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1. 发明申请

WO2023091714A1 METHODS FOR ASSESSING AN IMMUNE RESPONSE AND PREDICTING CANCER RECURRENCE AND ASSESSMENT OF CURRENT AND PRIOR CANCER STATUS 审中-公开
公开(公告)号：WO2023091714A1
公开(公告)日：2023-05-25
申请号：PCT/US2022/050474
申请日：2022-11-18
申请人： GREENWICH LIFESCIENCES, INC. , PATEL, Snehal S. , THOMPSON, Jaye
发明人： PATEL, Snehal S. , THOMPSON, Jaye
IPC分类号： G01N33/574
摘要： The present disclosure provides methods for using an immune response to a peptide, such as a peptide that correlates with a cancer, for instance an oncogenic protein, to determine if a subject is at an increased risk for recurrence of a cancer including increased risk of reduced time to recurrence of a cancer, if a cancer is present in the subject, or if the subject had a cancer prior to the testing and developed an immune response to the peptide. The methods include testing a subject's immune response to a peptide, such as a peptide that correlates with a cancer, for instance an oncogenic protein. The testing can occur at baseline, after baseline, or before baseline. In one embodiment, the peptide is a peptide of the oncogenic protein HER2/neu, such as GP2.

2. 发明申请

WO2021207347A1 SUPPLEMENTS AND COMPOSITIONS CONTAINING AMINO ACIDS AND IGF-1 AND METHODS OF USE 审中-公开
公开(公告)号：WO2021207347A1
公开(公告)日：2021-10-14
申请号：PCT/US2021/026157
申请日：2021-04-07
申请人： PURETEIN BIOSCIENCE LLC , CASEBOLT, Brett , VAUGHN, Matthew
发明人： CASEBOLT, Brett , VAUGHN, Matthew
IPC分类号： A23K20/142 , A23K20/184 , A23K50/30 , A23K50/60 , A23K50/75 , A23L33/17 , A23L33/175 , A23L33/195 , A61K31/198 , A61K38/30
摘要： Provided herein are supplements that include free amino acids L-glutamine or a salt thereof, L-leucine or a salt thereof, and L-arginine or a salt thereof, and active IGF-1. The L-glutamine or salt thereof, L-leucine or salt thereof, and L-arginine or salt thereof can be present at a ratio of approximately 3:1:1. Also provided are compositions that include the supplement, such as a food product. The disclosure also includes, but is not limited to, methods for using the supplements, including improving the performance of an animal, improving a processing factor of an animal, or increasing intestinal health of an animal, where the method includes administering to the animal a food product that has the supplement.

3. 发明申请

WO2019036373A2 PROTEINS HAVING PNEUMOCOCCAL CAPSULE DEGRADING ACTIVITY AND METHODS OF USE 审中-公开
公开(公告)号：WO2019036373A2
公开(公告)日：2019-02-21
申请号：PCT/US2018/046521
申请日：2018-08-13
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC.
发明人： AVCI, Fikri, Y. , MIDDLETON, Dustin , PASCHALL, Amy, Victoria
摘要： Provided herein is a protein, referred to as a Pn3Pase protein, that degrades the capsular polysaccharide of serotype 3 Streptococcus pneumoniae . The disclosure includes a genetically modified cell that includes a Pn3Pase protein, and compositions that include the protein, the polynucleotide encoding the protein, the genetically modified cell, or a combination thereof. Also provided are methods for using a Pn3Pase protein, including methods for contacting a S. pneumoniae having a type III capsular polysaccharide with a Pn3Pase protein, increasing deposition of at least one complement component on the surface of a S. pneumoniae , treating an infection in a subject, treating a symptom in a subject, decreasing colonization of a subject by S. pneumoniae , or a combination thereof.

4. 发明申请

WO2018223014A1 DNA-GLYCAN CONJUGATES AND METHODS OF USE 审中-公开
公开(公告)号：WO2018223014A1
公开(公告)日：2018-12-06
申请号：PCT/US2018/035629
申请日：2018-06-01
申请人： GEORGIA STATE UNIVERSITY RESEARCH FOUNDATON, INC.
发明人： WANG, Peng George , SONG, Jing , KONDENGADEN, Muhammed Shukkor , PARAMESWARAN, Aishwarya
IPC分类号： C12Q1/6837 , C12N15/10 , G06F19/22
摘要： Provided herein are DNA-glycan conjugates that include a glycan and a covalently attached polynucleotide. The polynucleotide includes a plurality of modules. Each module includes a nucleotide string, and the plurality of modules includes a monomer module that corresponds to each carbohydrate monomer present in the DNA-glycan conjugate, and a linkage module that corresponds to each glycosidic linkage present between each carbohydrate monomer in the DNA-glycan conjugate. The nucleotide sequence of the plurality of modules corresponds to the glycan structure. Also provided herein are methods for making and using the DNA-glycan conjugates. Further provided is a computer-implemented method for translating data from a nucleotide sequence to a glycan structure, a system for converting data from a glycan structure to a nucleotide sequence, and a system for translating data from a nucleotide sequence to a glycan structure.

