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1. 发明申请

WO2021148811A1 HDAC DEGRADER 审中-公开
公开(公告)号：WO2021148811A1
公开(公告)日：2021-07-29
申请号：PCT/GB2021/050156
申请日：2021-01-22
申请人： UNIVERSITY OF LEICESTER
发明人： COWLEY, Shaun , HODGKINSON, James , CROSS, Jasmine M. , SCHWABE, John , SMALLEY, Joshua , ADAMS, Grace , MILLARD, Chris
IPC分类号： C07D207/16 , C07D401/04 , C07D417/12 , C07D417/14 , A61P35/00 , A61K31/4015 , A61K31/427
摘要： The disclosure provides compounds of formula (I). The compounds may be used to degrade the Histone Deacetylase (HDAC) family of enzymes, particularly HDAC1, 2 and 3 that exist in corepressor complexes. Accordingly, the compounds may be used to treat cancer. The invention extends to pharmaceutical compositions comprising these compounds, and the use of these compounds in therapy.

2. 发明申请

WO2020065302A1 THERAPEUTIC BACTERIOPHAGES 审中-公开
公开(公告)号：WO2020065302A1
公开(公告)日：2020-04-02
申请号：PCT/GB2019/052695
申请日：2019-09-24
申请人： UNIVERSITY OF LEICESTER
发明人： CLOKIE, Martha , THANKI, Anisha
IPC分类号： A61K35/76 , C12N7/00 , C12N9/36
摘要： There is provided a bacteriophage of the Myoviridae family, comprising a genome of circularly permuted double-stranded DNA at a length of 200kbp or more; characterised in that the phage has any one or more of the following features: a) does not have a holin gene; and/or b) binds to the Salmonella lipopolysaccharide; and/or c) has only one tail fibre protein; and d) has a sequence with at least 95% sequence identity to SEQ ID NO. 7 and/or a sequence with at least 80% sequence identity to SEQ ID NO.8. Suitably, the bacteriophage may be used to treat salmonella, in particular in the treatment of salmonella in pigs and fowl.

3. 发明申请

WO2019234417A1 ELECTROCHEMICAL SENSOR 审中-公开
公开(公告)号：WO2019234417A1
公开(公告)日：2019-12-12
申请号：PCT/GB2019/051551
申请日：2019-06-05
申请人： UNIVERSITY OF LEICESTER
发明人： PILETSKY, Sergey , AHMAD, Omar Sheej , CRUZ, Alvaro Garcia
IPC分类号： G01N27/327
摘要： An electrochemical sensor comprising first and second electrodes. The first electrode has a molecular imprinted polymer (MIP) immobilised thereon and the MIP comprises a redox label and is imprinted with an analyte. The disclosure also provides methods of producing such sensors, methods of detecting and determining the concentration of analytes and the use of the electrochemical sensors for the detection of analytes.

4. 发明申请

WO2019102231A1 A FLOW ASSEMBLY FOR AN AXIAL TURBOMACHINE 审中-公开
公开(公告)号：WO2019102231A1
公开(公告)日：2019-05-31
申请号：PCT/GB2018/053426
申请日：2018-11-27
申请人： UNIVERSITY OF LEICESTER
发明人： RONA, Aldo
IPC分类号： F04D29/52 , F04D29/68
CPC分类号： F04D29/526 , F04D29/685
摘要： A flow assembly for an axial turbomachine is disclosed. The flow assembly comprises: an outer shroud; an inner hub; and, at least one blade mounted to one of the shroud and hub and comprising pressure and suction surfaces. The other one of the shroud and hub comprises a wall and the or each blade extends towards the wall such that a clearance gap is provided therebetween. The flow assembly is configured such that, in use, fluid flows through the flow assembly from an upstream side to a downstream side of the flow assembly. The wall comprises a recirculation channel comprising an outlet and an inlet located between the outlet and the downstream side of the flow assembly. The recirculation channel is configured such that when fluid flows through the flow assembly from the upstream side to the downstream side, fluid flow from the pressure surface side of the at least one blade enters the inlet and flows along the recirculation channel to be expelled from the outlet to impede leakage of fluid flow in the clearance gap from the pressure surface side to the suction surface side of the or one of the blades.

