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1. 发明申请

WO2006040534A2 METHOD 审中-公开
标题翻译：方法
公开(公告)号：WO2006040534A2
公开(公告)日：2006-04-20
申请号：PCT/GB2005/003900
申请日：2005-10-11
申请人： PARADIGM THERAPEUTICS LIMITED , ELLERY, Jonathan
发明人： ELLERY, Jonathan
CPC分类号： A61K31/711 , G01N33/74 , G01N2333/726
摘要： We describe a method comprising detecting GPR92 modulated expression of an NF-κB, API, CRE or p53 sensitive reporter, preferably for detecting the presence, quantity, activity or a change in any of these of a GPCR. These methods are useful for identifying agonists and antagonists or inverse agonist of GPCRs. We also provide cells for use in these methods.
摘要翻译：我们描述了一种方法，其包括检测NF-κB，API，CRE或p53敏感性报告物的GPR92调节表达，优选用于检测GPCR中任何一种的存在，数量，活性或变化。这些方法可用于鉴定GPCR的激动剂和拮抗剂或反向激动剂。我们还提供用于这些方法的细胞。

2. 发明申请

WO2006027545A2 METHOD 审中-公开
标题翻译：方法
公开(公告)号：WO2006027545A2
公开(公告)日：2006-03-16
申请号：PCT/GB2005/003206
申请日：2005-08-17
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , LIM, Sai, Kiang , QUE, Jian, Wen , EL OAKLEY, Reida, Menshawe
发明人： LIM, Sai, Kiang , QUE, Jian, Wen , EL OAKLEY, Reida, Menshawe
IPC分类号： C12N5/06 , A61K38/45 , A61K31/436 , A61K31/045 , A61K31/661 , G01N33/50 , A01K67/027
CPC分类号： C12N5/0611 , A01K2217/075 , A01K2227/105 , A61K31/045 , A61K31/436 , A61K31/661 , A61K38/45 , C12N5/0604 , C12N5/0606 , C12N2501/04 , C12N2501/06 , C12N2501/40 , C12N2501/70
摘要： We provide a method comprising modulating the activity of mTOR in a stem cell, preferably increasing the activity of mTOR to enable a stem cell to self-renew, or decreasing it to enable a stem cell to differentiate. The stem cell may be exposed to an agonist of mTOR for the former, preferably phosphatidic acid, or an antagonist of mTOR for the latter, preferably 1-butanol or rapamycin or a derivative thereof.
摘要翻译：我们提供了一种方法，其包括调节干细胞中mTOR的活性，优选增加mTOR的活性以使干细胞自我更新或降低干细胞以使其能够分化。干细胞可暴露于前者的mTOR激动剂，优选磷脂酸，或后者的mTOR拮抗剂，优选1-丁醇或雷帕霉素或其衍生物。

3. 发明申请

WO2006090283A2 CELL COUNTING 审中-公开
标题翻译：细胞计数
公开(公告)号：WO2006090283A2
公开(公告)日：2006-08-31
申请号：PCT/IB2006/000613
申请日：2006-02-06
申请人： DAKO DENMARK A/S , CHRISTENSEN, Nanna, K. , LAURSEN, Jesper , WINTHER, Lars
发明人： CHRISTENSEN, Nanna, K. , LAURSEN, Jesper , WINTHER, Lars
IPC分类号： G01N33/543 , B01L3/00 , B01L3/14
CPC分类号： G01N15/1459 , G01N33/543 , G01N33/54366 , G01N33/54393 , G01N2015/1486 , Y10T436/101666
摘要： The inventions relates to compositions and method for determining the absolute counts of cells per unit volume of a sample. Such a method comprises: (a) providing a container containing: (i) a predetermined quantity of microparticles; and (ii) a cell-binding agent; in which the microparticles are disposed in or on a matrix which adheres to at least one wall of the container such that substantially all the microparticles are thereby attached to the container; (b) adding a known volume of sample to the container; (c) determining the ratio of microparticles to cells by counting microparticles and cells in a volume of the sample; and (d) determining the absolute count of cells by multiplying the number of cells per microparticle by the concentration of microparticles in the sample. Preferably, the matrix retains substantially all the microparticles in or on the container during routine handling, including inversion, of the container, in the absence of mechanical retaining means such as a retainer grid in the container.
摘要翻译：本发明涉及用于确定样品每单位体积的细胞的绝对计数的组合物和方法。这种方法包括：（a）提供容器，其包含：（i）预定量的微粒; 和（ii）细胞结合剂; 其中微粒设置在基质中或基体上，该基质附着在容器的至少一个壁上，使得基本上所有的微粒从而附着到容器上; （b）向容器中加入已知体积的样品; （c）通过计数样品体积中的微粒和细胞来确定微粒与细胞的比例; 和（d）通过将每个微粒的细胞数乘以样品中微粒的浓度来确定细胞的绝对计数。优选地，在没有诸如容器中的保持架网格的机械保持装置的情况下，基体在基本上将容器内的所有微粒保持在容器的常规处理（包括反转）中。

