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1. 发明申请

WO2011080191A1 MONITORING BLOOD PRESSURE 审中-公开
标题翻译：监测血压
公开(公告)号：WO2011080191A1
公开(公告)日：2011-07-07
申请号：PCT/EP2010/070557
申请日：2010-12-22
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian
发明人： OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36 , A61B5/021
CPC分类号： A61B5/021 , A61B5/02125 , A61B5/022 , A61M1/3639
摘要： A device (25) is configured to determine a blood pressure value of a subject, based on a combination of signals obtained from sensors (35, 40) associated at least with an extracorporeal blood flow circuit (20) that is connected in fluid communication with the vascular system of the subject. The combination of signals may be a first signal from a first pulse sensor (40) arranged to detect pressure waves in the extracorporeal blood flow circuit (20) and a second signal indicative of an activation of a pulse generator (30) associated with the patient. Alternatively the combination of signals may be a first signal from a first pulse sensor arranged to detect pressure waves in the vascular system and a second signal indicative of an activation of a pulse generator (3) associated with the extracorporeal blood flow circuit (20). The device comprises a signal processor which is configured to process the first and second signals to determine a time difference between a first time point associated with the first signal and a second time point associated with the second signal; and calculate the blood pressure value based on the time difference. The device (25) may be included in an apparatus (200) for blood treatment, such as a dialysis machine.
摘要翻译：设备（25）被配置为基于从至少与体外血流回路（20）相关联的传感器（35,40）获得的信号的组合来确定对象的血压值，所述体外流血回路（20）与受试者的血管系统。信号的组合可以是来自第一脉冲传感器（40）的第一信号，其布置成检测体外血流回路（20）中的压力波，以及指示与患者相关联的脉冲发生器（30）的激活的第二信号。或者，信号的组合可以是来自布置成检测血管系统中的压力波的第一脉冲传感器的第一信号和指示与体外血流回路（20）相关联的脉冲发生器（3）的激活的第二信号。所述设备包括信号处理器，其被配置为处理所述第一和第二信号以确定与所述第一信号相关联的第一时间点和与所述第二信号相关联的第二时间点之间的时间差; 并根据时差计算血压值。装置（25）可以包括在用于血液处理的装置（200）中，例如透析机。

2. 发明申请

WO2011080190A1 APPARATUS AND METHOD FOR PREDICTION OF RAPID SYMPTOMATIC BLOOD PRESSURE DECREASE 审中-公开
标题翻译：用于预测快速症状性血压降低的装置和方法
公开(公告)号：WO2011080190A1
公开(公告)日：2011-07-07
申请号：PCT/EP2010/070555
申请日：2010-12-22
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian
发明人： OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36 , A61B5/0215
CPC分类号： A61B5/0215 , A61M1/3639
摘要： A monitoring device (29) is included in a medical system to implement a method for prediction of a rapid symptomatic drop in a subject's blood pressure, e.g. during a medical treatment such as dialysis. To this aim, a pulse shape parameter (p PS ) with respect to a pulse generator of the subject is registered by means of a pressure sensor (4a, 4b, 4c) arranged in an extracorporeal blood flow circuit coupled to a cardiovascular system of the subject (P). The pressure sensor (4a, 4b, 4c) is adapted to detect pressure variations in blood vessels of the subject (P). It is investigated, during measurement period, whether or not one or more of the pulse shape parameters fulfil a decision criterion. An output signal (α) is generated if the decision criterion is found to be fulfilled, to indicate a predicted rapid symptomatic blood pressure decrease in the subject (P). The decision criterion may operate on pulse magnitude measures calculated for the received pulse shape parameters (p PS ), or statistical dispersion measures calculated based on the thus-calculated pulse magnitude measures.
摘要翻译：监测装置（29）包括在医疗系统中以实现用于预测受试者血压中快速症状下降的方法，例如，在透析等医疗过程中。为此，相对于被检体的脉冲发生器的脉冲形状参数（pPS）通过布置在与被检体的心血管系统耦合的体外血流回路中的压力传感器（4a，4b，4c）来记录（P）。压力传感器（4a，4b，4c）适于检测被检体（P）的血管中的压力变化。在测量期间，对脉冲形状参数中的一个或多个是否满足判定标准进行了研究。如果发现判定标准被满足，则产生输出信号（a），以指示对象（P）中预测的快速有症状的血压下降。决策标准可以对针对接收的脉冲形状参数（pPS）计算的脉冲幅度测量值进行操作，或者基于由此计算的脉冲幅度测量值计算的统计色散测量值。

