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1. 发明申请

WO2012004103A1 AN AMBULATORY ULTRAFILTRATION DEVICE, RELATED METHODS AND A COMPUTER PROGRAM PRODUCT 审中-公开
标题翻译：一种超声波超声装置，相关方法和计算机程序产品
公开(公告)号：WO2012004103A1
公开(公告)日：2012-01-12
申请号：PCT/EP2011/060019
申请日：2011-06-16
申请人： GAMBRO LUNDIA AB , JÖNSSON, Lennart , STERNBY, Jan , WIESLANDER, Anders
发明人： JÖNSSON, Lennart , STERNBY, Jan , WIESLANDER, Anders
IPC分类号： A61M1/30
CPC分类号： A61M1/30 , A61M1/302 , A61M1/303 , A61M1/3427 , A61M1/3604 , A61M1/365 , A61M1/3672 , A61M2209/088
摘要： An ultrafiltration device is designed to be used for ambulatory SCUF or other types of continuous or intermittent ultrafiltration, typically while being worn or otherwise carried by the subject (S) that is being treated. The ambulatory ultrafiltration device comprises a blood filter (4) that has a blood side (6) for fluid communication with the vascular system of the subject (S), an ultrafiltrate side (7), and a semipermeable membrane (8) disposed between the blood side (6) and the ultrafiltrate side (7). The ambulatory ultrafiltration also comprises a buffer vessel (3) in fluid communication with the blood side (6) of the blood filter (4), and a blood pump (9). The blood pump (9) is controlled to alternate between a withdrawal phase and a return phase. In the withdrawal phase, blood is withdrawn on a blood path from the subject (S) via the blood filter (4) to the buffer vessel (3). In the return phase, blood is returned from the buffer vessel (3) to the subject (S) on the blood path. The blood filter (4) is arranged to remove ultrafiltrate from the blood during at least one of the withdrawal and return phases. The use of a single blood path for withdrawal of blood and return of treated blood makes the device suitable for ambulatory ultrafiltration.
摘要翻译：超滤装置设计用于移动SCUF或其他类型的连续或间歇超滤，通常在正在治疗的受试者（S）穿着或以其他方式携带时。动态超滤装置包括血液过滤器（4），其具有用于与受试者（S）的血管系统流体连通的血液侧（6），超滤液侧（7）和设置在所述受试者的血液系统之间的半透膜（8）血液侧（6）和超滤液侧（7）。动态超滤还包括与血液过滤器（4）的血液侧（6）流体连通的缓冲容器（3）和血液泵（9）。血泵（9）被控制为在抽出阶段和返回阶段之间交替。在取出阶段，血液在血液路径上从被检体（S）经由血液过滤器（4）抽出到缓冲容器（3）。在返回阶段，将血液从缓冲容器（3）返回到血液路径上的受试者（S）。血液过滤器（4）布置成在至少一个抽出和返回阶段期间从血液中除去超滤液。使用单个血液路径来取出血液并返回处理过的血液，使得该装置适合于动态超滤。

2. 发明申请

WO2010043595A1 BLOOD TREATMENT APPARATUS AND METHOD 审中-公开
标题翻译：血液处理装置和方法
公开(公告)号：WO2010043595A1
公开(公告)日：2010-04-22
申请号：PCT/EP2009/063290
申请日：2009-10-12
申请人： GAMBRO LUNDIA AB , HOLMER, Mattias , JÖNSSON, Lennart , WALLENBORG, Anders , HANSSON, Per
发明人： HOLMER, Mattias , JÖNSSON, Lennart , WALLENBORG, Anders , HANSSON, Per
IPC分类号： A61M1/10 , A61M1/16 , A61M1/30 , A61M1/34
CPC分类号： A61M1/16 , A61M1/1601 , A61M2205/50
摘要： A blood treatment apparatus, comprising a blood treatment unit (D) configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid, a pair of fluid pumps ( PF1, PF2; PF3, PF4) configured to pass blood treatment fluid through the blood treatment unit (D), a pair of blood pumps ( PB1, PB2) configured to extract untreated blood from a blood source (BS), pass extracted blood through the blood treatment unit (D) and deliver treated blood to a target vessel (BT), each blood pump comprising a pump chamber and a flexible member ( FM1; FM2) separating the pumping chamber into a first blood accumulating container (B1; B2) and a second working fluid accumulating container (F1; F2) where the flexible member is configured to vary a volume relationship between the first and the second accumulation containers. Further the apparatus comprises a control unit (P) and a measuring means configured to emit a feedback signal indicative of the amount of working fluid received into, or discharged from at least one of the second accumulation containers (F1; F2) whereby the pumped mass or volume of working fluid is determined by the control unit (P) at an arbitrary position of the flexible member (FM1, FM2).
摘要翻译：一种血液处理装置，包括：血液处理单元（D），被配置为接收未经处理的血液和新鲜血液处理液，并且发射处理过的血液和使用的血液处理液;一对流体泵（PF1，PF2; PF3，PF4）通过血液处理单元（D）通过血液处理液，构成为从血液源（BS）中提取未经处理的血液的一对血液泵（PB1，PB2），通过血液处理单元（D）将提取的血液通过，每个血液泵包括泵室和将泵送室分成第一血液积聚容器（B1; B2）和第二工作流体积聚容器（F1; B2）的柔性构件（FM1; FM2） F2），其中柔性构件构造成改变第一和第二蓄积容器之间的体积关系。此外，该装置包括控制单元（P）和测量装置，该测量装置被配置为发射指示接收到或从第二积聚容器（F1; F2）中的至少一个排出的工作流体的量的反馈信号，由此泵送的质量或者在柔性构件（FM1，FM2）的任意位置处由控制单元（P）确定工作流体的体积。

