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1. 发明申请

WO2017121990A1 CALIBRATION DEVICE AND METHOD 审中-公开
标题翻译：校准装置和方法
公开(公告)号：WO2017121990A1
公开(公告)日：2017-07-20
申请号：PCT/GB2017/050040
申请日：2017-01-10
申请人： RENISHAW PLC , METROLOGY SOFTWARE PRODUCTS LIMITED
发明人： HAMMOND, Peter, Russell
IPC分类号： B23Q17/22 , G01B21/04 , G01B3/22 , G05B19/401
CPC分类号： B23Q17/2233 , G01B21/042 , G05B19/401
摘要： A calibration device (30) for a machine tool is described that includes a base (36) attachable to a machine tool and a calibration artefact (32), such as a sphere of known radius. A deflection mechanism attaches the calibration artefact to the base and allows movement of the calibration artefact (32) relative to the base (36) when an external force is applied to the calibration artefact (32). The deflection mechanism also maintains the calibration artefact (32) in a defined rest position relative to the base (36) in the absence of an applied external force. A sensor (46) is provided for sensing the extent of movement of the calibration artefact (32) relative to the base (36). A method of using the device (30) with a reference tool to accurately determine a position of a calibration artefact (32) is also described.
摘要翻译：描述了用于机床的校准装置（30），其包括可附接到机床的基座（36）和校准制品（32），例如已知半径的球体。偏转机构将校准制品附接到基座并且允许校准制品（32）相对于基座（36）在外力施加到校准制品（32）时移动。偏转机构还在没有施加外力的情况下将校准制品（32）保持在相对于基座（36）的限定的静止位置中。提供传感器（46）用于感测校准制品（32）相对于基座（36）的移动程度。还描述了使用具有参考工具的装置（30）来准确地确定校准制品（32）的位置的方法。

2. 发明申请

WO2012098367A1 DELIVERY OF A SELECTIVELY REPLICATING HERPES SIMPLEX VIRAL VECTOR TO THE BRAIN BY CONVECTION- ENHANCED DELIVERY (CED) 审中-公开
标题翻译：通过对话加强交付（CED），选择性地向大脑递送简单的病毒载体
公开(公告)号：WO2012098367A1
公开(公告)日：2012-07-26
申请号：PCT/GB2012/000062
申请日：2012-01-23
申请人： RENISHAW PLC , RENISHAW (IRELAND) LIMITED , WHITE, Edward , GILL, Steven Streatfield
发明人： WHITE, Edward , GILL, Steven Streatfield
IPC分类号： C07K14/765 , C12N15/869 , C12N15/87 , C12N15/86 , A61K48/00
CPC分类号： A61K48/0083 , A61K48/0008 , A61K48/0075 , C07K14/765 , C12N15/86 , C12N15/87 , C12N2710/16643
摘要： The invention relates to a composition comprising albumin and a therapeutic agent, particularly a gene therapy vector. The composition is useful in the treatment of glioma.
摘要翻译：本发明涉及包含白蛋白和治疗剂，特别是基因治疗载体的组合物。该组合物可用于治疗胶质瘤。

3. 发明申请

WO2012010836A2 METROLOGY APPARATUS 审中-公开
标题翻译：计量器具
公开(公告)号：WO2012010836A2
公开(公告)日：2012-01-26
申请号：PCT/GB2011/001086
申请日：2011-07-20
申请人： RENISHAW PLC , McMURTRY, David, Roberts , HUNTER, Stephen, Paul
发明人： McMURTRY, David, Roberts , HUNTER, Stephen, Paul
IPC分类号： G01B5/012
CPC分类号： G01B5/0016 , F16C39/063 , G01B5/012 , G01B5/016 , G01B7/016
摘要： Metrology apparatus is described that comprises a first structure (20) rotatably connected to a second structure (22) by a bearing arrangement. The bearing arrangement includes at least a first friction bearing comprising parts (28, 34, 30, 36) in sliding contact during rotation of the first structure (20) relative to the second structure (22). The apparatus comprises at least one magnet (52, 54; 60, 62) that relieves the load on the first friction bearing. Multiple magnets, provided in an attracting or repelling arrangement, may be used. The metrology apparatus may comprise an articulating probe head (12) for a coordinate positioning apparatus (2).
摘要翻译：描述了计量装置，其包括通过轴承装置可旋转地连接到第二结构（22）的第一结构（20）。所述轴承装置包括至少第一摩擦轴承，所述第一摩擦轴承包括在所述第一结构（20）相对于所述第二结构（22）旋转期间以滑动接触的部分（28,34,30,36）。该设备包括至少一个磁体（52,54; 60,62），其减轻了第一摩擦轴承上的负载。可以使用以吸引或排斥布置提供的多个磁体。度量装置可以包括用于坐标定位设备（2）的铰接探头（12）。

