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1. 发明申请

WO2020126700A1 METHOD FOR REDUCING MISINCORPORATION OF NON-CANONICAL BRANCHED-CHAIN AMINO ACIDS 审中-公开
公开(公告)号：WO2020126700A1
公开(公告)日：2020-06-25
申请号：PCT/EP2019/084504
申请日：2019-12-10
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , TECHNISCHE UNIVERSITÄT BERLIN
发明人： HAUPTMANN, Peter , CORCOLES GARCIA, Angel , LATTEMANN, Claus Tobias , MATZEN, Arne , NEUBAUER, Peter
IPC分类号： C12P21/00 , C12N9/04 , C12N9/10 , C12N9/88
摘要： The present invention relates to a method for producing a recombinant polypeptide of interest in a microbial host cell, comprising (a) introducing a polynucleotide encoding the polypeptide of interest into a microbial host cell which has been modified such that an enzymatic activity selected from the group consisting of ketol-acid reductoisomerase (NADP(+)) activity (EC 1.1.1.86), acetohydroxyacid synthase activity (EC 2.2.1.6), aspartate kinase activity (EC 2.7.2.4), homoserine dehydrogenase activity (EC 1.1.1.3), and L-threonine dehydratase activity (EC 4.3.1.19) is modulated in said microbial host cell as compared to the enzymatic activity in an unmodified microbial host cell, and (b) expressing said polypeptide of interest in said microbial host cell. Moreover, the present invention relates to a method for reducing misincorporation of at least one non-canonical branched-chain amino acid into a recombinant polypeptide of interest expressed in a microbial host cell.

2. 发明申请

WO2020043686A1 IMPROVED METERING MECHANISM AND INJECTION DEVICE 审中-公开
公开(公告)号：WO2020043686A1
公开(公告)日：2020-03-05
申请号：PCT/EP2019/072760
申请日：2019-08-27
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： DAHMEN, Michael , OBEX, Hannes
IPC分类号： A61M5/315 , A61M5/24
摘要： The present invention refers to a metering mechanism for an injection device. The mechanism comprises an actuating element (1) for setting or discharging a dose from the injection device, a piston rod (2) for producing an advance movement for dispensing a dose, a piston rod sleeve (3) in which the piston rod (2) is accommodated such that the piston rod (2) can be non- rotatably connected to the piston rod sleeve (3), and a coupling element (4) with which the actuating element (1) and the piston rod sleeve (3) can be coupled for discharge of the dose set with the actuating element (1) in such a way that a dispensing movement of the actuating element (1) is transmitted to the piston rod (2) by way of the piston rod sleeve (3) connected to the piston rod (2). To prevent underdosage, the piston rod (2) comprises a stop (2c) and the coupling element (4) comprises a counter-stop (4e) which move relative to each other at least during setting of a dose and which abut each other in a maximum dose stop position, thereby preventing further setting of a dose. Further, the present invention refers to an injection device with such a metering mechanism.

3. 发明申请

WO2019091882A1 INJECTION DEVICE WITH A PRESELECTOR 审中-公开
公开(公告)号：WO2019091882A1
公开(公告)日：2019-05-16
申请号：PCT/EP2018/080081
申请日：2018-11-05
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： HELMER, Michael , RAAB, Ernst , TOPOREK, Maurice
IPC分类号： A61M5/20 , A61M5/315
CPC分类号： A61M5/31541 , A61M5/20 , A61M5/3157 , A61M5/31575 , A61M5/31583 , A61M5/31593
摘要： The present disclosure relates to an injection device for setting and injecting a dose of a medicament, the injection device comprising: - a housing (10) extending along an axial direction (z), a dose setting mechanism (9) arranged in the housing (10), a dose dial (12) displaceable relative to the housing (10) for setting of the dose, a dose tracker (50; 150) operably connectable to the dose dial (12), the dose tracker (50; 150) is at least one of translationally or rotationally displaceable relative to the housing (10) during setting of a dose, wherein a positional state (54) of the dose tracker (50; 150) relative to the housing (10) is indicative of a size of the dose, and a preselector (70; 170) configured to define a maximum dose positional state (55) of the dose tracker (50;150) relative to the housing (10), at least a first marker (85; 185) provided on one of the dose tracker (50) and the preselector (70; 170) and configured to indicate the positional state (54) of the dose tracker (50; 150) relative to the preselector (70; 170).

