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1. 发明申请

WO2020096689A1 SYSTEM AND METHOD FOR DISPLAYING ELECTROPHYSIOLOGICAL SIGNALS FROM MULTI-DIMENSIONAL CATHETERS 审中-公开
公开(公告)号：WO2020096689A1
公开(公告)日：2020-05-14
申请号：PCT/US2019/049547
申请日：2019-09-04
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： HAGFORS, Mark , DENO, Don Curtis , CHEN, Luke
IPC分类号： G06T19/00
摘要： A method of displaying a virtual electrogram for a virtual bipole includes receiving a plurality of electrophysiological signals from a respective plurality of electrodes carried by a multi-dimensional catheter; using the received electrophysiological signals to compute a plurality of virtual electrograms associated with a respective plurality of virtual bipoles, each having a corresponding virtual bipole orientation; selecting a virtual bipole orientation; and displaying the virtual electrogram associated with the virtual bipole having the selected virtual bipole orientation. Aspects of the disclosure can be executed through a graphical user interface of an electroanatomical mapping system that also incorporates a visualization processor.

2. 发明申请

WO2018160631A1 SYSTEM AND METHOD FOR DIFFERENTIATION OF ADIPOSE TISSUE FROM SCAR TISSUE DURING ELECTROPHYSIOLOGICAL MAPPING 审中-公开
公开(公告)号：WO2018160631A1
公开(公告)日：2018-09-07
申请号：PCT/US2018/020116
申请日：2018-02-28
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： MANGUAL-SOTO, Jan O. , MARKOVITZ, Craig , JIANG, Chunlan , RICHER, Louis-Philippe , CASSET, Cyrille
IPC分类号： A61B5/00 , A61B5/053 , A61B5/04 , A61B5/042
摘要： Methods, apparatuses, and systems to differentiate adipose tissue from scar tissue are disclosed. One or more electrophysiology data points, each of which includes an electrophysiological signal associated with a tissue location that possesses certain signal characteristics, can be collected. An adipose tissue probability and/or a scar tissue probability can be computed using the characteristics of the electrophysiological signal, such as signal duration, signal amplitude, signal fractionation, and/or late potentials. The probability computation can also utilize dielectric properties, such as tissue impedance, tissue conductivity, and/or tissue permittivity, measured at the tissue location. Graphical representations of the adipose tissue probability and/or scar tissue probability can also be output.

3. 发明申请

WO2018089172A1 SYSTEM AND METHOD FOR GENERATING ELECTROPHYSIOLOGY MAPS 审中-公开
标题翻译：用于产生电生理学图谱的系统和方法
公开(公告)号：WO2018089172A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/056593
申请日：2017-10-13
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： MARKOVITZ, Craig
IPC分类号： A61B5/00 , A61B5/0408 , A61B5/042
摘要： A method of generating an electrophysiology map of a portion of a patient's anatomy includes receiving a plurality of electrophysiology data points, each including an associated electrophysiological signal. A template electrophysiology data point and one or more unwanted electrophysiology data points are selected from the plurality of electrophysiology data points. The electrophysiological signal associated with the template electrophysiology data point is defined as a template electrophysiological signal, while the electrophysiological signal(s) associated with the unwanted electrophysiology data point(s) is/are defined as unwanted electrophysiological signal(s). For any given electrophysiology data point, if the morphology of its associated electrophysiological signal is more similar to the morphology of an unwanted electrophysiological signal than to the morphology of the template electrophysiological signal, the given electrophysiology data point is rejected/excluded from an electrophysiology map.
摘要翻译：生成患者解剖结构的一部分的电生理学图的方法包括接收多个电生理学数据点，每个电生理学数据点包括相关联的电生理学信号。从多个电生理学数据点中选择模板电生理学数据点和一个或多个不想要的电生理学数据点。与模板电生理学数据点相关的电生理学信号被定义为模板电生理学信号，而与不想要的电生理学数据点相关联的电生理学信号被定义为不需要的电生理学信号。对于任何给定的电生理学数据点，如果其相关电生理学信号的形态与不想要的电生理信号的形态比模板电生理信号的形态更相似，则给定的电生理学数据点被拒绝/从电生理学图中排除。

