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1. 发明申请

WO2013186630A2 HUMANIZED ANTIBODIES TO CA215 审中-公开
标题翻译：人类抗体CA215
公开(公告)号：WO2013186630A2
公开(公告)日：2013-12-19
申请号：PCT/IB2013/001834
申请日：2013-06-13
申请人： VANCOUVER BIOTECH LTD
发明人： LEE, Gregory
IPC分类号： C07K16/46
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , C07K16/30 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/565 , A61K2300/00
摘要： Provided herein are humanized forms of murine RP215 monoclonal antibodies and methods of using the same. These humanized RP215 monoclonal antibodies were characterized in terms of their respective affinity and specificity to the corresponding tumor-associated antigen, CA215, and shown to be comparable to those of murine RP215.
摘要翻译：本文提供了鼠RP215单克隆抗体的人源化形式及其使用方法。这些人源化RP215单克隆抗体的特征在于它们对相应的肿瘤相关抗原CA215的亲和力和特异性，并且显示出与鼠RP215相当。

2. 发明申请

WO2012068667A1 METHOD AND DEVICE FOR PRODUCING A DENTAL COMPONENT 审中-公开
标题翻译：用于生产牙齿组件的方法和装置
公开(公告)号：WO2012068667A1
公开(公告)日：2012-05-31
申请号：PCT/CA2011/001275
申请日：2011-11-18
申请人： BIOCAD MEDICAL INC. , MIQUEL, Florent , ARNAULD, Gilles
发明人： MIQUEL, Florent , ARNAULD, Gilles
IPC分类号： A61C13/00 , A61C13/003 , A61C13/38
CPC分类号： A61C13/0022 , A61C5/77 , A61C13/0006 , A61C13/12 , B23B31/307 , Y10T29/49567
摘要： The present invention relates to a method and device for producing a dental component. The method comprises: a) providing a piece of material (10) attached to or held by a first holding means (12); b) shaping the piece of material to form the dental component (16) and at least one support pin (18) maintaining the dental component attached to the first holding means or the initial piece of material; c) engaging a second holding means (24) to the dental component while the dental component still is attached to the first holding means or the initial piece of material via the at least one support pin; and d) removing the at least one support pin from the dental component while the dental component is engaged by the second holding means.
摘要翻译：本发明涉及牙科部件的制造方法和装置。该方法包括：a）提供附接到或由第一保持装置（12）保持的一块材料（10）; b）使所述材料成形以形成所述牙齿部件（16）和至少一个支撑销（18），所述支撑销将所述牙科部件保持在所述第一保持装置或所述初始材料上; c）当牙科部件仍经由至少一个支撑销附接到第一保持装置或初始材料片时，将第二保持装置（24）接合到牙科部件; 以及d）当所述牙科部件与所述第二保持装置接合时，将所述至少一个支撑销从所述牙科部件移除。

3. 发明申请

WO2012061926A1 BISARYLSULFONE AND DIALKYLARYLSULFONE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS 审中-公开
标题翻译：作为钙通道阻滞剂的双联砜和二烷基磺酸盐化合物
公开(公告)号：WO2012061926A1
公开(公告)日：2012-05-18
申请号：PCT/CA2011/001240
申请日：2011-11-04
申请人： ZALICUS PHARMACEUTICALS LTD. , PAJOUHESH, Hassan , HOLLAND, Richard , ZHOU, Yuanxi , ZHU, Yongbao , GRIMWOOD, Michael Edward , CHAHAL, Navjot
发明人： PAJOUHESH, Hassan , HOLLAND, Richard , ZHOU, Yuanxi , ZHU, Yongbao , GRIMWOOD, Michael Edward , CHAHAL, Navjot
IPC分类号： C07D213/81 , A61K31/165 , A61K31/166 , A61K31/35 , A61K31/382 , A61K31/40 , A61K31/404 , A61K31/415 , A61K31/4188 , A61K31/437 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/4985 , A61K31/505 , A61P25/00 , C07C317/32 , C07C317/44 , C07D207/16 , C07D211/60 , C07D213/60 , C07D401/12 , C07D471/04
CPC分类号： C07D487/04 , C07C317/28 , C07C317/32 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D207/16 , C07D209/30 , C07D211/60 , C07D213/62 , C07D213/71 , C07D213/75 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/28 , C07D239/36 , C07D295/073 , C07D295/195 , C07D295/26 , C07D309/08 , C07D317/60 , C07D335/02 , C07D471/04
摘要： The invention relates to bisarylsulfone and dialkylarylsulfone compounds (e.g., compounds according to any of Formulas (I)-(IX) or compounds (1)-(227) of Tables 4 and 5) useful in treating conditions associated with calcium channel function, and particularly conditions associated with N-type calcium channel activity. The invention also relates to pharmaceutical compositions that include these bisarylsulfone compounds, as well methods for the treatment of conditions such as cardiovascular disease, epilepsy, cancer and pain.
摘要翻译：本发明涉及可用于治疗与钙通道功能相关的病症的二芳基砜和二烷基芳基砜化合物（例如，表4和5的式（I） - （IX）或化合物（1） - （227）中任一项的化合物）特别是与N型钙通道活性相关的病症。本发明还涉及包含这些二芳基砜化合物的药物组合物，以及用于治疗诸如心血管疾病，癫痫，癌症和疼痛的病症的方法。

