专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010062150A2 SURFACE PLASMON RESONANCE SENSOR USING BEAM PROFILE ELLIPSOMETRY 审中-公开
标题翻译：表面等离子体共振传感器的光束轮廓椭圆测量法
公开(公告)号：WO2010062150A2
公开(公告)日：2010-06-03
申请号：PCT/KR2009/007084
申请日：2009-11-30
申请人： KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE , CHO, Hyun Mo , CHO, Yong Jai , CHEGAL, Won
发明人： CHO, Hyun Mo , CHO, Yong Jai , CHEGAL, Won
IPC分类号： G01N21/55 , G01N21/25 , G01N21/00
CPC分类号： G01N21/553 , G01N2021/212
摘要： Provided is a multi-channel surface plasmon resonance sensor using beam profile ellipsometry; and, more particularly, to a high sensitive measuring technology, which is coupled with a vertical illumination type focused-beam ellipsometer using a multi-incident angle measurement method, and a surface plasmon resonance (SPR) sensing part deposited with a metal thin film. The multi-channel surface plasmon resonance sensor includes a vertical illumination type focused-beam ellipsometer, in which light is polarized; a surface plasmon resonance (SPR) sensing part which is provided at the objective lens part of the focused-beam ellipsometer so as to generate SPR according to an angle change of the polarized light; and a flow unit which supplies a buffer solution containing a bio material binding to or dissociation from the metal thin film generating surface plasmon, wherein the SPR and the ellipsometric phase change by change in an angle and a wavelength are simultaneously detected.
摘要翻译：提供了一种使用光束轮廓椭圆光度法的多通道表面等离子体共振传感器; 更具体地涉及与使用多入射角度测量方法的垂直照明型聚焦光束椭偏仪和沉积有金属薄膜的表面等离子体共振（SPR）感测部件耦合的高灵敏度测量技术。多通道表面等离子体共振传感器包括垂直照明型聚焦光椭圆偏振仪，其中光被偏振; 表面等离子体共振（SPR）感测部分，其设置在聚焦光椭圆偏振仪的物镜部分处，以根据偏振光的角度变化产生SPR; 以及流动单元，所述流动单元供应包含与产生金属薄膜的表面等离子体激元结合或解离的生物材料的缓冲溶液，其中通过角度和波长的变化来同时检测SPR和椭偏相位。

2. 发明申请

WO2010062149A2 MULTI-CHANNEL SURFACE PLASMON RESONANCE SENSOR USING BEAM PROFILE ELLIPSOMETRY 审中-公开
标题翻译：多通道表面等离子体共振传感器使用光束廓线ELLIPSOMETRY
公开(公告)号：WO2010062149A2
公开(公告)日：2010-06-03
申请号：PCT/KR2009/007083
申请日：2009-11-30
申请人： KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE , CHO, Hyun Mo , CHO, Yong Jai , CHEGAL, Won
发明人： CHO, Hyun Mo , CHO, Yong Jai , CHEGAL, Won
IPC分类号： G01N21/21 , G01N21/55
CPC分类号： G01N21/553 , G01N2021/212
摘要： Provided is a multi-channel surface plasmon resonance sensor using beam profile ellipsometry; and, more particularly, to a high sensitive measuring technology, which is coupled with a vertical illumination type focused-beam ellipsometer using a multi-incident angle measurement method, and a surface plasmon resonance (SPR) sensing part deposited with a metal thin film. The multi-channel surface plasmon resonance sensor includes a vertical illumination type focused-beam ellipsometer in which light is polarized; a surface plasmon resonance (SPR) sensing part which is provided at the objective lens part of the focused-beam ellipsometer; and a multi-channel flow unit which supplies a buffer solution containing a bio material binding to or dissociation from a metal thin film generating surface plasmon.
摘要翻译：提供了使用光束轮廓椭偏仪的多通道表面等离子体共振传感器; 更具体地说，涉及一种高灵敏度测量技术，其与使用多入射角测量方法的垂直照明型聚焦光束椭偏仪和沉积有金属薄膜的表面等离子体共振（SPR）感测部件相结合。多通道表面等离子体共振传感器包括其中光被极化的垂直照明型聚焦光束椭偏仪; 设置在聚焦光束椭偏仪的物镜部分的表面等离子体共振（SPR）感测部分; 以及多通道流动单元，其提供包含与金属薄膜产生表面等离子体激元结合或解离的生物材料的缓冲溶液。

