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1. 发明申请

WO2021236922A1 ZWITTERIONIC POLYMER PARTICLE COMPOSITIONS AND RELATED METHODS 审中-公开
公开(公告)号：WO2021236922A1
公开(公告)日：2021-11-25
申请号：PCT/US2021/033393
申请日：2021-05-20
申请人： WAYNE STATE UNIVERSITY
发明人： CAO, Zhiqiang
IPC分类号： A61K38/00 , A61K47/50 , A61P3/10
摘要： Compositions and methods for oral and/or mucosal administration of a biologically active agent are provided according to aspects of the present disclosure which include: a plurality of particles, wherein each particle has an exterior surface, the exterior surface defining a particle interior, the exterior surface having at least one type of zwitterionic polymer and/or zwitterionic copolymer disposed thereon and/or extending therefrom; and a biologically active agent disposed on the exterior surface and/or in the particle interior, wherein the biologically active agent is or includes a protein, peptide, or dietary supplement. According to particular aspects, compositions and methods for oral and/or mucosal administration of an anti diabetes biological agent, such as insulin and/or an insulin analog.

2. 发明申请

WO2020198734A1 METHODS, COMPOSITIONS RELATING TO TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2020198734A1
公开(公告)日：2020-10-01
申请号：PCT/US2020/025693
申请日：2020-03-30
申请人： THE PENN STATE RESEARCH FOUNDATION
发明人： DINAVAHI, Venkata Saketh Sriram , DORESWAMY, Raghavendra Gowda Chandagalu , ROBERTSON, Gavin P.
IPC分类号： A61K35/17 , A61K45/06 , A61P35/00
摘要： According to aspects of the present disclosure, methods and compositions are provided which relate to treating cancer in a subject in need thereof, including: administering 1) an anti-cancer immune therapeutic agent, and 2) a stimulator of p53 levels and/or p53 activity, as a combination formulation or separately, thereby increasing levels and/or activity of p53, and activating NK cell activity in the cancer, providing therapeutic benefits, converting a "cold tumor" into a "hot tumor" leading to a TME responsive to immunotherapy via tumor cell recognition and killing that is not dependent on T-cell mediated immunity.

3. 发明申请

WO2018209344A1 NSG MICE LACKING MHC CLASS I AND CLASS II 审中-公开
公开(公告)号：WO2018209344A1
公开(公告)日：2018-11-15
申请号：PCT/US2018/032548
申请日：2018-05-14
申请人： THE JACKSON LABORATORY , UNIVERSITY OF MASSACHUSETTS
发明人： BREHM, Michael, A. , WILES, Michael, V. , GREINER, Dale, L. , SHULTZ, Leonard, D.
IPC分类号： A01K67/027
摘要： A NOD.Cg- Prkdc scid H2rg tm1 Wjl /SzJ .(NOD- scid -IL2rϒ null , NSG) mouse which is genetically modified such that the NSG mouse lacks functional major histocompatibility complex I (MHC I) and lacks functional major histocompatibility complex II (MHC II) is provided according to aspects of the present, invention. According to specific aspects the genetically modified NSG mouse, is a NOD.Cg- Prkdc scid H2-K1 tml Bpe H2-Ab1 eml Mvw H2-D1 tml Bpe H2rg tm Wjl /SzJ (NSG -K b D b ) null ( IA null )) mouse, NSG - RIP-DTR ( K b D b ) null ( IA null ) mouse, or a NOD.Cg- B 2 m tml Une PrKdc scid H2 dlAb1-E α H2rg tm1 Wjl /SzJ (NSG- B2M null (IA IE null )) mouse. Human, immune cells and/or human: tumor cells are administered to a genetically modified immunodeficient mouse according to aspects described herein and assays of one or more test substances can be performed using the provided mice.

4. 发明申请

WO2018160712A8 REGENERATING FUNCTIONAL NEURONS FOR TREATMENT OF NEURAL INJURY CAUSED BY DISRUPTION OF BLOOD FLOW 审中-公开
公开(公告)号：WO2018160712A8
公开(公告)日：2018-09-07
申请号：PCT/US2018/020251
申请日：2018-02-28
申请人： THE PENN STATE RESEARCH FOUNDATION
发明人： CHEN, Gong
IPC分类号： A61K38/17 , C12N15/861 , C12N15/11
摘要： Methods of treating the effects of disruption of normal blood flow in the CNS in an individual subject in need thereof are provided according to aspects of the present invention which include administering a therapeutically effective dose of exogenous NeuroDl to an area where normal blood flow has been disrupted. Compositions are provided including 1) a recombinant adeno-associated adenovirus expression vector comprising a glial cell specific promoter operably linked to a nucleic acid encoding a site-specific recombinase and 2) a recombinant adeno-associated adenovirus expression vector comprising a ubiquitous promoter operably linked to a nucleic acid encoding NeuroDl, wherein the nucleic acid encoding NeuroDl is inverted and flanked by two sets of site-specific recombinase recognition sites such that action of the recombinase irreversibly inverts the nucleic acid encoding NeuroDl such that NeuroDl is expressed in a mammalian cell.