4. 发明申请

WO2017062248A1 METHODS AND SYSTEMS FOR MAPPING CARDIAC RESTITUTION 审中-公开
标题翻译：用于绘制心脏衰竭的方法和系统
公开(公告)号：WO2017062248A1
公开(公告)日：2017-04-13
申请号：PCT/US2016/054281
申请日：2016-09-29
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： RELAN, Jatin S. , AFONSO, Valtino X.
IPC分类号： A61B5/042 , A61B5/00
CPC分类号： A61B5/0422 , A61B5/743
摘要： A method of mapping cardiac restitution includes: receiving a plurality of EP data points including location and restitution data; identifying a subset of the EP data points forming an EP data point cluster; fitting a restitution curve to the restitution data of the EP data points forming the cluster; and identifying at least one restitution metric for a region of the cardiac surface corresponding to the cluster from the restitution curve. The restitution curve can be an exponential function using quiescent interval data ( e.g ., DI and/or CL) as the independent variable and cardiac repolarization activity data ( e.g ., APD, ARI, and/or EGM width) as the dependent variable. The parameters of the exponential function can be determined by optimizing a cost function. A graphical representation of the restitution metric can also be output on a three-dimensional model of the cardiac surface.
摘要翻译：一种映射心脏复原的方法包括：接收多个EP数据点，包括位置和恢复数据; 识别形成EP数据点簇的EP数据点的子集; 将恢复曲线拟合成形成所述簇的EP数据点的恢复数据; 以及根据所述恢复曲线来识别对应于所述簇的所述心脏表面的区域的至少一个恢复度量。恢复曲线可以是使用静态间隔数据（例如DI和/或CL）作为独立变量和心脏复极化活动数据（例如，APD，ARI和/或EGM宽度）作为因变量的指数函数。指数函数的参数可以通过优化成本函数来确定。还可以在心脏表面的三维模型上输出恢复度量的图形表示。

5. 发明申请

WO2016182877A1 SYSTEM AND METHOD FOR REAL-TIME ELECTROPHYSIOLOGICAL MAPPING 审中-公开
标题翻译：用于实时电生理映射的系统和方法
公开(公告)号：WO2016182877A1
公开(公告)日：2016-11-17
申请号：PCT/US2016/031108
申请日：2016-05-06
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： ERDEMIR, Erhan , LI, Wenwen , PAPPONE, Carlo
IPC分类号： A61B5/042 , A61B5/044
CPC分类号： A61B5/743 , A61B5/0422 , A61B5/044 , A61B5/046 , A61B5/6859 , A61B5/7207 , A61B5/7285
摘要： A method of generating a real-time electrophysiology map, such as a cardiac electrophysiology map, includes displaying a cardiac surface model and receiving a plurality of electrophysiology data points (e.g., using a plurality of intracardiac electrodes). The electrophysiology data from the received electrophysiology data points can be displayed and updated on the cardiac surface model in real-time when it satisfies a preset inclusion criteria, such as a projection distance criterion (e.g., the electrophysiology data point is within a preset distance of the cardiac surface model), a contact force criterion (e.g., the intracardiac catheter is exerting at least a preset contact force on the tissue surface), and/or an electrical coupling criterion (e.g., the electrode-tissue electrical coupling exceeds a preset threshold). New electrophysiology data points can be received when a triggering event, such as a point in the cardiac cycle, occurs, or according to a preset timer interval.
摘要翻译：生成心电生理图的实时电生理学图的方法包括显示心脏表面模型并接收多个电生理学数据点（例如，使用多个心内电极）。来自接收的电生理学数据点的电生理数据可以在其满足预设的入选标准（例如，投影距离标准）（例如，电生理学数据点在预设的距离内）时，在心脏表面模型上实时显示和更新心脏表面模型），接触力标准（例如，心内导管至少在组织表面上施加预设的接触力）和/或电耦合标准（例如，电极组织电耦合超过预设阈值）。当触发事件（例如心动周期中的一个点）发生时，或根据预设的定时器间隔时，可以接收新的电生理学数据点。

