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1. 发明申请

WO2007100489A1 SULFONATED AROMATIC POLYESTER POLYOL CMPOSITIONS 审中-公开
标题翻译：磺化芳族聚酯多元醇
公开(公告)号：WO2007100489A1
公开(公告)日：2007-09-07
申请号：PCT/US2007/003761
申请日：2007-02-12
申请人： OXID, L.P. , DELEON, Alberto , SHIEH, David, J.
发明人： DELEON, Alberto , SHIEH, David, J.
IPC分类号： C08G18/42 , C08G18/46 , C08J9/08 , C08J9/12 , C08J9/14
CPC分类号： C08G18/4676 , C08G18/4202 , C08G2101/0025 , C08G2101/005 , C08G2101/0083 , C08G2105/02
摘要： Aromatic polyester polyols comprising the inter-esterification product of at least one phthalic acid based material, at least one hydroxylated material having a functionality of at least 2, and at least one low molecular weight sulfonated compound, are provided. These polyols may optionally include at least one hydrophobic material as an inter-esterification reactant. Also provided are methods for preparing such polyols. Further described are polyol-based compositions prepared using such polyols and a blowing agent, as well as methods for preparing such polyol-based compositions. Polyisocyanurate and polyurethane foams made from such polyol-based compositions, and to methods for preparing such polyisocyanurate and polyurethane foams are also described.
摘要翻译：提供了包含至少一种邻苯二甲酸基材料的至少一种羟基化物质和至少一种官能度为2的羟基化材料和至少一种低分子量磺化化合物的芳族聚酯多元醇。这些多元醇可以任选地包括至少一种作为酯化反应物的疏水材料。还提供了制备这种多元醇的方法。进一步描述的是使用这种多元醇和发泡剂制备的基于多元醇的组合物，以及制备这种多元醇基组合物的方法。还描述了由这种多元醇基组合物制备的聚异氰脲酸酯和聚氨酯泡沫以及制备这种聚异氰脲酸酯和聚氨酯泡沫的方法。

2. 发明申请

WO2006107293A1 METHOD FOR IMPROVING REFUGE EFFICIENCY 审中-公开
标题翻译：提高REF效率的方法
公开(公告)号：WO2006107293A1
公开(公告)日：2006-10-12
申请号：PCT/US2005/011362
申请日：2005-04-01
申请人： MONSANTO TECHNOLOGY LLC , ADDISON, Stewart, J.
发明人： ADDISON, Stewart, J.
IPC分类号： A01N25/00
CPC分类号： A01N25/00 , A01N63/02 , Y02A50/356 , A01N27/00 , A01N31/08 , A01N31/14 , A01N35/02 , A01N37/40 , A01N49/00 , A01N61/00 , A01N65/08 , A01N65/44
摘要： A method to improve the efficiency of refuge crops in preventing the development of insects that are resistant to an insecticide. The method involves using an attractant to lure insects to the refuge and increase the population of survivors. The protected crops include cotton and corn. The refuge crop may be the same crop, a different crop, or a naturally occurring plant population.
摘要翻译：提高避难作物在防止杀虫剂抗性的昆虫发育效率方面。该方法涉及使用引诱剂将昆虫吸引到避难所，并增加幸存者的人口。受保护的作物包括棉花和玉米。避难作物可能是相同的作物，不同的作物或天然存在的植物种群。

3. 发明申请

WO2006047669A2 NON-RANDOM METHOD OF GENE SHUFFLING 审中-公开
标题翻译：非随机基因组方法
公开(公告)号：WO2006047669A2
公开(公告)日：2006-05-04
申请号：PCT/US2005/038725
申请日：2005-10-26
申请人： MONSANTO TECHNOLOGY LLC , HAUGE, Brian, M. , DONG, Fenggao
发明人： HAUGE, Brian, M. , DONG, Fenggao
CPC分类号： C12N15/1031 , C12N15/1027 , C12N15/1093 , C12N15/64 , C12N15/66
摘要： The present invention concerns the non-random assembling of DNA molecules in a DNA construct and methods of using such constructs, including the production of nucleic acid libraries. The non-random gene shuffling is preferably accomplished by the following steps. First, optionally, the amino acid sequences of proteins encoded by related gene families of interest are aligned and inspected for regions of conserved amino acid residues. These conserved regions, preferably of at least 4 (e.g. about 4 to 10) consecutive conserved amino acid residues are candidate regions for the subsequent design of PCR primers to amplify the variable or less conserved regions in between them, followed by non-random reassembly to create a recombinant nucleic acid genetic library of gene family variants.
摘要翻译：本发明涉及DNA构建体中DNA分子的非随机组装以及使用这些构建体的方法，包括产生核酸文库。非随机基因改组优选通过以下步骤完成。首先，任选地，由感兴趣的相关基因家族编码的蛋白质的氨基酸序列进行比对并检查保守氨基酸残基的区域。这些保守区域，优选至少4个（例如约4至10个）连续的保守氨基酸残基是候选区域，用于后续设计的PCR引物以扩增它们之间的可变的或较不保守的区域，随后是非随机重组创建基因家族变体的重组核酸基因文库。