4. 发明申请

WO2011032291A1 SELECTIVE CALCIUM CHANNEL MODULATORS 审中-公开
标题翻译：选择性钙通道调制器
公开(公告)号：WO2011032291A1
公开(公告)日：2011-03-24
申请号：PCT/CA2010/001471
申请日：2010-09-17
申请人： ZALICUS PHARMACEUTICALS LTD . , PAJOUHESH , Hassan , ZHU, Yongbao , ZHOU, Yuanxi , GRIMWOOD, Mike , SIMONSON, Eric
发明人： PAJOUHESH , Hassan , ZHU, Yongbao , ZHOU, Yuanxi , GRIMWOOD, Mike , SIMONSON, Eric
IPC分类号： C07D211/34 , A61K31/397 , A61K31/40 , A61K31/4465 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61P25/00 , C07D205/04 , C07D207/08 , C07D211/48 , C07D401/12 , C07D413/06
CPC分类号： C07D401/12 , C07D205/04 , C07D207/08 , C07D207/09 , C07D211/22 , C07D211/34 , C07D211/48 , C07D211/58 , C07D401/06 , C07D413/06
摘要： Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T- type calcium channel activity are disclosed using a series of compounds containing N-acylated cyclic amines linked to an aπl ring as shown in formula (I).
摘要翻译：使用一系列含有与apl环连接的N-酰化的环胺的化合物（如式（I）所示），公开了有效改善由不需要的钙通道活性，特别是不需要的T型钙通道活性表征的病症的方法和化合物。

5. 发明申请

WO2009146539A8 4-(AMINOMETHYL)CYCLOHEXANAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS 审中-公开
公开(公告)号：WO2009146539A8
公开(公告)日：2009-12-10
申请号：PCT/CA2009/000767
申请日：2009-06-02
申请人： NEUROMED PHARMACEUTICALS LTD. , PAJOUHESH, Hassan , KAUL, Ramesh , GRIMWOOD, Mike , TAN, Jason , ZHOU, Yuanxi
发明人： PAJOUHESH, Hassan , KAUL, Ramesh , GRIMWOOD, Mike , TAN, Jason , ZHOU, Yuanxi
IPC分类号： A61K31/166 , A61K31/40 , A61K31/426 , A61K31/44 , A61K31/5375 , A61P3/04 , C07C233/78 , C07C235/14 , C07C237/06 , C07C271/20 , C07C271/24 , C07C275/26 , C07D207/06 , C07D211/06 , C07D213/72 , C07D265/30 , C07D277/46 , C07D295/32
摘要： Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing 4-(aminomethyl)cyclohexanamine derivatives as shown in formula (1).

6. 发明申请

WO2009140753A1 VANE PUMP 审中-公开
标题翻译：叶片泵
公开(公告)号：WO2009140753A1
公开(公告)日：2009-11-26
申请号：PCT/CA2009/000658
申请日：2009-05-12
申请人： STACKPOLE LIMITED , MOOY, Robert H. , MORTON, Paul M.
发明人： MOOY, Robert H. , MORTON, Paul M.
IPC分类号： F04C2/344 , F04C15/00
CPC分类号： F04C2/3442 , F04C15/0073 , F04C2240/60
摘要： In a traditional vane pump a rotor is supported on a shaft which is in turn supported by a pair of bearings on opposing walls of a housing. Any misalignment in the bearings can cause premature wear and a loss of efficiency in the pump. Provided is a vane pump (10) comprising a case (30), a rotor (60) disposed in the case (30), the rotor (60) having a bore (70), a plurality of vanes (64) radially moveable with respect to the rotor (60) extend from the rotor (60), a drive shaft (90) engaged with the bore (70), a second shaft (46) fixedly connected to the case (30) and extending from the case (30) to slidmgly engage the bore (70), a land (74, 76) extending from each end of the rotor (60), each land (74, 76) cooperating with the case (30) to seal a fluid flow, and each land (74, 76) further axially controlling a rotor position within the case (30) by a sliding engagement, and the drive shaft (90) retamable in a predetermined position with respect to the case (30).
摘要翻译：在传统的叶片泵中，转子支撑在轴上，转轴由壳体的相对壁上的一对轴承支撑。轴承中的任何未对准会导致泵的过早磨损和效率损失。提供一种叶片泵（10），其包括壳体（30），设置在壳体（30）中的转子（60），转子（60）具有孔（70），多个叶片（64）可径向移动相对于转子（60）从转子（60）延伸，与孔（70）接合的驱动轴（90），固定地连接到壳体（30）并从壳体（30）延伸的第二轴（70），从转子（60）的每个端部延伸的平台（74,76），每个平台（74,76）与壳体（30）协作以密封流体流动，并且每个陆地（74,76）通过滑动接合进一步轴向地控制壳体（30）内的转子位置，并且驱动轴（90）可相对于壳体（30）可预复位。