6. 发明申请

WO2016061384A1 METHODS AND SYSTEMS FOR MAPPING LOCAL CONDUCTION VELOCITY 审中-公开
标题翻译：用于映射本地导航速度的方法和系统
公开(公告)号：WO2016061384A1
公开(公告)日：2016-04-21
申请号：PCT/US2015/055790
申请日：2015-10-15
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： LI, Wenwen , ERDEMIR, Erhan , VOTH, Eric , AFONSO, Valtino , PAPPONE, Carlo
IPC分类号： A61B5/0452 , A61B5/042 , A61B5/00
CPC分类号： A61B5/7278 , A61B5/0422 , A61B5/0452 , A61B5/0538 , A61B5/6852 , A61B5/7264 , A61B5/7282 , A61B5/743 , A61B2505/05 , A61B2562/04
摘要： The local conduction velocity of a cardiac activation wavefront can be computed by collecting a plurality of electrophysiology ("EP") data points using a multi-electrode catheter, with each EP data point including both position data and local activation time ("LAT") data. For any EP data point, a neighborhood of EP data points, including the selected EP data point and at least two additional EP data points, can be defined. Planes of position and LATs can then be defined using the positions and LATs, respectively, of the EP data points within the neighborhood. A conduction velocity can be computed from an intersection of the planes of positions and LATs. The resultant plurality of conduction velocities can be output as a graphical representation (e.g., an electrophysiology map), for example by displaying vector icons arranged in a uniform grid over a three-dimensional cardiac model.
摘要翻译：可以通过使用多电极导管收集多个电生理学（“EP”）数据点来计算心脏激活波前的局部传导速度，每个EP数据点包括位置数据和局部激活时间（“LAT”）数据。对于任何EP数据点，可以定义包括所选EP数据点和至少两个附加EP数据点的EP数据点的邻域。然后可以分别使用邻域内的EP数据点的位置和LAT来定义位置和LAT的平面。可以从位置平面和LAT的交叉点计算传导速度。所得到的多个传导速度可以作为图形表示（例如，电生理学图）输出，例如通过在三维心脏模型上显示以均匀网格排列的矢量图标。

7. 发明申请

WO2015171393A1 SYSTEM AND METHOD FOR RENDERING A MOTION MODEL OF A BEATING HEART 审中-公开
标题翻译：渲染心脏运动模型的系统和方法
公开(公告)号：WO2015171393A1
公开(公告)日：2015-11-12
申请号：PCT/US2015/028206
申请日：2015-04-29
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： OLSON, Eric S.
IPC分类号： G06T13/00 , G06T17/00 , A61B5/11 , A61B5/0452 , A61B5/042 , A61B5/00 , A61B5/06 , G06F19/00
CPC分类号： A61B5/6852 , A61B5/0422 , A61B5/0452 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/1107 , A61B5/6869 , A61B5/7285 , A61B5/742 , G06F19/00 , G06T13/40 , G06T15/04 , G06T19/00 , G06T2207/10072 , G06T2207/30048 , G06T2210/41 , G06T2210/56 , G16H50/50
摘要： Location data associated with a cardiac wall motion during a cardiac cycle can be received. The cardiac cycle can be divided into incremental phases. The location data associated with the cardiac wall motion can be assigned to the incremental phases. A fiducial pair of coordinates can be determined for each of the incremental phases. The fiducial pair of coordinates can include location data for an intermediate cardiac phase and location data for a reference cardiac phase. A fiducial ioop can be determined from the fiducial pair of coordinates for each of the incremental phases. A learned cardiac mapping between the reference cardiac phase and the intermediate cardiac phase can be determined using the fiducial loop.
摘要翻译：可以接收在心动周期期间与心脏壁运动相关联的位置数据。心动周期可以分为增量阶段。与心脏壁运动相关联的位置数据可以分配给增量阶段。可以为每个增量阶段确定基准坐标对。基准坐标对可以包括中间心脏相位的位置数据和参考心脏相位的位置数据。可以从每个增量阶段的基准坐标对确定基准ioop。可以使用基准回路来确定参考心脏相和中间心脏相之间的学习心脏图。

8. 发明申请

WO2015168200A1 DEPICTING FORCE 审中-公开
标题翻译：授权
公开(公告)号：WO2015168200A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/028119
申请日：2015-04-29
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： QUINN, Michael A. , STARKS, Daniel R.
IPC分类号： A61B18/14 , A61B5/042 , G06F3/00
CPC分类号： A61B34/20 , A61B5/042 , A61B5/6852 , A61B5/6885 , A61B5/7445 , A61B18/1492 , A61B90/06 , A61B90/37 , A61B90/92 , A61B2018/00577 , A61B2018/00839 , A61B2034/2046 , A61B2090/064 , A61B2090/065 , A61M25/0105 , A61M2025/0166 , G06F3/016
摘要： A force exerted on a distal end of an elongate medical device can be determined. A graphical representation of the distal end of the elongate medical device and a graphical representation of the force exerted on the distal end of the elongate medical device can be computed. The graphical representation of the force can emanate from the graphical representation of the distal end of the elongate medical device. A first dimension of the graphical representation of the force can be increased in response to a longitudinal force being exerted on the distal end of the elongate medical device. A second dimension of the graphical representation of force can be increased in response to a lateral force being exerted on the distal end of the elongate medical device.
摘要翻译：可以确定施加在细长医疗装置的远端上的力。可以计算细长医疗装置的远端的图形表示以及施加在细长医疗装置的远端上的力的图示。力的图形表示可以从细长医疗装置的远端的图示表示出来。可以响应于施加在细长医疗装置的远端上的纵向力而增加力的图形表示的第一尺寸。可以响应于施加在细长医疗装置的远端上的横向力而增加力的图形表示的第二尺寸。

