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1. 发明申请

WO2007059065A2 DIAGNOSTIC METHOD FOR PROTEINACEOUS BINDING PAIRS, CARDIOVASCULAR CONDITIONS AND PREECLAMPSIA 审中-公开
标题翻译：蛋白质结合对，心血管病和前列腺疾病的诊断方法
公开(公告)号：WO2007059065A2
公开(公告)日：2007-05-24
申请号：PCT/US2006/044059
申请日：2006-11-14
申请人： ABBOTT LABORATORIES , SOGIN, David, C. , LAIRD, Donald, M. , YU, Zhiguang , DOSS, Robert, C.
发明人： SOGIN, David, C. , LAIRD, Donald, M. , YU, Zhiguang , DOSS, Robert, C.
IPC分类号： G01N33/566 , G01N33/74 , G01N33/53 , G01N33/50
CPC分类号： G01N33/566 , G01N33/689 , G01N33/74 , G01N2800/368
摘要： Method of measuring the quantity of a first proteinaceous specific binding partner (sbp) in a biological sample comprising detecting the binding of the first proteinaceous sbp with a labeled second proteinaceous sbp, wherein neither the first or second sbp is an antibody or fragment thereof, which is preferably a method of determining the amount of sFlt-1, particularly free sFlt-1, and the amount of PlGF, particularly free PlGF, in a sample, which is preferably used in a method of predicting risk of preeclampsia comprising comparing free PlGF to free sFlt-1.
摘要翻译：测量生物样品中第一蛋白质特异性结合配偶体（sbp）的量的方法，包括检测第一蛋白质sbp与标记的第二蛋白质sbp的结合，其中第一或第二sbp 是抗体或其片段，其优选是测定样品中sFlt-1，特别是游离sFlt-1的量和PlGF，尤其是游离PlGF的量的方法，其优选用于预测先兆子痫的风险包括将游离PlGF与游离sFlt-1进行比较。

2. 发明申请

WO2009006244A1 WEIGHTED SCORING METHODS AND USE THEREOF IN SCREENING 审中-公开
标题翻译：加权评分方法及其在筛选中的应用
公开(公告)号：WO2009006244A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/068462
申请日：2008-06-27
申请人： ABBOTT LABORATORIES , FROST, Stephen, J.
发明人： FROST, Stephen, J.
IPC分类号： G06F19/00 , G01N33/68
CPC分类号： G01N33/6848 , G01N33/57423 , G16H50/20 , Y02A90/26
摘要： The present invention relates among other things to methods for scoring one or more biomarkers in or associated with a test sample and determining a subject's risk of developing a medical condition.
摘要翻译：本发明还涉及评估测试样品中或与测试样品相关联的一种或多种生物标志物并确定受试者发展医学状况的风险的方法。

3. 发明申请

WO2008054517A2 IMMUNOSUPPRESSANT BINDING ANTIBODIES AND METHODS OF OBTAINING AND USING SAME 审中-公开
标题翻译：免疫抑制剂结合抗体及其获得和使用方法
公开(公告)号：WO2008054517A2
公开(公告)日：2008-05-08
申请号：PCT/US2007/010076
申请日：2007-04-24
申请人： ABBOTT LABORATORIES , SIEGEL, Robert, W. , TYNER, Joan, D. , NAKAGAWA, Terry, Y.
发明人： SIEGEL, Robert, W. , TYNER, Joan, D. , NAKAGAWA, Terry, Y.
IPC分类号： A61K39/395
CPC分类号： C07K14/4702 , A61K38/00 , A61K2039/505 , C07K16/1292 , C07K16/18
摘要： The present invention relates among other things to antibodies that immunospecifically bind to at least one agent of interest (e.g., an immunosuppressive agent), methods for producing such antibodies, and immunoassays that employ said antibodies. Additionally, the present invention also relates to methods for selecting an antibody for use in a diagnostic immunoassay and methods for selecting an antigen for use in a diagnostic immunoassay. The present invention further relates to the improvement of antibody recognition of an active parent drug in the presence of one or more of its major metabolites.
摘要翻译：除其他之外，本发明涉及免疫特异性结合至少一种感兴趣试剂（例如免疫抑制剂）的抗体，生产此类抗体的方法和采用所述抗体的免疫分析。另外，本发明还涉及用于选择用于诊断免疫测定中的抗体的方法和用于选择用于诊断免疫测定中的抗原的方法。本发明进一步涉及活性母体药物在一种或多种主要代谢物存在下对抗体识别的改进。

4. 发明申请

WO2007056064A1 METHODS FOR THE DETERMINATION OF ANTIBODY IGG AVIDITY 审中-公开
标题翻译：用于确定抗体IgG抗体的方法
公开(公告)号：WO2007056064A1
公开(公告)日：2007-05-18
申请号：PCT/US2006/042818
申请日：2006-11-02
申请人： ABBOTT LABORATORIES , MAINE, Gregory, T. , HSU, Stephen, C. , SMITH, JR., Darwin, D. , PUCCI, Dominick, L. , HERZOGENRATH, Jörg , CURDT, Ingo , CHRIST, Heike, Maria
发明人： MAINE, Gregory, T. , HSU, Stephen, C. , SMITH, JR., Darwin, D. , PUCCI, Dominick, L. , HERZOGENRATH, Jörg , CURDT, Ingo , CHRIST, Heike, Maria
IPC分类号： G01N33/569
CPC分类号： G01N33/56905 , G01N33/56994 , G01N33/6854 , G01N2333/45
摘要： The present invention relates to methods of determining anti-infectious agent IgG avidity, for example, human anti-cytomegalovirus and human anti-toxoplasma IgG, using a competitive assay format.
摘要翻译：本发明涉及使用竞争性测定形式测定抗感染剂IgG亲合性的方法，例如人抗巨细胞病毒和人抗弓形体IgG。