4. 发明申请

WO2011098768A1 IMPLANTABLE FLUID ROUTER 审中-公开
标题翻译：可植入流体路由器
公开(公告)号：WO2011098768A1
公开(公告)日：2011-08-18
申请号：PCT/GB2011/000182
申请日：2011-02-11
申请人： RENISHAW (IRELAND) LIMITED , FIELDER, Paul, David , JOHNSON, David, Ewen , WOOLLEY, Maxwell, Roy
发明人： FIELDER, Paul, David , JOHNSON, David, Ewen , WOOLLEY, Maxwell, Roy
IPC分类号： A61M5/142
CPC分类号： A61M39/0247 , A61B17/1739 , A61M5/14276 , A61M5/36 , A61M39/105 , A61M39/223 , A61M2039/0261 , A61M2039/0276 , A61M2039/0282 , A61M2039/1083 , A61M2039/1088 , A61M2205/02 , A61M2205/7518 , A61M2210/0687
摘要： An implantable fluid router (12; 512) is described that comprises one or more inlets, one or more outlets and at least one gas vent (526) for removing gas from liquid routed from the one or more inlets to the one or more outlets. The implantable router (12; 512) may be used with implantable drug delivery apparatus. A catheter device comprising such a fluid router is also described.
摘要翻译：描述了可植入流体路由器（12; 512），其包括一个或多个入口，一个或多个出口和至少一个用于从一个或多个入口路由到一个或多个出口的液体中除去气体的气体排出口（526）。可植入式路由器（12; 512）可与可植入药物输送装置一起使用。还描述了包括这种流体路由器的导管装置。

5. 发明申请

WO2010103258A1 APPARATUS AND METHOD FOR DIGITISING IMPEDANCE 审中-公开
标题翻译：用于消除阻抗的装置和方法
公开(公告)号：WO2010103258A1
公开(公告)日：2010-09-16
申请号：PCT/GB2010/000363
申请日：2010-03-01
申请人： RENISHAW PLC , THOMAS, David, Kenneth
发明人： THOMAS, David, Kenneth
IPC分类号： G01D5/24 , G01R27/26
CPC分类号： G01D5/24
摘要： Apparatus for digitising an impedance is described that comprises a first impedance element (22; 122) having a first impedance (C1;A1) that varies with a property to be measured and a second impedance element (24; 124) having a second impedance (C2;A2). The apparatus also includes a drive signal generator (26,30) for applying a first alternating drive signal (44) to the first impedance element (22; 122) and a second alternating drive signal (46) to the second impedance element (24; 124). An analogue-to-digital converter, ADC (42; 142), receives a resultant signal (41;52; 141 ) comprising the combination of the signals produced by the application of the first and second alternating drive signals (44,46) to the first and second impedance elements (22,24; 122, 124). The first alternating drive signal (44) is phase shifted relative to the second alternating drive signal (46) such that the resultant signal (41;52;141) received and sampled by the ADC (42; 142) sequentially relates to the sum of, and the difference between, the first and second impedances. The apparatus also comprises a signal separator (56;156A,156B) that receives sample values from the ADC (42; 142) and generates a sum channel (58; 158A) and a difference channel (60; 160A) therefrom.
摘要翻译：描述了用于对阻抗进行数字化的装置，其包括具有随被测量特性变化的第一阻抗（C1; A1）的第一阻抗元件（22; 122）和具有第二阻抗的第二阻抗元件（24; 124） C2; A2）。该装置还包括用于将第一交替驱动信号（44）施加到第一阻抗元件（22; 122）的驱动信号发生器（26,30）和到第二阻抗元件（24; 122）的第二交替驱动信号（46）。 124）。模数转换器ADC（42; 142）接收包括通过施加第一和第二交替驱动信号（44,46）而产生的信号的组合的合成信号（41; 52; 141）到第一和第二阻抗元件（22,24; 122,124）。第一交变驱动信号（44）相对于第二交替驱动信号（46）相移，使得由ADC（42; 142）接收和采样的合成信号（41; 52; 141）顺序地与，以及第一和第二阻抗之间的差异。该装置还包括从ADC（42; 142）接收采样值并从其生成和通道（58; 158A）和差分通道（60; 160A）的信号分离器（56; 156A，156B）。