5. 发明申请

WO2018026722A8 COMPOSITIONS AND METHODS OF INHIBITING MASP-3 FOR THE TREATMENT OF VARIOUS DISEASES AND DISORDERS 审中-公开
公开(公告)号：WO2018026722A8
公开(公告)日：2018-02-08
申请号：PCT/US2017/044714
申请日：2017-07-31
申请人： OMEROS CORPORATION , UNIVERSITY OF LEICESTER
发明人： CUMMINGS, W., Jason , DEMOPULOS, Gregory, A. , DUDLER, Thomas , SCHWAEBLE, Hans-Wilhelm , TJOELKER, Larry, W. , WOOD, Christi, L. , YABUKI, Munehisa
IPC分类号： A61K39/395 , A61K45/06 , C07K16/40
摘要： The present invention relates to MASP-3 inhibitory antibodies and compositions comprising such antibodies for use in inhibiting the adverse effects of MASP-3 dependent complement activation.

6. 发明申请

WO2017149272A1 URINE WEIGHING APPARATUS 审中-公开
标题翻译：尿液称量设备
公开(公告)号：WO2017149272A1
公开(公告)日：2017-09-08
申请号：PCT/GB2017/050436
申请日：2017-02-21
申请人： UNIVERSITY OF LEICESTER
发明人： HOLT, John , BUSTIN, Gareth , SIMS, Mark , COATS, Tim
IPC分类号： A61B5/20 , A61B5/00
CPC分类号： A61B5/208 , A61B5/7207 , A61B2562/0261
摘要： A urine weighing apparatus comprises support means configured to support a urine collection vessel, a transducer for converting the weight of the vessel into an electrical signal, and a processor for processing the electrical signal to continuously calculate the weight of the vessel. The processor calculates the weight of urine therein and allows the urine output rate to be determined.
摘要翻译：尿液称重设备包括：支撑装置，被配置为支撑尿液收集容器;换能器，用于将容器的重量转换为电信号;以及处理器，用于处理电信号以连续地计算重量的船只。处理器计算其中的尿液重量并允许确定尿液排出量。

7. 发明申请

WO2016193687A1 X-RAY ANALYSIS DEVICE 审中-公开
标题翻译： X射线分析装置
公开(公告)号：WO2016193687A1
公开(公告)日：2016-12-08
申请号：PCT/GB2016/051559
申请日：2016-05-27
申请人： UNIVERSITY OF LEICESTER
发明人： HANSFORD, Graeme Mark
IPC分类号： G01N23/20
CPC分类号： G01N23/20008
摘要： An X-Ray analysis device comprising an X-Ray source and an X-ray detector and a method of analysis are disclosed. The X-ray source is arranged to emit a first characteristic X-Ray line and a second characteristic X-Ray line both incident on the sample. The X-Ray detector is adapted to detect X-rays diffracted by the sample. Each of the first and second characteristic X-Ray lines is diffracted at a distinct diffraction angle determined by each of the first and second lattice spacings to produce four diffraction angles, and two of the diffraction angles correspond to one another.
摘要翻译：公开了包括X射线源和X射线检测器的X射线分析装置和分析方法。 X射线源被布置成发射入射到样品上的第一特征X射线和第二特征X射线。 X射线检测器适用于检测样品衍射的X射线。第一和第二特征X射线中的每一个以由第一和第二晶格间隔中的每一个确定的不同的衍射角衍射，以产生四个衍射角，并且两个衍射角彼此对应。

8. 发明申请

WO2016128744A1 SENESCENCE 审中-公开
标题翻译：衰老
公开(公告)号：WO2016128744A1
公开(公告)日：2016-08-18
申请号：PCT/GB2016/050315
申请日：2016-02-10
申请人： UNIVERSITY OF LEICESTER
发明人： MACIP, Salvador
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K39/395 , A61K31/519 , C12Q1/485 , G01N33/5011 , G01N33/5023 , G01N33/5041 , G01N33/574 , G01N2333/9121 , G01N2800/7042
摘要： The invention provides an inhibitor of a Tec family tyrosine kinase and uses thereof. The invention also extends to methods of treating, ameliorating or preventing senescence or an age-related disorder or a solid tumour in a subject. The invention also extends to Tec family tyrosine kinase gene-silencing molecules, pharmaceutical compositions, methods of making the compositions and compound screening assays.
摘要翻译：本发明提供了Tec家族酪氨酸激酶的抑制剂及其用途。本发明还涉及在受试者中治疗，改善或预防衰老或年龄相关疾病或实体瘤的方法。本发明还延伸至Tec家族酪氨酸激酶基因沉默分子，药物组合物，制备组合物的方法和化合物筛选测定。

