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1. 发明申请

WO2012057529A2 METHOD FOR PURIFYING HUMAN GRANULOCYTE-COLONY STIMULATING FACTOR FROM RECOMBINANT E. COLI 审中-公开
标题翻译：从重组大肠杆菌纯化人颗粒细胞 - 集落刺激因子的方法
公开(公告)号：WO2012057529A2
公开(公告)日：2012-05-03
申请号：PCT/KR2011008046
申请日：2011-10-26
申请人： HANMI HOLDINGS CO LTD , CHOI SUNG CHUL , KIM JIN KI , OH YOUNG HAK , LEE JONG SOO
发明人： CHOI SUNG CHUL , KIM JIN KI , OH YOUNG HAK , LEE JONG SOO
IPC分类号： C07K14/53 , C07K1/16 , C12N15/27 , C12N15/70
CPC分类号： C07K1/36 , C07K14/535
摘要： The present invention provides a method for purifying a large amount of human granulocyte-colony stimulating factors (hG-CSFs) from a recombinant E. coli with high yield and purity. According to the method of the present invention, human granulocyte-colony stimulating factor, identical to the native form expressed in the human body, can be easily purified with high yield and purity without an additional activation process. In particular, according to the purification method of the present invention, hG-CSF variants expressed in E. coli are efficiently removed to obtain physiologically active hG-CSFs with high purity.
摘要翻译：本发明提供了从重组大肠杆菌以高产率和高纯度纯化大量人粒细胞集落刺激因子（hG-CSF）的方法。根据本发明的方法，与人体中表达的天然形式相同的人粒细胞集落刺激因子可以容易地以高收率和纯度纯化而无需额外的活化过程。具体而言，根据本发明的纯化方法，在大肠杆菌中表达的hG-CSF变体被有效地去除以获得高纯度的生理活性hG-CSF。

2. 发明申请

WO2012057525A2 LIQUID FORMULATIONS OF LONG ACTING INTERFERON ALPHA CONJUGATE 审中-公开
标题翻译：长效干扰素ALPHA联合液的液体制剂
公开(公告)号：WO2012057525A2
公开(公告)日：2012-05-03
申请号：PCT/KR2011/008038
申请日：2011-10-26
申请人： HANMI HOLDINGS CO., LTD. , IM, Dae Seong , LEE, Jae Min , LEE, Jong Soo , BAE, Sung Min , KWON, Se Chang
发明人： IM, Dae Seong , LEE, Jae Min , LEE, Jong Soo , BAE, Sung Min , KWON, Se Chang
IPC分类号： A61K9/08 , A61K47/36 , A61K38/21 , A61P31/12
CPC分类号： A61K47/48415 , A61K9/0019 , A61K38/212 , A61K47/26 , A61K47/68 , A61K47/6813 , C07K14/56 , C07K16/46 , C07K2319/30
摘要： Disclosed is a liquid formulation in which a long-acting INFα conjugate that has improved in vivo duration and stability can be stored stably for a long period of time. It comprises a stabilizer comprising a buffer, a sugar alcohol, a non-ionic surfactant and an isotonic agent. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting INFα conjugates.
摘要翻译：公开了一种液体制剂，其中可长期稳定地存储具有改善的体内持续时间和稳定性的长效INFa缀合物。它包括稳定剂，其包含缓冲剂，糖醇，非离子表面活性剂和等渗剂。没有人体血清白蛋白和其他对身体有害的潜在因素，液体制剂没有对病毒感染的担忧，并保证了对长效INFa共轭物的极好的储存稳定性。