4. 发明申请

WO2006114647A1 ION CHANN 审中-公开
标题翻译：离子通
公开(公告)号：WO2006114647A1
公开(公告)日：2006-11-02
申请号：PCT/GB2006/001595
申请日：2006-04-28
申请人： PARADIGM THERAPEUTICS LIMITED , BRICE, Nicola , CARLTON, Mark , DIXON, John , MALINGE, Isabelle , ZAHN, Dirk
发明人： BRICE, Nicola , CARLTON, Mark , DIXON, John , MALINGE, Isabelle , ZAHN, Dirk
IPC分类号： C07K14/705 , C12N15/09 , C12N15/63 , C12Q1/68
CPC分类号： C07K14/705 , A61K49/0008
摘要： We disclose a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of pain, the method comprising determining whether a candidate molecule is an agonist or antagonist, including a opener, blocker or modulator, of Kv9.2 polypeptide, in which the Kv9.2 polypeptide comprises the amino acid sequence shown in SEQ ID NO. 3 or SEQ ID NO: 5, or a sequence which is at least 90% identical thereto.
摘要翻译：我们公开了鉴定适于治疗，预防或缓解疼痛的分子的方法，所述方法包括确定候选分子是否是Kv9.2多肽的激动剂或拮抗剂，包括开放剂，阻断剂或调节剂，其中 Kv9.2多肽包含SEQ ID NO：1所示的氨基酸序列。 3或SEQ ID NO：5，或与其至少90％相同的序列。

5. 发明申请

WO2008048193A3 BREAST TUMOUR GRADING 审中-公开
公开(公告)号：WO2008048193A3
公开(公告)日：2008-04-24
申请号：PCT/SG2007/000357
申请日：2007-10-19
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , MILLER, Lance, D. , KUZNETSOV, Vladimir , IVSHINA, Anna
发明人： MILLER, Lance, D. , KUZNETSOV, Vladimir , IVSHINA, Anna
IPC分类号： C12Q1/68
摘要： We describe a method of assigning a grade to a breast tumour, which grade is indicative of the aggressiveness of the tumour, the method comprising detecting the expression of a gene selected from the genes set out in Table D1 (SWS Classifier 0).

6. 发明申请

WO2007007053A1 MODIFIED AMYLASE FROM PSEUDOMONAS SACCHAROPHILIA 审中-公开
标题翻译：来自PSEUDOMONAS SACCHAROPHILIA的修饰的AMYLASE
公开(公告)号：WO2007007053A1
公开(公告)日：2007-01-18
申请号：PCT/GB2006/002513
申请日：2006-07-07
申请人： DANISCO A/S , GENENCOR INTERNATIONAL, INC. , BERG, Casper, Tune , DERKX, Patrick, Maria, Franciscus , FIORESI, Carol , GERRITSE, Gijsbert , KELLET-SMITH, Anja, Hemmingen , KRAGH, Karsten, Matthias , LIU, Wei , SHAW, Andrew , SØRENSEN, Bo, Spange , THOUDAHL, Charlotte, Refdahl
发明人： BERG, Casper, Tune , DERKX, Patrick, Maria, Franciscus , FIORESI, Carol , GERRITSE, Gijsbert , KELLET-SMITH, Anja, Hemmingen , KRAGH, Karsten, Matthias , LIU, Wei , SHAW, Andrew , SØRENSEN, Bo, Spange , THOUDAHL, Charlotte, Refdahl
IPC分类号： C12N9/28
CPC分类号： A21D8/042 , A23L33/18 , C12N9/2411 , C12N9/2414 , C12N9/2417 , C12N9/2425 , C12N9/2428
摘要： We describe a PS4 variant polypeptide derivable from a parent polypeptide having amylase activity selected from the group consisting of: (a) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 161, 178, 179, 223, 229, 272, 303, 307, 309 and 334; (b) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 145, 146, 157, 178, 179, 223, 229, 272, 303, 307 and 334; (c) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 178, 179, 223, 229, 272, 303, 307, 309 and 334; and (d) a polypeptide comprising an amino acid mutation at each of positions 3, 33, 34, 70, 121, 134, 141, 146, 157, 178, 179, 223, 229, 272, 303, 307, 309 and 334; with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1 , uses of such a polypeptide as a food or feed additive, and nucleic acids encoding such.
摘要翻译：我们描述了可从具有选自以下的淀粉酶活性的亲本多肽衍生的PS4变体多肽：（a）包含位置33,34,121,134,141,146,157,161中的每一个的氨基酸突变的多肽，178,179,223,229,272,303,307,309和334; （b）包含位置33,34,121,134,141,145,146,157,177,179,223,229,272,303,307和334的氨基酸突变的多肽; （c）包含位置33,34,121,134,141,146,157,178,179,223,229,272,303,307,309和334的氨基酸突变的多肽; 和（d）包含位置3,33,34,70,121,134,141,146,157,178,179,223,229,272,303,307,309和334中的每一个上的氨基酸突变的多肽 ; 参考如SEQ ID NO：1所示的假单胞菌属（Saccharophilia）淀粉酶序列的位置编号，使用这样的多肽作为食品或饲料添加剂，以及编码其的核酸。