9. 发明申请

WO2015114347A1 SYSTEM FOR A BRAIN-COMPUTER INTERFACE 审中-公开
标题翻译：脑电脑界面系统
公开(公告)号：WO2015114347A1
公开(公告)日：2015-08-06
申请号：PCT/GB2015/050217
申请日：2015-01-29
申请人： UNIVERSITY OF LEICESTER , UNIVERSITY OF NEWCASTLE UPON TYNE , IMPERIAL INNOVATIONS LIMITED
发明人： JACKSON, Andrew , CONSTANDINOU, Tim , EFTEKHAR, Amir , QUIROGA, Rodrigo Quian , AHUMADA, Joaquin Navajas
IPC分类号： G06F3/01
CPC分类号： A61B5/04 , A61B5/4064 , G06F3/015
摘要： The invention provides a two-step approach to providing a BCI system. In a first step the invention provides a low-power implantable platform for amplifying and filtering the extracellular recording, performing analogue to digital conversion (ADC) and detecting action potentials in real-time, which is connected to a remote device capable of performing the processor-intensive tasks of feature extraction and spike classification, thus generating a plurality of predetermined templates for each neuron to be used in a second processing step. In the second step the low-power implantable platform amplifies and filters the extracellular recording, performs ADC and detects action potentials, which can be matched on-chip to the predetermined templates generated by the external receiver in the first step. This two-step approach exploits the advantages of both offline and online processing, providing an effective and safe method for performing multiple recordings of single-neuron activity, for research or monitoring applications or for control of a remote device.
摘要翻译：本发明提供了一种提供BCI系统的两步法。在第一步中，本发明提供了一种用于放大和过滤细胞外记录，执行模数转换（ADC）和实时检测动作电位的低功率可植入平台，其连接到能够执行处理器的远程设备特征提取和尖峰分类的重点任务，从而为在第二处理步骤中使用的每个神经元生成多个预定模板。在第二步中，低功率可植入平台对细胞外记录进行放大和滤波，执行ADC并检测动作电位，该动作电位可以在片内匹配到第一步中由外部接收器生成的预定模板。这种两步法利用了离线和在线处理的优点，为进行单神经元活动的多个记录，研究或监控应用程序或远程设备的控制提供了有效和安全的方法。

10. 发明申请

WO2014091220A1 PRODUCTION OF HETEROLOGOUS POLYSACCHARIDES IN PLANTS 审中-公开
标题翻译：在植物中生产异物多糖
公开(公告)号：WO2014091220A1
公开(公告)日：2014-06-19
申请号：PCT/GB2013/053246
申请日：2013-12-10
申请人： THE UNIVERSITY OF MANCHESTER , THE UNIVERSITY OF LEICESTER
发明人： ROBERTS, Ian , ANDREW, Peter
IPC分类号： C12N15/82 , C07K14/31 , A01H5/00
CPC分类号： A61K39/092 , A61K2039/517 , C08B37/006 , C12N9/1048 , C12N15/8246 , C12N15/8257 , C12P19/04
摘要： The invention relates to a novel method for producing bacterial or viral saccharides, such as capsular, immunogenic or membrane saccharides, in a plant cell. Also provided plants, plant cells, plant parts, and plant products comprising such a bacterial or viral saccharide. The invention is based upon the novel finding that bacterial enzymes can be used in a plant cell to produce bacterial or viral capsular, immunogenic and/or membrane saccharides.
摘要翻译：本发明涉及一种在植物细胞中生产细菌或病毒糖，如荚膜，免疫原性或膜糖的新方法。还提供植物，植物细胞，植物部分和包含这种细菌或病毒糖的植物产品。本发明基于新颖的发现，细菌酶可用于植物细胞中以产生细菌或病毒荚膜，免疫原性和/或膜糖。

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