7. 发明申请

WO2007074408A2 MAINTAINING WRITE ORDER FIDELITY ON A MULTI-WRITER SYSTEM 审中-公开
标题翻译：维持多个WRITER系统上的写入顺序清晰度
公开(公告)号：WO2007074408A2
公开(公告)日：2007-07-05
申请号：PCT/IB2006/004062
申请日：2006-07-14
申请人： YOTTA YOTTA, INC. , BROMLING, Steve , HAGGLUND, Dale , HAYWARD, Geoff , VAN DER GOOT, Roel , KARPOFF, Wayne
发明人： BROMLING, Steve , HAGGLUND, Dale , HAYWARD, Geoff , VAN DER GOOT, Roel , KARPOFF, Wayne
CPC分类号： H04L67/1095 , G06F11/2058 , G06F11/2064 , G06F11/2071 , G06F11/2074 , G06F11/2079 , H04L67/1097 , H04L67/2842
摘要： ABSTRACT OF THE DISCLOSURE Write order fidelity (WOF) is maintained for totally-active implementations wherein a plurality of access nodes at geographically separated sites can concurrently read and/or write data in a "totally active" fashion on a distributed data system. From the hosts' perspective at diverse geographic locations, a synchronous, cache-coherent view of data is provided. Data transfer is asynchronous. A time ordered data image is created and maintained so operations can be restarted after a partial system failure that causes loss of data not yet asynchronously transferred across the network, but that has been write-acknowledged to the originating host. Time ordered asynchronous data transfer is implemented as a pipeline of changes that reflect contributions from all nodes. WOF also improves network performance and lowers bandwidth consumption. Extensions can provide, in a totally-active context, features such as point-in-time snapshots, time firewalls, on-demand backend storage allocation, synchronous / asynchronous distribution of data, and continuous data protection.
摘要翻译：公开内容的摘要针对全局主动实现维护写命令保真度（WOF），其中在地理上分离的站点处的多个接入节点可以在分布式数据系统上以“完全主动”的方式同时读取和/或写入数据。从主机的角度来看，在不同的地理位置，提供了同步，缓存一致的数据视图。数据传输是异步的。创建和维护时间有序的数据映像，以便在部分系统故障后重新启动操作，导致数据丢失尚未通过网络异步传输，但已被写入确认给始发主机。时间排序的异步数据传输实现为反映来自所有节点的贡献的变化流水线。 WOF还提高了网络性能并降低了带宽消耗。扩展可以在完全活跃的环境中提供诸如时间点快照，时间防火墙，按需后端存储分配，数据的同步/异步分发和连续数据保护等功能。

8. 发明申请

WO2006039804A1 UNDIVIDED ELECTROLYTIC CHLORATE CELLS WITH COATED CATHODES 审中-公开
标题翻译：不具有涂层阴离子的电解氯离子电池
公开(公告)号：WO2006039804A1
公开(公告)日：2006-04-20
申请号：PCT/CA2005/001567
申请日：2005-10-12
申请人： CANEXUS CHEMICALS CANADA LTD. , CHOW, Norman , SOCOL, Julia , OEHR, Klaus , REMPLE, Glen
发明人： CHOW, Norman , SOCOL, Julia , OEHR, Klaus , REMPLE, Glen
IPC分类号： C25B11/04
CPC分类号： C25B1/265 , C25B11/0478
摘要： The present invention provides novel undivided electrolytic chlorate cells with one or more cathodes in fluid communication with a catalytic metal cathode electrodepositing solution. The invention further includes undivided electrolytic chlorate cells including one or more dimensionally stable anodes and one or more cathodes coated with a catalytic metal cathode coating. Also provided are methods of coating a cathode, where the cathode forms part of an undivided electrolytic chlorate cell.
摘要翻译：本发明提供了具有一个或多个与催化金属阴极电沉积溶液流体连通的阴极的新颖的未分离的电解氯酸盐电池。本发明还包括包含一个或多个尺寸稳定的阳极的不分开的电解氯酸盐电池和涂覆有催化金属阴极涂层的一个或多个阴极。还提供了涂覆阴极的方法，其中阴极形成不分开的电解氯酸盐电池的一部分。