4. 发明申请

WO2019091877A1 INJECTION DEVICE WITH A DOSE LIMITER 审中-公开
公开(公告)号：WO2019091877A1
公开(公告)日：2019-05-16
申请号：PCT/EP2018/080076
申请日：2018-11-05
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： HELMER, Michael , SCHABBACH, Michael , JUGL, Michael , NOBER, Peter , KEIM, Moritz , RAU, Matthias
IPC分类号： A61M5/315
摘要： The present disclosure relates to an injection device for setting and injecting a dose of a medicament, the injection device comprising: - an elongated housing (10) extending along an axial direction (z) and configured to accommodate a dose setting mechanism (9), wherein the housing (10) comprises a sidewall (43; 143) with at least a first fastening feature (41; 141) - a dose dial (12) rotatable relative to the housing (10) for setting of a dose, - a dose tracker (50) arranged inside the housing (10) and operably connectable to the dose dial (12), the dose tracker (50) comprises at least one tracking stop feature (51), wherein the dose tracker (50) is one of translationally or rotationally displaceable relative to the housing (10) during setting of a dose and wherein a positional state of the dose tracker (50) relative to the housing (10) is indicative of a size of the dose, and - a limiter (70; 170) attachable to the sidewall (43; 143) of the housing (10) from outside the housing (10) and engageable with the at least first fastening feature (41, 41), wherein the limiter (70; 170) comprises at least one limiter stop feature (71; 171) extending inwardly from the sidewall (43; 143) when the limiter (70; 170) is attached to the sidewall (43), wherein the limiter stop feature (71; 171) and the tracking stop feature (51) are configured to mutually engage and to block a displacement of the dose tracker (50) beyond a predefined maximum dose positional state.

5. 发明申请

WO2018202667A1 AUTO-INJECTOR STORAGE DEVICE 审中-公开
公开(公告)号：WO2018202667A1
公开(公告)日：2018-11-08
申请号：PCT/EP2018/061119
申请日：2018-05-02
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： WENDLAND, Stefan , HARMS, Michael
IPC分类号： A61M5/178 , B65D1/00 , A61M5/24 , A61M5/20 , A61M5/00 , A61M5/32 , A61B5/15 , A45C11/00 , H01R29/00
摘要： A storage device for storing a plurality of auto-injectors, the device configured to activate an auto-injector upon removal of the auto-injector from the device.

6. 发明申请

WO2018115317A1 DATA MANAGEMENT UNIT FOR SUPPORTING HEALTH CONTROL 审中-公开
公开(公告)号：WO2018115317A1
公开(公告)日：2018-06-28
申请号：PCT/EP2017/084152
申请日：2017-12-21
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： TEUCHER, Axel , SCHAUDERNA, Florian , TUBB, Andrew , ENGELHARDT, Ashley , ROSENZWEIG, Alyssa
IPC分类号： G06F19/00 , G16H10/65
摘要： The present invention refers to a data management unit for supporting health control, the unit comprising: a processor (140), a display (162) connected to the processor (140) and adapted to visibly and/or audibly and/or tangibly display received messages, and a data storage (130) connected to the processor (140), wherein the data storage stores (130) at least one predefined primary information (501) and at least one predefined secondary information (502) assigned to the at least one predefined primary information (501), wherein the processor (140) is further adapted to send the one of the at least one predefined primary information (501 ) and additionally the at least one predefined secondary information (502) to the display, wherein the at least one predefined primary information (501) and the at least one predefined secondary information (502) are displayed on one screen of the display (162). The invention further refers to a respective method and computer program for operating the data management unit, and a respective computer program product.