5. 发明申请

WO2018005913A1 METHOD FOR IMPROVING THE QUALITY AND QUANTITY OF OFFSPRING IN MAMMALS 审中-公开
标题翻译：提高哺乳动物性能和数量的方法
公开(公告)号：WO2018005913A1
公开(公告)日：2018-01-04
申请号：PCT/US2017/040180
申请日：2017-06-30
申请人： VONNAHME, Kimberly A. , KENNEDY, Victoria C.
发明人： VONNAHME, Kimberly A. , KENNEDY, Victoria C.
IPC分类号： G01N33/53 , G01N33/558 , G01N33/543 , A61B5/00 , A61B5/021 , A61B5/024
摘要： The present disclosure relates to methods for predicting fertility and/or confirming the success of pregnancy and/or litter size in mammals. Novel methods and devices for field testing of mammal samples for pregnancy success and reproduction prosperity (fecundity) are also included.
摘要翻译：本公开涉及用于预测哺乳动物的生育力和/或确认妊娠成功和/或产仔数的方法。还包括用于哺乳动物样品的现场测试以用于怀孕成功和繁殖繁荣（繁殖力）的新方法和装置。

6. 发明申请

WO2017165397A1 GENETICALLY ENGINEERED MICROBES AND METHODS FOR PRODUCING CITRAMALATE 审中-公开
标题翻译：遗传工程微生物和生产CITRAMALATE的方法
公开(公告)号：WO2017165397A1
公开(公告)日：2017-09-28
申请号：PCT/US2017/023380
申请日：2017-03-21
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , WU, Xianghao , EITEMAN, Mark
发明人： WU, Xianghao , EITEMAN, Mark
IPC分类号： C12N15/70 , C12N9/10 , C12P7/46
CPC分类号： C12P7/46 , C12N9/10 , C12N9/1025 , C12N9/1029 , C12N15/70 , C12Y203/01182 , C12Y203/03001
摘要： Provided herein is a genetically engineered microbe which accumulates citramalate. In one embodiment, the microbe includes an exogenous polynucleotide encoding a citramalate synthase which catalyzes the condensation of acetyl CoA and pyruvic acid. Optionally, the microbe also includes a second exogenous polynucleotide encoding a citrate synthase which catalyzes the condensation of acetyl CoA and oxaloacetate, and the citrate synthase activity in the microbe is reduced compared to a control microbe. In one embodiment, the citrate synthase includes at least one amino acid substitution in the acetyl-CoA binding pocket, the mobile loop, the NADH binding site, and the oxaloacetate binding site, or a combination thereof. Also provided herein are methods for using the genetically engineered microbe, including a method is for producing citramalate. The method can further include isolating the citramalate.
摘要翻译：本文提供了一种积聚柠苹果酸酯的基因工程微生物。在一个实施方案中，微生物包括编码柠檬酸苹果酸合酶的外源多核苷酸，其催化乙酰CoA和丙酮酸的缩合。任选地，微生物还包括编码柠檬酸合酶的第二外源多核苷酸，其催化乙酰CoA和草酰乙酸的缩合，并且微生物中的柠檬酸合酶活性与对照微生物相比降低。在一个实施方案中，柠檬酸合酶在乙酰-CoA结合袋，移动环，NADH结合位点和草酰乙酸结合位点或其组合中包含至少一个氨基酸取代。本文还提供了使用基因工程微生物的方法，包括生产柠苹酸的方法。该方法可以进一步包括分离柠檬酸苹果酸酯。

7. 发明申请

WO2017106481A9 DISTINGUISHING METHYLATION LEVELS IN COMPLEX BIOLOGICAL SAMPLES 审中-公开
公开(公告)号：WO2017106481A9
公开(公告)日：2017-06-22
申请号：PCT/US2016/066901
申请日：2016-12-15
申请人： ILLUMINA, INC.
发明人： TOUNG, Jonathan , LIU, Li , SHEN, Min-jui, Richard , ZHANG, Ruoyu
IPC分类号： C12Q1/68
摘要： Provided herein is a method for distinguishing an aberrant methylation level for DNA from a first cell type, including steps of (a) providing a test data set that includes (i) methylation states for a plurality of sites from test genomic DNA from at least one test organism, and (ii) coverage at each of the sites for detection of the methylation states; (b) providing methylation states for the plurality of sites in reference genomic DNA from one or more reference individual organisms, (c) determining, for each of the sites, the methylation difference between the test genomic DNA and the reference genomic DNA, thereby providing a normalized methylation difference for each site; and (d) weighting the normalized methylation difference for each site by the coverage at each of the sites, thereby determining an aggregate coverage-weighted normalized methylation difference score. Also provided herein are sensitive methods for using genomic DNA methylation levels to distinguish cancer cells from normal cells and to classify different cancer types according to their tissues of origin.