9. 发明申请

WO2015066113A1 CARDIAC MAPPING SYSTEM AND METHOD FOR BI-DIRECTIONAL ACTIVATION DETECTION OF ELECTROGRAMS 审中-公开
公开(公告)号：WO2015066113A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/062779
申请日：2014-10-29
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： YANG, Chin-Ann , AFONSO, Valtino X.
IPC分类号： A61B5/0452
CPC分类号： A61B5/04012 , A61B5/0044 , A61B5/0452 , A61B2576/023
摘要： In a system and computer implemented method for mapping of an anatomic structure and bi-directional activation detection of electrograms such as atrial and/or ventricular electrograms, both positive and negative deflections of an electrogram signal are analyzed over an analysis time period of the signal. At least one characteristic of the electrogram signal is determined based at least in part on analyzing both positive and negative deflections of the signal over the analysis time period. The determined at least one characteristic of the atrial electrogram signal is then associated with a generated three-dimensional model of the anatomic structure.
摘要翻译：在用于映射解剖结构和诸如心房和/或心室电图的电描记图的双向激活检测的系统和计算机实现的方法中，在信号的分析时间段内分析电描记图信号的正和负偏转。至少部分地基于在分析时间段内分析信号的正和负偏转来确定电描记图信号的至少一个特征。所确定的心房电描记图信号的至少一个特征然后与生成的解剖结构的三维模型相关联。

10. 发明申请

WO2014182822A1 UTILIZATION OF ELECTRODE SPATIAL ARRANGEMENTS FOR CHARACTERIZING CARDIAC CONDUCTION CONDITIONS 审中-公开
标题翻译：用于表征心脏导管条件的电极空间安排的应用
公开(公告)号：WO2014182822A1
公开(公告)日：2014-11-13
申请号：PCT/US2014/037160
申请日：2014-05-07
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC.
发明人： BALACHANDRAN, Ram K. , DENO, D. Curtis
IPC分类号： A61B5/042 , A61B5/06 , A61B19/00 , A61B18/14 , A61B5/0452
CPC分类号： A61B5/0422 , A61B5/0452 , A61B5/061 , A61B5/062 , A61B5/7203 , A61B5/7239 , A61B18/1492 , A61B34/20 , A61B2017/00039 , A61B2017/00044 , A61B2017/00053 , A61B2018/00577 , A61B2018/00839 , A61B2034/2051 , A61B2034/2053 , A61B2218/002
摘要： A system and method are provided for determining electrophysiological data. The system comprises an electronic control unit that is configured to receive electrical signals from a set of electrodes, receive position and orientation data for the set of electrodes from a mapping system, compensate for position and orientation artifacts of the set of electrodes, compose cliques of a subset of neighboring electrodes in the set of electrodes, determine catheter orientation independent information of a target tissue, and output the orientation independent information to a display. The method comprising receiving electrogram data for a set of electrodes (80), compensating for artifacts in sensor positions in the mapping system (81), resolving the bipolar signals into a 3D vector electrogram in the mapping system coordinates (82), manipulating observed unipolar voltage signals and the tangent component of the e-field to estimate the conduction velocity vector (83), and outputting the catheter orientation independent information (84).
摘要翻译：提供了一种用于确定电生理数据的系统和方法。该系统包括电子控制单元，其被配置为从一组电极接收电信号，从映射系统接收用于该组电极的位置和取向数据，补偿该组电极的位置和取向伪像，电极组中的相邻电极的子集，确定目标组织的导管取向独立信息，并将取向独立信息输出到显示器。该方法包括接收用于一组电极（80）的电描记图数据，补偿映射系统（81）中的传感器位置中的伪像，将双极性信号解析为映射系统坐标（82）中的3D矢量电描记图，操纵观察到的单极性电压信号和电场的切线分量来估计传导速度矢量（83），并输出导管取向独立信息（84）。

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