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1. 发明申请

WO2017053423A1 ANTI-CD47 ANTIBODIES AND METHODS OF USE 审中-公开
标题翻译：抗CD47抗体及其使用方法
公开(公告)号：WO2017053423A1
公开(公告)日：2017-03-30
申请号：PCT/US2016/052878
申请日：2016-09-21
申请人： ERASMUS UNIVERSITY MEDICAL CENTER , SURFACE ONCOLOGY, INC.
发明人： GROSVELD, Frank , PALOMBELLA, Vito , HOLLAND, Pamela, M. , PATERSON, Alison , HILL, Jonathan
IPC分类号： C07K16/28 , A61P35/00 , A61K39/00
CPC分类号： C07K16/2803 , A61K2039/505 , A61K2039/507 , C07K16/2887 , C07K16/2896 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： Disclosed herein are anti-CD47 antibody molecules, their manufacture and use in treating disorders associated with CD47 expression, for example, certain hematological cancers and solid tumors.
摘要翻译：本文公开了抗CD47抗体分子，其制备和用于治疗与CD47表达相关的疾病，例如某些血液癌症和实体瘤。

2. 发明申请

WO2016210120A1 METHODS AND COMPOSITIONS FOR TREATING NEURODEGENERATIVE DISORDERS 审中-公开
标题翻译：用于治疗神经损伤性疾病的方法和组合物
公开(公告)号：WO2016210120A1
公开(公告)日：2016-12-29
申请号：PCT/US2016/039003
申请日：2016-06-23
申请人： LYSOSOMAL THERAPEUTICS INC.
发明人： LANSBURY, Peter, T. , SKERLJ, Renato, T.
IPC分类号： A61K31/17 , A61K31/423 , A61K31/513 , A61P25/16 , A61P25/28
CPC分类号： A61K31/513 , A61K31/423
摘要： The invention relates to the treatment of neurodegenerative disorders with ceramidase inhibitor.
摘要翻译：本发明涉及用神经酰胺酶抑制剂治疗神经变性疾病。

3. 发明申请

WO2014039908A1 METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS 审中-公开
标题翻译：用于再生细胞和/或支持细胞的方法和组合物
公开(公告)号：WO2014039908A1
公开(公告)日：2014-03-13
申请号：PCT/US2013/058626
申请日：2013-09-06
申请人： MASSACHUSETTS EYE AND EAR INFIRMARY
发明人： CHEN, Zheng-Yi
IPC分类号： A61K31/195 , A61K38/02 , A61K48/00 , C12N5/10 , C12N5/071 , A61P25/28 , C12N15/63
CPC分类号： A61K38/177 , A61K31/65 , A61K35/30 , A61K38/16 , A61K38/1709 , A61K48/00 , A61K48/005 , C12N5/062 , C12N2501/42 , C12N2501/606 , C12N2710/10341
摘要： Provided are methods and compositions for inducing cells of the inner ear (for example, cochlear and utricular hair cells) to reenter to cell cycle and to proliferate. More particularly, the invention relates to the use of agents that increase c-myc activity and/or Notch activity for inducing cell cycle reentry and proliferation of cochlear or utricular hair cells and/or cochlear or utricular supporting cells. The methods and compositions can be used to promote the proliferation of hair cells and/or supporting cells to treat a subject at risk of, or affected with, hearing loss or a subject at risk of, or affected with vestibular dysfunction.
摘要翻译：提供了用于诱导内耳细胞（例如，耳蜗和小脑毛细胞）重新进入细胞周期并增殖的方法和组合物。更具体地，本发明涉及增加c-myc活性和/或Notch活性以诱导耳蜗或小脑毛细胞和/或耳蜗或小室支持细胞的细胞周期再入和增殖的试剂的用途。所述方法和组合物可用于促进毛细胞和/或支持细胞的增殖以治疗患有听力损失或受其影响的受试者或患有前庭功能障碍的风险的受试者。

4. 发明申请

WO2008124814A2 SUBLINGUAL FORMULATIONS OF D-CYCLOSERINE AND METHODS OF USING SAME 审中-公开
标题翻译： D-环糊精的次生配方及其使用方法
公开(公告)号：WO2008124814A2
公开(公告)日：2008-10-16
申请号：PCT/US2008/059876
申请日：2008-04-10
申请人： MCDEVITT, Jason, P. , DAVIS, Michael , RESSLER, Kerry, J.
发明人： MCDEVITT, Jason, P. , DAVIS, Michael , RESSLER, Kerry, J.
IPC分类号： A61K9/00 , A61K31/42
CPC分类号： A61K9/006 , A61K9/0056 , A61K31/42
摘要： The invention provides methods and compositions for treating anxiety-related disorders in a subject. The methods include sublingually administering D-cycloserine to a subject with the anxiety-related disorder, either alone or in combination with extinction training.
摘要翻译：本发明提供用于治疗受试者中焦虑相关疾病的方法和组合物。方法包括单独给予D-环丝氨酸给焦虑相关疾病的受试者，或与灭绝训练结合使用。

