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1. 发明申请

WO2013142326A1 5-CARBONYLAMINO-/(SULFONAMIDO-) SUBSTITUTED BENZ IMIDAZOLES AND USE THEREOF TREATMENT OF TUBERCULOSIS 审中-公开
标题翻译： 5-亚苄氨基 - /（磺酰氨基）取代的苯并咪唑及其用于治疗结肠癌的用途
公开(公告)号：WO2013142326A1
公开(公告)日：2013-09-26
申请号：PCT/US2013/032083
申请日：2013-03-15
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： OJIMA, Iwao
IPC分类号： C07D235/08 , C07D235/18 , C07D405/04 , A61K31/4184 , A61P31/06
CPC分类号： C07D235/18 , C07D235/08 , C07D405/04
摘要： The present invention discloses novel 5-/6- or 5-/7- substituded benzimidazoles and pharmaceutically acceptable salts thereof. Another aspect of the invention relates to their use in treating a patient infected by Mycobacterium tuberculosis or Francisella tularensis.
摘要翻译：本发明公开了新颖的5- / 6-或5- / 7-取代苯并咪唑及其药学上可接受的盐。本发明的另一方面涉及其用于治疗感染结核分枝杆菌或土拉弗朗西斯氏菌的患者。

2. 发明申请

WO2013116823A1 BENZIMIDAZOLES AND USES THEREOF 审中-公开
标题翻译：苯并咪唑及其用途
公开(公告)号：WO2013116823A1
公开(公告)日：2013-08-08
申请号：PCT/US2013/024601
申请日：2013-02-04
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： OJIMA, Iwao
IPC分类号： C07D235/08 , A61K31/4184 , A61P31/06
CPC分类号： C07D235/08
摘要： The present invention relates to novel 2,5,6-benzimidazole derivatives of formula I and pharmaceutically acceptable salts thereof. Another aspect of the invention relates to methods of treating a patient infected by Mycobacterium tuberculosis or Mycobacterium avium complex by administering to the patient a 2,5,6- benzimidazole derivative or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及式I的新的2,5,6-苯并咪唑衍生物及其药学上可接受的盐。本发明的另一方面涉及通过向患者施用2,5,6-苯并咪唑衍生物或其药学上可接受的盐来治疗由结核分枝杆菌或鸟分枝杆菌复合物感染的患者的方法。

3. 发明申请

WO2012047645A2 COMBINATION TREATMENT FOR ROSACEA 审中-公开
标题翻译： ROSACEA的组合治疗
公开(公告)号：WO2012047645A2
公开(公告)日：2012-04-12
申请号：PCT/US2011/053440
申请日：2011-09-27
申请人： GALDERMA LABORATORIES INC. , GRAEBER, Michael , LEONI, Matthew, James , WAGNER, Nathalie
发明人： GRAEBER, Michael , LEONI, Matthew, James , WAGNER, Nathalie
IPC分类号： A61K31/498 , A61K31/4168 , A61K31/4164 , A61P17/00 , A61P29/00
CPC分类号： A61K31/498 , A61K9/0014 , A61K9/06 , A61K9/08 , A61K31/4174 , A61K47/06 , A61K47/10 , A61K47/32 , A61K47/38 , A61K2300/00
摘要： The invention relates to a method of treating erythema and/or telangiectasia associated with rosacea in a patient in need thereof by topically administering an effective amount of a combination of brimonidine or a pharmaceutically acceptable salt thereof and oxymetazoline or a pharmaceutically acceptable salt thereof to the site of erythema and/or telangiectasia on the skin of the patient. The invention further relates to topical compositions including the combination of compounds and a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及一种通过局部给药有效量的溴莫尼定或其药学上可接受的盐和羟甲唑啉的组合来治疗有需要的患者中与红斑痤疮相关的红斑和/或毛细血管扩张的方法，或者其药学上可接受的盐与患者皮肤上的红斑和/或毛细血管扩张部位相接触。本发明还涉及包含化合物和药学上可接受的载体的组合的局部用组合物。

