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1. 发明申请

WO2004002374A1 SELF-TRANSITIONING SPINAL DISC ANULUS OCCLUSION DEVICE AND METHOD OF USE 审中-公开
标题翻译：自转脊柱椎间盘突出症患者及其使用方法
公开(公告)号：WO2004002374A1
公开(公告)日：2004-01-08
申请号：PCT/US2003/016943
申请日：2003-05-29
申请人： RAYMEDICA, INC.
发明人： GAINOR, John , NORTON, Britt, K. , MAY, Orson, James , PHILLIPS, Anthony, C.
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61B17/00234 , A61B17/0057 , A61B17/0401 , A61B17/06166 , A61B2017/00659 , A61B2017/0404 , A61B2017/0406 , A61F2/30744 , A61F2/30965 , A61F2/4611 , A61F2002/30354 , A61F2002/30441 , A61F2002/30494 , A61F2002/305 , A61F2002/30507 , A61F2002/30512 , A61F2002/4435 , A61F2002/444 , A61F2002/4627 , A61F2002/4635 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2310/00017
摘要： An occlusion device for occluding a defect in a spinal disc anulus, including a plate and a retention device. The plate defines an anulus contact face. The retention device extends from the contact face of the plate and defines an annulus engagement portion. The retention device is deflectable relative to the plate such that in a deployed state, the retention device biases the plate against material disposed between the contact face of the plate and the anulus engagement portion. Upon final deployment, the retention device bears against the exterior surface of the anulus, biasing the plate into contact with the interior surface of the anulus. In a preferred embodiment, the retention device includes a pair of L-shaped arms each extending in an opposing, angular fashion from the plate.
摘要翻译：一种用于封闭脊椎盘环的缺损的闭塞装置，包括板和保持装置。该板限定了一个环形接触面。保持装置从板的接触面延伸并限定环形接合部分。保持装置相对于板可偏转，使得在展开状态下，保持装置将板抵靠设置在板的接触面和环形接合部之间的材料。在最终展开时，保持装置抵靠环的外表面，偏压板与环的内表面接触。在优选实施例中，保持装置包括一对L形臂，每个L形臂以与板相对的角度方式延伸。

2. 发明申请

WO2004047690A3 PROSTHETIC SPINAL DISC NUCLEUS WITH ELEVATED SWELLING RATE 审中-公开
标题翻译：假性脊柱盘核具有升高的膨胀率
公开(公告)号：WO2004047690A3
公开(公告)日：2004-07-08
申请号：PCT/US0337870
申请日：2003-11-25
申请人： RAYMEDICA INC , SHERMAN TARA NICOLE , NORTON BRITT KEENAN , BAIN ALLISON C
发明人： SHERMAN TARA NICOLE , NORTON BRITT KEENAN , BAIN ALLISON C
IPC分类号： A61F2/30 , A61F2/44 , A61L27/52
CPC分类号： A61L27/52 , A61F2/3094 , A61F2/441 , A61F2002/444 , A61F2002/4495 , A61L2430/38
摘要： A method of manufacturing a prosthetic spinal disc nucleus. The method including forming a hydrogel core from a hydrogel material in a natural state. The hydrogel material in the natural state is characterized by a natural swelling rate. The hydrogel is treated in an alkaline solution having a pH of at least about 8. This treatment transitions the hydrogel core from the natural state to a treated state characterized by an elevated swelling rate. The elevated swelling rate is greater that the natural swelling rate. The resultant, treated hydrogel core forms at least a portion of a prosthetic spinal disc nucleus. In one particular embodiment, the hydrogel core is inserted into a constraining jacket. Another aspect of the present invention relates to a prosthetic spinal disc nucleus including a hydrogel core having the elevated swelling rate.
摘要翻译：一种制造假肢脊椎椎间盘核的方法。该方法包括由天然状态的水凝胶材料形成水凝胶芯。天然状态下的水凝胶材料的特征在于自然膨胀率。该水凝胶在具有至少约8的pH的碱性溶液中处理。该处理将水凝胶芯从天然状态转变为特征在于升高的溶胀速率的处理状态。升高的肿胀率大于自然肿胀率。所得到的经处理的水凝胶芯形成假体脊椎盘核的至少一部分。在一个特定实施例中，水凝胶芯被插入约束护套中。本发明的另一方面涉及包括具有升高的膨胀率的水凝胶芯的假体脊椎盘核。