7. 发明申请

WO2018091256A1 NEEDLE ARRANGEMENT 审中-公开
公开(公告)号：WO2018091256A1
公开(公告)日：2018-05-24
申请号：PCT/EP2017/077713
申请日：2017-10-30
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： WENDLAND, Stefan
IPC分类号： A61M5/32 , A61M5/28 , A61M5/20 , A61M5/24 , A61B5/15
摘要： The present disclosure relates to a needle arrangement (1) for a drug delivery device, the needle arrangement (1) comprising a distal needle tip (2) and a proximal needle tip (3), wherein the distal needle tip (2) is held in a distal needle holder (4) and wherein the proximal needle tip (3) is held in a proximal needle holder (5), wherein the distal needle tip (2) and the proximal needle tip (3) are in fluid communication with each other through a fluid channel (6), wherein the fluid channel (6) is adapted to allow axial movement of the distal needle tip (2) and relative to the proximal needle tip (3) between a compact state (S1) and an extended state (S2), wherein a length of the needle arrangement (1) over the distal needle tip (2) and the proximal needle tip (3) in the extended state (S2) is greater than in the compact state (S1).

8. 发明申请

WO2018083062A1 VOLUME MEASURING ARRANGEMENT 审中-公开
标题翻译：体积测量安排
公开(公告)号：WO2018083062A1
公开(公告)日：2018-05-11
申请号：PCT/EP2017/077773
申请日：2017-10-30
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： RICHTER, René , WITT, Robert , GUENTHER, Richard , NAGEL, Thomas
IPC分类号： A61M5/168 , A61M5/14 , A61M5/20
摘要： In one aspect the present disclosure refers to a measuring arrangement (10; 110; 210; 310; 410; 510) for measuring of a volume change of a liquid medium (14) located inside a liquid reservoir (24), the measuring arrangement comprising: - a gas tight enclosure (20; 120; 220; 320) having an interior volume (21; 121) containing a gas reservoir (22; 122) and containing the liquid reservoir (24), wherein the liquid reservoir (24) is filled with a liquid medium (14), - a gas inlet (30; 130) in flow connection with the gas reservoir (22; 122) and extending through a boundary (19) of the gas tight enclosure (20; 120; 220; 320) to an exterior (5) of the gas tight enclosure (20; 120; 220; 320), - an outlet (42) connectable with the liquid reservoir (24) and extending through the boundary (19) of the gas tight enclosure (20; 120; 220; 320), - wherein the gas reservoir (22; 122) and the liquid reservoir (24) are hermetically separated by an impenetrable separation wall (25), and - a flow meter (28) arranged in or across the gas inlet (30; 130) to measure an ingress of a gaseous medium (15) through the inlet (30; 130) in response to a withdrawal of the liquid medium (14) from the liquid reservoir (24) through the outlet (42).
摘要翻译：在一个方面，本公开涉及用于测量位于液体储存器内的液体介质（14）的体积变化的测量装置（10; 110; 210; 310; 410; 510）（24），所述测量装置包括： - 具有包含气体储存器（22; 122）并容纳所述液体储存器（24）的内部容积（21; 121）的气密外壳（20; 120; 220; 320）其中所述液体储存器（24）填充有液体介质（14）， - 与所述气体储存器（22; 122）流动连接并且延伸穿过所述气密边界（19）的气体入口（30; 130）（20; 120; 220; 320）连接到所述气密外壳（20; 120; 220; 320）的外部（5）， - 可与所述液体储存器（24）连接并且延伸穿过所述边界（20; 120; 220; 320）的至少一部分（19），其中所述气体储存器（22; 122）和所述液体储存器（24）被不可渗透的分隔壁（25）气密地分隔开，以及 - 流量计（28）布置在气体入口（30; 响应于通过出口（42）从液体贮存器（24）中抽出液体介质（14），测量通过入口（30; 130）的气体介质（15）的进入。 >