4. 发明申请

WO2011053487A1 METHODS OF TREATING OR PREVENTING ACUTE ERYTHEMA 审中-公开
标题翻译：治疗或预防急性艾滋病的方法
公开(公告)号：WO2011053487A1
公开(公告)日：2011-05-05
申请号：PCT/US2010/053198
申请日：2010-10-19
申请人： GALDERMA PHARMA S.A. , ANDRES, Philippe , LOESCHE, Christian , GRAEBER, Michael
发明人： ANDRES, Philippe , LOESCHE, Christian , GRAEBER, Michael
IPC分类号： A01N43/50 , A61P17/00
CPC分类号： A61K31/498 , A61K31/4164
摘要： A method of treating or preventing acute erythema in a human in need thereof by topical administration of an effective amount of an alpha adrenergic receptor agonist or pharmaceutically acceptable salt thereof is claimed. The preferred alpha adrenergic receptor agonist is brimonidine. A method of preventing secondary inflammation caused by acute erythema by topical administration of an effective amount of an alpha adrenergic receptor agonist or a pharmaceutically acceptable salt thereof is also claimed.
摘要翻译：一种通过局部施用有效量的α肾上腺素能受体激动剂或其药学上可接受的盐来治疗或预防有此需要的人的急性红斑的方法。优选的α肾上腺素能受体激动剂是溴莫尼定。还要求保护通过局部施用有效量的α肾上腺素能受体激动剂或其药学上可接受的盐来预防由急性红斑引起的继发性炎症的方法。

5. 发明申请

WO2009082452A1 PRE-SURGICAL TREATMENT 审中-公开
标题翻译：预先手术治疗
公开(公告)号：WO2009082452A1
公开(公告)日：2009-07-02
申请号：PCT/US2008/013797
申请日：2008-12-17
申请人： DEJOVIN, Jack, A.
发明人： DEJOVIN, Jack, A.
IPC分类号： A01N43/58 , A61K31/50 , A01N43/60 , A61K31/495
CPC分类号： A61K31/495 , A61K31/50
摘要： The invention relates to a method of reducing post-surgical bleeding and/or bruising in a patient scheduled to be subjected to a surgical procedure and a patient that was subjected to a surgical procedure. The method involves topically applying to the area and the surrounding area of skin of the patient where the surgical procedure will be or was performed, a pharmaceutical composition comprising an effective amount of brimonidine or a pharmaceutically acceptable salt thereof, prior to performing the surgical procedure and/or following the surgical procedure.
摘要翻译：本发明涉及一种减少计划经受外科手术的患者和经受外科手术的患者的手术后出血和/或瘀伤的方法。该方法包括局部施用于执行外科手术的患者皮肤区域和周边区域，在执行外科手术之前，包含有效量的溴莫尼定或其药学上可接受的盐的药物组合物，以及 /或遵循外科手术。

6. 发明申请

WO2008133664A3 CARBORANYLPORPHYRINS AND USES THEREOF 审中-公开
公开(公告)号：WO2008133664A3
公开(公告)日：2008-11-06
申请号：PCT/US2007/024767
申请日：2007-12-03
申请人： BROOKHAVEN SCIENCE ASSOCIATES, LLC , MIURA, Michiko , RENNER, Mark, W.
发明人： MIURA, Michiko , RENNER, Mark, W.
IPC分类号： A01N55/02 , A61K31/555
摘要： The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity carborane-containing porphyrin compounds with halide, amine, or nitro groups and methods for their use particularly in boron neutron capture therapy (BNCT), X-ray radiation therapy (XRT), and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these carborane-containing porphyrin compounds in methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.

7. 发明申请

WO2008069974A1 RADIATION ENHANCEMENT AGENTS FOR X-RAY RADIATION THERAPY AND BORON NEUTRON-CAPTURE THERAPY 审中-公开
标题翻译：用于X射线辐射治疗的放射增强剂和硼中毒治疗
公开(公告)号：WO2008069974A1
公开(公告)日：2008-06-12
申请号：PCT/US2007/024657
申请日：2007-11-30
申请人： BROOKHAVEN SCIENCE ASSOCIATES, LLC , MIURA, Michiko , WU, Haitao
发明人： MIURA, Michiko , WU, Haitao
IPC分类号： A61K49/04
CPC分类号： C07D487/22
摘要： Low toxicity halogenated carborane-containing tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT), X-ray radiation therapy (XRT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention also includes methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET using these halogenated carborane-containing tetraphenylporphyrin compounds.
摘要翻译：低毒卤代碳硼烷的四苯基卟啉化合物及其用于特别是用于治疗脑，头和颈肿瘤的硼中子俘获治疗（BNCT），X射线放射治疗（XRT）和光动力疗法（PDT）和周围组织。本发明还包括使用这些卤代碳硼烷的四苯基卟啉化合物的肿瘤成像和/或诊断方法，例如MRI，SPECT或PET。

