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1. 发明申请

WO2017160836A1 SYSTEMS AND METHODS FOR PERFORMING BIOLOGICAL ASSAYS 审中-公开
标题翻译：用于进行生物测定的系统和方法
公开(公告)号：WO2017160836A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/022300
申请日：2017-03-14
申请人： DIASSESS INC.
发明人： MITRA, Debkishore , MYERS, Frank, B., III , WALDEISEN, John, Robert , DIMOV, Ivan, Krastev
IPC分类号： B01L3/00 , B01L7/00 , C12M1/34 , C12Q1/68 , G01N27/447
摘要： Systems and methods for performing biological assays are provided herein. The systems and methods determine one or more characteristics of a nucleic acid amplification sample based on a modified optical property of the sample.
摘要翻译：本文提供了用于进行生物测定的系统和方法。该系统和方法基于样品的改进的光学性质确定核酸扩增样品的一个或多个特征。

2. 发明申请

WO2018185573A1 IMAGE-BASED DISEASE DIAGNOSTICS USING A MOBILE DEVICE 审中-公开
公开(公告)号：WO2018185573A1
公开(公告)日：2018-10-11
申请号：PCT/IB2018/051326
申请日：2018-03-01
申请人： DIASSESS INC.
发明人： DIMOV, Ivan Krastev , MYERS, Frank B., III , WALDEISEN, John Robert , MITRA, Debkishore
IPC分类号： G01N33/50 , G01N21/76 , G01N21/78 , G01N21/75 , C12Q1/6804 , C12Q1/6806
CPC分类号： G16H30/20 , A61B5/0059 , A61B5/742 , C12Q1/701 , G01N33/56983 , G06F19/321 , G06F19/3456 , G06T7/0012 , G06T7/90 , G06T2207/20076 , G06T2207/30072 , G16H10/40 , G16H20/10 , G16H20/60 , G16H30/40 , G16H50/20
摘要： A diagnostic system performs disease diagnostic tests using at least an optical property modifying device and a mobile device. A user provides a biological sample from a patient to the optical property modifying device that reacts with a reagent in one or more reaction chambers of the device. The user captures one or more images of the one or more reaction chambers using an optical sensor of the mobile device. The diagnostic system can determine a quality level of the images based on factors such as skew, scale, focusing, shadowing, or white-balancing. Based on an analysis of the captured image, the diagnostic system can determine a test result of a disease diagnostic test for the patient. The diagnostic system may communicate the test result, as well as instructions for the disease diagnostic test, to the user via the mobile device.

3. 发明申请

WO2019055135A1 MULTIPLEXED BIOLOGICAL ASSAY DEVICE WITH ELECTRONIC READOUT 审中-公开
公开(公告)号：WO2019055135A1
公开(公告)日：2019-03-21
申请号：PCT/US2018/044044
申请日：2018-07-27
申请人： DIASSESS INC.
发明人： MYERS, Frank, B., III , REBER, Clay, D. , SMITH, Taber, H. , MANIAR, Faisal, S.
IPC分类号： G01N15/14 , G01N21/00 , G01N21/01 , G01N21/17 , G01N21/27
摘要： This invention relates generally to devices, systems, and methods for performing biological assays by using indicators that modify one or more optical properties of the assayed biological samples. The subject methods include generating a reaction product by carrying out a biochemical reaction on the biological sample introduced into a device and reacting the reaction product with an indicator capable of generating a detectable change in an optical property of the biological sample to indicate the presence, absence, or amount of analyte suspected to be present in the sample.

4. 发明申请

WO2017160840A1 SELECTIVELY VENTED BIOLOGICAL ASSAY DEVICES AND ASSOCIATED METHODS 审中-公开
标题翻译：选择性排放的生物测定装置和相关方法
公开(公告)号：WO2017160840A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/022306
申请日：2017-03-14
申请人： DIASSESS INC.
发明人： MITRA, Debkishore , MYERS, Frank B. III , WALDEISEN, John Robert , DIMOV, lvan Krastev
IPC分类号： A61J1/14 , B01D33/35 , B01L3/00 , C12M1/34 , F16K24/04 , G01N7/10
摘要： Selectively vented biological assay devices and methods of performing biological assays with such devices are provided herein. Disclosed devices include a selective venting element having passively tunable porosity. The methods include controlling fluid flow within the subject devices with the selective venting element.
摘要翻译：本文提供了选择性排放的生物测定装置和用这种装置进行生物测定的方法。公开的装置包括具有被动可调节孔隙率的选择性通气元件。该方法包括用选择性通气元件控制主体装置内的流体流动。