4. 发明申请

WO2005044992A2 METHOD OF PREVENTING VIRUS: CELL FUSION BY INHIBITING THE FUNCTION OF THE FUSION INITIATION REGION IN RNA VIRUSES HAVING CLASS I MEMBRANE FUSOGENIC ENVELOPE PROTEINS 审中-公开
标题翻译：通过抑制具有I类膜蛋白包膜蛋白的RNA病毒中的融合启动区的功能来预防病毒：细胞融合的方法
公开(公告)号：WO2005044992A2
公开(公告)日：2005-05-19
申请号：PCT/US2004/036578
申请日：2004-11-03
申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , GARRY, Robert, F. , RUSSELL, Wilson
发明人： GARRY, Robert, F. , RUSSELL, Wilson
IPC分类号： C12N
CPC分类号： C07K14/005 , A61K38/00 , A61K38/04 , A61K38/162 , C07K7/00 , C07K7/06 , C07K7/08 , C12N7/00 , C12N2760/10022 , C12N2760/14122 , C12N2760/18422 , C12N2760/18433 , C12N2770/20022 , C12Q1/18 , G01N33/56988
摘要： The present invention relates to a method of preventing or inhibiting viral infection of a cell and/or fusion between the envelope of a virus and the membranes of a cell targeted by the virus (thereby preventing delivery of the viral genome into the cell cytoplasm, a step required for. viral infection). The present invention particularly relates to the families of RNA viruses, including the arenaviruses, coronaviruses, filoviruses, orthomyxoviruses, paramyxoviruses, and retroviruses, having Class I membrane fusion proteins as the fusion proteins that mediate this fusion process. The present invention provides for a method of identifying a conserved motif or domain called the fusion initiation region (FIR) in these viruses. The present invention further provides for methods of preventing infection by such viruses, by interfering with their FIR. The present invention further provides for methods of treatment and prophylaxis of diseases induced by such viruses.
摘要翻译：本发明涉及一种预防或抑制病毒感染病毒感染和/或病毒包膜与病毒靶向细胞膜（从而防止病毒基因组递送到细胞质中的融合物）的方法病毒感染所需的步骤）。本发明特别涉及RNA病毒家族，其包括具有I类膜融合蛋白作为介导该融合过程的融合蛋白的氨甲威病毒，冠状病毒，弧菌病毒，正粘病毒，副粘病毒和逆转录病毒。本发明提供了鉴定这些病毒中称为融合起始区（FIR）的保守基序或结构域的方法。本发明进一步提供了通过干扰它们的FIR来防止这种病毒感染的方法。本发明还提供了治疗和预防由这些病毒引起的疾病的方法。

