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1. 发明申请

WO2007021317A1 DETECTING MOLECULAR COMPLEXES 审中-公开
标题翻译：检测分子复合物
公开(公告)号：WO2007021317A1
公开(公告)日：2007-02-22
申请号：PCT/US2006/010756
申请日：2006-03-24
申请人： MONOGRAM BIOSCIENCES, INC. , MACEVICZ, Stephen
发明人： MACEVICZ, Stephen
IPC分类号： A61K39/395
CPC分类号： G01N33/542 , C12Q1/25 , C12Q1/26 , C12Q1/485 , G01N33/53 , G01N33/532 , G01N33/535 , G01N33/566 , G01N33/58 , G01N33/581 , G01N33/68 , G01N33/6845 , G01N2458/10
摘要： The invention provides methods and compositions for detecting the presence of, or for measuring amounts of, molecular complexes, particularly complexes comprising two or more proteins, such as receptor complexes of cell surface membranes. In one aspect of the invention, reagent pairs are provided that comprise a cleaving probe that specifically binds to at least one component of a molecular complex and one or more signaling reagents that specifically bind to one or more components of the molecular complex, at least one of which is different from the component to which the cleaving probe is attached. Each signaling reagent comprises a binding compound specific for a component of the molecular complex and a signaling polynucleotide attached thereto by a cleavable linkage. When the reagent pairs are bound to the same molecular complex, the cleaving probe may be induced to generate a reactive species that is capable of cleaving cleavable linkages within an effective proximity, thereby releasing a signaling polynucleotide by which the molecular complex is detected.
摘要翻译：本发明提供用于检测分子复合物，特别是包含两种或更多种蛋白质如细胞表面膜的受体复合物的复合物的存在或用于测量量的方法和组合物。在本发明的一个方面，提供了试剂对，其包含特异性结合分子复合物的至少一种组分的切割探针和特异性结合分子复合物的一种或多种组分的一种或多种信号试剂，至少一种其与分离探针连接的部件不同。每种信号传导试剂包含对分子复合物的组分特异的结合化合物和通过可切割连接键与其连接的信号多核苷酸。当试剂对被结合到相同的分子复合物时，可以诱导裂解探针产生能够在有效接近度内切割可切割键的反应性物质，从而释放检测分子复合物的信号多核苷酸。

2. 发明申请

WO2004048399A3 SKIN OR HAIR BINDING PEPTIDES 审中-公开
公开(公告)号：WO2004048399A3
公开(公告)日：2004-06-10
申请号：PCT/US2003/036234
申请日：2003-11-12
申请人： GENENCOR INTERNATIONAL, INC. , JANSSEN, Giselle, G. , MURRAY, Christopher, J. , WINETZKY, Deborah, S.
发明人： JANSSEN, Giselle, G. , MURRAY, Christopher, J. , WINETZKY, Deborah, S.
IPC分类号： A61K7/06
摘要： The invention is directed to peptides. Specifically, the invention is directed to peptides which bind skin and do not bind hair. Alternatively, the invention is drawn to peptides which bind hair and do not bind skin.

3. 发明申请

WO2004033482A3 PHENOLIC BINDING PEPTIDES 审中-公开
公开(公告)号：WO2004033482A3
公开(公告)日：2004-04-22
申请号：PCT/US2003/031776
申请日：2003-10-06
申请人： GENENCOR INTERNATIONAL, INC. , MURRAY, Christopher, J. , TIJERINA, Pilar , VAN GASTEL, Franciscus, J.C.
发明人： MURRAY, Christopher, J. , TIJERINA, Pilar , VAN GASTEL, Franciscus, J.C.
IPC分类号： A61K38/00
摘要： The present application relates to peptides which bind to tannin, polyphenolic or anthocyanin compounds, and particularly to tea and wine stains on a fabric or other surface. The invention also concerns binding peptide conjugates which includes a binding peptide coupled to an agent and the use of the binding peptide conjugate for delivering an agent to a desired target.

4. 发明申请

WO2018227202A1 DETERMINATION OF CANCER TYPE IN A SUBJECT BY PROBABILISTIC MODELING OF CIRCULATING NUCLEIC ACID FRAGMENT ENDPOINTS 审中-公开
公开(公告)号：WO2018227202A1
公开(公告)日：2018-12-13
申请号：PCT/US2018/036950
申请日：2018-06-11
申请人： BELLWETHER BIO, INC.
发明人： SNYDER, Matthew, William , DEAN, Jason, Thaddeus
IPC分类号： C12Q1/68 , G06F19/18 , G06F19/22 , G06F19/24 , G06F7/00
摘要： Method for diagnosis of one or more physiological conditions with probabilistic methods using cfDNAs are disclosed.