3. 发明申请

WO2005116598A2 IMAGING METHOD AND APPARATUS 审中-公开
标题翻译：成像方法和装置
公开(公告)号：WO2005116598A2
公开(公告)日：2005-12-08
申请号：PCT/US2005/016314
申请日：2005-05-10
申请人： MAVEN TECHNOLOGIES LLC , RASSMAN, William , RALIN, David , LIEBERMAN, Robert A. , KEMPEN, Lothar U. , SHAPIRO, Herbert
发明人： RASSMAN, William , RALIN, David , LIEBERMAN, Robert A. , KEMPEN, Lothar U. , SHAPIRO, Herbert
IPC分类号： G01J4/00
CPC分类号： G01N21/211 , G01N21/21 , G01N21/253 , G01N21/552 , G01N2021/212 , Y10S436/805
摘要： An imaging method and apparatus are provided, including a light source emitting a polarized light beam, and an optical assembly including a control layer and/or a light reflection surface. The control layer advantageously allows for control over the properties of a generated evanescent wave to optimize an image of a specimen array within the evanescent wave. The light reflection surface includes coupling means used to couple a receptor/capture agent advantageously allowing for flexible control over receptor specific regions.
摘要翻译：提供了一种成像方法和装置，包括发射偏振光束的光源和包括控制层和/或光反射表面的光学组件。控制层有利地允许控制所产生的ev逝波的性质以优化ev逝波内的样本阵列的图像。光反射表面包括用于耦合受体/捕获剂的偶联装置，其有利地允许对受体特异性区域的灵活控制。

4. 发明申请

WO2009143275A1 APPARATUS AND METHOD FOR PERFORMING LIGAND BINDING ASSAYS ON MICROARRAYS IN MULTIWELL PLATES 审中-公开
标题翻译：用于在多层板中对微阵列进行配体结合测定的装置和方法
公开(公告)号：WO2009143275A1
公开(公告)日：2009-11-26
申请号：PCT/US2009/044717
申请日：2009-05-20
申请人： MAVEN TECHNOLOGIES, LLC , DULTZ, Shane, C. , RALIN, David
发明人： DULTZ, Shane, C. , RALIN, David
IPC分类号： G01N21/21 , G01B5/04
CPC分类号： G01N21/211 , G01N21/253 , G01N33/54373 , G01N2021/212 , G02B5/045 , Y10S436/805 , Y10S436/809
摘要： Ellipsometry systems for imaging binding events between analytes in a sample and an array of ligands in an evanescent field generated by a beam of light reflected from the plane of the ligands is adapted to a multiwell plate structure in common use. In one example, a film of prism arrays is affixed to the underside of the plate with each prism array located in registry with a well and ligand arrays being immobilized on the (planar) bottom surface of the wells. The prism array may be formed in a film and juxtaposed with the bottom surface of the plate or a prism array can be made integral with the plate bottom of a multiwell plate.
摘要翻译：用于在样品中的分析物和由从配体的平面反射的光束产生的消逝场中的配体阵列之间的成像结合事件的椭圆偏光测量系统适用于通常使用的多孔板结构。在一个示例中，棱镜阵列的膜被固定到板的下侧，每个棱镜阵列与阱对准，并且将配体阵列固定在孔的（平面）底表面上。棱镜阵列可以形成为薄膜并且与板的底表面并列，或者棱镜阵列可以与多孔板的板底一体地形成。

5. 发明申请

WO2007121406A3 POLARIZATION BASED INTERFEROMETRIC DETECTOR 审中-公开
标题翻译：基于偏振的干涉检测器
公开(公告)号：WO2007121406A3
公开(公告)日：2008-12-24
申请号：PCT/US2007066723
申请日：2007-04-16
申请人： BIOPTIX LLC , HALL JOHN , PETROPAVLOVSKIKH VIATCHESLAV , NILSEN OYVIND
发明人： HALL JOHN , PETROPAVLOVSKIKH VIATCHESLAV , NILSEN OYVIND
IPC分类号： G01J4/00
CPC分类号： G01N21/45 , G01N21/21 , G01N21/253 , G01N21/41 , G01N21/552 , G01N21/553 , G01N2021/212
摘要： A sensor and method for determining the optical properties of a sample material is disclosed. The sensor comprises a light source that generates a linearly polarized light beam having a predetermined polarization orientation with respect to the plane of incidence. The linearly polarized light beam is reflected off the sample and is split into second and third light beams where the second and third light beam consist of the combined projections of mutually orthogonal components of the first light beam. A signal processor measures the intensity difference between the second and third light beams to calculate the phase difference induced by the sample material.
摘要翻译：公开了一种用于确定样品材料的光学性质的传感器和方法。该传感器包括产生相对于入射平面具有预定极化取向的线偏振光束的光源。线偏振光束被从样品反射并被分裂成第二和第三光束，其中第二和第三光束由第一光束的相互正交分量的组合投影组成。信号处理器测量第二和第三光束之间的强度差，以计算由样品材料引起的相位差。