3. 发明申请

WO2012002663A2 HIGH-SPEED SEALIFT SYSTEM 审中-公开
标题翻译：高速密封系统
公开(公告)号：WO2012002663A2
公开(公告)日：2012-01-05
申请号：PCT/KR2011004465
申请日：2011-06-20
申请人： LEE JONG SOO
发明人： LEE JONG SOO
IPC分类号： B63B35/00 , B60F3/00 , B63B1/18 , B63H19/00
CPC分类号： B63H19/00 , B60F3/00 , B60F3/0061 , B63B1/16 , B63B35/00
摘要： The present invention relates to a high-speed sealift system which meets the requirement of the 21st century. In the 21st century, the indispensable requisites for a commercial sealift system that is to be deployed across the five oceans are high speed and stability. The present invention relates to a high-speed sealift system which operates at the super-high speed of 40 knots to 70 knots, and which is capable of the marine transport, in a quick and safe manner, of perishable goods, expensive capital goods, goods the volume or weight of which result in them being incapable of being transported via the air, strategic military goods, and capable of the large-scale redeployment of forces, and particularly, parts or equipment and materials which require a timely arrival. The sealift system of the present invention operates by means a marine transportation principle in which elevation force, found from Newton's law of physics that indicates that "the change of momentum of a body is proportional to the impulse impressed on the body," is applied to tires. When a planning gear of the high-speed sealift system is lowered to enable tires to contact water at a speed higher than a predetermined threshold speed, the elevation force corresponding to the distribution weight of the system is generated at the contact surfaces of the tires, such that the system travels on the water at the travel speed of the tires. That is, the transportation effects of the system are the same as those achieved when a vehicle travels at a high speed on a highway with the tires thereof on the ground. According to one embodiment of the present invention, in which a 2000 ton high-speed sealift system is designed in accordance with the marine transportation principle of the present invention, the system is propelled by two 55,000 horsepower water-jet pumps when traveling at a maximum high speed of 65 knots, while a total of 80 tires including 16 front tires and 64 rear tires support the weight of the system on the water at a speed of 5 knots or higher by planning components.
摘要翻译：本发明涉及一种满足21世纪要求的高速密封系统。在二十一世纪，要在五个海洋中部署的商业密封系统的不可或缺的必要条件是高速稳定。本发明涉及一种以40节至70节的超高速运转的高速密封系统，能够快速，安全地运输易腐货物，昂贵的资本品，货物的数量或重量使其无法通过空运，战略军事物品运输，并能够大规模重新部署部队，特别是需要及时到达的部件或设备和材料。本发明的密封系统通过海洋运输原理运行，其中由牛顿的物理学定律发现的提升力表示“身体动量的变化与冲击身体的冲动成比例”，被应用于轮胎。当降低高速密封系统的规划装置以使轮胎以高于预定阈值速度的方式接触水时，在轮胎的接触表面处产生与系统的分配重量相对应的升力，使得系统以轮胎的行进速度在水上行进。也就是说，该系统的运输效果与当车辆在地面上的高速公路上高速行驶时实现的运输效果相同。根据本发明的一个实施例，其中根据本发明的海洋运输原理设计了2000吨高速密封装置系统，当最大行驶时，该系统由两台55,000马力的喷水泵推动高速65节，而共有80个轮胎，包括16个前轮胎和64个后轮胎，通过规划部件以5节或以上的速度支持系统在水面上的重量。