7. 发明申请

WO2006059069A2 ION CHANNEL 审中-公开
标题翻译：离子通道
公开(公告)号：WO2006059069A2
公开(公告)日：2006-06-08
申请号：PCT/GB2005/004508
申请日：2005-11-24
申请人： PARADIGM THERAPEUTICS LIMITED , APARICIO, Samuel , BRICE, Nicola , HORWOOD, Jennifer, Marie , MA, Dan
发明人： APARICIO, Samuel , BRICE, Nicola , HORWOOD, Jennifer, Marie , MA, Dan
CPC分类号： G01N33/6872 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0356 , C07K14/705 , G01N33/6896 , G01N2500/00 , G01N2800/2821
摘要： We disclose KCNMA3 ion channel polypeptides comprising the amino acid sequence shown in SEQ ID NO. 3, SEQ ID NO: 5 or SEQ ID NO: 6, and homologues, variants and derivatives thereof. Nucleic acids capable of encoding KCNMA3 polypeptide are also disclosed, in particular, those comprising the nucleic acid sequences shown in SEQ ID No. 1, SEQ ID No.2 or SEQ ID NO: 4.
摘要翻译：我们公开了包含SEQ ID NO.1所示氨基酸序列的KCNMA3离子通道多肽。 3，SEQ ID NO：5或SEQ ID NO：6，及其同系物，变体和衍生物。还公开了能够编码KCNMA3多肽的核酸，特别是包含SEQ ID No.1，SEQ ID No.2或SEQ ID NO：4中所示的核酸序列的那些。

8. 发明申请

WO2006003461A2 POLYPEPTIDE 审中-公开
标题翻译：多肽
公开(公告)号：WO2006003461A2
公开(公告)日：2006-01-12
申请号：PCT/GB2005/002675
申请日：2005-07-07
申请人： DANISCO A/S , GENENCOR INTERNATIONAL, INC. , BERG, Casper, Tune , DERKX, Patrick, M., F. , FIORESI, Carol , GERRITSE, Gijsbert , KELLET-SMITH, Anja, Hemmingen , KRAGH, Karsten, Matthias , LIU, Wei , SHAW, Andrew , SØRENSEN, Bo, Spange , THOUDAHL, Charlotte, Refdahl
发明人： BERG, Casper, Tune , DERKX, Patrick, M., F. , FIORESI, Carol , GERRITSE, Gijsbert , KELLET-SMITH, Anja, Hemmingen , KRAGH, Karsten, Matthias , LIU, Wei , SHAW, Andrew , SØRENSEN, Bo, Spange , THOUDAHL, Charlotte, Refdahl
IPC分类号： C12N9/00
CPC分类号： C12Y302/0106 , A21D8/042 , A23K20/189 , A23L7/107 , A23L29/35 , A23V2002/00 , C12N9/2417 , A23V2300/21
摘要： We describe a PS4 variant polypeptide derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the PS4 variant polypeptide comprises an amino acid mutation at one or more positions selected from the group consisting of: 121, 161, 223, 146, 157, 158, 198, 229, 303, 306, 309, 316, 353, 26, 70, 145, 188, 272, 339, with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1.
摘要翻译：我们描述了源自具有非麦芽糖外淀粉酶活性的亲本多肽的PS4变体多肽，其中PS4变体多肽在选自以下的一个或多个位置包含氨基酸突变：121 ，161,223,146,157,158,198,229,303,306,309,316,353,26,70,145,188,272,339，参考嗜糖假单胞菌（Pseudomonas saccharophilia）的位置编号如SEQ ID NO：1所示的外切淀粉酶序列。