5. 发明申请

WO2017176985A1 ISOLATION AND ANALYSIS OF FETAL DNA FROM EXTRAVILLOUS TROPHOBLAST CELLS RETRIEVED FROM THE ENDOCERVICAL CANAL 审中-公开
标题翻译：从宫颈管上皮细胞回收的胎盘DNA的分离与分析
公开(公告)号：WO2017176985A1
公开(公告)日：2017-10-12
申请号：PCT/US2017/026335
申请日：2017-04-06
申请人： WAYNE STATE UNIVERSITY
发明人： DREWLO, Sascha , ARMANT, Randall, D.
IPC分类号： C12N15/10 , C12Q1/68 , G01N33/50
摘要： Methods of isolating DNA of a fetus of an ongoing pregnancy are provided according to the present invention which include obtaining a maternal endocervical sample containing maternal cells and fetal extravillous trophoblast cells from a pregnant subject; isolating fetal extravillous trophoblast cells from the maternal endocervical sample, producing isolated fetal extravllous trophoblast cells contaminated with maternal DNA; lysing the isolated fetal extravillous trophoblast cells; isolating fetal nuclei from the lysed fetal extravillous trophoblast cells, producing isolated fetal nuclei, thereby removing at least a portion of the contaminating maternal DNA; and purifying genomic DNA from the isolated fetal nuclei, producing purified fetal genomic DNA. The purified fetal genomic DNA can be assayed to determine a characteristic of a genomic DNA sequence of the purified fetal genomic DNA, thereby determining a characteristic of DNA of a fetus of an ongoing pregnancy.
摘要翻译：根据本发明提供了分离持续妊娠胎儿的DNA的方法，其包括获得含有来自怀孕受试者的母体细胞和胎儿绒毛外滋养层细胞的母体宫颈内膜样品; 从母体宫颈内样品中分离胎儿绒毛外滋养层细胞，产生被母体DNA污染的分离的胎儿外绒毛滋养层细胞; 裂解分离的胎儿绒毛外滋养层细胞; 从裂解的胎儿绒毛外滋养细胞分离胎儿核，产生分离的胎儿细胞核，由此除去至少一部分污染的母体DNA; 并从分离的胎儿细胞核中纯化基因组DNA，产生纯化的胎儿基因组DNA。可以测定纯化的胎儿基因组DNA以确定纯化的胎儿基因组DNA的基因组DNA序列的特征，从而确定正在进行的妊娠的胎儿DNA的特征。