3. 发明申请

WO2011080186A1 CONTROLLING AN APPARATUS FOR FLUID TRANSFER TO AND/OR FROM A SUBJECT 审中-公开
标题翻译：控制流体转移到和/或从主体的流体装置
公开(公告)号：WO2011080186A1
公开(公告)日：2011-07-07
申请号：PCT/EP2010/070547
申请日：2010-12-22
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian , HERTZ, Thomas , STERNBY, Jan , WIESLANDER, Anders
发明人： OLDE, Bo , SOLEM, Kristian , HERTZ, Thomas , STERNBY, Jan , WIESLANDER, Anders
IPC分类号： A61M1/36
CPC分类号： A61M1/3656 , A61B5/02125 , A61B5/0215 , A61B5/02405 , A61B5/4836 , A61M1/30 , A61M1/3643 , A61M1/3644 , A61M1/3653 , A61M1/3659 , A61M2205/3331 , A61M2205/6018
摘要： A control system (23) is arranged to control the operation of an apparatus (200) for for extracorporeal blood treatment. The apparatus (200) comprises an extracorporeal blood circuit (20) and a connection system (C) for connecting the blood circuit (20) to the vascular system of a patient. The blood circuit (20) comprises a blood processing device (6), and at least one pumping device (3). The control system is operable to switch between a pre-treatment mode and a blood treatment mode. The blood treatment mode involves operating the blood circuit (20) to pump blood from the vascular system via the connection system (C) through the blood processing device (6) and back to the vascular system via the connection system (C). The control system (23) is operable to obtain measurement data from at least one energy transfer sensor (40) arranged to sense a transfer of energy between the patient and the connection system (C) or between the patient and the blood circuit (20). The control system (23) is configured to, in the pre-treatment mode, process the measurement data for identification of a characteristic change indicating a connection of the blood circuit (20) to the vascular system of the patient, and, upon such identification, take dedicated action. The action may involve activating at least part of a patient protection system and/or enabling entry into the blood treatment mode. The control system may be included in an apparatus (200) for blood treatment, such as a dialysis machine.
摘要翻译：控制系统（23）被布置成控制用于体外血液处理的装置（200）的操作。装置（200）包括用于将血液回路（20）连接到患者血管系统的体外血液回路（20）和连接系统（C）。血液回路（20）包括血液处理装置（6）和至少一个泵送装置（3）。控制系统可操作以在预处理模式和血液处理模式之间切换。血液处理模式包括操作血液回路（20），以经由连接系统（C）从血管系统通过血液处理装置（6）泵送血液，并通过连接系统（C）返回血管系统。控制系统（23）可操作以从至少一个能量传递传感器（40）获得测量数据，所述能量传递传感器（40）布置成感测患者和连接系统（C）之间或病人与血液回路（20）之间的能量传递，。控制系统（23）被配置为在预处理模式下处理用于识别指示血液回路（20）与患者的血管系统的连接的特征变化的测量数据，并且在这种识别，采取专门的行动。该动作可以涉及激活患者保护系统的至少一部分和/或使得能够进入血液处理模式。控制系统可以包括在用于血液处理的装置（200）中，例如透析机。