5. 发明申请

WO2005038017A2 PREVENTION OF INCORPORATION OF NON-STANDARD AMINO ACIDS INTO PROTEIN 审中-公开
标题翻译：预防将非标准氨基酸并入蛋白质中
公开(公告)号：WO2005038017A2
公开(公告)日：2005-04-28
申请号：PCT/US2004/031224
申请日：2004-09-23
申请人： MONSANTO TECHNOLOGY LLC , BOGOSIAN, Greeg , O'NEIL, Julia, P. , SMITH, Hong, Q.
发明人： BOGOSIAN, Greeg , O'NEIL, Julia, P. , SMITH, Hong, Q.
IPC分类号： C12N9/00
CPC分类号： C12N9/0016 , C07K14/61 , C12P21/02
摘要： The instant invention is drawn to the methods and compositions necessary to provide recombinant proteins with a substantially reduced or eliminated content of norleucine or other non-standard amino acids. Various embodiments of the invention provide for the substantial elimination of the incorporation of non-standard amino acids into recombinant proteins by the co-expression or enhanced expression of a protein (or the enzymatically active portion thereof) capable of degrading norleucine or other non-standard amino acids, including norvaline, beta-methylnorleucine, and homoisoleucine. In certain particular embodiments of the invention, the norleucine is degraded by a glutamate dehydrogenase, a leucine dehydrogenase, a valine dehydrogenase, a phenylalanine dehydrogenase, a glutamate/leucine/phenylalanine/valine dehydrogenase, or an opine dehydrogenase. Also provided are the cells and DNA constructs for carrying out these methods.
摘要翻译：本发明涉及提供具有正亮氨酸或其他非标准氨基酸的含量显着降低或消除的重组蛋白所必需的方法和组合物。本发明的各种实施方案通过共表达或增强的能够降解正亮氨酸或其他非标准蛋白质（或其酶促活性部分）的表达来提供基本消除将非标准氨基酸掺入重组蛋白质中的步骤包括正缬氨酸，β-甲基正亮氨酸和高异亮氨酸。在本发明的某些具体实施方案中，正亮氨酸被谷氨酸脱氢酶，亮氨酸脱氢酶，缬氨酸脱氢酶，苯丙氨酸脱氢酶，谷氨酸/亮氨酸/苯丙氨酸/缬氨酸脱氢酶或冠op碱脱氢酶降解。还提供了用于实施这些方法的细胞和DNA构建体。

6. 发明申请

WO2003096797A3 METHOD OF INCREASING PLANT ORGAN AND SEED SIZE IN A PLANT 审中-公开
公开(公告)号：WO2003096797A3
公开(公告)日：2003-11-27
申请号：PCT/US2003/014989
申请日：2003-05-14
申请人： MONSANTO TECHNOLOGY LLC , FERNANDES, Mary , XIE, Zhidong , DOTSON, Stanton B.
发明人： FERNANDES, Mary , XIE, Zhidong , DOTSON, Stanton B.
IPC分类号： C12N15/82
摘要： The present invention provides methods and DNA molecules useful for producing transgenic plants with agronomically desired traits based on altered sizes of plant organs and tissues.

7. 发明申请

WO2003045372A1 FORMULATION OF AMINO ACIDS AND RIBOFLAVIN USEFUL TO REDUCE TOXIC EFFECTS OF CYTOTOXIC CHEMOTHERAPY 审中-公开
标题翻译：制备氨基酸和利比托因有效减少细胞毒性的毒性作用
公开(公告)号：WO2003045372A1
公开(公告)日：2003-06-05
申请号：PCT/US2002/037354
申请日：2002-11-21
申请人： BURZYNSKI, Stanislaw, R.
发明人： BURZYNSKI, Stanislaw, R.
IPC分类号： A61K31/195
CPC分类号： A61K31/198 , A61K31/195 , A61K31/525 , A61K2300/00
摘要： Pharmaceutical compositions effective in alleviating or reducing the effects of fatigue and weakness associated with cancer and cytotoxic cancer chemotherapy are disclosed. The pharmaceutical compositions of the present invention comprise riboflavin, effectors of the urea cycle in free form or pharmacologically acceptable salts thereof, and amino acids selected from the gorups of essential and non-essential amino acids, in free form or pharmaceutically acceptable salts thereof, suitably combined with appropriate carriers, diluents, or excipients. Also disclosed are methods of alleviating or reducing the effects of fatigue and weakness associated with cancer and cytotoxic cancer chemotherapy by administration of pharmaceutical compositions of the present invention.
摘要翻译：公开了有效减轻或减少与癌症和细胞毒性癌化疗相关的疲劳和虚弱的作用的药物组合物。本发明的药物组合物包含核黄素，游离形式的尿素循环的效应物或其药理学上可接受的盐，以及选自游离形式或其药学上可接受的盐的必需氨基酸和非必需氨基酸的氨基酸，与适当的载体，稀释剂或赋形剂组合。还公开了通过施用本发明的药物组合物来减轻或减轻与癌症和细胞毒性癌化疗相关的疲劳和虚弱的影响的方法。

8. 发明申请

WO2002040677A3 COTTON EVENT PV-GHBK04 (531) AND COMPOSITIONS AND METHODS FOR DETECTION THEREOF 审中-公开
公开(公告)号：WO2002040677A3
公开(公告)日：2002-05-23
申请号：PCT/US2001/043297
申请日：2001-11-20
申请人： MONSANTO TECHNOLOGY LLC , BEAZLEY, Kim, A. , HILLYARD, Jeanna, R. , PANG, Shengzhi , ROBERTS, James, K.
发明人： BEAZLEY, Kim, A. , HILLYARD, Jeanna, R. , PANG, Shengzhi , ROBERTS, James, K.
IPC分类号： C12N15/29
摘要： The present invention provides assays for detecting the presence of the 531 cotton event nucleic acid sequences in a biological sample based on the DNA sequence of the recombinant construct inserted into the cotton genome and of genomic sequences flanking the insertion site in a cotton genome.