4. 发明申请

WO2010124212A3 MATERIALS AND METHODS FOR THE PREPARATION OF NANOCOMPOSITES 审中-公开
标题翻译：制备纳米复合材料的材料和方法
公开(公告)号：WO2010124212A3
公开(公告)日：2011-03-10
申请号：PCT/US2010032246
申请日：2010-04-23
申请人： UNIV CHICAGO , TALAPIN DMITRI V , KOVALENKO MAKSYM V , LEE JONG-SOO , JIANG CHENGYANG
发明人： TALAPIN DMITRI V , KOVALENKO MAKSYM V , LEE JONG-SOO , JIANG CHENGYANG
IPC分类号： G02B6/00
CPC分类号： H01L35/16 , B82Y30/00 , B82Y40/00 , C01B19/002 , C01B19/007 , C01P2002/52 , C01P2002/72 , C01P2002/84 , C01P2002/85 , C01P2004/03 , C01P2004/04 , C01P2004/16 , C09D1/00 , C09D5/22 , C09D5/24 , C09K11/025 , C09K11/562 , C09K11/565 , C09K11/883 , C30B7/00 , C30B29/40 , C30B29/46 , C30B29/60 , H01B1/06 , H01B1/10
摘要： Disclosed herein is an isolable colloidal particle comprising a nanoparticle and an inorganic capping agent bound to the surface of the nanoparticle, a solution of the same, a method for making the same from a biphasic solvent mixture, and the formation of structures and solids from the isolable colloidal particle. The process can yield photovoltaic cells, piezoelectric crystals, thermoelectric layers, optoelectronic layers, light emitting diodes, ferroelectric layers, thin film transistors, floating gate memory devices, imaging devices, phase change layers, and sensor devices.
摘要翻译：本文公开了一种可分离的胶体颗粒，其包含与纳米颗粒的表面结合的纳米颗粒和无机封端剂，其溶液，从双相溶剂混合物制备该纳米颗粒的方法，以及从可分离胶体颗粒。该方法可以产生光伏电池，压电晶体，热电层，光电子层，发光二极管，铁电层，薄膜晶体管，浮动栅极存储器件，成像器件，相变层和传感器器件。

5. 发明申请

WO2010082804A3 METHOD FOR PRODUCING PHYSIOLOGICALLY ACTIVE PROTEIN OR PEPTIDE USING IMMUNOGLOBULIN FRAGMENT 审中-公开
标题翻译：使用免疫球蛋白片段生产生理活性蛋白或肽的方法
公开(公告)号：WO2010082804A3
公开(公告)日：2010-11-25
申请号：PCT/KR2010000342
申请日：2010-01-19
申请人： HANMI HOLDINGS CO LTD , KIM JIN-SUN , JUNG SUNG YOUB , LEE JONG-SOO , LEE BYUNG SUN , KWON SE CHANG , LEE GWAN SUN
发明人： KIM JIN-SUN , JUNG SUNG YOUB , LEE JONG-SOO , LEE BYUNG SUN , KWON SE CHANG , LEE GWAN SUN
IPC分类号： C12N15/62 , C07K19/00 , C12N15/09 , C12N15/52
CPC分类号： C07K14/00 , C07K2319/30
摘要： The present invention provides a method for mass-producing a physiologically active protein or peptide using a fusion protein composed of the physiologically active protein or peptide and an immunoglobulin fragment. The present invention also provides such a fusion protein, a DNA encoding the fusion protein, an expression vector comprising the DNA, and a microorganism transformed with the expression vector.
摘要翻译：本发明提供使用由生理活性蛋白质或肽组成的融合蛋白质和免疫球蛋白片段大规模生产生理活性蛋白质或肽的方法。本发明还提供了这样的融合蛋白，编码融合蛋白的DNA，包含DNA的表达载体和用表达载体转化的微生物。