9. 发明申请

WO2018083056A1 VOLUME MEASURING ARRANGEMENT 审中-公开
标题翻译：体积测量安排
公开(公告)号：WO2018083056A1
公开(公告)日：2018-05-11
申请号：PCT/EP2017/077735
申请日：2017-10-30
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： RICHTER, René , WITT, Robert , GUENTHER, Richard , NAGEL, Thomas
IPC分类号： A61M5/14 , A61M5/168 , A61M5/24
摘要： The present invention relates in one aspect to a measuring arrangement (10; 110; 210) for measuring a volume occupied by a liquid medium (14) inside a liquid reservoir (24), the measuring arrangement comprising:• - a container (20; 120) having an interior volume (21; 121) containing a gas reservoir (22; 122) filled with a gaseous medium and containing a liquid reservoir (24) filled with a liquid medium (14), • - wherein the gas reservoir (22; 122) and the liquid reservoir (24) are hermetically separated by an impenetrable separation wall (25) • - a volume modulator (30) to induce a volume change of the gas reservoir (22; 122), • - a pressure sensor (28) arranged inside the gas reservoir (22; 122) to measure a pressure change of the gaseous medium in response to the volume change of the gas reservoir (22; 122), and • - a controller (40) connectable to the pressure sensor (28), wherein the controller (40) is configured to calculate the volume of the liquid reservoir (24) on the basis of the pressure change and the volume change
摘要翻译：一方面，本发明涉及一种用于测量由液体储存器（24）内的液体介质（14）占据的体积的测量装置（10; 110; 210），该测量装置包括： - 具有内部容积（21; 121）的容器（20; 120），所述内部容积包含充满气体介质并且包含充满液体介质（14）的液体储存器（24）的气体储存器（22; 122） - 其中所述气体储存器（22; 122）和所述液体储存器（24）被不可渗透的分隔壁（25）气密地分隔开来; - 体积调节器（30），用于引起所述气体储存器（22; 122 ）， - 设置在气体储存器（22; 122）内的压力传感器（28），用于响应气体储存器（22; 122）的体积变化来测量气体介质的压力变化，以及 - 控制器（40），其可连接到所述压力传感器（28），其中所述控制器（40）被配置成计算所述液体储存器 ir（24）根据压力变化和体积变化

10. 发明申请

WO2018060025A1 A MEDICAMENT DELIVERY DEVICE 审中-公开
标题翻译：药物输送装置
公开(公告)号：WO2018060025A1
公开(公告)日：2018-04-05
申请号：PCT/EP2017/073723
申请日：2017-09-20
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： SCHABBACH, Michael , FRANKE, Beate , PRADEL, Giuliano , MELZI, Ilario , VERLAAK, Stefan , NELSON, Andrew
IPC分类号： A61M5/148 , A61M5/20 , A61M5/142 , A61M5/145
摘要： The present invention relates to a medicament delivery device. The medicament delivery device comprises a housing, a needle and a reservoir. The needle is configured to project from a distal end of the housing. The reservoir is disposed in the housing and has a flexible wall. The medicament delivery device further comprises a dispensing member and a biasing member. The dispensing member is disposed in the housing and the biasing member is configured to bias the dispensing member to move in an arcuate path relative to the housing such that the dispensing member moves across the flexible wall of the reservoir to dispense medicament from the reservoir when the reservoir contains medicament.
摘要翻译：药物输送装置技术领域本发明涉及一种药物输送装置。药物输送装置包括壳体，针和储存器。针被构造成从壳体的远端伸出。储存器设置在壳体中并具有柔性壁。药物输送装置还包括分配构件和偏置构件。分配构件设置在壳体中，并且偏置构件配置为偏置分配构件以相对于壳体沿弧形路径移动，使得分配构件移动越过储存器的柔性壁，以当分配构件从储存器分配药物时水库含有药物。

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