5. 发明申请

WO2008109832A3 VIABLE NEAR-INFRARED FLUOROCHROME LABELED CELLS AND METHODS OF MAKING AND USING SAME 审中-公开
公开(公告)号：WO2008109832A3
公开(公告)日：2008-09-12
申请号：PCT/US2008/056235
申请日：2008-03-07
申请人： VISEN MEDICAL, INC. , PETERSON, Jeffrey, D. , RAJOPADHYE, Milind
发明人： PETERSON, Jeffrey, D. , RAJOPADHYE, Milind
IPC分类号： A61B5/00 , G01N33/58 , A61K9/00 , C12N5/00
摘要： The invention provides viable near-infrared fluorochrome labeled cells and in vivo imaging methods for tracking, locating or determining the quantity of the viable cells once they have been administered to a subject.

6. 发明申请

WO2006138666A2 ITERATED BRANCHING REACTION PATHWAYS VIA NUCLEIC ACID-MEDIATED CHEMISTRY 审中-公开
标题翻译：通过核酸介导化学的迭代分支反应途径
公开(公告)号：WO2006138666A2
公开(公告)日：2006-12-28
申请号：PCT/US2006/023654
申请日：2006-06-16
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CALDERONE, Christipher, T. , LIU, David, R.
发明人： CALDERONE, Christipher, T. , LIU, David, R.
CPC分类号： C12N15/1068
摘要： The present invention provides methods and compositions for performing multi-step nucleic acid mediated synthesis of a highly diverse collection of molecules, for example, small molecules and polymers. In the method, in at least two steps, multiple reaction intermediates and/or products are produced in the same step by different chemical reactions.
摘要翻译：本发明提供用于进行多步骤核酸介导的高度多样化分子收集的方法和组合物，例如小分子和聚合物。在该方法中，在至少两个步骤中，通过不同的化学反应在同一步骤中产生多个反应中间体和/或产物。

7. 发明申请

WO2006130669A2 ANCHOR-ASSISTED FRAGMENT SELECTION AND DIRECTED ASSEMBLY 审中-公开
标题翻译：锚固辅助片段选择和指导性大会
公开(公告)号：WO2006130669A2
公开(公告)日：2006-12-07
申请号：PCT/US2006/021088
申请日：2006-05-31
申请人： ENSEMBLE DISCOVERY CORPORATION , STERN, Andrew, M. , HARBESON, Scott, L. , DRIGGERS, Edward, M. , SPEAR, Kerry, L.
发明人： STERN, Andrew, M. , HARBESON, Scott, L. , DRIGGERS, Edward, M. , SPEAR, Kerry, L.
CPC分类号： C12Q1/6804 , C12Q2563/179
摘要： The invention provides methods for compound and lead generation and discovery. In particular, the present invention provides a method for generating compounds and for selecting compounds that bind to a target. The present invention provides a way by which anchors (e.g., weak binders) and anchor-scaffold conjugates can be evolved into new generations of compounds having improved target binding and other desired pharmaceutical properties through control of both synthetic input and selection criteria.
摘要翻译：本发明提供了化合物和引物产生和发现的方法。特别地，本发明提供了一种产生化合物和选择与靶标结合的化合物的方法。本发明提供了通过控制合成输入和选择标准，锚（例如，弱粘合剂）和锚 - 支架共轭物可以通过其改进的靶结合和其它期望的药物性质而演变成新一代化合物的方式。

8. 发明申请

WO2019126776A1 CRYSTALLINE SUBSTITUTED CYCLOHEXYL PYRAZOLO[1,5-A]PYRIMIDINYL CARBOXAMIDE COMPOUND AND THERAPEUTIC USES THEREOF 审中-公开
公开(公告)号：WO2019126776A1
公开(公告)日：2019-06-27
申请号：PCT/US2018/067330
申请日：2018-12-21
申请人： LYSOSOMAL THERAPEUTICS INC.
发明人： SKERLJ, Renato, T. , BRANDS, Karel Marie Joseph
IPC分类号： C07D487/04 , A61K31/519 , A61P25/00
CPC分类号： C07D487/04 , A61P25/00
摘要： The invention provides crystalline 5,7-dimethyl- N -(( 1S *, 4S )-4-(pentyloxy)cyclohexyl) pyrazolo[1,5-a]pyrimidine-3-carboxamide, compositions containing the crystalline compound, methods for making the crystalline compound, medical kits, and methods for using the crystalline compound and compositions to treat a medical disorder, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient.