6. 发明申请

WO2007083893A1 CELL SURFACE EXPRESSION VECTOR OF WHITE SPOT SYNDROME VIRUS ANTIGEN AND MICROORGANISM TRANSFORMED WITH THE SAME 审中-公开
标题翻译：白点病毒抗原和微生物转化的细胞表面表达载体
公开(公告)号：WO2007083893A1
公开(公告)日：2007-07-26
申请号：PCT/KR2006/005686
申请日：2006-12-22
申请人： BIOLEADERS CORPORATION , SUNG, Moon Hee , KIM, Chul Joong , HONG, Seung Pyo , LEE, Jong-Soo , KIM, Jong-Taik
发明人： SUNG, Moon Hee , KIM, Chul Joong , HONG, Seung Pyo , LEE, Jong-Soo , KIM, Jong-Taik
IPC分类号： C12N15/64 , C12N15/74 , C12N15/70
CPC分类号： C12N15/74 , A61K39/12 , A61K2039/523 , A61K2039/542 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N15/70 , C12N2710/18022 , C12N2710/18034
摘要： The present invention relates to a surface expression vector of an antigen of shrimp white spot syndrome virus (WSSV) and a microorganism transformed with the vector. More particularly, the present invention relates to a surface expression vector comprising a gene encoding an antigen of shrimp WSSV and a gene encoding a poly-gamma-glutamate synthetase complex, a bacterium transformed with the vector, and a vaccine for treating or preventing disease caused by shrimp WSSV and a feedstuff additive, which contain a bacterium having the shrimp WSSV antigen expressed on the surface thereof or a crude extracted antigen from the bacterium as an effective ingredient. The inventive bacterium having the shrimp WSSV antigen expressed on the surface thereof or a crude extracted antigen of shrimp WSSV from the bacterium can be used as a vaccine or a feedstuff additive to prevent and treat viral disease caused by shrimp WSSV, thus it contributes to avoiding mass death of crustaceans caused by shrimp WSSV as well as increasing profits in fish farming and fisheries.
摘要翻译：本发明涉及虾白点综合征病毒（WSSV）的抗原表面表达载体和用载体转化的微生物。更具体地，本发明涉及包含编码虾WSSV的抗原的基因和编码聚-γ-谷氨酸合成酶复合物的基因，用载体转化的细菌和用于治疗或预防疾病的疫苗的表面表达载体通过虾WSSV和饲料添加剂，其含有在其表面上表达的虾WSSV抗原的细菌或来自细菌的粗提取抗原作为有效成分。具有表面的虾WSSV抗原的本发明细菌或来自细菌的虾WSSV的粗提取抗原可以用作疫苗或饲料添加剂，以预防和治疗由虾WSSV引起的病毒性疾病，因此有助于避免由虾虾WSSV造成的甲壳类动物大规模死亡，并增加了养鱼业和渔业的利润。

7. 发明申请

WO2006090968A1 COMPOSITION FOR ADJUVANT CONTAINING POLY-GAMMA-GLUTAMIC ACID 审中-公开
标题翻译：用于含有聚氨基酸谷氨酸的混合物的组合物
公开(公告)号：WO2006090968A1
公开(公告)日：2006-08-31
申请号：PCT/KR2005/004160
申请日：2005-12-06
申请人： BIOLEADERS CORPORATION , M.D. LAB CO. LTD. , KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , SUNG, Moon Hee , KIM, Chul Joong , POO, Ha Ryoung , HONG, Seung Pyo , LEE, Jong Soo , KIM, Ji Youn
发明人： SUNG, Moon Hee , KIM, Chul Joong , POO, Ha Ryoung , HONG, Seung Pyo , LEE, Jong Soo , KIM, Ji Youn
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K2039/55516
摘要： The present invention relates to a composition for an immunopotentiator(adjuvant) containing poly-gamma-glutamic acid and a composition for a vaccine containing the immunopotentiator, and more particularly, to an immunopotentiator containing poly-gamma-glutamic acid capable of enhancing antibody production rate by administering it to an animal together with antigen having low immunogenicity, and a composition for a vaccine containing the immunopotentiator and antigen. The inventive adjuvant has almost no toxicity and side effects, and show high antibody titer even when it is used with antigen having poor immunogenicity, so it can be used by adding to medical composition including preventive or curative vaccine for non-contagious chronic diseases as well as cancer, especially prostatic carcinoma, colon carcinoma, lung cancer, breast cancer, ovarian cancer, head and neck cancer, pudendum cancer, bladder cancer, brain tumor and glioma.
摘要翻译：本发明涉及含有聚-γ-谷氨酸的免疫增强剂（佐剂）组合物和含有免疫增强剂的疫苗组合物，更具体地说，涉及含有能够提高抗体产生率的聚-γ-谷氨酸的免疫增强剂通过将其与抗免疫原性低的抗原一起施用于动物，以及含有免疫增强剂和抗原的疫苗组合物。本发明的佐剂几乎没有毒性和副作用，即使与抗免疫原性差的抗原一起使用也显示高抗体滴度，因此可以通过向非传染性慢性疾病中加入包括预防或治疗性疫苗的医药组合物作为癌症，特别是前列腺癌，结肠癌，肺癌，乳腺癌，卵巢癌，头颈癌，pudendum癌，膀胱癌，脑肿瘤和胶质瘤。