3. 发明申请

WO2009127683A1 METHOD AND DEVICES FOR MONITORING FLOW CIRCUITS 审中-公开
标题翻译：用于监测流量电路的方法和装置
公开(公告)号：WO2009127683A1
公开(公告)日：2009-10-22
申请号：PCT/EP2009/054514
申请日：2009-04-16
申请人： GAMBRO LUNDIA AB , FURMANSKI, Martin , ROSLUND, Anders , OLDE, Bo , SOLEM, Kristian
发明人： FURMANSKI, Martin , ROSLUND, Anders , OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36 , A61M5/168 , G01M3/00 , A61M205/15 , A61M230/06
CPC分类号： G01M3/2815 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M5/16859 , A61M2205/15 , A61M2205/18 , A61M2230/06
摘要： A device is provided for monitoring the integrity of a flow circuit in fluid communication with a receptacle. The flow circuit comprises a pumping device for transferring fluid through the flow circuit. The device operates according to a monitoring method in which a pressure signal is received (401) from a pressure sensor, the pressure signal being indicative of fluid pressure in the receptacle or the flow circuit. The pressure signal is then processed (406-407) for detection of a beating signal. The beating signal manifests itself as an amplitude modulation of the pressure signal and is formed by interference between pressure waves generated by a pulse generator associated with the receptacle and pressure waves generated by the pumping device. The integrity of the flow circuit is determined (408-409) based at least partly on the presence or absence of the beating signal. The device and the flow circuit may be part of an apparatus for extracorporeal blood treatment, and the method may be implemented as a computer program product.
摘要翻译：提供了一种用于监测与容器流体连通的流动回路的完整性的装置。流动回路包括用于通过流动回路传送流体的泵送装置。该装置根据从压力传感器接收压力信号（401）的监测方法进行操作，压力信号表示容器或流路中的流体压力。然后对压力信号进行处理（406-407）以检测跳动信号。跳动信号表现为压力信号的幅度调制，并且由与由插座相关联的脉冲发生器产生的压力波和由泵送装置产生的压力波之间的干扰形成。至少部分地基于跳动信号的存在或不存在来确定流动电路的完整性（408-409）。装置和流路可以是用于体外血液处理的装置的一部分，并且该方法可以被实现为计算机程序产品。

4. 发明申请

WO2009127624A3 BLOOD TREATMENT APPARATUS 审中-公开
公开(公告)号：WO2009127624A3
公开(公告)日：2009-10-22
申请号：PCT/EP2009/054406
申请日：2009-04-14
申请人： GAMBRO LUNDIA AB , JÖNSSON, Lennart , JANSSON, Olof , HOLMER, Mattias , STERNBY, Jan , NILSSON, Anders , HANSSON, Per
发明人： JÖNSSON, Lennart , JANSSON, Olof , HOLMER, Mattias , STERNBY, Jan , NILSSON, Anders , HANSSON, Per
IPC分类号： A61M1/10 , A61M1/16 , A61M1/30 , A61M1/34
摘要： A proposed blood treatment apparatus includes : a blood treatment unit (8), a pair of fluid pumps (14, 15) and a pair of blood pumps (1a, 1b). The blood treatment unit (8) is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps (14, 15) are configured to pass blood treatment fluid through the blood treatment unit (8). The blood pumps (1a, 1b) are configured to extract untreated blood from a blood source (S), pass extracted blood through the blood treatment unit (8) and deliver treated blood to a target vessel (T). Additionally, the fluid pumps (14, 15) are configured to control the operation of the blood pumps (1a, 1b) via the blood treatment fluid. Moreover, a flow control means (16a) is configured to control a trans- membrane flow between the blood side (8B) and the a fluid side (8F) of the blood treatment unit (8). Hence, for instance ultrafiltration can be adjusted to a desired level in a very straightforward manner.