3. 发明申请

WO1996011643A1 METHOD FOR SURGICAL IMPLANTATION OF A PROSTHETIC SPINAL DISC NUCLEUS 审中-公开
标题翻译：前列腺脊髓核的外科手术植入方法
公开(公告)号：WO1996011643A1
公开(公告)日：1996-04-25
申请号：PCT/US1995013268
申请日：1995-10-17
申请人： RAYMEDICA, INC.
发明人： RAYMEDICA, INC. , RAY, Charles, D. , DICKHUDT, Eugene, A.
IPC分类号： A61B17/56
CPC分类号： A61F2/4611 , A61B17/1604 , A61B17/1671 , A61B17/320016 , A61B17/88 , A61B2017/00261 , A61B2017/00473 , A61B2017/0256 , A61F2/3094 , A61F2/441 , A61F2/442 , A61F2002/3008 , A61F2002/30235 , A61F2002/30461 , A61F2002/30619 , A61F2002/444 , A61F2002/448 , A61F2220/0075 , A61F2230/0069 , A61F2250/0097 , A61F2250/0098
摘要： A method for surgically implanting a prosthetic spinal disc nucleus body (52) into a human spinal disc space (10) is disclosed. The spinal disc space (10) contains adjacent vertebrae (12, 14) and an anulus (15) having a posterior side. The method includes cutting a flap (30) through the anulus (15) in the disc space (10) to create an opening (40). The vertebrae adjacent (12, 14) to the disc space (10) are slightly separated and a prosthetic spinal disc nucleus body (52) is inserted through the opening (40) into the disc space (10).
摘要翻译：公开了将人造脊椎椎间盘细胞核（52）手术植入人脊椎盘空间（10）中的方法。椎间盘空间（10）包含相邻的椎骨（12,14）和具有后侧的环（15）。该方法包括通过盘空间（10）中的环（15）切割翼片（30）以形成开口（40）。与椎间盘间隙（10）相邻的椎骨（12,14）略微分开，并且假肢脊椎椎间盘核心体（52）通过开口（40）插入椎间盘空间（10）中。

4. 发明申请

WO1996011642A1 PROSTHETIC SPINAL DISC NUCLEUS 审中-公开
标题翻译： PROSTHETIC脊椎盘核
公开(公告)号：WO1996011642A1
公开(公告)日：1996-04-25
申请号：PCT/US1995013172
申请日：1995-10-17
申请人： RAYMEDICA, INC.
发明人： RAYMEDICA, INC. , RAY, Charles, D. , DICKHUDT, Eugene, A. , LE DOUX, Philip, J. , FRUTIGER, Beth, A.
IPC分类号： A61B17/56
CPC分类号： A61F2/441 , A61F2/3094 , A61F2/442 , A61F2002/3008 , A61F2002/30156 , A61F2002/30235 , A61F2002/30291 , A61F2002/30461 , A61F2002/30579 , A61F2002/30581 , A61F2002/30619 , A61F2002/30841 , A61F2002/30878 , A61F2002/444 , A61F2002/448 , A61F2002/4495 , A61F2220/0075 , A61F2230/0023 , A61F2230/0069 , A61F2230/0091 , A61F2250/0097 , A61F2250/0098
摘要： An elongated, pillow shaped prosthetic spinal disc nucleus body (10) for implantation into a human intervertebral spinal disc (32), made of a hydrogel core (12) and a flexible constraining jacket (14) surrounding the hydrogel material core (12) that permits the hydrogel core (12) to expand and contract. The hydrogel core (12) has a length approximating the sagittal diameter of a nucleus of the human disc, a width less than the length, and a height less than the length or width. The hydrogel core will expand and contract in a desired fashion as it imbibes and expels fluids in response to various loads placed upon the spinal tract. The constraining jacket (14) is porous to allow fluids to pass through to the hydrogel core (12), but prevents the hydrogel (12) from escaping, thus fostering the natural physiology of the human intervertebral disc. By implanting two prosthetic spinal disc nucleus bodies (10) side-by-side into a damaged disc (32) of a human spine, both height and motion can be maintained.
摘要翻译：一种用于植入到由水凝胶芯（12）和围绕水凝胶材料芯（12）的柔性约束套（14）制成的人椎间盘脊（32）中的细长的枕形假脊椎椎间盘核体（10），允许水凝胶核心（12）膨胀和收缩。水凝胶芯（12）的长度近似于人盘的核的矢状径，宽度小于长度，并且高度小于长度或宽度。水凝胶芯将以所需的方式膨胀和收缩，因为其响应于放置在脊柱上的各种负载而吸收和排出流体。约束护套（14）是多孔的，以允许流体通过到水凝胶核心（12），但是防止水凝胶（12）逸出，从而促进人类椎间盘的天然生理学。通过将两个假肢脊椎椎间盘核体（10）并排植入人脊椎的损伤椎间盘（32）中，可以保持高度和运动。

