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1. 发明申请

WO2008124814A2 SUBLINGUAL FORMULATIONS OF D-CYCLOSERINE AND METHODS OF USING SAME 审中-公开
标题翻译： D-环糊精的次生配方及其使用方法
公开(公告)号：WO2008124814A2
公开(公告)日：2008-10-16
申请号：PCT/US2008/059876
申请日：2008-04-10
申请人： MCDEVITT, Jason, P. , DAVIS, Michael , RESSLER, Kerry, J.
发明人： MCDEVITT, Jason, P. , DAVIS, Michael , RESSLER, Kerry, J.
IPC分类号： A61K9/00 , A61K31/42
CPC分类号： A61K9/006 , A61K9/0056 , A61K31/42
摘要： The invention provides methods and compositions for treating anxiety-related disorders in a subject. The methods include sublingually administering D-cycloserine to a subject with the anxiety-related disorder, either alone or in combination with extinction training.
摘要翻译：本发明提供用于治疗受试者中焦虑相关疾病的方法和组合物。方法包括单独给予D-环丝氨酸给焦虑相关疾病的受试者，或与灭绝训练结合使用。

2. 发明申请

WO2008118785A3 METHODS FOR TREATING DEPRESSION USING IMMEDIATE-IMPACT TREATMENTS AND D-CYCLOSERINE 审中-公开
标题翻译：使用立即冲击疗法和D-环胞素治疗抑郁症的方法
公开(公告)号：WO2008118785A3
公开(公告)日：2008-10-02
申请号：PCT/US2008/057844
申请日：2008-03-21
申请人： TIKVAH THERAPEUTICS , MCDEVITT, Jason, P. , DAVIS, Michael , RESSLER, Kerry, J. , SHAPIRA, Nathan, Andrew
发明人： MCDEVITT, Jason, P. , DAVIS, Michael , RESSLER, Kerry, J. , SHAPIRA, Nathan, Andrew
IPC分类号： A61K31/135 , A61K31/42
摘要： Methods are provided for treating depression in humans. The methods comprise administering D-cycloserine to a subject and administering an immediate-impact depression treatment. Exemplary immediate-impact treatments for depression include administration of ketamine, as well as non-pharmacologic treatments such as electroconvulsive shock therapy.
摘要翻译：提供了治疗人类抑郁症的方法。该方法包括给受试者施用D-环丝氨酸并施用即刻冲击抑制治疗。用于抑郁症的示例性直接冲击治疗包括施用氯胺酮以及非药物治疗，例如电惊厥休克疗法。

3. 发明申请

WO2002078629A2 ACUTE PHARMACOLOGIC AUGMENTATION OF PSYCHOTHERAPY WITH ENHANCERS OF LEARNING OR CONDITIONING 审中-公开
标题翻译：加强学习或调节的急性药物疗法增加精神病
公开(公告)号：WO2002078629A2
公开(公告)日：2002-10-10
申请号：PCT/US2002/009467
申请日：2002-03-28
申请人： EMORY UNIVERSITY , DAVIS, Michael , LU, Kwok-Tung , RESSLER, Kerry, J.
发明人： DAVIS, Michael , LU, Kwok-Tung , RESSLER, Kerry, J.
IPC分类号： A61K
CPC分类号： A61K31/535 , A61K31/00 , A61K31/135 , A61K31/215 , A61K31/42
摘要： Methods for treating an individual with a psychiatric order with a pharmacologic agent that enhances learning or conditioning in combination with a session of psychotherapy are provided. These methods of the invention encompass a variety of methods of psychotherapy, and psychodynamically oriented psychotherapy, and psychiatric orders including fear and anxiety disorders, addictive disorders, addictive disorders including substance-abuse disorders, and mood disorders. The pharmacologic agents used for the methods of the present invention are ones that generally enhance learning or conditioning, including those that increase the level of norepinephrine in the brain, those that increase the level of acetylcholine in the brain, and those that enhance N-methyl-D-aspartate(NMDA) receptor transmission in the brain.
摘要翻译：提供了用药理学药物治疗具有精神病顺序的个体的方法，所述药理学药物结合心理治疗会话增强学习或调节。本发明的这些方法包括心理治疗和心理动力学导向心理治疗的各种方法，以及包括恐惧和焦虑障碍，成瘾障碍，包括物质滥用障碍在内的成瘾障碍和心境障碍在内的精神障碍。用于本发明方法的药理学试剂通常是增强学习或调理的药剂，包括增加脑中去甲肾上腺素水平的那些药剂，增加脑中乙酰胆碱水平的药剂和增强N-甲基 -D-天冬氨酸（NMDA）受体在大脑中的传播。

4. 发明申请

WO2005016319A2 ACUTE PHARMACOLOGIC AUGMENTATION OF PSYCHOTHERAPY WITH ENHANCERS OF LEARNING OR CONDITIONING 审中-公开
标题翻译：加强学习或调节的急性药物疗法增加精神病
公开(公告)号：WO2005016319A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/024841
申请日：2004-08-03
申请人： EMORY UNIVERSITY , DAVIS, Michael , RESSLER, Kerry, J.
发明人： DAVIS, Michael , RESSLER, Kerry, J.
IPC分类号： A61K9/22
CPC分类号： A61K31/42 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/205 , A61K9/2054 , A61K9/2077 , A61K9/209
摘要： Methods and compositions for treating an individual with a psychiatric order with a pharmacologic agent that enhances learning or conditioning in combination with a session of psychotherapy are provided. The methods of the invention encompass a variety of methods of psychotherapy, including exposure-based psychotherapy, cognitive psychotherapy, and psychodynamically oriented psychotherapy, and psychiatric orders including fear and anxiety disorders, addictive disorders including substance-abuse disorders, and mood disorders. The pharmacologic agents used for the methods of the present invention are ones that generally enhance learning or conditioning, including those that increase the level of norepinephrine in the brain, those that increase the level of acetylcholine in the brain, and those that enhance N-methyl-D-aspartate (NMDA) receptor transmission in the brain. Pharmaceutical compositions comprising pharmacologic agents of the invention in a sustained-release matrix are also provided.
摘要翻译：提供了用药物剂治疗具有精神病顺序的个体的方法和组合物，所述药物剂与心理治疗的组合一起增强学习或调节。本发明的方法包括各种心理治疗方法，包括基于暴露的心理治疗，认知心理治疗和以心理动力学为导向的心理治疗，以及包括恐惧和焦虑症的精神病学秩序，包括物质滥用障碍的成瘾性障碍和心境障碍。用于本发明方法的药理学试剂通常是增强学习或调理的药剂，包括增加脑中去甲肾上腺素水平的那些药剂，增加脑中乙酰胆碱水平的药剂和增强N-甲基 -D-天冬氨酸（NMDA）受体在大脑中的传播。还提供了在缓释基质中包含本发明药物的药物组合物。

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