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    • 3. 发明申请
    • PROSTATE SPECIFIC ANTIGENS, CONJUGATES THEREOF, METHODS FOR THEIR PREPARATION AND USES THEREOF.
    • 前列腺特异性抗原,与其结合,其制备方法及其用途。
    • WO2004060915A2
    • 2004-07-22
    • PCT/US2003/038453
    • 2003-12-03
    • SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCHDANISHEFSKY, Samuel, J.DUDKIN, VadimMILLER, Justin
    • DANISHEFSKY, Samuel, J.DUDKIN, VadimMILLER, Justin
    • C07K14/47
    • C07K14/005A61K38/00A61K39/12A61K39/21A61K2039/55577A61K2039/6018A61K2039/6081A61K2039/627C07K9/00C07K16/3069C12N9/6445C12N2740/16122C12N2740/16134C12Y304/21077
    • The present invention provides compounds having formula (I): wherein W 1 , W 2 , R 1 , R 3 , R 4 , R 2A and R 2B are as defined herein; and additionally provides methods for the synthesis thereof, compositions thereof, and methods of use thereof in the treatment of cancer, methods for the prevention of recurrence of cancer, and methods for inducing antibodies in a subject, comprising administering to a subject in need thereof, an effective amount of any of the inventive compounds as disclosed herein, either in conjugated form or unconjugated and in combination with a suitable immunogenic carrier. In another aspect, the invention provides an antibody or antibody fragment which binds specifically to a normal or transformed PSA glycan or glycopeptide of the invention. In another aspect, the invention provides an immunoassay method for the quantitative determination of normal or transformed PSA in a biological sample. In another aspect, the invention provides an immunoassay kit for assessing the presence and/or amount of normal or transformed PSA in a sample. In another aspect, the invention provides a diagnostic kit for diagnosing an adenocarcinoma of the prostate in an individual suspected of suffering therefrom, or for differentiating between a benign pathology of the prostate and an adenocarcinoma of the prostate in an individual suspected of suffering therefrom.
    • 本发明提供具有式(I)的化合物:其中W 1,W 2,R 1,R 3,R 4,R 2A和R 2B如本文所定义 ; 并且另外提供其合成方法,其组合物及其在癌症治疗中的应用方法,用于预防癌症复发的方法,以及在受试者中诱导抗体的方法,包括向有需要的受试者施用, 有效量的本文公开的任何本发明化合物,其以缀合形式或未偶联并与合适的免疫原性载体组合。 另一方面,本发明提供了与本发明的正常或转化的PSA聚糖或糖肽特异性结合的抗体或抗体片段。 另一方面,本发明提供了用于定量测定生物样品中正常或转化的PSA的免疫测定方法。 另一方面,本发明提供了用于评估样品中正常或转化的PSA的存在和/或量的免疫测定试剂盒。 另一方面,本发明提供了一种诊断试剂盒,用于诊断怀疑患有其的个体中的前列腺腺癌,或用于区分怀疑患有前列腺的前列腺的良性病理学和前列腺腺癌之间的差异。