5. 发明申请

WO1996011639A1 SPINAL ANULUS CUTTER 审中-公开
标题翻译：脊柱螺旋切割机
公开(公告)号：WO1996011639A1
公开(公告)日：1996-04-25
申请号：PCT/US1995013269
申请日：1995-10-17
申请人： RAYMEDICA, INC.
发明人： RAYMEDICA, INC. , RAY, Charles, D. , DICKHUDT, Eugene, A.
IPC分类号： A61B17/32
CPC分类号： A61B17/320016 , A61B17/1604 , A61B17/1671 , A61B17/32053 , A61B2017/00261
摘要： A spinal anulus cutter for cutting (10) a multisided flap (64) in an encapsulating ligament, such as an anulus (58) of a human intervertebral disc, to provide access to an interior space or material surrounded by the ligament. The spinal anulus cutter (10) is characterized by a knife blade (14) comprised of a plurality of walls which are connected together to define a closed side (36) and an open side (40). Further, a cutting edge (24) is formed at the forward edge of the walls (34) which is configured to cut the multisided flap (64) in the ligament when an axial force is transmitted to the knife blade (14) in a direction towards the cutting edge (24). The flap will conform in shape and size to the form of the knife blade (14), whereby the open side of the knife blade (14) will not cut the ligamentary tissue.
摘要翻译：一种用于在诸如人椎间盘的环（58）的包封韧带中切割（10）多瓣瓣（64）的脊椎环切刀，以提供对由所述韧带包围的内部空间或材料的通路。脊椎环切刀（10）的特征在于包括多个壁的刀片（14），所述多个壁连接在一起以限定封闭侧（36）和开口侧（40）。此外，在壁（34）的前边缘处形成切削刃（24），该切削刃被构造成当轴向力沿轴向方向（14）传递到刀片（14）时，在该韧带中切割多边翼片（64）朝向切削刃（24）。翼片的形状和尺寸将符合刀片（14）的形状，由此刀片（14）的开口侧不会切割韧带组织。

6. 发明申请

WO2004047690A2 PROSTHETIC SPINAL DISC NUCLEUS WITH ELEVATED SWELLING RATE 审中-公开
标题翻译：假性脊柱盘核具有升高的膨胀率
公开(公告)号：WO2004047690A2
公开(公告)日：2004-06-10
申请号：PCT/US2003/037870
申请日：2003-11-25
申请人： RAYMEDICA, INC. , SHERMAN, Tara, Nicole , NORTON, Britt, Keenan , BAIN, Allison, C.
发明人： SHERMAN, Tara, Nicole , NORTON, Britt, Keenan , BAIN, Allison, C.
IPC分类号： A61F2/44
CPC分类号： A61L27/52 , A61F2/3094 , A61F2/441 , A61F2002/444 , A61F2002/4495 , A61L2430/38
摘要： A method of manufacturing a prosthetic spinal disc nucleus. The including forming a hydrogel core from a hydrogel material in a natural state. The hydrogel material in the natural state is characterized by a natural swelling rate. The hydrogel is treated in an alkaline solution having a pH of at least about 8. This treatment transitions the hydrogel core from the natural state to a treated state characterized by an elevated swelling rate. The elevated swelling rate is greater that the natural swelling rate. The resultant, treated hydrogel core forms at least a portion of a prosthetic spinal disc nucleus that is otherwise sized for insertion into a spinal disc nucleus cavity. In one particular embodiment, the hydrogel core is inserted into a constraining jacket. Another aspect of the present invention relates to a prosthetic spinal disc nucleus including a hydrogel core having the elevated swelling rate.
摘要翻译：制造假体脊椎椎间盘髓核的方法
包括由天然状态下的水凝胶材料形成水凝胶芯。天然状态下的水凝胶材料的特征在于自然膨胀率。该水凝胶在具有至少约8的pH的碱性溶液中处理。该处理将水凝胶芯从天然状态转变为特征在于升高的溶胀速率的处理状态。升高的肿胀率大于自然肿胀率。所得到的经处理的水凝胶芯形成至少一部分的假体脊椎盘核，所述脊椎盘髓核的尺寸被设定为插入脊椎盘髓核腔中。在一个特定实施例中，水凝胶芯被插入约束护套中。本发明的另一方面涉及包括具有升高的溶胀率的水凝胶芯的假体脊椎盘核。