6. 发明申请

WO2016205523A1 GENETICALLY MODIFIED NON-HUMAN ANIMALS AND METHODS RELATING TO COMPLEMENT DEPENDENT CYTOTOXICITY 审中-公开
标题翻译：遗传修饰的非人动物及相关依赖性细胞毒性相关方法
公开(公告)号：WO2016205523A1
公开(公告)日：2016-12-22
申请号：PCT/US2016/037882
申请日：2016-06-16
申请人： THE JACKSON LABORATORY , UNIVERSITY OF MASSACHUSETTS
发明人： SHULTZ, Leonard, D. , VERMA, Mohit, Kumar , GREINER, Dale, L. , BREHM, Michael, A.
IPC分类号： A01K67/027 , C07K14/705 , G01N33/15
CPC分类号： A01K67/0275 , A01K2217/07 , A01K2227/105 , A01K2267/0387 , A61K49/0008 , C07K14/472 , C12N15/907
摘要： The present invention relates generally to genetically modified non-human animals and immunodeficient non-human animals characterized by restored complement-dependent cytotoxicity, as well as methods and compositions for assessment of therapeutic antibodies in the genetically modified immunodeficient non- human animals. In specific aspects, the present invention relates to immunodeficient non-obese diabetic (NOD), A/J, A/He, AKR, DBA/2, NZB/BIN, B10.D2/oSn and other mouse strains genetically modified to restore complement-dependent cytotoxicity which is lacking in the unmodified immunodeficient mice. In further specific aspects, the present invention relates to NOD.Cg- Prkdc scid IL2rg tm1Wjl /SzJ (NSG), NOD. Cg- Rag1 tm1Mom IL 2rg tmlWjl /SzJ (NRG) and NOD.Cg- Prkdc scid IL2rg tm1Sug /JicTAc (NOG) mice genetically modified to restore complement-dependent cytotoxicity which is lacking in unmodified NSG, NRG and NOG mice. Methods for assessment of therapeutic antibodies or putative therapeutic antibodies in the genetically modified immunodeficient mice characterized by an intact complement system are provided according to specific aspects of the present invention.
摘要翻译：本发明一般涉及以遗传修饰的免疫缺陷型非人类动物评估治疗性抗体为基础的遗传修饰的非人类动物和以恢复的补体依赖性细胞毒性为特征的免疫缺陷型非人类动物，以及用于评估治疗性抗体的方法和组合物。在具体方面，本发明涉及免疫缺陷型非肥胖性糖尿病（NOD），A / J，A / He，AKR，DBA / 2，NZB / BIN，B10D2 / oSn和其他经遗传修饰以恢复补体的小鼠在未修饰的免疫缺陷小鼠中缺乏依赖性细胞毒性。在其它具体方面，本发明涉及NOD.Cg-Prkdc scid IL2rg tm1Wj1 / SzJ（NSG），NOD。 Cg-Rag1 tm1Mom IL2rg tmlWj1 / SzJ（NRG）和NOD.Cg-Prkdc scid IL2rg tm1Sug / JicTAc（NOG）小鼠遗传修饰以恢复未修饰的NSG，NRG和NOG小鼠缺乏的补体依赖性细胞毒性。根据本发明的具体方面提供了用完整的补体系统表征的遗传修饰的免疫缺陷小鼠中治疗性抗体或推定的治疗性抗体的评估方法。

7. 发明申请

WO2016138528A1 METHODS AND COMPOSITIONS RELATING TO BIOCOMPATIBLE IMPLANTS 审中-公开
标题翻译：与植物植入相关的方法和组成
公开(公告)号：WO2016138528A1
公开(公告)日：2016-09-01
申请号：PCT/US2016/020099
申请日：2016-02-29
申请人： WAYNE STATE UNIVERSITY
发明人： CAO, Zhiqiang , WANG, Wei , YUE, Zhanguo
IPC分类号： A61K9/50
CPC分类号： A61K9/5036 , A61K9/0024 , A61K9/06 , A61K47/34 , A61K47/36 , A61L27/52 , A61L27/54 , C12N5/0677 , C12N2533/30 , C12N2533/74
摘要： Biocompatible hydrogel compositions according to aspects of the present invention are provided wherein the biocompatible hydrogel composition is or includes a physical hydrogel, a chemical hydrogel or both a physical hydrogel and a chemical hydrogel, along with biocompatible hydrogel compositions encapsulating a therapeutic agent and methods of use thereof.
摘要翻译：提供了根据本发明方面的生物相容性水凝胶组合物，其中生物相容性水凝胶组合物是包含物理水凝胶，化学水凝胶或物理水凝胶和化学水凝胶以及包封治疗剂的生物相容性水凝胶组合物和使用方法它们。