5. 发明申请

WO2017160839A1 DEVICES AND METHODS FOR MODIFYING OPTICAL PROPERTIES 审中-公开
标题翻译：用于修改光学性质的装置和方法
公开(公告)号：WO2017160839A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/022305
申请日：2017-03-14
申请人： DIASSESS INC.
发明人： MYERS, Frank B., III , MITRA, Debkishore , WALDEISEN, John Robert , DIMOV, Ivan Krastev
IPC分类号： G01N21/01
摘要： Devices and methods for modifying optical properties of biological samples or aspects thereof are provided. The subject methods include generating a reaction product with a device and reacting the reaction product to sufficiently modify an optical property to allow detection of the modified optical property.
摘要翻译：提供了用于修改生物样品或其方面的光学性质的装置和方法。主题方法包括用装置产生反应产物并使反应产物反应以充分改变光学性质以允许检测改变的光学性质。

6. 发明申请

WO2017160838A1 DEVICES AND METHODS FOR BIOLOGICAL ASSAY SAMPLE PREPARATION AND DELIVERY 审中-公开
标题翻译：用于生物分析样品制备和递送的装置和方法
公开(公告)号：WO2017160838A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/022304
申请日：2017-03-14
申请人： DIASSESS INC.
发明人： MYERS, Frank B., III , HO, Wei Hsuan , MITRA, Debkishore , WALDEISEN, John Robert , DIMOV, Ivan Krastev , GRISWOLD, Ryan C. , RICHARDSON, Bruce
IPC分类号： G01N1/28
摘要： Devices and methods for preparing and delivering biological assay samples are provided herein. Components of such devices include a sample receiving module within which a biological assay sample can be prepared and a cap, which when operatively coupled with the sample receiving module, pressurizes the module. These devices can be employed for subsequently delivering a biological assay sample.
摘要翻译：本文提供了用于制备和递送生物测定样品的装置和方法。这样的装置的部件包括样品接收模块，在该样品接收模块内可以制备生物测定样品，以及帽，当与样品接收模块可操作地耦合时，该模块对模块加压。这些装置可用于随后递送生物测定样品。

7. 发明申请

WO2015164770A1 COLORIMETRIC DETECTION OF NUCLEIC ACID AMPLIFICATION 审中-公开
标题翻译：核酸扩增的颜色检测
公开(公告)号：WO2015164770A1
公开(公告)日：2015-10-29
申请号：PCT/US2015/027556
申请日：2015-04-24
申请人： DIASSESS INC.
发明人： MITRA, Debkishore , DIMOV, Ivan, Krastev , WALDEISEN, John, Robert
IPC分类号： C12Q1/68 , C12P19/34 , C07H19/20
CPC分类号： C12Q1/6844 , C12Q1/6846 , C12Q2527/119 , C12Q2527/125 , C12Q2563/173
摘要： Colorimetry is used to detect amplification reaction products. A sample is contacted with a reaction mix under conditions such that an amplification reaction occurs and produces an amplification reaction product if the sample contains a target nucleic acid template molecule. The reaction mix includes an enzyme for catalyzing the amplification reaction, and at least one halochromic agent. If the target nucleic acid template molecule is present, the amplification reaction changes the starting pH of the reaction mix to cause a detectable colorimetric change of the halochromic agent, thereby indicating the presence of the target nucleic acid. If the target nucleic acid template molecule is not present, the amplification reaction does not generate an adequate number of protons to sufficiently change the starting pH of the reaction mix to cause a detectable colorimetric change of the halochromic agent, thereby indicating that the amplification reaction product has not been produced.
摘要翻译：比色法用于检测扩增反应产物。在发生扩增反应的条件下使样品与反应混合物接触，如果样品含有靶核酸模板分子，则产生扩增反应产物。反应混合物包括用于催化扩增反应的酶和至少一种卤代色素。如果存在靶核酸模板分子，则扩增反应改变反应混合物的起始pH，以引起卤色变色剂的可检测的比色变化，从而指示靶核酸的存在。如果靶核酸模板分子不存在，则扩增反应不产生足够数量的质子，以充分改变反应混合物的起始pH，以引起卤色变色剂的可检测的比色变化，从而表明扩增反应产物尚未制作。

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