8. 发明申请

WO2016048949A1 PICHINDE VIRUS REVERSE GENETICS SYSTEM AND METHODS OF USE 审中-公开
标题翻译： PICHINDE VIRUS逆向遗传系统及其使用方法
公开(公告)号：WO2016048949A1
公开(公告)日：2016-03-31
申请号：PCT/US2015/051337
申请日：2015-09-22
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , LY, Hinh , LIANG, Yuying
发明人： LY, Hinh , LIANG, Yuying
IPC分类号： C12N7/00 , C12N15/86 , A61K39/00
CPC分类号： C12N7/00 , A61K2039/5256 , A61K2039/70 , C12N15/86 , C12N2760/10043 , C12N2760/16134
摘要： Provided herein are genetically engineered Pichinde viruses that include three ambisense genomic segments. The first genomic segment includes a coding region encoding a Z protein and a coding region encoding a L RdRp protein. The second genomic segment includes a coding region encoding a nucleoprotein (NP) and the third genomic segment includes a coding region encoding a glycoprotein. Each of the second and third genomic segments optionally include an additional coding region that may encode an antigen or a detectable marker. Also provided herein is a reverse genetics system for making a genetically engineered Pichinde virus, and a collection of vectors that can be used to produce a genetically engineered Pichinde virus. Further provided are methods for using a reverse genetics system, and methods for producing an immune response in a subject.
摘要翻译：本文提供了包括三个ambisense基因组片段的基因工程的Pichinde病毒。第一基因组片段包括编码Z蛋白的编码区和编码L RdRp蛋白的编码区。第二基因组片段包括编码核蛋白（NP）的编码区，第三基因组片段包括编码糖蛋白的编码区。第二和第三基因组片段中的每一个任选地包括可以编码抗原或可检测标记的另外的编码区。本文还提供了用于制备基因工程的Pichinde病毒的反向遗传学系统，以及可用于产生遗传工程化的Pichinde病毒的载体的集合。还提供了使用反向遗传学系统的方法和用于在受试者中产生免疫应答的方法。

9. 发明申请

WO2014176360A1 METHODS FOR REDUCING ACUTE AXONAL INJURY 审中-公开
标题翻译：降低急性心肌损伤的方法
公开(公告)号：WO2014176360A1
公开(公告)日：2014-10-30
申请号：PCT/US2014/035182
申请日：2014-04-23
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , WU, Ping , KENT, Thomas, A.
发明人： WU, Ping , KENT, Thomas, A.
IPC分类号： A61K38/00 , A61P3/04 , A61K35/30 , C07K5/00
CPC分类号： A61K9/0043 , A61K35/28 , A61K35/30 , A61K38/185 , C12N5/0619 , C12N2501/13
摘要： Provided herein are methods for treating an acute axonal injury by intranasally administering to a subject in need thereof an effective amount of a composition that includes a compound having the biological activity of inhibiting the effect of rapid stretch injury on neural stem-cell derived neurons. An example of such a compound is a Ret receptor ligand, such as a GDNF polypeptide. The compound is optionally associated with a delivery reagent. In one embodiment, the method further includes intranasally administering to the subject stem cells, such as neuronal stem cells or adipose-derived stem cells. Also provided herein are methods for decreasing impairment of long term potentiation of hippocampal synapses in a subject after an acute axonal injury.
摘要翻译：本文提供了通过鼻内给予有需要的受试者有效量的组合物来治疗急性轴索损伤的方法，该组合物包括具有抑制神经干细胞衍生神经元的快速拉伸损伤作用的生物活性的化合物。这种化合物的实例是Ret受体配体，例如GDNF多肽。该化合物任选地与递送试剂结合。在一个实施方案中，该方法还包括鼻内施用受试者干细胞，例如神经元干细胞或脂肪来源的干细胞。本文还提供了减少急性轴索损伤后受试者中海马突触的长期增强的损伤的方法。

10. 发明申请

WO2011130666A2 PLANTS WITH ALTERED CELL WALL BIOSYNTHESIS AND METHODS OF USE 审中-公开
标题翻译：具有改变细胞壁生物学的植物和使用方法
公开(公告)号：WO2011130666A2
公开(公告)日：2011-10-20
申请号：PCT/US2011/032733
申请日：2011-04-15
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , MOHNEN, Debra, A. , BISWAL, Ajaya, Kumar , HAO, Zhangying , HUNT, Kimberly, D. , GELINEO-ALBERSHEIM, Ivana , KATAEVA, Irina , ADAMS, Michael W.,W.
发明人： MOHNEN, Debra, A. , BISWAL, Ajaya, Kumar , HAO, Zhangying , HUNT, Kimberly, D. , GELINEO-ALBERSHEIM, Ivana , KATAEVA, Irina , ADAMS, Michael W.,W.
IPC分类号： A01H5/00 , C12N15/82 , C12N15/29 , C07K14/415 , A01H5/08
CPC分类号： C12N15/8243 , C12N15/8255 , C12P7/06 , D21B1/04 , Y02E50/17
摘要： Provided herein are plants having altered expression of a GAUT polypeptide. Such plants have phenotypes that may include decreased recalcitrance, increased growth, decreased lignin content, or a combination thereof. Also provided herein are methods of making and using such plants.
摘要翻译：本文提供具有GAUT多肽表达改变的植物。这样的植物具有表型，其可以包括降低的顽固性，增加的生长，降低的木质素含量或其组合。本文还提供了制造和使用这种植物的方法。

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