8. 发明申请

WO2016057894A1 AMMONIA-BASED THERMOELECTROCHEMICAL SYSTEMS AND METHODS 审中-公开
标题翻译：基于氨基酸的热电化学系统和方法
公开(公告)号：WO2016057894A1
公开(公告)日：2016-04-14
申请号：PCT/US2015/054882
申请日：2015-10-09
申请人： THE PENN STATE RESEARCH FOUNDATION
发明人： ZHANG, Fang , LIU, Jia , YANG, Wulin , LOGAN, Bruce
IPC分类号： H01M2/14
CPC分类号： H01M8/182 , H01G9/21 , H01M4/366 , H01M4/38 , H01M4/625 , H01M8/188 , H01M14/00 , H01M2300/0002 , H01M2300/0005 , Y02E60/528
摘要： Thermally regenerative ammonia-based battery systems and methods of their use to produce electricity are provided according to aspects described herein in which ammonia is added into an anolyte to charge the battery, producing potential between the electrodes. At the anode, metal corrosion occurs in the ammonia solution to form an ammine complex of the corresponding metal, while reduction of the same metal occurs at the cathode. After the discharge of electrical power produced, ammonia is separated from the anolyte which changes the former anolyte to catholyte, and previous anode to cathode by deposition of the metal. When ammonia is added to the former catholyte to make it as anolyte, the previous cathode becomes the anode. This alternating corrosion/deposition cycle allows the metal of the electrodes to be maintained in closed- loop cycles, and waste heat energy is converted to electricity by regeneration of ammonia, such as by distillation.
摘要翻译：根据本文所述的方面提供热再生氨基电池系统及其用于产生电力的方法，其中将氨加入阳极电解液中以对电池充电，在电极之间产生电位。在阳极处，在氨溶液中发生金属腐蚀，形成相应金属的氨络合物，同时在阴极发生相同金属的还原。在产生的电力放电之后，氨从阳极电解液分离，阳极电解液通过金属沉积将前者的阳极电解液变成阴极电解液，以及先前的阳极到阴极。当将氨加入到前阴极电解液中以使其成为阳极电解液时，前一个阴极成为阳极。这种交替的腐蚀/沉积循环允许电极的金属保持在闭环循环中，并且例如通过蒸馏通过再生氨将废热能转化为电。

9. 发明申请

WO2013112743A1 BIOMIMETIC SURFACES FOR ENHANCING MUSCULOSKELETAL REGENERATION 审中-公开
标题翻译：用于增强肌球蛋白再生的生物表面
公开(公告)号：WO2013112743A1
公开(公告)日：2013-08-01
申请号：PCT/US2013/022999
申请日：2013-01-24
申请人： THE PENN STATE RESEARCH FOUNDATION , LAKHTAKIA, Akhlesh , DONAHUE, Henry, J.
发明人： LAKHTAKIA, Akhlesh , DONAHUE, Henry, J.
IPC分类号： A61L27/02 , A61L27/42 , A61F2/28
CPC分类号： A61F2/30767 , A61F2002/3084 , A61F2310/00293 , A61L27/32 , A61L31/086 , A61L2400/12 , A61L2420/02 , A61L2430/02
摘要： Bone transplant compositions, soft musculoskeletal tissue implants, and orthopedic device implants are provided according to the present invention which include an exterior surface, the exterior surface at least partially coated with an applied hydroxyapatite coating, the applied hydroxyapatite coating characterized by an average overall thickness in the range of 45-70 nm, inclusive, more preferably 48-65 nm, inclusive, and still more preferably, 50-60 nm, inclusive. Methods of production and use of bone transplant compositions, soft musculoskeletal tissue implants, and orthopedic device implants according to the present invention are provided herein.
摘要翻译：提供根据本发明的骨移植组合物，软肌肉骨骼组织植入物和矫形装置植入物，其包括外表面，外表面至少部分地涂覆有施用的羟基磷灰石涂层，所施用的羟基磷灰石涂层的特征在于平均总厚度 45-70nm的范围，更优选为48-65nm，进一步优选为50-60nm。本文提供了根据本发明的骨移植组合物，软肌肉骨骼组织植入物和矫形装置植入物的生产和使用方法。

10. 发明申请

WO2013110026A1 COMPOSITIONS AND METHODS RELATING TO LYME DISEASE 审中-公开
标题翻译：与LYME疾病有关的组合物和方法
公开(公告)号：WO2013110026A1
公开(公告)日：2013-07-25
申请号：PCT/US2013/022379
申请日：2013-01-21
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION , RUSSELL, Theresa, M. , JOHNSON, Barbara, J.B.
发明人： RUSSELL, Theresa, M. , JOHNSON, Barbara, J.B.
IPC分类号： G01N33/68 , C07K14/195 , G01N33/50
CPC分类号： G01N33/573 , C07K16/12 , C07K2317/32 , G01N33/56911 , G01N33/581 , G01N33/6863 , G01N33/6869 , G01N2333/20 , G01N2333/952 , G01N2469/10 , G01N2469/20 , G01N2800/26 , G01N2800/52 , Y02A50/57
摘要： Compositions and methods of the present invention relating to B. burgdorferi HtrA sensu lato (BbHtrA) protease activity, its substrates, cleavage products, biological effects and use in detection, diagnosis and/or treatment of Lyme disease are provided.
摘要翻译：本发明的组合物和方法涉及Burgdorferi HtrA感染（BbHtrA）蛋白酶活性，其底物，裂解产物，生物学效应以及在莱姆病的检测，诊断和/或治疗中的应用。

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