5. 发明申请

WO2014009111A1 FILTERING OF PRESSURE SIGNALS FOR SUPPRESSION OF PERIODIC PULSES 审中-公开
标题翻译：用于抑制周期性脉冲的压力信号的滤波
公开(公告)号：WO2014009111A1
公开(公告)日：2014-01-16
申请号：PCT/EP2013/062616
申请日：2013-06-18
申请人： GAMBRO LUNDIA AB
发明人： SOLEM, Kristian , OLDE, Bo , STERNBY, Jan
IPC分类号： A61M1/36 , G01M3/28
CPC分类号： A61M1/3621 , A61M1/3653 , A61M1/3656 , A61M2205/3331 , A61M2205/50 , G01M3/2815
摘要： A filtering device receives a pressure signal (P) from a pressure sensor in a fluid containing system, the pressure signal (P) comprising first pulses originating from a first periodic pulse generator and second pulses. The device acquires a reference signal which is indicative of a current operating frequency of the first periodic pulse generator. The device identifies, based on the reference signal, a plurality of harmonics ( v̅ 1 − v̅ 8 ) associated with the current operating frequency, computes correlation values (λ̂ 1 − λ̂ 8 ) between the harmonics and the pressure signal (P) within a time window in the pressure signal (P), and generates a filtered signal by subtracting, as a function of the correlation values (λ̂ 1 − λ̂ 8 ), the harmonics from the pressure signal (P). The use of correlation values is a direct, fast, robust and computation-efficient approach for estimating the signal contribution (d̂) from first pulses in the pressure signal (P).
摘要翻译：过滤装置从流体容纳系统中的压力传感器接收压力信号（P），压力信号（P）包括源自第一周期性脉冲发生器的第一脉冲和第二脉冲。该装置获取指示第一周期性脉冲发生器的当前工作频率的参考信号。该设备基于参考信号识别与当前操作频率相关联的多个谐波（v-1-v 8），在时间窗口内计算谐波和压力信号（P）之间的相关值（lambd-lambdâ8）在压力信号（P）中，并且通过从压力信号（P）中减去作为相关值（lambd1-lambd'8）的函数的谐波来产生滤波信号。相关值的使用是用于从压力信号（P）中的第一脉冲估计信号贡献（d）的直接，快速，鲁棒和计算有效的方法。

6. 发明申请

WO2012175435A1 DISPOSABLES FOR BLOOD TREATMENT, AND METHODS OF OPERATING THE SAME 审中-公开
标题翻译：用于血液治疗的药物及其操作方法
公开(公告)号：WO2012175435A1
公开(公告)日：2012-12-27
申请号：PCT/EP2012/061551
申请日：2012-06-18
申请人： GAMBRO LUNDIA AB , JANSSON, Olof , HOLMER, Mattias , NILSSON, Eddie , JÖNSSON, Lennart
发明人： JANSSON, Olof , HOLMER, Mattias , NILSSON, Eddie , JÖNSSON, Lennart
IPC分类号： A61M1/30 , A61M1/36
CPC分类号： A61M1/367 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/306 , A61M1/3621 , A61M2205/125 , A61M2205/128 , Y10T137/0318 , Y10T137/85986 , Y10T137/86035
摘要： A disposable for use in blood treatment comprises a blood treatment unit (8) and a pump arrangement (11) operable to pump blood through the blood treatment unit (8). The pump arrangement (11) comprises two membrane pumps (6, 7) connected in parallel on one side of the blood treatment unit (8). The disposable is operable in a single-needle mode, in which the pump arrangement (11) is operable to generate a pulsatile flow of blood through the blood treatment unit (8), and in a double-needle mode, in which the pump arrangement (11) is operable to generate an essentially continuous flow of blood through the blood treatment unit (8). The pump arrangement (11) is configured for connection to a supply system (1) of treatment fluid for the blood treatment unit (8) such that alternating flows of treatment fluid generated by the supply system (1) and supplied to the first and second membrane pumps (6, 7) causes the pump arrangement (11) to generate the desired flows of blood in the single-needle and double- needle modes. The treatment fluid may be used as motive fluid for displacing the blood in the membrane pumps (6, 7) and/or as control fluid for controlling opening and/or closing of upstream and downstream commutation valves (34, 35) in the membrane pumps (6, 7).
摘要翻译：用于血液处理的一次性用品包括血液处理单元（8）和可操作以将血液泵送通过血液处理单元（8）的泵装置（11）。泵装置（11）包括在血液处理单元（8）的一侧上并联连接的两个膜泵（6,7）。一次性可以单针模式操作，其中泵装置（11）可操作以通过血液处理单元（8）产生脉动血液流，并且在双针模式中，泵装置（11）可操作以通过血液处理单元（8）产生基本上连续的血液流。泵装置（11）构造成用于连接到用于血液处理单元（8）的处理流体的供应系统（1），使得由供应系统（1）产生并供应到第一和第二膜泵（6,7）使泵装置（11）以单针和双针模式产生所需的血液流。处理流体可以用作移动膜泵（6,7）中的血液的运动流体和/或用作控制膜泵中上游和下游换向阀（34,35）的打开和/或关闭的控制流体（6,7）。