9. 发明申请

WO2010093335A1 ANTIBODIES FOR DIAGNOSIS AND TREATMENT OF FLAVIVIRAL INFECTIONS 审中-公开
标题翻译：用于诊断和治疗感染病毒的抗体
公开(公告)号：WO2010093335A1
公开(公告)日：2010-08-19
申请号：PCT/SG2010/000049
申请日：2010-02-10
申请人： NANYANG TECHNOLOGICAL UNIVERSITY , VASUDEVAN, Subhash , LESCAR, Julien , RAJAMANONMANI, Ravikumar
发明人： VASUDEVAN, Subhash , LESCAR, Julien , RAJAMANONMANI, Ravikumar
IPC分类号： C07K16/10 , C12P21/08 , A61K39/42 , G01N33/577
CPC分类号： C07K16/1081 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N2333/185 , Y02A50/386 , Y02A50/388 , Y02A50/394 , Y02A50/396 , Y02A50/53
摘要： We describe an immunoglobulin capable of binding to a dengue envelope glycoprotein (E) polypeptide, in which the immunoglobulin is capable of binding to an epitope bound by antibody 9Fl 2, or a variant, homologue, derivative or fragment thereof. The epitope may comprise residues K305, K307, K310 and G330 of a dengue envelope glycoprotein (E) sequence, with reference to the position numbering shown as SEQ ID NO: 2. The immunoglobulin may comprise the variable region of monoclonal antibody 9Fl 2 (SEQ ID NO: 4, SEQ ID NO: 6).
摘要翻译：我们描述了能够结合登革热包膜糖蛋白（E）多肽的免疫球蛋白，其中免疫球蛋白能够结合由抗体9F12结合的表位或其变体，同系物，衍生物或片段。参考如SEQ ID NO：2所示的位置编号，表位可以包含登革热包膜糖蛋白（E）序列的残基K305，K307，K310和G330。免疫球蛋白可以包含单克隆抗体9F12（SEQ ID NO： SEQ ID NO：4，SEQ ID NO：6）。

10. 发明申请

WO2006003422A1 USE OF THE RECEPTOR GPR86 审中-公开
标题翻译：受体GPR86的使用
公开(公告)号：WO2006003422A1
公开(公告)日：2006-01-12
申请号：PCT/GB2005/002601
申请日：2005-07-01
申请人： PARADIGM THERAPEUTICS LIMITED , BRICE, Nicola , CARLTON, Mark , DIXON, John , HENDRICK, Alan , MALINGE, Isabelle , MESSAGER, Sophie , ZAHN, Dirk
发明人： BRICE, Nicola , CARLTON, Mark , DIXON, John , HENDRICK, Alan , MALINGE, Isabelle , MESSAGER, Sophie , ZAHN, Dirk
IPC分类号： G01N33/566
CPC分类号： G01N33/566 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0356 , A61K49/0008 , C07K14/70571 , C12N15/8509 , G01N33/6893 , G01N2333/726 , G01N2500/00 , G01N2800/24 , G01N2800/52
摘要： We disclose a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of a GPR86 associated disease, in particular inflammatory disease or pain, the method comprising determining whether a candidate molecule is an agonist or antagonist of GPR86 polypeptide, in which the GPR86 polypeptide comprises the amino acid sequence shown in SEQ ID NO. 3 or SEQ ID NO: 5 or SEQ ID NO: 7, a fragment thereof or a sequence which is at least 90% identical thereto.
摘要翻译：我们公开了鉴定适合于治疗，预防或减轻GPR86相关疾病，特别是炎性疾病或疼痛的分子的方法，所述方法包括确定候选分子是否是GPR86多肽的激动剂或拮抗剂，其中GPR86 多肽包含SEQ ID NO：1所示的氨基酸序列。 3或SEQ ID NO：5或SEQ ID NO：7，其片段或与其至少90％相同的序列。

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