9. 发明申请

WO2005003619A3 REUSABLE FLUID DISPENSER 审中-公开
公开(公告)号：WO2005003619A3
公开(公告)日：2005-01-13
申请号：PCT/CA2004/000994
申请日：2004-07-07
申请人： A.T.S. ELECTRO-LUBE HOLDINGS LTD. , ORLITZKY, Tony , LENCAR, Diana , SHEREMETA, Danny , OEHR, Klaus , OLOMAN, Colin
发明人： ORLITZKY, Tony , LENCAR, Diana , SHEREMETA, Danny , OEHR, Klaus , OLOMAN, Colin
IPC分类号： F16N11/10
摘要： The invention provides, in general, a reusable gas driven fluid transportation apparatus having subsystems or components that are adapted to be reused, replaced and/or recycled. All or a portion of the subsystems or components of the apparatus may be reused by replacement of parts (such as the gas generating unit) or by replacement of consumed components such as gas generating reactants, batteries or fluid. The apparatus may be used, for example, for applying lubricant to machine components such as a bearing.

10. 发明申请

WO2004021455A1 ELECTRODE FOR PHOTOVOLTAIC CELLS, PHOTOVOLTAIC CELL AND PHOTOVOLTAIC MODULE 审中-公开
标题翻译：光电池，光伏电池和光伏电池
公开(公告)号：WO2004021455A1
公开(公告)日：2004-03-11
申请号：PCT/CA2003/001278
申请日：2003-08-21
申请人： DAY4 ENERGY INC. , RUBIN, Leonid, B. , RUBIN, George, L.
发明人： RUBIN, Leonid, B. , RUBIN, George, L.
IPC分类号： H01L31/0224
CPC分类号： H01L31/022425 , H01L31/0508 , H01L31/0512 , H01L2924/0002 , H05K3/10 , Y02E10/50 , H01L2924/00
摘要： An electrode is described for contacting an electrically conductive surface, in particular for contacting at least one surface of a photovoltaic element wafer 3, the electrode comprising an electrically insulating optically transparent film 10, an adhesive layer 11 provided on one surface of said film 10, and a first plurality of substantially parallel, electrically conductive wires 5' being embedded into the adhesive layer 11, a part of the surfaces of said wires 5' protruding from the adhesive layer 11 and at least on the surface protruding from the adhesive layer 11 being covered by a coating 2 consisting of an alloy with a low melting point, wherein the wires 5' of the first plurality are electrically connected to a first terminal bar 20. A plurality of said electrodes may be formed as an endless, continuous strip, which can be cut to a length corresponding to that of an array of adjacent photovoltaic elements 3 to be connected for forming a PV module, wherein the wires 5' running in longitudinal direction of the strip are cut at distances corresponding to the distances of the PV cells. A PV cell or a PV module comprising at least one electrode 16 or one electrode strip 16 as described above may comprise one or more photovoltaic cells 3 with an electrically conductive, antireflective, optically transparent coating 4 on at least one of its surfaces, the wires 5' of the first plurality being soldered onto the coating 4 and onto the respective terminal bars 20 or terminal frames 17 by means of the alloy 2.
摘要翻译：描述了用于接触导电表面的电极，特别是用于接触光电元件晶片3的至少一个表面，该电极包括电绝缘光学透明膜10，设置在所述膜10的一个表面上的粘合层11，并且第一组多个基本上平行的导电线5'嵌入到粘合剂层11中，从粘合剂层11突出并且至少在从粘合剂层11突出的表面上的所述电线5'的一部分表面是由由低熔点合金组成的涂层2覆盖，其中第一多个的导线5'电连接到第一端子条20.多个所述电极可以形成为环形连续带，其中可以切割成与待连接的相邻光伏元件3的阵列相对应的长度，以形成PV模块，其中导线5'运行在对应于PV电池的距离的距离处切割带的纵向方向。包括如上所述的至少一个电极16或一个电极条16的PV电池或PV模块可以包括在其至少一个表面上具有导电的，抗反射的，光学透明的涂层4的一个或多个光伏电池3，第一组中的5'通过合金2焊接到涂层4上并连接到相应的端子条20或端子框架17上。

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