8. 发明申请

WO2008033113A2 ELECTROCATALYSTS HAVING GOLD MONOLAYERS ON PLATINUM NANOPARTICLE CORES, AND USES THEREOF 审中-公开
标题翻译：具有铂金纳米棒的金属单体的电解质及其用途
公开(公告)号：WO2008033113A2
公开(公告)日：2008-03-20
申请号：PCT/US2006/029960
申请日：2006-08-01
申请人： BROOKHAVEN SCIENCE ASSOCIATES , ADZIC, Radoslav, R. , ZHANG, Junliang
发明人： ADZIC, Radoslav, R. , ZHANG, Junliang
IPC分类号： H01M4/90 , H01M4/96 , B01J23/52
CPC分类号： H01M4/90 , B82Y30/00 , H01M4/9083 , H01M4/921 , H01M4/926
摘要： The invention relates to gold-coated particles useful as fuel cell electrocatalysts. The particles are composed of an electrocatalytically active core at least partially encapsulated by an outer shell of gold or gold alloy. The invention more particularly relates to such particles having a noble metal-containing core, and more particularly, a platinum or platinum alloy core. In other embodiments, the invention relates to fuel cells containing these electrocatalysts and methods for generating electrical energy therefrom.
摘要翻译：本发明涉及可用作燃料电池电催化剂的金涂层颗粒。颗粒由至少部分地由金或金合金的外壳封装的电催化活性芯组成。本发明更具体地涉及具有含贵金属的芯，更具体地说是铂或铂合金芯的这种颗粒。在其它实施方案中，本发明涉及含有这些电催化剂的燃料电池及其从其产生电能的方法。

9. 发明申请

WO2006132959A2 INHIBITION OF THROMBIN GENERATION 审中-公开
标题翻译：抑制血栓生成
公开(公告)号：WO2006132959A2
公开(公告)日：2006-12-14
申请号：PCT/US2006/021436
申请日：2006-06-02
申请人： COLLAGENEX PHARMACEUTICALS, INC. , LEVY, Jerrold, H. , THEOBALD, Klaus
发明人： LEVY, Jerrold, H. , THEOBALD, Klaus
IPC分类号： A61K31/65
CPC分类号： A61K31/65
摘要： The present invention is a method for inhibiting undesirable thrombin generation in a mammal in need thereof. The method comprises administering to the mammal an effective amount of a non-antibacterial tetracycline formulation.
摘要翻译：本发明是在有需要的哺乳动物中抑制不希望的凝血酶产生的方法。该方法包括向哺乳动物施用有效量的非抗菌四环素制剂。

10. 发明申请

WO2006107622A1 METHOD OF SENSING TILT, TILT SENSOR, AND METHOD OF MANUFACTURING SAME 审中-公开
标题翻译：感测倾斜方法，倾斜传感器及其制造方法
公开(公告)号：WO2006107622A1
公开(公告)日：2006-10-12
申请号：PCT/US2006/010889
申请日：2006-03-23
申请人： SPECTRON GLASS AND ELECTRONICS, INC. , GOLDSOBEL, Norman , LEMARIE, Pascal
发明人： GOLDSOBEL, Norman , LEMARIE, Pascal
IPC分类号： G01C9/06
CPC分类号： G01C9/06 , G01C9/20 , G01C2009/068
摘要： A method of sensing tilt includes applying an electrical signal, such as voltage, current, a constant signal, or a time-varying signal to at least one electrode of a first set of electrodes and measuring an electrical parameter using at least one electrode of a second set of electrodes. The electrodes are disposed in a conductive medium within an envelope. The electrical parameter represents tilt relative to a first axis. The electrical roles of the first and second sets of electrodes are reversed to determine tilt relative to a second axis. No more than four electrodes are used to determine tilt relative to two axes. A tilt sensor includes an envelope, conductive medium in the envelope, and four electrodes. A method of making a tilt sensor includes providing at least four electrodes, forming an envelope to receive at least a portion of the electrodes, placing a conductive medium into the envelope, and sealing the conductive medium in the envelope.
摘要翻译：感测倾斜的方法包括将诸如电压，电流，恒定信号或时变信号的电信号施加到第一组电极的至少一个电极并使用至少一个电极的电极测量电参数第二组电极。电极设置在封套内的导电介质中。电参数表示相对于第一轴的倾斜度。第一组和第二组电极的电气角色相反，以确定相对于第二轴的倾斜度。不超过四个电极用于确定相对于两个轴的倾斜度。倾斜传感器包括外壳，外壳中的导电介质和四个电极。一种制造倾斜传感器的方法包括：提供至少四个电极，形成一个外壳，以容纳至少一部分电极，将一个导电介质放入外壳中，并将导电介质密封在外壳中。

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