5. 发明申请

WO2009085883A1 THE ACCURACY OF MYELOPEROXIDASE ASSAYS AND THE DETECTION OF MYELOPEROXIDASE AUTOANTIBODIES 审中-公开
标题翻译：甲氧氯丙酸酶测定的准确性和检测肌醇四氧化酶自身抗体
公开(公告)号：WO2009085883A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/087306
申请日：2008-12-18
申请人： ABBOTT LABORATORIES , ADAMCZYK, Maciej B. , DOSS, Robert C. , MATTINGLY, Phillip G.
发明人： ADAMCZYK, Maciej B. , DOSS, Robert C. , MATTINGLY, Phillip G.
IPC分类号： C12Q1/28 , G01N33/564 , G01N33/573
CPC分类号： C12Q1/28 , G01N33/564 , G01N33/573 , G01N2333/908
摘要： The present disclosure relates to methods and kits for determining autoantibodies to myeloperoxidase or a myeloperoxidase fragment and myeloperoxidase or a myeloperoxidase fragment in a test sample. The presence of said autoantibodies in the test sample negatively affects the accuracy of the myeloperoxidase assay. The reliability of the assay is evaluated by comparing myeloperoxidase activity and mass in the sample.
摘要翻译：本公开涉及用于在测试样品中测定髓过氧化物酶或髓过氧化物酶片段和髓过氧化物酶或髓过氧化物酶片段的自身抗体的方法和试剂盒。测试样品中所述自身抗体的存在对髓过氧化物酶测定的准确性产生不利影响。通过比较样品中的髓过氧化物酶活性和质量来评估测定的可靠性。

6. 发明申请

WO2009076331A1 INTERDEPENDENT ASSAYS FOR DETECTING TWO OR MORE ANALYTES OF INTEREST IN A TEST SAMPLE 审中-公开
标题翻译：用于检测两个或更多分析测试样本中的利益相关性测定
公开(公告)号：WO2009076331A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/086005
申请日：2008-12-09
申请人： ABBOTT LABORATORIES , MATTINGLY, Phillip G. , ADAMCZYK, Maciej B. , BRASHEAR, Roy Jeffrey
发明人： MATTINGLY, Phillip G. , ADAMCZYK, Maciej B. , BRASHEAR, Roy Jeffrey
IPC分类号： C12Q1/28 , C12Q1/26
CPC分类号： C12Q1/28 , C12Q1/26
摘要： The present disclosure relates to interdependent assays and kits for detecting and at least two analytes of interest in a single test sample, wherein the first analyte is reacted with a hydrogen peroxide generating analyte specific enzyme and wherein the second analyte is a haloperoxidase. The assay and kit involve the use of acridinium-9-carboxamide (s).
摘要翻译：本公开涉及用于在单个测试样品中检测和至少两种感兴趣的分析物的相互依赖性测定和试剂盒，其中所述第一分析物与产生分析物特异性酶的过氧化氢反应，并且其中所述第二分析物是卤过氧化物酶。测定和试剂盒涉及使用吖啶-9-甲酰胺。

7. 发明申请

WO2007076013A2 HOMOCYSTEINE IMMUNOASSAY 审中-公开
公开(公告)号：WO2007076013A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/049024
申请日：2006-12-21
申请人： ABBOTT LABORATORIES , YOSHIMURA, Toru
发明人： YOSHIMURA, Toru
IPC分类号： G01N33/50
CPC分类号： G01N33/6815
摘要： In homocysteine immunoassays, it is known that the measured values are dispersed due to the influence of inhibiting substances present in a biological sample on the immunoreaction. The present invention provides among other things a method whereby the influence of the immunoreaction inhibiting substances is easily and efficiently suppressed or eliminated, and also provides a kit used for such a method. The influence of the immunoreaction inhibiting substances is suppressed or eliminated when the homocysteine contained in biological samples is reacted with an antibody in the presence of extrinsic polyanion.
摘要翻译：在同型半胱氨酸免疫测定中，已知由于存在于生物样品中的抑制物质对免疫反应的影响而使测量值分散。本发明尤其提供了一种方法，其中免疫反应抑制物质的影响被容易和有效地抑制或消除，并且还提供了用于这种方法的试剂盒。当生物样品中含有的高半胱氨酸在外源性聚阴离子存在下与抗体反应时，抑制或消除免疫反应抑制物质的影响。

8. 发明申请

WO2007056507A1 HUMAN BNP IMMUNOSPECIFIC ANTIBODIES 审中-公开
标题翻译：人体免疫球蛋白抗体
公开(公告)号：WO2007056507A1
公开(公告)日：2007-05-18
申请号：PCT/US2006/043608
申请日：2006-11-09
申请人： ABBOTT LABORATORIES , SHIH, Jessie, W. , PINKUS, Mary, S. , TYNER, Joan, D. , BROPHY, Susan, E. , TU, Bailin
发明人： SHIH, Jessie, W. , PINKUS, Mary, S. , TYNER, Joan, D. , BROPHY, Susan, E. , TU, Bailin
IPC分类号： C07K16/26 , C12N5/10 , G01N33/53
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/24 , C07K2317/622 , C07K2317/92 , G01N33/74 , G01N2333/58 , G01N2800/325 , Y10S435/975
摘要： The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.
摘要翻译：本发明涉及以高结合亲和力免疫特异性结合人脑利钠肽或人脑利钠肽片段的抗体，用于制备和选择所述抗体的方法，人脑利钠肽的免疫测定法或人脑利钠肽片段所述抗体和含有所述抗体的治疗组合物。

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