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1. 发明申请

WO2017004454A1 USE OF CHLOROQUINE AND CLEMIZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATORY AND CANCEROUS CONDITIONS 审中-公开
标题翻译：氯胺酮和CLEMIZOLE化合物用于治疗炎症和致癌条件的应用
公开(公告)号：WO2017004454A1
公开(公告)日：2017-01-05
申请号：PCT/US2016/040566
申请日：2016-06-30
申请人： EIGER GROUP INTERNATIONAL, INC.
发明人： GLENN, Jeffrey, S. , PHAM, Edward, A.
IPC分类号： C07D451/02 , C07D403/06
CPC分类号： A61K31/4184 , A61K31/4706 , A61K45/06 , A61P1/16 , A61P29/00 , A61P35/00 , C07D215/46 , C07D235/14
摘要： Disclosed herein are methods for use of R-chloroquine or clemizole or combinations of R- chloroquine and clemizole for the treatment of a subject in need thereof. Uses include methods of treating inflammatory' conditions, treating liver cancer or reducing the risk of developing liver cancer in a subject. Uses also include methods of treating non-alcoholic steatohepatitis in a subject.
摘要翻译：本文公开了使用R-氯喹或克立咪唑或R-氯喹和克立咪唑的组合来治疗有此需要的受试者的方法。用途包括治疗炎症状况，治疗肝癌或降低患者发生肝癌风险的方法。用途还包括在受试者中治疗非酒精性脂肪性肝炎的方法。

2. 发明申请

WO2016205820A1 SYNTHESIS AND APPLICATION OF MICROBUBBLE-FORMING COMPOUNDS 审中-公开
标题翻译：微生物形成化合物的合成和应用
公开(公告)号：WO2016205820A1
公开(公告)日：2016-12-22
申请号：PCT/US2016/038428
申请日：2016-06-20
申请人： CALIFORINA INSTITUTE OF TECHNOLOGY , MARX, Vanessa, M. , GRUBBS, Robert, H.
发明人： MARX, Vanessa, M. , GRUBBS, Robert, H.
IPC分类号： C07F9/38 , A61K31/66 , A61K31/195 , A61K9/107
CPC分类号： A61K9/0009 , A61K9/107 , A61K9/1075 , A61K9/12 , A61K31/663 , A61N5/02 , A61N7/02 , A61N2007/0004 , A61N2007/0039 , C07B41/12 , C07B43/06 , C07F9/3873
摘要： The present disclosure is directed to fatty-acid glycerol ester derivative compounds containing a targeting bisphosphonate group. The disclosure further include pharmaceutical or biomedical compositions comprising these compounds, and methods of using these compounds and compositions forming microbubbles. The microbubbles have affinity for metal-containing, especially calcium-containing, bodies and/or biological targets. In certain embodiments, these compositions are useful for providing targeted placement of microbubbles capable of cavitation on application of high frequency energy.
摘要翻译：本公开涉及含有靶向双膦酸酯基团的脂肪酸甘油酯衍生物化合物。本公开还包括包含这些化合物的药物或生物医学组合物，以及使用这些化合物和组合物形成微泡的方法。微泡对含金属，特别是含钙，物体和/或生物靶标具有亲和力。在某些实施方案中，这些组合物可用于在施加高频能量时提供能够产生气蚀的微泡的靶向放置。

3. 发明申请

WO2015164770A1 COLORIMETRIC DETECTION OF NUCLEIC ACID AMPLIFICATION 审中-公开
标题翻译：核酸扩增的颜色检测
公开(公告)号：WO2015164770A1
公开(公告)日：2015-10-29
申请号：PCT/US2015/027556
申请日：2015-04-24
申请人： DIASSESS INC.
发明人： MITRA, Debkishore , DIMOV, Ivan, Krastev , WALDEISEN, John, Robert
IPC分类号： C12Q1/68 , C12P19/34 , C07H19/20
CPC分类号： C12Q1/6844 , C12Q1/6846 , C12Q2527/119 , C12Q2527/125 , C12Q2563/173
摘要： Colorimetry is used to detect amplification reaction products. A sample is contacted with a reaction mix under conditions such that an amplification reaction occurs and produces an amplification reaction product if the sample contains a target nucleic acid template molecule. The reaction mix includes an enzyme for catalyzing the amplification reaction, and at least one halochromic agent. If the target nucleic acid template molecule is present, the amplification reaction changes the starting pH of the reaction mix to cause a detectable colorimetric change of the halochromic agent, thereby indicating the presence of the target nucleic acid. If the target nucleic acid template molecule is not present, the amplification reaction does not generate an adequate number of protons to sufficiently change the starting pH of the reaction mix to cause a detectable colorimetric change of the halochromic agent, thereby indicating that the amplification reaction product has not been produced.
摘要翻译：比色法用于检测扩增反应产物。在发生扩增反应的条件下使样品与反应混合物接触，如果样品含有靶核酸模板分子，则产生扩增反应产物。反应混合物包括用于催化扩增反应的酶和至少一种卤代色素。如果存在靶核酸模板分子，则扩增反应改变反应混合物的起始pH，以引起卤色变色剂的可检测的比色变化，从而指示靶核酸的存在。如果靶核酸模板分子不存在，则扩增反应不产生足够数量的质子，以充分改变反应混合物的起始pH，以引起卤色变色剂的可检测的比色变化，从而表明扩增反应产物尚未制作。