4. 发明申请

WO2009156175A3 METHOD AND DEVICE FOR PROCESSING A TIME-DEPENDENT MEASUREMENT SIGNAL 审中-公开
标题翻译：用于处理时间相关测量信号的方法和设备
公开(公告)号：WO2009156175A3
公开(公告)日：2010-04-01
申请号：PCT/EP2009004641
申请日：2009-06-26
申请人： GAMBRO LUNDIA AB , SOLEM KRISTIAN , OLDE BO
发明人： SOLEM KRISTIAN , OLDE BO
IPC分类号： A61M1/36
CPC分类号： G01M3/2846 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , G01L27/002 , G01M3/2815 , G01N33/49
摘要： A monitoring device is arranged to receive a time-dependent measurement signal (d(n)) from a pressure sensor in a fluid containing system, which is associated with a first pulse generator and a second pulse generator. The pressure sensor is arranged in the fluid containing system to detect a first pulse originating from the first pulse generator and a second pulse originating from the second pulse generator. The monitoring device is configured to process the measurement signal (d(n)) to remove the first pulse. In this process, the monitoring device receives (201) the measurement signal (d(n)), obtains (202) a first pulse profile (u(n)) which is a predicted temporal signal profile of the first pulse, and filters (203) the measurement signal (d(n)) in the time-domain, using the first pulse profile (u(n)), to essentially eliminate the first pulse while retaining the second pulse. The fluid containing system may include an extracorporeal blood flow circuit, e.g. as part of a dialysis machine, and a blood circuit of a human patient.
摘要翻译：监视装置被布置成从与第一脉冲发生器和第二脉冲发生器相关联的流体容纳系统中的压力传感器接收与时间相关的测量信号（d（n））。压力传感器布置在流体容纳系统中以检测源自第一脉冲发生器的第一脉冲和源自第二脉冲发生器的第二脉冲。监视装置被配置为处理测量信号（d（n））以去除第一脉冲。在该过程中，监视装置接收（201）测量信号（d（n）），获得（202）作为第一脉冲的预测时间信号轮廓的第一脉冲轮廓（u（n））和滤波器 203）使用第一脉冲轮廓（u（n））的时域中的测量信号（d（n））基本上消除第一脉冲同时保持第二脉冲。流体容纳系统可以包括体外血流回路，例如，作为透析机的一部分，以及人类患者的血液回路。

5. 发明申请

WO2007141246A2 PREDICTION OF RAPID SYMPTOMATIC BLOOD PRESSURE DECREASE 审中-公开
标题翻译：快速症状性血压降低预测
公开(公告)号：WO2007141246A2
公开(公告)日：2007-12-13
申请号：PCT/EP2007/055477
申请日：2007-06-04
申请人： GAMBRO LUNDIA AB , SÖRNMO, Leif , SOLEM, Kristian , OLDE, Bo
发明人： SÖRNMO, Leif , SOLEM, Kristian , OLDE, Bo
IPC分类号： A61B5/021 , A61B5/1455
CPC分类号： A61B5/14551 , A61B5/021 , A61B5/02116 , A61M1/3639 , A61M2205/18 , A61M2205/50 , A61M2230/30
摘要： The invention relates to prediction of a rapid symptomatic drop in a subject's blood pressure, e.g. during a medical treatment or when operating an aircraft. To this aim, a pulse shape parameter (Pps) with respect to a peripheral body part (105) of the subject (P) is registered by means of a pulse oximetry instrument (110) adapted to detect light response variations in blood vessels. An initial pulse magnitude measure is calculated based on a pulse shape parameter (Pps) received at a first instance. During a measurement period subsequent to the first instance, a respective pulse magnitude measure is calculated based on each of a number of received pulse shape parameters (Pps). It is further investigated, for each pulse magnitude measure in the measurement period, whether or not the measure fulfils a decision criterion relative to the initial pulse magnitude measure. An alarm triggering signal (α) is generated if the decision criterion is found to be fulfilled.
摘要翻译：本发明涉及预测受试者血压中快速有症状的下降，例如，在治疗期间或在操作飞行器时。为此目的，通过适于检测血管中的光反应变化的脉搏血氧仪（110）来记录相对于被检体（P）的外周身体部分（105）的脉搏形状参数（Pps）。基于在一次接收的脉冲形状参数（Pps）来计算初始脉冲幅度测量。在第一次之后的测量周期期间，基于接收的脉冲形状参数（Pps）的数量来计算相应的脉冲幅度测量。对于测量周期中的每个脉冲幅度测量，进一步研究测量是否满足相对于初始脉冲幅度测量的判定标准。如果发现满足判定标准，则产生报警触发信号（a）。