7. 发明申请

WO2012035040A1 BLOOD TREATMENT APPARATUS WITH FLOW DIVIDER FOR LIMITING AN ELECTRICAL CURRENT 审中-公开
标题翻译：用于限制电流的流量分配器的血液处理装置
公开(公告)号：WO2012035040A1
公开(公告)日：2012-03-22
申请号：PCT/EP2011/065894
申请日：2011-09-14
申请人： GAMBRO LUNDIA AB , HANSSON, Per , HERTZ, Thomas , HOLMER, Mattias , JÖNSSON, Lennart , NILSSON, Anders , WALLENBORG, Anders , ANDERSSON, Johan
发明人： HANSSON, Per , HERTZ, Thomas , HOLMER, Mattias , JÖNSSON, Lennart , NILSSON, Anders , WALLENBORG, Anders , ANDERSSON, Johan
IPC分类号： A61M1/14 , A61M1/36
CPC分类号： A61M1/367 , A61M1/14 , A61M1/1601 , A61M1/3621 , A61M2205/3317 , A61M2205/3334 , A61M2205/50 , Y10T29/49002
摘要： A blood treatment apparatus (2) comprising: a blood treatment unit (10); a blood line (20) configured to extract blood from a blood source (21), pass the blood through the blood treatment unit (10) and deliver treated blood to a target vessel (22); and a fluid line (30) configured pass treatment fluid through the blood treatment unit (10) and deliver used treatment fluid to a fluid sink (32). A flow divider (40) is arranged in the fluid line (30) separates treatment fluid into to a first fluid section (51) and a second fluid section (53), thereby electrically isolating the fluid sections (51, 53) such that electrical current flowing in the fluid line (30) between the fluid sections (51, 53) is limited. Related manufacturing and verification methods are also described.
摘要翻译：一种血液处理装置（2），包括：血液处理单元（10）; 构成为从血液源（21）取出血液的血液线（20），使血液通过血液处理单元（10），将处理后的血液输送到目标血管（22）。并且流体管线（30）构造成通过处理液通过血液处理单元（10）并将使用的处理流体输送到流体槽（32）。在流体管线（30）中布置有分流器（40），其将处理流体分离成第一流体部分（51）和第二流体部分（53），从而将流体部分（51,53）电隔离，使得电气在流体管线（30）内流动的流体部分（51,53）之间的电流受到限制。还描述了相关的制造和验证方法。

8. 发明申请

WO2011161064A1 PREPARATION OF MEDICAL SOLUTIONS FROM POWDERY MATERIAL 审中-公开
标题翻译：从粉末材料制备医疗解决方案
公开(公告)号：WO2011161064A1
公开(公告)日：2011-12-29
申请号：PCT/EP2011/060255
申请日：2011-06-20
申请人： GAMBRO LUNDIA AB , JANSSON, Olof , JÖNSSON, Lennart , LINDEN, Torbjörn , STERNBY, Jan , TRYGGVASON, Ragnar , WIESLANDER, Anders
发明人： JANSSON, Olof , JÖNSSON, Lennart , LINDEN, Torbjörn , STERNBY, Jan , TRYGGVASON, Ragnar , WIESLANDER, Anders
IPC分类号： A61J1/20 , A61M1/16
CPC分类号： A61J1/20 , A61J1/2093 , A61M1/1656 , A61M1/1666 , A61M1/1668 , A61M1/167 , A61M1/287 , B65D31/14 , B65D81/18 , B65D81/20 , B65D81/2007 , B65D81/2023 , B65D81/2046
摘要： A package has a transport/storage state for storing powdery material which is to be mixed with a solvent to form a medical solution, e.g. for use in dialysis treatment. The package comprises a compartment (6) which is at least partially defined by two opposing wall portions, and a connector (10). In the transport/storage state, the compartment contains the powdery material in the form of at least two distinct sets (2A-2D) of powdery material of different compositions, where the opposing wall portions are brought into engagement with the powdery material so as to immobilize the sets of powdery material (2A-2D). When used for preparation of the medical solution, a fluid is selectively admitted into the package via the connector (10) so as to expand the compartment (6) and enable mixing of the sets (2A-2D) of powdery material with the solvent in the compartment (6).
摘要翻译：包装具有用于储存待与溶剂混合以形成医用溶液的粉末状材料的运输/储存状态，用于透析治疗。该包装件包括至少部分地由两个相对的壁部分限定的隔室（6）和连接器（10）。在运输/储存状态下，隔室含有至少两种不同组成的粉末材料组（2A-2D）形式的粉状材料，其中相对的壁部分与粉末材料接合，以便固定一组粉状材料（2A-2D）。当用于制备医用溶液时，通过连接器（10）将流体选择性地进入包装中，以便使隔室（6）膨胀，并使粉末材料组（2A-2D）与溶剂的组合隔室（6）。