6. 发明申请

WO2005029077A1 METHOD AND SYSTEM FOR MOLECULAR INTERACTION ANALYSIS 审中-公开
标题翻译：用于分子相互作用分析的方法和系统
公开(公告)号：WO2005029077A1
公开(公告)日：2005-03-31
申请号：PCT/SE2004/001356
申请日：2004-09-22
申请人： BIACORE AB , ANDERSSON, Karl , BORG, Peter , ÖNELL, Annica
发明人： ANDERSSON, Karl , BORG, Peter , ÖNELL, Annica
IPC分类号： G01N33/543
CPC分类号： G01N21/272 , G01N21/05 , G01N21/21 , G01N21/45 , G01N21/553 , G01N21/648 , G01N21/658 , G01N21/7703 , G01N2021/0346 , G01N2021/212 , G01N2021/458 , G06F19/702
摘要： The invention relates to a computer-implemented method for determining at least one kinetic parameter for the interaction of an analyte in solution with an immobilized ligand from a data set comprising a plurality of different binding curves, each of which represents the progress of the interaction of the analyte with the ligand with tune, comprising the steps of: a) performing at least one fit of the whole data set or subsets thereof to a predetermined kinetic model for the interaction; b) based on the result of the fit or fats performed in step a), identifying and excluding binding curves of unacceptable quality; c) performing a final fit to the remaining data set; and d) obtaining therefrom the kinetic parameter or parameters. The invention also relates to an analytical system for carrying out the method, as well as a computer program, computer program product and computer system for performing the method.
摘要翻译：本发明涉及一种计算机实现的方法，用于确定溶液中的分析物与固定的配体与包含多个不同结合曲线的数据集的相互作用的至少一个动力学参数，每个动力学参数表示相互作用的进展具有调谐配体的分析物包括以下步骤：a）将整个数据集或其子集的至少一个拟合执行到用于相互作用的预定动力学模型; b）基于步骤a）中进行的适合或脂肪的结果，鉴定和排除不可接受的质量的结合曲线; c）对剩余的数据集执行最后拟合; 和d）从其获得动力学参数或参数。本发明还涉及一种用于执行该方法的分析系统，以及用于执行该方法的计算机程序，计算机程序产品和计算机系统。

7. 发明申请

WO98034098A1 ANALYTICAL METHOD AND APPARATUS 审中-公开
标题翻译：分析方法和装置
公开(公告)号：WO98034098A1
公开(公告)日：1998-08-06
申请号：PCT/SE1998/000196
申请日：1998-02-03
IPC分类号： G01N33/543 , G01B11/06 , G01N21/27 , G01N21/55
CPC分类号： G01B11/0625 , G01N21/552 , G01N21/553 , G01N2021/212 , G01N2021/215
摘要： A method of examining thin layer structures on a surface for differences in respect of optical thickness, which method comprises the steps of: irradiating the surface with light so that the light is internally or externally reflected at the surface; imaging the reflected light on a first two-dimensional detector; sequentially or continuously scanning the incident angle and/or wavelength of the light over an angular and/or wavelength range; measuring the intensities of light reflected from different parts of the surface and impinging on different parts of the detector, and determining from the detected light intensities at the different light incident angles and/or wavelengths an optical thickness image of the thin layer structures on the surface. According to the invention, part of the light reflected at said surface is detected on a second detector to determine the incident angle or wavelength of the polarized light irradiating the surface.
摘要翻译：一种检查表面上薄层结构相对于光学厚度差异的方法，该方法包括以下步骤：用光照射表面，使得光在表面内部或外部反射; 对第一二维检测器上的反射光进行成像; 在角度和/或波长范围内顺序地或连续地扫描光的入射角和/或波长; 测量从表面的不同部分反射并撞击检测器的不同部分的光的强度，并且根据检测到的不同光入射角和/或波长处的光强度确定表面上的薄层结构的光学厚度图像。根据本发明，在第二检测器上检测在所述表面反射的光的一部分，以确定照射表面的偏振光的入射角或波长。