6. 发明申请

WO2013000777A9 FILTERING OF A TIME-DEPENDENT PRESSURE SIGNAL 审中-公开
标题翻译：时间压力信号的滤波
公开(公告)号：WO2013000777A9
公开(公告)日：2013-10-03
申请号：PCT/EP2012061765
申请日：2012-06-20
申请人： GAMBRO LUNDIA AB , OLDE BO , SOLEM KRISTIAN , HOLMER MATTIAS , STERNBY JAN
发明人： OLDE BO , SOLEM KRISTIAN , HOLMER MATTIAS , STERNBY JAN
IPC分类号： A61B5/021 , A61M1/36
CPC分类号： A61M1/3607 , A61B5/02108 , A61B5/6866 , A61B5/7217 , A61M1/34 , A61M1/3403 , A61M1/3621 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M2205/3331 , A61M2205/3368 , A61M2205/50 , B01D61/30 , B01D61/32 , G01L19/00
摘要： A device removes first pulses in a pressure signal of a pressure sensor which is arranged in a fluid containing system to detect the first pulses, which originate from a first pulse generator, and second pulses, which originate from a second pulse generator. The first pulse generator is known to operate in a sequence of pulse cycles, each pulse cycle resulting in at least one first pulse. The device repetitively obtains a current data sample, calculates corresponding a reference value and subtracts the reference value from the current data sample. The reference value is calculated as a function of other data sample(s) in the same pressure signal. These data sample(s) may be either cycle-synchronized so as to have a corresponding location in one or more other pulse cycles (e.g. in a preceding pulse cycle) as the current data sample, or be located in proximity to the current data sample. The fluid containing system may include an extracorporeal blood flow circuit, e.g. as part of a dialysis machine, and a cardiovascular system of a human patient.
摘要翻译：装置去除布置在流体容纳系统中的压力传感器的压力信号中的第一脉冲，以检测源自第一脉冲生成器的第一脉冲和源自第二脉冲生成器的第二脉冲。已知第一脉冲发生器以一系列脉冲周期操作，每个脉冲周期导致至少一个第一脉冲。该装置重复获得当前数据样本，计算相应的参考值并从当前数据样本中减去参考值。参考值是根据同一压力信号中的其他数据样本计算的。这些数据样本可以是循环同步的，从而在一个或多个其他脉冲循环（例如在先前的脉冲循环中）中具有与当前数据样本相对应的位置，或者位于当前数据样本附近。流体容纳系统可以包括体外血流回路，例如，作为透析机的一部分，以及人类患者的心血管系统。