4. 发明申请

WO2015100431A8 PLANTS CONTAINING BENEFICIAL ENDOPHYTES 审中-公开
公开(公告)号：WO2015100431A8
公开(公告)日：2015-07-02
申请号：PCT/US2014/072399
申请日：2014-12-24
申请人： INDIGO AG, INC. , AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH
发明人： MITTER, Birgit , NAVEED, Muhammad , BERNINGER, Teresa , COMPANT, Stephane , SESSITSCH, Angela , VON MALTZAHN, Geoffrey , FLAVELL, Rihard, Bailey , TOLEDO, Gerardo, V. , DJONOVIC, Slavica , MARQUEZ, Luis, Miguel , JOHNSTON, David, Morris , MILLET, Yves, Alain , LYFORD, Jeffrey , LEFF, Jonathan, W. , SAMAYOA, Phillip , SADOWSKI, Craig
IPC分类号： A01N63/00 , A01N63/02
摘要： This application relates to methods and materials for providing a benefit to a seed, seedling or plant by producing seeds that are internally colonized with endophytes. Beneficial endophytes with particular characteristics are provided. These may be used in the methods described to provide a benefit to a seed, seedling or plant.

5. 发明申请

WO2014210219A1 MULTIPLEXED BIOMARKER QUANTITATION BY NANOPORE ANALYSIS OF BIOMARKER-POLYMER COMPLEXES 审中-公开
标题翻译：生物标记聚合物复合物的纳米分析的多重生物标记定量
公开(公告)号：WO2014210219A1
公开(公告)日：2014-12-31
申请号：PCT/US2014/044185
申请日：2014-06-25
申请人： TWO PORE GUYS, INC.
发明人： MORIN, Trevor J.
IPC分类号： G01N33/00 , G01N33/50 , G01N33/53 , G01N33/68 , C12Q1/68
CPC分类号： G01N33/48721
摘要： Devices and methods for detecting a target molecule are provided herein. The methods entail contacting a sample with a polymer scaffold, the polymer comprising at least one association site configured to associate with the target molecule. The sample is brought into contact with the polymer to determine whether the target molecule is present in the sample under conditions allowing the target molecule, if present, to associate with the polymer scaffold. The methods further involve loading the polymer into a device comprising a pore or channel that connects two volumes, configuring the device to pass the polymer through the pore or channel from one volume to the other volume, and determining, with a sensor configured to detect objects passing through the pore or channel, whether the target molecule is associated with the association site, and thereby detecting the presence or absence of the target molecule in the sample.
摘要翻译：本文提供了用于检测靶分子的装置和方法。所述方法需要使样品与聚合物支架接触，所述聚合物包含至少一个配位成与靶分子缔合的缔合位点。使样品与聚合物接触以确定靶分子是否存在于样品中，允许目标分子（如果存在）与聚合物支架缔合的条件下。所述方法还涉及将聚合物加载到包括连接两个体积的孔或通道的装置中，将所述装置配置成将所述聚合物通过所述孔或通道从一个体积传递到另一个体积，以及通过配置成检测物体的传感器来确定通过孔或通道，靶分子是否与缔合位点相关联，从而检测样品中靶分子的存在或不存在。

6. 发明申请

WO2013192570A1 SYSTEM AND METHODS FOR GENETIC ANALYSIS OF MIXED CELL POPULATIONS 审中-公开
标题翻译：用于混合细胞群体遗传分析的系统和方法
公开(公告)号：WO2013192570A1
公开(公告)日：2013-12-27
申请号：PCT/US2013/047142
申请日：2013-06-21
申请人： GIGAGEN, INC.
发明人： JOHNSON, David, Scott , LOEHR, Andrea , HUNT, Thomas , MEYER, Everett, Hurteau , HOWELL, Walter, Mathias , WITHEY, Gary
IPC分类号： G06F19/10 , C12Q1/68 , C12N15/11 , G01N33/48
CPC分类号： G06F19/22 , C12Q1/6809 , C12Q1/686 , C12Q1/6881 , C12Q2600/16 , G01N33/487 , G01N33/5005 , G01N33/68 , C12Q2535/122 , C12Q2537/165
摘要： Methods and systems are provided for massively parallel genetic analysis of single cells in emulsions or droplets. A biological sample is divided into subsamples of single cells or cell supbopulations, and a fusion complex is formed by molecular linkage and amplification techniques. Methods, apparatuses, and systems are provided for high-throughput, massively parallel analysis of the subsamples. These methods integrate molecular, algorithmic, and enginering approaches. They have broad and useful application in a number of biological and medical fields, including immunology, noninvasive prenatal diagnosis, and noninvasive cancer diagnosis.
摘要翻译：提供了方法和系统用于在乳液或液滴中对单个细胞的大规模并行遗传分析。将生物样品分为单细胞或细胞支原体的子样本，通过分子连锁和扩增技术形成融合复合体。提供了方法，装置和系统用于子采样的高通量，大规模并行分析。这些方法集成了分子，算法和工作方法。它们在许多生物和医学领域具有广泛和有用的应用，包括免疫学，无创产前诊断和非侵入性癌症诊断。

