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1. 发明申请

WO2021173206A1 SYSTEMS AND METHODS FOR MAPPING LOCAL ACTIVATION TIMES 审中-公开
公开(公告)号：WO2021173206A1
公开(公告)日：2021-09-02
申请号：PCT/US2020/063871
申请日：2020-12-09
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： AFONSO, Valtino X. , BIRD, Nathaniel , KASI, Patrick , RELAN, Jatin , KIM, Steven
IPC分类号： A61B5/367
摘要： The present disclosure provides systems and methods for generating a local activation time (LAT) map. A method includes receiving at least one reference electrogram, receiving at least one roving electrogram, detecting cardiac activations in the at least one reference electrogram, detecting roving cardiac activations in the at least one roving electrogram, identifying, at a trigger time, a most recent reference cardiac activation of the detected reference cardiac activations, identifying, a corresponding roving cardiac activation of the detected roving cardiac activations that is closest in time to the most recent reference cardiac activation, the corresponding roving cardiac activation identified independent of any roving activation interval (RAI), computing, a LAT as a time difference between the most recent reference cardiac activation and the corresponding roving cardiac activation, and generating and displaying, a LAT map based on the computed LAT.

2. 发明申请

WO2015066112A1 CARDIAC MAPPING SYSTEM AND METHOD FOR VOLTAGE-BASED EVALUATION OF ELECTROGRAMS 审中-公开
标题翻译： CARDIAC映射系统和电压电压评估方法
公开(公告)号：WO2015066112A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/062778
申请日：2014-10-29
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： YANG, Chin-Ann , AFONSO, Valtino X.
IPC分类号： A61B5/0452 , A61B5/046 , A61B5/0464
CPC分类号： G16H50/30 , A61B5/04012 , A61B5/0422 , A61B5/046 , G06F19/00
摘要： Systems and methods for evaluating electrograms are described. An example method of evaluating an electrogram such as an atrial and/or ventricular electrogram containing a plurality of data samples each having a voltage includes selecting an activity interval for the electrogram, calculating an energy level for each window of a plurality of windows of the electrogram based on the voltages of the data samples in each window, assigning the calculated energy levels to a plurality of bins, and calculating an index based at least in part on a number of energy levels assigned to a particular bin of the plurality of bins.
摘要翻译：描述用于评估电描记图的系统和方法。评估包含多个具有电压的多个数据样本的心电图和/或心室电描记图的电描记图的示例性方法包括选择电描记图的活动间隔，计算电描记图的多个窗口中的每个窗口的能级基于每个窗口中的数据样本的电压，将所计算的能量级分配给多个箱，以及至少部分地基于分配给所述多个箱的特定箱的能量等级的数量来计算索引。

3. 发明申请

WO2017040581A1 METHODS AND SYSTEMS FOR IDENTIFYING AND MAPPING CARDIAC ACTIVATION WAVEFRONTS 审中-公开
标题翻译：识别和定位心脏激活波形的方法和系统
公开(公告)号：WO2017040581A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/049580
申请日：2016-08-31
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： HAN, Dongfeng , AFONSO, Valtino X. , YANG, Chin-Ann , MORGAN, Dennis J. , PAPPONE, Carlo
IPC分类号： A61B5/00 , A61B5/042
CPC分类号： A61B5/04011 , A61B5/02028 , A61B5/04012 , A61B5/0422 , A61B5/044 , A61B5/0452 , A61B5/7278 , A61B5/743
摘要： A map of cardiac activation wavefronts can be created from a plurality of mesh nodes, each of which is assigned a conduction velocity vector. Directed edges are defined to interconnect the mesh nodes, and weights are assigned to the directed edges, thereby creating a weighted directed conduction velocity graph. A user can select one or more points within the weighted directed conduction velocity graph (which do not necessarily correspond to nodes), and one or more cardiac activation wavefronts passing through these points can be identified using the weighted directed conduction velocity graph. The cardiac activation wavefronts can then be displayed on a graphical representation of the cardiac geometry.
摘要翻译：可以从多个网格节点创建心脏激活波前图，每个网格节点被分配传导速度矢量。定义边缘以互连网状节点，并且将权重分配给有向边缘，从而创建加权的定向传导速度图。用户可以选择加权定向传导速度图（其不一定对应于节点）内的一个或多个点，并且可以使用加权的定向传导速度图来识别通过这些点的一个或多个心脏激活波前。然后可以以心脏几何图形表示来显示心脏激活波前。