6. 发明申请

WO2010055301A1 METHOD, APPARATUS AND PHANTOM FOR MEASURING AND CORRECTING TOMOGRAM ERRORS 审中-公开
标题翻译：用于测量和校正TOMOGRAM错误的方法，装置和方法
公开(公告)号：WO2010055301A1
公开(公告)日：2010-05-20
申请号：PCT/GB2009/002659
申请日：2009-11-13
申请人： RENISHAW (IRELAND) LIMITED , ASHTON, Sharon, Ann , DERRICK, Hugo, George , MORTIMER, James, David
发明人： ASHTON, Sharon, Ann , DERRICK, Hugo, George , MORTIMER, James, David
IPC分类号： G01R33/58 , G06T3/00 , G06T7/00 , G01R33/565 , G06T5/00
CPC分类号： G06T3/00 , G01R33/56572 , G01R33/58 , G06T5/006 , G06T7/97 , G06T11/008
摘要： A tomogram taken on an imaging path of a tomograph is corrected by using sets of tomogram correction data for neighbouring positions on that path, in an interpolative process. An error map of a tomograph is built up by comparing tomograms of a phantom with the expected appearance of the phantom at the tomogram positions. Also provided is a phantom having a body with one or more imaging fluid receptacles formed therein
摘要翻译：在内插处理中，通过对该路径上的相邻位置使用一组断层图像校正数据来校正在层析机的成像路径上拍摄的断层图像。通过将体模的断层图与断层图像位置处的幻像的预期外观进行比较，建立断层摄影术的误差图。还提供了具有身体的体模，其中形成有一个或多个成像液体容器

7. 发明申请

WO2009112819A3 TOUCH TRIGGER MEASUREMENT PROBE 审中-公开
公开(公告)号：WO2009112819A3
公开(公告)日：2009-09-17
申请号：PCT/GB2009/000640
申请日：2009-03-09
申请人： RENISHAW plc , WOOLDRIDGE, Michael, John , HELLIER, Peter, Kenneth , UMFREVILLE, Robert, Charles, D'Olier
发明人： WOOLDRIDGE, Michael, John , HELLIER, Peter, Kenneth , UMFREVILLE, Robert, Charles, D'Olier
IPC分类号： G01B7/012 , G01B21/04
摘要： A measurement probe (2), for a co-ordinate positioning apparatus such as a machine tool, is described that comprises a stylus holder (10) that is deflectably mounted to a probe housing (4). One or more sensors (20) are provided for sensing deflection of the stylus holder relative to the probe housing. A processor (22;40) is included for producing a trigger signal (T) when the deflection sensed by the one or more sensors (46) meets a trigger condition, such as a deflection threshold. The probe also includes an accelerometer (28) for measuring acceleration of the measurement probe. The trigger condition applied by the processor is alterable, during use, in response to the acceleration measured by the accelerometer (28). In this manner, false triggering can be suppressed.

8. 发明申请

WO2007141509A1 A METHOD FOR MEASURING AN OBJECT 审中-公开
标题翻译：一种用于测量对象的方法
公开(公告)号：WO2007141509A1
公开(公告)日：2007-12-13
申请号：PCT/GB2007/002058
申请日：2007-06-06
申请人： RENISHAW PLC , HELLIER, Peter, Kenneth
发明人： HELLIER, Peter, Kenneth
IPC分类号： G01B21/04
CPC分类号： G01B21/04
摘要： A 'go, no-go' method is described for determining whether the dimensions of an object, such as a workpiece (40), conform to tolerance. The method uses a measurement probe, such as a touch trigger, analogue, or non-contact probe, mounted on a measuring apparatus such as a coordinate measuring machine, machine tool, or a lathe. The method comprises the step of driving the measurement probe around a path relative to the object, said path being based on a tolerance of the object. The path relative to the object may include at least a first path (46) based on the maximum tolerance of the object and a second path (44) based on the minimum tolerance of the object. The method additionally comprises the steps of monitoring any probe measurement data acquired by the measurement probe as the probe is driven around the path, and indicating if the dimensions of the object do not conform to tolerance only if there is a change in state of the probe measurement data that is acquired as the measurement probe is driven around the path.
摘要翻译：描述了用于确定诸如工件（40）的物体的尺寸是否符合公差的“去，不去”方法。该方法使用安装在诸如坐标测量机，机床或车床的测量装置上的测量探针，例如触摸触发器，模拟或非接触式探头。该方法包括围绕相对于物体的路径驱动测量探针的步骤，所述路径基于对象的公差。基于对象的最大容限，相对于对象的路径可以包括至少第一路径（46）和基于对象的最小容差的第二路径（44）。该方法另外包括以下步骤：当探针围绕路径被驱动时，监测由测量探针获取的任何探针测量数据，并且仅当探针的状态发生变化时才指示对象的尺寸是否不符合公差作为测量探针获取的测量数据围绕路径被驱动。