7. 发明申请

WO2012175267A1 DETECTING BLOOD PATH DISRUPTION IN EXTRACORPOREAL BLOOD PROCESSING 审中-公开
标题翻译：检测血液中血液中的血液流失
公开(公告)号：WO2012175267A1
公开(公告)日：2012-12-27
申请号：PCT/EP2012/059521
申请日：2012-05-23
申请人： GAMBRO LUNDIA AB , HOLMER, Mattias , OLDE, Bo , SOLEM, Kristian
发明人： HOLMER, Mattias , OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36
CPC分类号： A61M1/367 , A61M1/3639 , A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M2205/13 , A61M2205/3331 , A61M2205/3351 , G01N19/00
摘要： A device (7) monitors a blood path from a blood vessel access (3) of a human subject through an extracorporeal blood processing apparatus and back to the blood vessel access (3). A pumping device (4) in the blood path is operable to pump blood through the blood path from the blood withdrawal device (2') to the blood return device (2"). The monitoring device (7) obtains pressure data from a pressure sensor (6a) arranged upstream of the pumping device (4) in the blood path, and processes the pressure data for detection of a disruption of the blood path downstream of the pumping device (4), e.g. caused by VND (Venous Needle Dislodgement). The disruption is detected by evaluating presence/absence of cross-talk pulses at the pressure sensor (6a), where the cross-talk pulses originate from one or more pulse generators in the extracorporeal blood processing apparatus (80) and have propagated on a propagation path (P2) in a direction downstream of the pumping device (4) through the blood return device (2"), the blood vessel access (3) and the blood withdrawal device (2') to the pressure sensor (6a).
摘要翻译：装置（7）通过体外血液处理装置监测来自人体受试者的血管通路（3）的血液通路并返回到血管通路（3）。血液通道中的抽吸装置（4）可操作用于将血液从血液提取装置（2'）泵送到血液返回装置（2“），血液通过血液通道从监测装置（7）获得压力数据传感器（6a），其布置在血液路径中的泵送装置（4）的上游，并且处理用于检测泵送装置（4）下游的血液路径中断的压力数据，例如由VND（静脉针头移动）通过评估压力传感器（6a）处的串扰脉冲的存在/不存在来检测中断，其中串扰脉冲源自体外血液处理设备（80）中的一个或多个脉冲发生器，并且在在泵送装置（4）的下游方向通过血液返回装置（2“），血管通路（3）和血液提取装置（2'）到压力传感器（6a）的传播路径（P2）。

8. 发明申请

WO2011080194A1 DEVICE AND METHOD FOR MONITORING A FLUID FLOW RATE IN A CARDIOVASCULAR SYSTEM 审中-公开
标题翻译：用于监测心脏血管系统中流体流量的装置和方法
公开(公告)号：WO2011080194A1
公开(公告)日：2011-07-07
申请号：PCT/EP2010/070565
申请日：2010-12-22
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian
发明人： OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36
CPC分类号： A61B5/026 , A61M1/3639 , A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3658 , A61M1/3659 , A61M1/3661 , A61M2230/04 , A61M2230/42
摘要： A device in an apparatus (200) for extracorporeal blood treatment is configured to monitor a fluid flow rate (Q) of a cardiovascular system of a subject. The apparatus comprises an extracorporeal blood circuit (20) and a connection (C) for connecting the extracorporeal blood circuit (20) to the cardiovascular system. The device comprises an input (28) for obtaining a time- dependent measurement signal (d(n)) from a pressure sensor (4a-4c) in the extracorporeal blood circuit (20). The pressure sensor (4a-4c) is arranged to detect a subject pulse originating from a subject pulse generator (30 in the cardiovascular system of the subject, wherein the system further comprises a signal processor (29) connected to the input (28). The signal processor is configured to process the measurement signal to obtain a pulse profile (e(n)) which is a temporal signal profile of the subject pulse, and to calculate a fluid flow rate (Q) based at least partly on the temporal signal profile.
摘要翻译：用于体外血液处理的装置（200）中的装置被配置为监测受试者的心血管系统的流体流速（Q）。该装置包括用于将体外血液回路（20）连接到心血管系统的体外血液回路（20）和连接（C）。该装置包括用于从体外血液回路（20）中的压力传感器（4a-4c）获得与时间相关的测量信号（d（n））的输入端（28）。压力传感器（4a-4c）被布置成检测源自对象脉冲发生器（在该对象的心血管系统中的30）的被摄体脉冲，其中系统还包括连接到输入端（28）的信号处理器（29）。信号处理器被配置为处理测量信号以获得作为对象脉冲的时间信号轮廓的脉冲轮廓（e（n）），并且至少部分地基于时间信号来计算流体流速（Q）个人资料。

