitro pentabenzoyl adenosine, or 2-nitro pentaacetyl adenosine, as intermediate is described: Formula (I) wherein R = C 1-6 alkoxy (straight or branched), a phenoxy group (unsubstituted, or mono-, or di-substituted by halo, amino, CF 3 -, cyano, nitro, C 1-6 alkyl, or C 1-6 alkoxy), a benzyloxy group (unsubstituted, or mono-, or di-substituted by halo, amino, CF 3 -, cyano, nitro, C 1-6 alkyl, or C 1-6 alkoxy), or a benzoyl group (unsubstituted, or mono-, or di-substituted by halo, amino, CF 3 -,cyano, nitro, C 1-6 alkyl, or C 1-6 alkoxy). The methods provide improved yield and purity of product.
摘要翻译：描述了使用2-硝基五苯甲酰基腺苷或2-硝基五乙酰基腺苷作为中间体合成式（I）的2-取代腺苷：式（I）其中R = C 1-6烷氧基（直链或支链），苯氧基（未取代的，或被卤素，氨基，CF 3 - ，氰基，硝基，C 1-6烷基或C 1-6烷氧基单取代或二取代），苄氧基卤素，氨基，CF 3 - ，氰基，硝基，C 1-6烷基或C 1-6烷氧基）或苯甲酰基（未取代的，或被卤素，氨基，CF 3 - ，氰基，硝基， C 1-6烷基或C 1-6烷氧基）。这些方法提供了产品的产率和纯度的提高。

7. 发明申请

WO2003025224A1 DIFFERENTIAL GENE EXPRESSION IN SCHIZOPHRENIA 审中-公开
标题翻译：精神分裂症患者的差异基因表达
公开(公告)号：WO2003025224A1
公开(公告)日：2003-03-27
申请号：PCT/GB2002/004285
申请日：2002-09-20
申请人： THE BABRAHAM INSTITUTE , BAHN, Sabine
发明人： BAHN, Sabine
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/92
摘要： Evidence for up-regulation of apolipoprotein L1, L2 and L4 gene expression in the prefrontal cortex of schizophrenia brains is presented. Methods of diagnosis of schizophrenia and methods of identifying compounds with potential activity in the prevention, treatment, or amelioration of schizophrenia are described.
摘要翻译：提出了在精神分裂症脑的前额皮质中上调载脂蛋白L1，L2和L4基因表达的证据。描述了精神分裂症的诊断方法和鉴定在预防，治疗或改善精神分裂症方面具有潜在活性的化合物的方法。

8. 发明申请

WO2013136083A1 METHODS FOR OBTAINING LIQUID FROM A SOLID PHASE 审中-公开
标题翻译：从固体相中获取液体的方法
公开(公告)号：WO2013136083A1
公开(公告)日：2013-09-19
申请号：PCT/GB2013/050653
申请日：2013-03-15
申请人： CAMBRIDGE ENTERPRISE LIMITED
发明人： CHUA, Yii Leng
IPC分类号： C12N15/10
CPC分类号： B01D15/20 , B01D11/02 , B01D11/0219 , B01D15/00 , B01D15/02 , B01D15/24 , B01D15/245 , B01D15/26 , B01D17/02 , B01D17/0202 , C12N15/1006 , C12N15/101 , C12N15/1017
摘要： A method for obtaining a liquid from a porous solid phase is described. The method comprises forming a liquid seal at a first end of a porous solid phase to which a liquid is bound, wherein liquid of the liquid seal is immiscible with the liquid bound to the solid phase, and applying a pressure differential across the porous solid phase to cause the immiscible liquid to move through the porous solid phase towards a second end of the porous solid phase, thereby displacing the liquid bound to the porous solid phase towards the second end and releasing this liquid from the second end. Recovery of liquid from the solid phase using such methods is increased compared with corresponding methods in which no liquid seal is formed. In preferred embodiments, the liquid used to form the liquid seal is a mineral oil. The methods have particular application in nucleic acid extractions which utilise capture of nucleic acid to a solid phase. Kits and apparatus for performing the methods are also described.
摘要翻译：描述了从多孔固相中获得液体的方法。该方法包括在多孔固相的第一端形成液体密封，液体与液体结合在一起，其中液体密封液体与与固相结合的液体不混溶，并在多孔固相上施加压力差以使不相容的液体朝向多孔固相的第二端移动通过多孔固相，从而将结合到多孔固相的液体移向第二端并从第二端释放该液体。与其中没有形成液体密封的相应方法相比，使用这种方法从固相中回收液体。在优选的实施方案中，用于形成液体密封的液体是矿物油。该方法在利用核酸捕获到固相的核酸提取中具有特别的应用。还描述了用于执行该方法的套件和装置。

9. 发明申请

WO2009007726A2 ABNORMAL BLOOD CONDITIONS 审中-公开
标题翻译：异常的血液情况
公开(公告)号：WO2009007726A2
公开(公告)日：2009-01-15
申请号：PCT/GB2008/002366
申请日：2008-07-10
申请人： EUROPEAN CARDIOVASCULAR GENETICS FOUNDATION , OUWEHAND, Willem , GOODALL, Alison, Helena
发明人： OUWEHAND, Willem , GOODALL, Alison, Helena
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： Methods for diagnosing whether a subject has, or is at risk of, an abnormal blood condition are described. The methods comprises determining the genotype of the subject at a single nucleotide polymorphism (SNP) position in a gene associated with platelet response, wherein an allele of the SNP is associated with enhanced platelet response. Probes and kits for use in such methods, and methods of prophylaxis or treatment of abnormal blood conditions are also described.
摘要翻译：描述了用于诊断受试者是否具有或有风险的血液异常的方法。该方法包括在与血小板反应相关的基因中的单核苷酸多态性（SNP）位置确定受试者的基因型，其中SNP的等位基因与增强的血小板反应相关。还描述了用于这种方法的探针和试剂盒，以及预防或治疗异常血液状况的方法。

10. 发明申请

WO2008044038A2 CONJUGATES FOR USE IN ANALITE DETECTION 审中-公开
标题翻译：用于模拟检测的结合
公开(公告)号：WO2008044038A2
公开(公告)日：2008-04-17
申请号：PCT/GB2007/003875
申请日：2007-10-11
申请人： E2V BIOSENSORS LIMITED , GILBERT, Richard
发明人： GILBERT, Richard
IPC分类号： G01N21/65 , G01N33/58
CPC分类号： G01N33/54373 , G01N21/658 , G01N33/58
摘要： Conjugates for use in analytical techniques for detection of an analyte in an analyte sample are described. The conjugates comprise a Raman-active chromophore covalently coupled to a binding moiety, wherein the binding moiety is: (i) a metal surface binding peptide or peptide analogue; (ii) a metal surface binding nucleic acid or nucleic acid analogue; (iii) an aptamer; or (iv) a binding partner for an analyte capture reagent. Conjugates of the invention may be used in Raman spectroscopy, especially surface enhanced Raman spectroscopy (SERS) or surface enhanced resonance Raman spectroscopy (SERRS).
摘要翻译：描述了用于检测分析物样品中分析物的分析技术的共轭物。共轭物包含与结合部分共价偶联的拉曼活性发色团，其中结合部分是：（i）金属表面结合肽或肽类似物; （ii）金属表面结合核酸或核酸类似物; （iii）适体; 或（iv）分析物捕获试剂的结合配偶体。本发明的共轭物可用于拉曼光谱，特别是表面增强拉曼光谱（SERS）或表面增强共振拉曼光谱（SERRS）。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式