9. 发明申请

WO2007129071A1 CONTACT SENSING PROBE 审中-公开
标题翻译：联系传感探头
公开(公告)号：WO2007129071A1
公开(公告)日：2007-11-15
申请号：PCT/GB2007/001663
申请日：2007-05-08
申请人： RENISHAW PLC , WESTON, Nicholas, John , ROBERTSON, James, Fergus
发明人： WESTON, Nicholas, John , ROBERTSON, James, Fergus
IPC分类号： G01B5/012 , G01B7/012
CPC分类号： G01B7/012
摘要： Contact sensing probe apparatus (2) is described that comprises a workpiece contacting stylus (6), a transducer (8;108) mechanically coupled to the stylus (6) and an oscillator (30,31) for supplying an alternating current to the transducer (8;108) to induce vibration of the stylus (6). A contact sensor is also provided for monitoring the phase difference between the voltage supplied to the transducer (8;108) and the current flow to the transducer. The oscillator (30,31) is arranged to supply the transducer (8;108) with an alternating current of a first frequency during contact sensing. This first frequency (46) is selected to induce mechanical resonance but to be away from the maximum (40) of the mechanical resonance peak. The probe may be used with co-ordinate positioning machines, such as portable articulated measuring arms, co-ordinate measuring machines (CMM) and the like.
摘要翻译：描述了接触传感探针装置（2），其包括工件接触触针（6），机械地耦合到触针（6）的换能器（8; 108）和用于向换能器提供交流电的振荡器（30,31）（8; 108）以引起触针（6）的振动。还提供接触传感器用于监测提供给换能器（8; 108）的电压与到换能器的电流之间的相位差。振荡器（30,31）布置成在接触感测期间向换能器（8; 108）提供第一频率的交流电流。选择该第一频率（46）以引起机械共振，但是远离机械共振峰的最大值（40）。探头可以与诸如便携式铰接测量臂，坐标测量机（CMM）等的坐标定位机一起使用。

10. 发明申请

WO2007083118A1 ROTARY ENCODER APPARATUS AND METHOD 审中-公开
标题翻译：旋转编码器装置和方法
公开(公告)号：WO2007083118A1
公开(公告)日：2007-07-26
申请号：PCT/GB2007/000145
申请日：2007-01-17
申请人： RENISHAW plc , CHASE, Joel, Barnabas , STICKLAND, Thomas, John , HOLDEN, Peter, Geoffrey
发明人： CHASE, Joel, Barnabas , STICKLAND, Thomas, John , HOLDEN, Peter, Geoffrey
IPC分类号： G01D5/244 , G01D5/245
CPC分类号： G01D5/3473 , G01D5/24452 , G01D5/24476 , G01D5/2449 , G01D5/2457
摘要： Rotary encoder apparatus (2) is described that comprises an encoder scale or ring (30) and an encoder scale reader. The encoder scale includes an incremental scale and one or more reference marks (32,34). The encoder scale reader comprises at least a first readhead (4) and a second readhead (6) that each produce a reference mark signal when passed over a reference mark of the encoder scale. The apparatus also comprises a reference position setter (40) for determining, as the encoder scale reader is rotated relative to the encoder scale, at least one angularly repeatable reference position of the encoder scale relative to the encoder scale reader using a first reference mark signal produced by the first readhead and a second reference mark signal subsequently produced by the second readhead.
摘要翻译：描述了包括编码器刻度尺或环（30）和编码器刻度读取器的旋转编码器装置（2）。编码器刻度包括增量刻度和一个或多个参考标记（32,34）。编码器刻度尺读取器至少包括第一读取头（4）和第二读取头（6），当第一读取头和第二读取头（6）在经过编码器刻度的参考标记时产生参考标记信号。该装置还包括参考位置设定器（40），用于当编码器刻度尺读取器相对于编码器刻度旋转时，确定编码器刻度相对于编码器刻度读取器的至少一个角度可重复的参考位置，该基准位置使用第一参考标记信号由第一读取头产生并且由第二读数头随后产生的第二参考标记信号。

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