8. 发明申请

WO2004035795A1 VECTOR FOR ANTI-HPV VACCINE AND TRANSFORMED MICROORGANISM BY THE VECTOR 审中-公开
标题翻译：抗病毒药物疫苗和转基因微生物的载体
公开(公告)号：WO2004035795A1
公开(公告)日：2004-04-29
申请号：PCT/KR2003/002163
申请日：2003-10-17
申请人： BIOLEADERS CORPORATION , KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , SUNG, Moon-Hee , POO, Ha-Ryoung , LEE, Jong-Soo , JUNG, Chang-Min , HONG, Seung-Pyo , KIM, Chul-Joong , PARK, Sue-nie , PYO, Hyun-mi
发明人： SUNG, Moon-Hee , POO, Ha-Ryoung , LEE, Jong-Soo , JUNG, Chang-Min , HONG, Seung-Pyo , KIM, Chul-Joong , PARK, Sue-nie , PYO, Hyun-mi
IPC分类号： C12N15/63
CPC分类号： C07K14/005 , A61K39/0011 , A61K2039/523 , C12N7/00 , C12N2710/20022 , C12N2730/10122 , C12N2830/008
摘要： The current invention relates to expression vectors that can efficiently produce virion capsid protein, tumor-associated protein of human papillomavirus on a microbial surface and bacterial strains harboring such surface display vectors and the use of the bacterial strains or it's extract, purified products as complex vaccines. More particularly, the present invention relates to surface display vectors contains one or more than two genes selected among pgsB, pgsC and pgsA, encoding a poly- -glutamic acid synthetase complex (pgsBCA) of a Bacillus sp. Strain and genes which encode virion capsid proteins, tumor-associated proteins of human papillomavirus, and method for preparing the same.
摘要翻译：本发明涉及可以有效地产生病毒体衣壳蛋白，人乳头瘤病毒的肿瘤相关蛋白在微生物表面上的表达载体和含有这种表面显示载体的细菌菌株以及使用细菌菌株或其提取物，纯化产物作为复合疫苗。更具体地，本发明涉及含有一个或多于两个选自pgsB，pgsC和pgsA的基因的表面显示载体，其编码芽孢杆菌属的多聚谷氨酸合成酶复合物（pgsBCA）。编码病毒载体衣壳蛋白，人乳头瘤病毒的肿瘤相关蛋白的菌株和基因及其制备方法。

9. 发明申请

WO2020027915A1 DEICING AND SNOW MELTING COMPOSITIONS AND METHODS OF USE 审中-公开
公开(公告)号：WO2020027915A1
公开(公告)日：2020-02-06
申请号：PCT/US2019/035514
申请日：2019-06-05
申请人： LEE, Jong Soo
发明人： LEE, Jong Soo
IPC分类号： E01H10/00 , C09K3/18 , B65D65/46 , B65D73/00 , B65D75/42 , C08J7/00 , C11D17/00
摘要： A composition and method for safely and easily melting snow and ice is disclosed. The composition includes a pellet comprising an active ingredient; and a base comprising a water-soluble film-forming material, the pellet being attached to the base.