7. 发明申请

WO2009137128A2 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF CD45 GENE 审中-公开
标题翻译：用于抑制CD45基因表达的组合物和方法
公开(公告)号：WO2009137128A2
公开(公告)日：2009-11-12
申请号：PCT/US2009/033931
申请日：2009-02-12
申请人： ALNYLAM PHARMACEUTICALS, INC. , GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY , DE FOUGEROLLES, Antonin , TAN, Pamela , BORODOVSKY, Anna , NOVOBRANTSEVA, Tatiana , BAVARI, Sina , WARFIELD, Kelly, Lyn
发明人： DE FOUGEROLLES, Antonin , TAN, Pamela , BORODOVSKY, Anna , NOVOBRANTSEVA, Tatiana , BAVARI, Sina , WARFIELD, Kelly, Lyn
IPC分类号： C12N15/11
CPC分类号： C12N15/1137 , C12N15/1138 , C12N2310/113 , C12N2310/14 , C12N2310/17 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the CD45 gene.
摘要翻译：本发明涉及用于抑制CD45基因表达的双链核糖核酸（dsRNA）。

8. 发明申请

WO2009111658A2 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 AND VEGF GENES 审中-公开
标题翻译：用于抑制EG5和VEGF基因表达的组合物和方法
公开(公告)号：WO2009111658A2
公开(公告)日：2009-09-11
申请号：PCT/US2009/036223
申请日：2009-03-05
申请人： ALNYLAM PHARMACEUTICALS, INC. , BUMCROT, David
发明人： BUMCROT, David
IPC分类号： A61K48/00
CPC分类号： A61K31/713 , C12N15/113 , C12N15/1136 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2310/3515 , C12N2320/31 , C12N2320/32 , C12N2310/3521
摘要： This invention relates to compositions containing double-stranded ribonucleic acid (dsRNA) in a SNALP formulation, and methods of using the compositions to inhibit the expression of the Eg5 and Vascular Endothelial Growth Factor (VEGF), and methods of using the compositions to treat pathological processes mediated by Eg5 and VEGF expression, such as cancer.
摘要翻译：本发明涉及在SNALP制剂中含有双链核糖核酸（dsRNA）的组合物，以及使用该组合物抑制Eg5和血管内皮生长因子（VEGF）表达的方法，以及使用该组合物治疗病理学由Eg5和VEGF表达介导的过程，如癌症。

9. 发明申请

WO2020257519A1 BACTERIA-ENGINEERED TO ELICIT ANTIGEN-SPECIFIC T-CELLS 审中-公开
公开(公告)号：WO2020257519A1
公开(公告)日：2020-12-24
申请号：PCT/US2020/038526
申请日：2020-06-18
申请人： CHAN ZUCKERBERG BIOHUB, INC. , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： FISCHBACH, Michael A. , NAGASHIMA, Kazuki , CHEN, Erin
IPC分类号： A61K39/02 , A61K39/08 , A61P31/04
摘要： Provided are modified microorganisms, such as live recombinant commensal bacteria, that express a heterologous antigen, and methods of using the modified microorganisms to induce an antigen-specific immune response to the heterologous antigen. The modified microorganism can be used to induce a regulatory T cell immune response to the heterologous antigen to treat an autoimmune disease in a subject in need thereof, or can be used to induce an effector T cell immune response to the heterologous antigen to treat a proliferative disease in a subject in need thereof.

10. 发明申请

WO2020237227A1 CIRCULAR RNA COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：WO2020237227A1
公开(公告)日：2020-11-26
申请号：PCT/US2020/034418
申请日：2020-05-22
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ORNA THERAPEUTICS, INC. , WESSELHOEFT, Alexander , ANDERSON, Daniel, G. , FUSE, Shinichiro , GOODMAN, Brian , HORHOTA, Allen , SQUILLONI, Raffaella
发明人： WESSELHOEFT, Alexander , ANDERSON, Daniel, G. , FUSE, Shinichiro , GOODMAN, Brian , HORHOTA, Allen , SQUILLONI, Raffaella
IPC分类号： A61K48/00 , A61K31/7088 , C12N15/115 , C12N15/64 , A61K31/7105 , C07K14/725 , C12N15/85 , C12N15/11
摘要： Circular RNA and transfer vehicles, along with related compositions and methods are described herein. In some embodiments, the inventive circular RNA comprises group I intron fragments, spacers, an IRES, duplex forming regions, and an expression sequence. In some embodiments, the expression sequence encodes a chimeric antigen receptor (CAR). In some embodiments, circular RNA of the invention has improved expression, functional stability, immunogenicity, ease of manufacturing, and/or half-life when compared to linear RNA. In some embodiments, inventive methods and constructs result in improved circularization efficiency, splicing efficiency, and/or purity when compared to existing RNA circularization approaches.

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