9. 发明申请

WO2011080193A1 METHOD AND DEVICE FOR MONITORING THE INTEGRITY OF A CONNECTION SYSTEM 审中-公开
标题翻译：用于监测连接系统完整性的方法和装置
公开(公告)号：WO2011080193A1
公开(公告)日：2011-07-07
申请号：PCT/EP2010/070560
申请日：2010-12-22
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian
发明人： OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36
CPC分类号： G01N19/08 , A61B5/024 , A61B2562/0247 , A61B2562/226 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M5/16859 , A61M2205/13 , A61M2205/15 , A61M2205/3331 , A61M2230/04 , A61M2230/06
摘要： A device is configured to monitor the integrity of a connection system between first and second fluid containing systems comprising first and second pulse generators. A pressure sensor is arranged in the first fluid containing system to detect first pulses originating from the first pulse generator and second pulses originating from the second pulse generator. The device operates a monitoring method, by generating (42) a time- dependent pressure signal based on measurement data obtained from the pressure sensor such that the pressure signal contains a sequence of apparent pulses. The apparent pulses represent a superposition of the second pulses on the first pulses when the connection system (C) is intact. The device processes (44) the pressure signal to calculate a parameter value based on a pulse feature of at least one of the apparent pulses in the pressure signal. The parameter value represents a disturbance caused by the superposition of the second pulses on the first pulses, and may be given as a measure of statistical dispersion, pulse-to- pulse symmetry, or first pulse similarity. The device determines (45) the integrity of the connection system based at least partly on the parameter value. The first fluid containing system may be an extracorporeal blood circuit, and the second fluid containing system may be a human or animal subject.
摘要翻译：设备被配置为监视包括第一和第二脉冲发生器的第一和第二流体容纳系统之间的连接系统的完整性。压力传感器布置在第一流体容纳系统中以检测源自第一脉冲发生器的第一脉冲和源自第二脉冲发生器的第二脉冲。该设备通过基于从压力传感器获得的测量数据产生（42）依赖于时间的压力信号来操作监测方法，使得压力信号包含明显脉冲序列。当连接系统（C）完好时，表观脉冲表示第一脉冲上的第二脉冲的叠加。装置处理（44）压力信号，以基于压力信号中的表观脉冲中的至少一个的脉冲特征来计算参数值。参数值表示由第二脉冲叠加在第一脉冲上引起的干扰，并且可以作为统计色散，脉冲对脉冲对称性或第一脉冲相似度的量度给出。该设备至少部分地基于参数值确定（45）连接系统的完整性。第一流体容纳系统可以是体外血液回路，并且第二流体容纳系统可以是人或动物受试者。

10. 发明申请

WO2011080187A1 METHOD AND DEVICE FOR DETECTING A FAULT CONDITION 审中-公开
标题翻译：用于检测故障条件的方法和装置
公开(公告)号：WO2011080187A1
公开(公告)日：2011-07-07
申请号：PCT/EP2010/070549
申请日：2010-12-22
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian
发明人： OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36
CPC分类号： G01N11/02 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3661 , A61M5/16859 , A61M2205/13 , A61M2205/15 , A61M2205/3331 , A61M2230/04
摘要： A device is configured to detect a fault condition in a fluid connection system between a first (e.g. extracorporeal blood circuit ) and second (e.g. vascular system of a patient) fluid containing systems. The first and second fluid containing systems comprise a first and second pulse generator, respectively. A pressure sensor is arranged in the first fluid containing system to detect pulses originating from the first and second pulse generator. The device operates according to a detection method, by generating a time - dependent monitoring signal based on measurement data obtained from said at least one pressure sensor, such that the monitoring signal at least comprises one or more first pulses; processing (42) the monitoring signal to calculate a parameter value which is indicative of the shape of at least part of a first pulse in the monitoring signal, and evaluating (44) the parameter value for detection of the fault condition.
摘要翻译：设备被配置为检测流体连接系统中的第一（例如体外血液回路）和第二（例如患者的血管系统）流体容纳系统之间的故障状况。第一和第二流体容纳系统分别包括第一和第二脉冲发生器。压力传感器布置在第一流体容纳系统中以检测源自第一和第二脉冲发生器的脉冲。该装置根据检测方法通过基于从所述至少一个压力传感器获得的测量数据产生与时间相关的监视信号，使得监视信号至少包括一个或多个第一脉冲; 处理（42）监视信号以计算指示监视信号中的第一脉冲的至少一部分的形状的参数值，并评估（44）用于检测故障状况的参数值。

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