10. 发明申请

WO2011025322A3 EXERCISE PRESCRIPTION SYSTEM 审中-公开
标题翻译：锻炼处方系统
公开(公告)号：WO2011025322A3
公开(公告)日：2011-09-15
申请号：PCT/KR2010005818
申请日：2010-08-27
申请人： NUGA MEDICAL CO LTD , KIM HONG JAE , KIM TAE KYUN , YOON UK JIN , CHO SYUNG HYUN , JEONG IN CHEOL , LEE JONG SOO , YI KYE HYOUNG
发明人： KIM HONG JAE , KIM TAE KYUN , YOON UK JIN , CHO SYUNG HYUN , JEONG IN CHEOL , LEE JONG SOO , YI KYE HYOUNG
IPC分类号： G06Q50/00
CPC分类号： G07F17/04 , A63B22/02 , A63B22/0605 , A63B22/0664 , A63B24/0062 , A63B24/0075 , A63B24/0087 , A63B2024/0065 , A63B2024/0068 , A63B2024/0093 , A63B2230/04 , A63B2230/06 , A63B2230/30 , A63B2230/40 , A63B2230/42 , A63B2230/436 , A63B2230/50 , G06F19/3481 , G07F17/0014 , G07F17/18
摘要： The present invention relates to an exercise prescription system which comprises an exercise machine management server, a plurality of exercise machine terminals, and a plurality of user terminals, and which is suitable for exercise facilities such as a fitness center. More particularly, the present invention relates to an exercise prescription system in which each of the exercise machine terminals indiscernibly and automatically detects a current user of a relevant exercise machine, reads exercise history information of the user from the exercise machine management server, measures the physical fitness and the like of the user during exercise through the user terminal or the like, determines a tailor-made exercise prescription suitable for the user, formulated and quantified by the thus-obtained basic personal information, physical fitness information, and maximum oxygen consumption (hereinafter, referred to as VO2Max), and provides feedback to the user through each exercise machine terminal on a real-time basis. The exercise prescription system of the present invention comprises said user terminals, each of which has a slave module worn on the chest of the user via a chest belt to obtain an electrocardiograph, a photoplethysmograph (PPG), the activity, and a biological signal of the body temperature of the user; said exercise machine terminals, each of which determines an exercise prescription using the biological signal received from the user terminals, and the last exercise prescription data, basic personal information, and physical fitness information, and controls the exercise machines in accordance with the exercise prescription; and said exercise machine management server which stores basic personal information and physical fitness information, receives exercise prescription data of the user from the exercise machine terminals, stores the received data, and transmits the last exercise prescription data, basic personal information, and physical fitness information to the exercise machine terminals in accordance with the requests from the exercise machine terminals.
摘要翻译：运动处方系统技术领域本发明涉及一种运动处方系统，该运动处方系统包括运动器械管理服务器，多个运动器械终端和多个用户终端，并且适合于诸如健身中心之类的运动设施。更具体地说，本发明涉及一种运动处方系统，其中每个运动器终端不可识别地和自动地检测相关运动器械的当前使用者，从运动器械管理服务器读取使用者的运动历史信息，通过用户终端等进行的锻炼期间的用户的健身等，通过由此获得的基本个人信息，身体素质信息和最大氧气消耗量来确定适合于用户的量身定制的锻炼处方（以下称为VO2Max），并通过每个锻炼机终端实时向用户提供反馈。本发明的运动处方系统包括所述用户终端，每个用户终端具有经由胸带佩戴在用户胸部上的从模块，以获得心电图仪，光电容积描记器（PPG），活动性和生物信号使用者的体温; 所述运动器械终端使用从用户终端接收到的生物信号和最后的运动处方数据，基本个人信息和身体素质信息来确定运动处方，并且根据运动处方控制运动器械; 以及所述健身器管理服务器，其存储基本个人信息和身体健康信息，从健身器终端接收用户的运动处方数据，存储所接收的数据，并将最后的运动处方数据，基本个人信息和身体健康信息根据锻炼机终端的要求将锻炼机终端连接到锻炼机终端。

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