9. 发明申请

WO2014126681A1 SHORT BIO-ACTIVE PEPTIDES FOR PROMOTING WOUND HEALING 审中-公开
标题翻译：短促生物活性肽促进创伤治疗
公开(公告)号：WO2014126681A1
公开(公告)日：2014-08-21
申请号：PCT/US2014/012378
申请日：2014-01-21
申请人： HELIX BIOMEDIX INC.
发明人： ZHANG, Lijuan , CARMICHAEL, Robin
IPC分类号： A61K38/16 , C07K14/435
CPC分类号： A61K38/1767 , A61K8/64 , A61K38/00 , A61K2800/74 , A61Q19/00 , A61Q19/08 , C07K5/1013 , C07K5/1021 , C07K7/06 , C07K14/43563 , C12Q1/6876 , G01N33/5014 , G01N33/5044
摘要： Peptides having four to six amino acid residues are disclosed that possess biological activity. These peptides constitute short fragments of the peptide HB-107 (MPKEKVFLKIEKMGRNIRN), which itself is a fragment of the antimicrobial protein cecropin B, and exhibit cell stimulatory and migratory properties. The inventive peptides comprise four to six contiguous amino acid residues located between position 11 and 16 of HB107 (MPKEKVFLKIEKMGRNIRN), namely EKMGRN. The disclosed peptides comprise a useful agent for the medical treatment of injury to the skin, such as from diabetic ulcers. The peptides also are effective in preventing and reversing skin surface damage resulting from various environmental insults. Importantly, the therapeutic effects of the peptides manifest at concentrations equal to or greater than those of peptide HB-107, and thus represent a less expensive, more versatile means for developing effective therapies. Methods for the production and use of these peptides are also disclosed.
摘要翻译：披露具有4-6个氨基酸残基的肽具有生物活性。这些肽构成肽HB-107（MPKEKVFLKIEKMGRNIRN）的短片段，其本身是抗微生物蛋白质天蚕素B的片段，并且具有细胞刺激和迁移性质。本发明的肽包含位于HB107（MPKEKVFLKIEKMGRNIRN）的位置11和16之间的四至六个连续的氨基酸残基，即EKMGRN。所公开的肽包括用于治疗皮肤损伤的有用试剂，例如来自糖尿病性溃疡。这些肽也有效地预防和逆转由各种环境污染引起的皮肤表面损伤。重要的是，肽的治疗效果以等于或大于肽HB-107的浓度表现，因此代表开发有效疗法的较便宜，更通用的手段。还公开了生产和使用这些肽的方法。

10. 发明申请

WO2012003176A1 N-ACYL AMINO ACID DERIVATIVES FOR TREATING SKIN CONDITIONS SUCH AS CELLULITE 审中-公开
标题翻译：用于治疗皮肤病症的N-亚氨基氨基酸衍生物如细胞
公开(公告)号：WO2012003176A1
公开(公告)日：2012-01-05
申请号：PCT/US2011/042123
申请日：2011-06-28
申请人： FALLA, Timothy, J. , ZHANG, Lijuan , HELIX BIOMEDIX, INC.
发明人： FALLA, Timothy, J. , ZHANG, Lijuan
IPC分类号： A61K31/20 , A61K8/44
CPC分类号： A61K31/198 , A61K8/42 , A61K8/44 , A61K31/20 , A61K45/06 , A61Q19/06 , C07C237/12
摘要： The invention relates to small molecules having biological and therapeutic activity. Particularly, the invention relates to small molecules having lipolytic and anti-adipogenic activity. Two examples of such molecules are 4-methyl-2-(octanoylamino) pentanoic acid and N-isopentyloctanamide. The invention further relates to methods of preventing or treating skin conditions such as cellulite using small molecules having lipolytic and anti-adipogenic activity.
摘要翻译：本发明涉及具有生物和治疗活性的小分子。特别地，本发明涉及具有脂肪分解和抗脂肪生成活性的小分子。这些分子的两个实例是4-甲基-2-（辛酰氨基）戊酸和N-异戊基辛酰胺。本发明还涉及使用具有脂肪分解和抗脂肪生成活性的小分子预防或治疗皮肤病症如脂肪团的方法。

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