4. 发明申请

WO2021216589A1 SYSTEM AND METHOD FOR MAPPING CARDIAC ACTIVITY 审中-公开
公开(公告)号：WO2021216589A1
公开(公告)日：2021-10-28
申请号：PCT/US2021/028215
申请日：2021-04-20
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： RELAN, Jatin , AFONSO, Valtino X. , KIM, Steven
IPC分类号： A61B5/339 , A61B5/347 , A61B5/366 , A61B5/00 , G16H50/20
摘要： A plurality of electrophysiology (EP) data points, each including an electrogram signal, can be used to visualize cardiac activity. Each EP data point can be characterized as substrate or healthy, and a cloud map of the substrate EP data points can be generated. A graphical representation of the cloud map can be output in combination with a graphical representation of an electrophysiology map of the healthy EP data points. In alternative embodiments, the electrogram signals can be transformed into the wavelet domain, thereby computing a plurality of scalograms, and computing a wave function of each scalogram, thereby computing a plurality of wave functions. A propagation map, such as a propagation wave map and/or propagation wave trail map, can then be generated from the wave functions and output graphically.

5. 发明申请

WO2018148026A1 SYSTEM AND METHOD FOR DETECTING CONSISTENT CARDIAC ACTIVITY 审中-公开
公开(公告)号：WO2018148026A1
公开(公告)日：2018-08-16
申请号：PCT/US2018/015242
申请日：2018-01-25
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： HAN, Dongfeng , AFONSO, Valtino X.
IPC分类号： A61B5/0452 , A61B5/04 , A61B5/00
摘要： The present disclosure provides systems and methods for detecting cardiac activations of a patient. A system includes a data acquisition system (DAQ) communicatively coupled to an activation detection module. The DAQ detects an electrogram generated at an electrode disposed on or in the patient. The activation detection module is configured to receive the electrogram from the DAQ and compute an activation response. The activation detection module is further configured to determine a set of candidate detection time points (CDTPs) in the activation response. The activation detection module is configured to compute respective deflection characteristics for each CDTP. The activation detection module is configured to identify a group of final detection time points (FDTPs) among the set of CDTPs for a metric corresponding to the respective deflection characteristics. The group of FDTPs has similar deflection characteristics. The activation detection module is configured to compute metrics based on the group of FDTPs.

6. 发明申请

WO2017062247A1 METHODS AND SYSTEMS FOR MAPPING CARDIAC REPOLARIZATION 审中-公开
标题翻译：用于映射心脏重构的方法和系统
公开(公告)号：WO2017062247A1
公开(公告)日：2017-04-13
申请号：PCT/US2016/054280
申请日：2016-09-29
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： RELAN, Jatin S. , AFONSO, Valtino X.
IPC分类号： A61B5/0452 , A61B5/042 , A61B5/00
CPC分类号： A61B5/0452 , A61B5/042 , A61B5/6852 , A61B5/7239 , A61B2505/05
摘要： Cardiac repolarization activity can be mapped using action potential duration ("APD") and/or activation recovery interval ("ARI"). APD can be measured using a bipolar electrogram signal measured, for example, using a monophasic action potential ("MAP") catheter. ARI can be measured using unipolar electrogram signals. The electrogram signal is used to identify a depolarization tick time. A repolarization tick time can be identified using either a point in time when the electrogram signal passes below a threshold or via local maxima and minima of a first derivative of the electrogram signal. Diastolic intervals can also be computed using depolarization and repolarization tick times.
摘要翻译：可以使用动作电位持续时间（“APD”）和/或激活恢复间隔（“ARI”）来映射心脏复极活动。可以使用例如使用单相动作电位（“MAP”）导管测量的双极电描记信号来测量APD。可以使用单极电描记信号测量ARI。电描记信号用于识别去极化蜱时间。可以使用电描记信号通过低于阈值的时间点或通过电描记信号的一阶导数的局部最大值和最小值来识别复极蜱时间。舒张期间隔也可以使用去极化和复极蜱时间来计算。