8. 发明申请

WO2010062149A3 MULTI-CHANNEL SURFACE PLASMON RESONANCE SENSOR USING BEAM PROFILE ELLIPSOMETRY 审中-公开
标题翻译：多通道表面等离子体共振传感器采用光束轮廓椭圆测量
公开(公告)号：WO2010062149A3
公开(公告)日：2010-09-10
申请号：PCT/KR2009007083
申请日：2009-11-30
申请人： KOREA RES INST OF STANDARDS , CHO HYUN MO , CHO YONG JAI , CHEGAL WON
发明人： CHO HYUN MO , CHO YONG JAI , CHEGAL WON
IPC分类号： G01N21/21 , G01N21/55
CPC分类号： G01N21/553 , G01N2021/212
摘要： Provided is a multi-channel surface plasmon resonance sensor using beam profile ellipsometry; and, more particularly, to a high sensitive measuring technology, which is coupled with a vertical illumination type focused-beam ellipsometer using a multi-incident angle measurement method, and a surface plasmon resonance (SPR) sensing part deposited with a metal thin film. The multi-channel surface plasmon resonance sensor includes a vertical illumination type focused-beam ellipsometer in which light is polarized; a surface plasmon resonance (SPR) sensing part which is provided at the objective lens part of the focused-beam ellipsometer; and a multi-channel flow unit which supplies a buffer solution containing a bio material binding to or dissociation from a metal thin film generating surface plasmon.
摘要翻译：提供了一种使用光束轮廓椭圆光度法的多通道表面等离子体共振传感器; 更具体地涉及与使用多入射角度测量方法的垂直照明型聚焦光束椭偏仪和沉积有金属薄膜的表面等离子体共振（SPR）感测部件耦合的高灵敏度测量技术。多通道表面等离子体共振传感器包括其中光被极化的垂直照明型聚焦光椭圆偏振仪; 表面等离子体共振（SPR）感测部分，其设置在聚焦光椭圆偏振仪的物镜部分处; 以及多通道流动单元，其提供包含与产生金属薄膜的表面等离子体激元结合或解离的生物材料的缓冲溶液。

9. 发明申请

WO2008103200A2 APPARATUS AND METHOD FOR PERFORMING LIGAND BINDING ASSAYS ON MICROARRAYS IN MULTIWELL PLATES 审中-公开
标题翻译：用于在多孔板中的微阵列上进行配体结合测定的装置和方法
公开(公告)号：WO2008103200A2
公开(公告)日：2008-08-28
申请号：PCT/US2007/084680
申请日：2007-11-14
申请人： MAVEN TECHNOLOGIES, LLC , DULTZ, Shane C. , TRAVIS, Jeffrey , RALIN, David
发明人： DULTZ, Shane C. , TRAVIS, Jeffrey , RALIN, David
IPC分类号： C40B60/12 , C40B30/04
CPC分类号： C40B60/12 , C40B30/04 , G01N21/552 , G01N2021/212 , Y10S436/809
摘要： An apparatus and method for real time, label-free imaging and quantitation of binding events at an array of positions are provided. Total internal reflection from a planar side wall of a well of a multiwell plate is used to create an evanescent field in the plane of a pattern of ligands immobilized on the wall. Embodiments include imaging and multiple analyte detection and quantitation of a single wall of a single well as well as the simultaneous imaging and multiple analyte detection and quantitation of a number of wells.
摘要翻译：提供了一种用于实时，无标记成像和定位一系列位置处的结合事件的装置和方法。使用来自多孔板的孔的平面侧壁的全内反射来在固定在壁上的配体图案的平面中产生消逝场。实施例包括成像和多个分析物检测和单个孔的单个壁的定量以及多个孔的同时成像和多个分析物检测和定量。

10. 发明申请

WO2005116598A3 IMAGING METHOD AND APPARATUS 审中-公开
标题翻译：成像方法和装置
公开(公告)号：WO2005116598A3
公开(公告)日：2007-04-19
申请号：PCT/US2005016314
申请日：2005-05-10
申请人： MAVEN TECHNOLOGIES LLC , RASSMAN WILLIAM , RALIN DAVID , LIEBERMAN ROBERT A , KEMPEN LOTHAR U , SHAPIRO HERBERT
发明人： RASSMAN WILLIAM , RALIN DAVID , LIEBERMAN ROBERT A , KEMPEN LOTHAR U , SHAPIRO HERBERT
IPC分类号： G01J4/00 , G01N21/01 , G01N21/21 , G01N21/25 , G01N21/55 , G01N33/53
CPC分类号： G01N21/211 , G01N21/21 , G01N21/253 , G01N21/552 , G01N2021/212 , Y10S436/805
摘要： An imaging method and apparatus are provided, including a light source (50) emitting a polarized light beam (20), and an optical assembly including a control layer (60) and/or a light reflection surface (66). The control layer (60) advantageously allows for control over the properties of a generated evanescent wave to optimize an image of a specimen array (64) within the evanescent wave. The light reflection surface (66) includes coupling means used to couple a receptor/capture agent advantageously allowing for flexible control over receptor specific regions.
摘要翻译：提供一种成像方法和装置，包括发射偏振光束（20）的光源（50）和包括控制层（60）和/或光反射表面（66）的光学组件。控制层（60）有利地允许控制所产生的ev逝波的性质以优化ev逝波内的样本阵列（64）的图像。光反射表面（66）包括用于耦合受体/捕获剂的偶联装置，其有利地允许对受体特异性区域的灵活控制。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式