5. 发明申请

WO2003091713A2 SYSTEM AND METHOD OF MEASURING MOLECULAR INTERACTIONS 审中-公开
标题翻译：测量分子相互作用的系统和方法
公开(公告)号：WO2003091713A2
公开(公告)日：2003-11-06
申请号：PCT/US2003/012865
申请日：2003-04-25
申请人： BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , GENENCOR INTERNATIONAL, INC. , GAST, Alice, P. , KELLIS, JR., James, T. , KIM, Joon-Hyung , POULOSE, Ayrookaran, J. , ROBERTSON, Channing , ROY, Shaunak
发明人： GAST, Alice, P. , KELLIS, JR., James, T. , KIM, Joon-Hyung , POULOSE, Ayrookaran, J. , ROBERTSON, Channing , ROY, Shaunak
IPC分类号： G01N21/64
CPC分类号： G01N21/553 , B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N21/648 , G01N2021/212
摘要： The present disclosure relates to a device for measuring surface plasmon resonance and fluorescence of a sample, a system for determining the rate of catalytic activity of an enzyme, a method of determining the rate of catalytic activity of an enzyme, and a method of measuring the adsorption and reactivity of a substance, all of which use SPR and SPEF methods simultaneously. This invention also relates generally to systems and methods for measuring diffusion and reactivity of macromolecules on a surface.
摘要翻译：本公开涉及一种用于测量样品的表面等离子体共振和荧光的装置，包括光源（205），第一检测器（260），第二检测器（280）和用于计算酶的催化活性的模块。

6. 发明申请

WO2003091713A3 SYSTEM AND METHOD OF MEASURING MOLECULAR INTERACTIONS 审中-公开
公开(公告)号：WO2003091713A3
公开(公告)日：2003-11-06
申请号：PCT/US2003/012865
申请日：2003-04-25
申请人： BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , GENENCOR INTERNATIONAL, INC. , GAST, Alice, P. , KELLIS, JR., James, T. , KIM, Joon-Hyung , POULOSE, Ayrookaran, J. , ROBERTSON, Channing , ROY, Shaunak
发明人： GAST, Alice, P. , KELLIS, JR., James, T. , KIM, Joon-Hyung , POULOSE, Ayrookaran, J. , ROBERTSON, Channing , ROY, Shaunak
IPC分类号： G01N21/64
摘要： The present disclosure relates to a device for measuring surface plasmon resonance and fluorescence of a sample comprising a light source (205), a first detector (260), a second detector (280) and a module for calculating catalytic activity of an enzyme.

7. 发明申请

WO2003023067A1 BINDING PHENOL OXIDIZING ENZYME-PEPTIDE COMPLEXES 审中-公开
标题翻译：结合苯酚氧化酶 - 复合物
公开(公告)号：WO2003023067A1
公开(公告)日：2003-03-20
申请号：PCT/US2002/027993
申请日：2002-09-03
申请人： GENENCOR INTERNATIONAL, INC. , AEHLE, Wolfgang , BALDWIN, Toby, L. , JANSSEN, Giselle, G. , MURRAY, Christopher, J. , VAN GASTEL, Franciscus, J, C. , WANG, Huaming , WINETZKY, Deborah, S.
发明人： AEHLE, Wolfgang , BALDWIN, Toby, L. , JANSSEN, Giselle, G. , MURRAY, Christopher, J. , VAN GASTEL, Franciscus, J, C. , WANG, Huaming , WINETZKY, Deborah, S.
IPC分类号： C12S9/00
CPC分类号： C11D3/38654 , C07K2319/00 , C12N9/0061
摘要： The present application relates to peptides which bind to a target stain, phenol oxidizing enzyme-binding peptide complexes wherein the binding peptide is attached to the C-terminus of the phenol oxidizing enzyme or is inserted or substituted into the phenol oxidizing enzyme. In a preferred embodiment the phenol oxidizing enzyme is a laccase specifically Stachybotrys oxidase B and variants thereof. The invention provides expression vectors comprising the phenol oxidizing enzyme-binding peptide complex as well as host cells comprising the vectors.
摘要翻译：本申请涉及与靶染色剂结合的肽，酚氧化酶结合肽复合物，其中结合肽连接到酚氧化酶的C末端或插入或取代到酚氧化酶中。在优选的实施方案中，酚氧化酶是漆酶特异性Stachybotrys氧化酶B及其变体。本发明提供了包含酚氧化酶结合肽复合物的表达载体以及包含载体的宿主细胞。

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