7. 发明申请

WO2004047690A8 PROSTHETIC SPINAL DISC NUCLEUS WITH ELEVATED SWELLING RATE 审中-公开
标题翻译：具有高度裂解率的前列腺脊髓核
公开(公告)号：WO2004047690A8
公开(公告)日：2004-10-21
申请号：PCT/US0337870
申请日：2003-11-25
申请人： RAYMEDICA INC , SHERMAN TARA NICOLE , NORTON BRITT KEENAN , BAIN ALLISON C
发明人： SHERMAN TARA NICOLE , NORTON BRITT KEENAN , BAIN ALLISON C
IPC分类号： A61F2/30 , A61F2/44 , A61L27/52
CPC分类号： A61L27/52 , A61F2/3094 , A61F2/441 , A61F2002/444 , A61F2002/4495 , A61L2430/38
摘要： A method of manufacturing a prosthetic spinal disc nucleus. The method including forming a hydrogel core from a hydrogel material in a natural state. The hydrogel material in the natural state is characterized by a natural swelling rate. The hydrogel is treated in an alkaline solution having a pH of at least about 8. This treatment transitions the hydrogel core from the natural state to a treated state characterized by an elevated swelling rate. The elevated swelling rate is greater that the natural swelling rate. The resultant, treated hydrogel core forms at least a portion of a prosthetic spinal disc nucleus. In one particular embodiment, the hydrogel core is inserted into a constraining jacket. Another aspect of the present invention relates to a prosthetic spinal disc nucleus including a hydrogel core having the elevated swelling rate.
摘要翻译：制造假肢脊椎椎间盘核的方法。该方法包括从天然状态的水凝胶材料形成水凝胶核心。天然状态的水凝胶材料的特征在于天然膨胀率。该水凝胶在pH为至少约8的碱性溶液中处理。该处理将水凝胶芯从天然状态转变为以膨胀率升高为特征的处理状态。升高的溶胀率大于自然膨胀率。所得到的经处理的水凝胶芯形成假肢脊椎椎间盘核的至少一部分。在一个具体实施方案中，将水凝胶核心插入约束套管中。本发明的另一方面涉及一种假体脊椎椎间盘核，其包括具有升高的溶胀速率的水凝胶核。

8. 发明申请

WO0193784A8 PACKAGED, PARTIALLY HYDRATED PROSTHETIC DISC NUCLEUS 审中-公开
标题翻译：包装，部分水化的人造椎间盘核
公开(公告)号：WO0193784A8
公开(公告)日：2002-06-06
申请号：PCT/US0117468
申请日：2001-05-29
申请人： RAYMEDICA INC
发明人： NORTON BRITT , SHERMAN TARA , BAUER LAURA
IPC分类号： A61F2/00 , A61F2/30 , A61F2/44 , A61L27/52
CPC分类号： A61L27/52 , A61F2/0095 , A61F2/3094 , A61F2/30965 , A61F2/441 , A61F2002/30014 , A61F2002/30016 , A61F2002/30075 , A61F2002/30092 , A61F2002/30281 , A61F2002/30326 , A61F2002/30914 , A61F2002/444 , A61F2002/4495 , A61F2210/0014 , A61F2210/0061 , A61F2230/0086 , A61F2240/001 , A61F2250/0018 , A61F2250/0019 , A61F2250/0037 , A61L2430/38
摘要： A packaged prosthetic disc nucleus (20) including a prosthetic disc nucleus (22) and a retainer (24). The prosthetic disc nucleus (22) includes a hydrogel core (26) formed to hydrate from a dehydrated state. Further, the prosthetic disc nucleus (22) is configured to such that following implantation into a nucleus cavity, the hydrogel core (26) hydrates to a final hydrated state. The retainer (24) selectively contains the prosthetic disc nucleus (22). Further, upon contact with a hydration liquid, the retainer (24) is configured to allow the hydrogel core (26) to hydrate from the dehydrated state while preventing the hydrogel core (26) from hydrating to the final hydrated state. Thus, the prosthetic disc nucleus (22) is constrained by the retainer (24) in a partially hydrated state. In one preferred embodiment, the combination prosthetic disc nucleus/retainer is sealed within an outer enclosure, such as a pouch, that also contains a hydration liquid for hyrating the hyrogel core. During use, the prosthetic disc nucleus is removed from the retainer and implanted in the partially hydrated state.
摘要翻译：包括人工椎间盘髓核（22）和保持器（24）的包装的人工椎间盘髓核（20）。假体盘核（22）包括形成为从脱水状态水合的水凝胶芯（26）。此外，假体盘核（22）被构造成使得在植入核腔后，水凝胶芯（26）水合成最终的水合状态。保持器（24）选择性地容纳假体盘核（22）。此外，在与水合液接触时，保持器（24）构造成允许水凝胶芯（26）从脱水状态水合，同时防止水凝胶芯（26）水合成最终水合状态。因此，假体盘核（22）被保持器（24）约束为部分水合状态。在一个优选实施方案中，组合人工椎间盘髓核/保持器被密封在外壳（例如小袋）内，所述外壳也含有用于对hyrogel芯进行处理的水合液。在使用期间，人造椎间盘髓核从保持器中移除并植入部分水合状态。

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