9. 发明申请

WO2016086103A1 FATTY ACID CYSTEAMINE CONJUGATES AND THEIR USE AS ACTIVATORS OF AUTOPHAGY 审中-公开
标题翻译：脂肪酸CYPTEAMINE CONJUGATES及其作为自动化的激活剂使用
公开(公告)号：WO2016086103A1
公开(公告)日：2016-06-02
申请号：PCT/US2015/062620
申请日：2015-11-25
申请人： CATABASIS PHARMACEUTICALS, INC.
发明人： VU, Chi, B. , JIROUSEK, Michael, R.
IPC分类号： A61K31/4425 , A61P29/00 , A61P11/00 , A61P21/00
CPC分类号： A61K31/105 , A61K31/095 , A61K31/121 , A61K31/195 , A61K31/4406 , A61K45/06 , A61K47/48023 , C07C323/23 , C07D213/82 , A61K2300/00
摘要： The invention relates to (i) 6-membered heteroaryl substituted fatty acid cystamine conjugates, compositions thereof, methods of treating diseases involving dysregulation of autophagy, such as cystic fibrosis, idiopathic pulmonary fibrosis (IPF), a neurodegenerative disease, inflammatory disease, liver disease, muscle disease, infection and immune disease with this compound, or (ii) a method of treating idiopathic pulmonary fibrosis, mitochondrial diseases, Leigh Syndrome, Diabetes Mellitus and Deafness (DAD), Leber's hereditary optic neuropathy, Neuropathy-ataxia-retinis pigmentosa and ptosis (NARP), myoneurogenic gastrointestinal encephalopathy (MNG1E), myoclonic epilepsy with ragged red fibers (MERRF), or mitochondrial myopathy- encephalomyopathy-lactic acidosis stroke like symptoms (MELAS), comprising administering to a patient the fatty acid cysteamine conjugate, (4Z, 7Z. 10Z, 13Z, 16Z, 19Z)-N-(2-mercaptoethyl) docosa-4,7,10,13,16,19-hexaenamide or (5Z,8Z, 11Z, 14Z, 17Z)-N-(2-mercaptoethyl) icosa-5, 8,11,14, 17-pentaenamide.
摘要翻译：本发明涉及（i）6-元杂芳基取代的脂肪酸胱氨酸缀合物，其组合物，治疗涉及自噬失调的疾病如囊性纤维化，特发性肺纤维化（IPF），神经变性疾病，炎症性疾病，肝脏疾病的方法，（ii）治疗特发性肺纤维化，线粒体疾病，Leigh综合征，糖尿病和耳聋（DAD），Leber遗传性视神经病变，神经病共济失调 - 视网膜色素变性和视网膜色素变性的方法，上睑下垂症（NARP），肌源性胃肠道脑病（MNG1E），具有粗糙红色纤维的肌阵挛性癫痫（MERRF）或线粒体肌病 - 脑病 - 乳酸性酸中毒症状（MELAS），包括向患者施用脂肪酸半胱胺缀合物（4Z ，7Z，10Z，13Z，16Z，19Z）-N-（2-巯基乙基）二十二碳-4,7,10,13,16,19-六烯酰胺或（5Z，8Z，11Z，14Z，17Z） 2- MERC 二甲苯基）二十碳-5,8,11,14,17-戊烯酰胺。

10. 发明申请

WO2014100435A1 ANTI-NOTCH3 ANTIBODIES 审中-公开
标题翻译： ANTI-NOTCH3抗体
公开(公告)号：WO2014100435A1
公开(公告)日：2014-06-26
申请号：PCT/US2013/076615
申请日：2013-12-19
申请人： AVEO PHARMACEUTICALS, INC.
发明人： OKAMURA, Heidi , ABBOTT, Sandra , BELL, Alisa, C. , KREUTER, Kelly , O'HAGAN, Ronan , PERINO, Samantha , TISSIRE, Hamid , WINSTON, William, M., Jr. , GYURIS, Jeno
IPC分类号： C07K16/28
CPC分类号： C07K16/28 , A61K39/3955 , A61K2039/505 , C07K16/2863 , C07K2317/14 , C07K2317/24 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N5/10 , C12N5/12 , C12N5/16 , C12N15/09 , C12N15/63
摘要： Monoclonal antibodies that bind and inhibit activation of human Notch3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of Notch3.
摘要翻译：公开了结合并抑制人Notch3激活的单克隆抗体。抗体可用于治疗与Notch3的激活相关的细胞增殖性疾病和病症，包括某些形式的癌症。

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