9. 发明申请

WO2008111903A1 A MEDICAL PRODUCT, AND A METHOD OF STERILIZING A MEDICAL PRODUCT 审中-公开
标题翻译：医疗产品和灭菌医疗产品的方法
公开(公告)号：WO2008111903A1
公开(公告)日：2008-09-18
申请号：PCT/SE2008/050253
申请日：2008-03-07
申请人： GAMBRO LUNDIA AB , TRYGGVASON, Ragnar
发明人： TRYGGVASON, Ragnar
IPC分类号： A61M39/16 , A61M39/22 , A61M39/10
CPC分类号： A61M39/22 , A61M39/10 , A61M39/16 , A61M39/20 , A61M2039/224 , A61M2039/229
摘要： A medical product is configured for use in a medical system. A method is provided for sterilizing the product. A connector (4) connects a first subsystem and a second subsystem, containing a medical fluid, for transport of the medical fluid from the second subsystem to the first sub-system. The connector comprises a valve device (10), a first connection pipe (11) connected to the first sub-system, and a second connection pipe (12) connected to the second sub-system. The valve device comprises a first part (21) and a second part (22) movable relatively each other to permit an opening movement from a closed 10 position, preventing a fluid communication between the connection pipes, and an open position establishing a channel permitting the fluid communication. The connector comprises at least one small passage (41, 42, 43) permitting, in the closed stable position, an introduction of a sterilizing gas to contact wall surfaces defining the channel.
摘要翻译：医疗产品配置用于医疗系统。提供了一种消毒产品的方法。连接器（4）连接包含医用流体的第一子系统和第二子系统，用于将医用流体从第二子系统运送到第一子系统。连接器包括阀装置（10），连接到第一子系统的第一连接管（11）和连接到第二子系统的第二连接管（12）。阀装置包括第一部分（21）和第二部分（22），第二部分（22）可相对于彼此移动，以允许从关闭的10位置开启运动，防止连接管之间的流体连通，以及建立允许流体通信。连接器包括至少一个小通道（41,42,43），其在封闭的稳定位置允许将消毒气体引入限定通道的接触壁表面。

10. 发明申请

WO2016174032A1 A MALE FLUID CONNECTOR, A FEMALE FLUID CONNECTOR AND A FLUID CONNECTION SYSTEM COMPRISING THE SAME 审中-公开
标题翻译：一个公用液体连接器，一个液体连接器和一个包含它的流体连接系统
公开(公告)号：WO2016174032A1
公开(公告)日：2016-11-03
申请号：PCT/EP2016/059281
申请日：2016-04-26
申请人： GAMBRO LUNDIA AB
发明人： CARLSSON, Ola
IPC分类号： A61M39/00 , A61M39/10 , A61M1/14
CPC分类号： A61M39/10 , A61M1/14 , A61M1/367 , A61M2039/1094 , A61M2205/6009
摘要： A male fluid connector, a female fluid connector, and a connection system comprising the connectors. The connection system comprises a male connector and a female connector that both are modified such that they cannot be engaged. The connection system removes the risk of unintentional connection of the two modified connectors not intended to be connected but still allows connection of the two modified connectors to other non-modified connectors
摘要翻译：一个公液体连接器，一个母液体连接器和一个包括连接器的连接系统。连接系统包括一个阳连接器和一个阴连接器，两者均被修改成不能接合。连接系统消除了不想连接的两个改进的连接器意外连接的风险，但仍然允许将两个修改的连接器连接到其他未修改的连接器

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