7. 发明申请

WO2019241079A1 SYSTEM AND METHOD FOR MAPPING CARDIAC ACTIVITY 审中-公开
公开(公告)号：WO2019241079A1
公开(公告)日：2019-12-19
申请号：PCT/US2019/036158
申请日：2019-06-07
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： AFONSO, Valtino X. , MILLER, Frank , CHOE, William , BOORMAN, Charles , DAVIES, Austin , MULLINS, Nate , SUNDARAM, Sri , STUCKY, Austin
IPC分类号： A61B5/044 , A61B5/00 , G06T17/20 , G16H50/50
摘要： Two or more electrophysiology characteristics can be graphically represented in a single representation output, for example, by an electroanatomical mapping system. The system can generate or receive multiple electrophysiology maps, one for each of a corresponding number of electrophysiological characteristics. The system can also generate or receive a three-dimensional anatomical model, such as a cardiac surface model, that includes a focal point. The system can identify a display region about the focal point and transform the display region from a three-dimensional surface into a plane. One or more of the electrophysiology maps can be represented by varying the elevation of the plane, e.g., according to value(s) of the represented electrophysiological characteristic(s). One or more additional electrophysiology maps can be represented on the elevation-varied plane, e.g., in color scale, grey scale, or the like.

8. 发明申请

WO2018148023A1 SYSTEM AND METHOD FOR DETECTING ASSOCIATED CARDIAC ACTIVATIONS 审中-公开
公开(公告)号：WO2018148023A1
公开(公告)日：2018-08-16
申请号：PCT/US2018/015224
申请日：2018-01-25
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： HAN, Dongfeng , AFONSO, Valtino X.
IPC分类号： A61B5/04 , A61B5/00
摘要： The present disclosure provides systems and methods for detecting cardiac activation times of a patient. A system includes a data acquisition system and a processor communicatively coupled thereto. The data acquisition system is configured to detect a plurality of electrograms generated at a plurality of respective electrodes coupled to the patient. The processor is configured to receive the plurality of electrograms from the data acquisition system. The processor is further configured to compute respective energies of the plurality of electrograms. The processor is further configured to detect a cardiac activation time for a first electrogram among the plurality of electrograms based on the respective energy of the first electrogram and the respective energy of a second electrogram that neighbors the first electrogram.

9. 发明申请

WO2017151347A1 METHODS AND SYSTEMS FOR MAPPING CARDIAC ACTIVITY 审中-公开
标题翻译：用于绘制心脏活动的方法和系统
公开(公告)号：WO2017151347A1
公开(公告)日：2017-09-08
申请号：PCT/US2017/018659
申请日：2017-02-21
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： RELAN, Jatin S. , AFONSO, Valtino X.
IPC分类号： A61B5/00 , A61B5/0452 , G06F17/14
摘要： Cardiac activity can be mapped by receiving an electrogram, transforming the electrogram into the wavelet domain (e.g., using a continuous wavelet transformation) to create a scalogram of the electrogram, computing at least one energy function of the scalogram, and computing at least one metric of the electrogram using the at least one energy function. The metrics of the electrogram can include, without limitation: a QRS activity duration for the electrogram; a near-field component duration for the electrogram; a far-field component duration for the electrogram; a number of multiple components for the electrogram; a slope of a sharpest component of the electrogram; a scalogram width; an energy ratio in the electrogram; and a cycle-length based metric of the electrogram.
摘要翻译：可以通过接收电描记图，将电描记图变换成小波域（例如，使用连续小波变换）来创建电描记图的尺度图，计算心电活动的至少一个能量函数使用所述至少一个能量函数来计算所述电描记图的至少一个度量。电描记图的度量可以包括但不限于：电描记图的QRS活动持续时间; 电描记图的近场分量持续时间; 电描记图的远场分量持续时间; 电描记图的多个组件; 电描记图的最锐利成分的斜率; 鳞片宽度; 电描记图中的能量比; 和电图的基于周期长度的度量。

10. 发明申请

WO2021188182A1 SYSTEM, METHOD, AND APPARATUS FOR MAPPING LOCAL ACTIVATION TIMES 审中-公开
公开(公告)号：WO2021188182A1
公开(公告)日：2021-09-23
申请号：PCT/US2020/066535
申请日：2020-12-22
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： RELAN, Jatin , AFONSO, Valtino X.
IPC分类号： A61B5/367 , A61B5/347 , A61B5/00 , A61B5/287
摘要： An electroanatomical mapping system graphically represents local activation time (LAT) information contained in data set including a plurality of electrophysiology (EP) data points. The system computes a spatial gradient over a spatial kernel centered at an EP data point and a plurality of temporal gradients for the EP data points set. Using the gradients, the electroanatomical mapping system can detect spatial outlier EP data points and temporal outlier EP data points. These outlier EP data points can then be corrected prior to outputting a graphical representation of the LAT map on a model of a cardiac surface.

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