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1. 发明申请

WO2017115322A3 PARTIAL ENZYMATIC HYDROLYSIS OF TRIACYLGLYCEROLS 审中-公开
标题翻译：三酰甘油的部分酶水解
公开(公告)号：WO2017115322A3
公开(公告)日：2017-08-10
申请号：PCT/IB2016058086
申请日：2016-12-29
申请人： DSM IP ASSETS BV
发明人： MUGFORD PAUL , MUELLER MONIKA , SCHURMANN MARTIN
IPC分类号： C12P7/64 , C11B3/00 , C12N9/20
CPC分类号： C12N9/20 , C11C1/045 , C12P7/6472
摘要： Disclosed herein are host cells expressing a polypeptide, wherein the polypeptide hydrolyzes an ester linkage of a triacylglycerol in an oil comprising at least one long-chain polyunsaturated fatty acid, methods for using such host cells, and processes for production of a lipase using such host cells.
摘要翻译：本文公开了表达多肽的宿主细胞，其中所述多肽水解包含至少一种长链多不饱和脂肪酸的油中三酰甘油酯的酯键，使用此类宿主细胞的方法，以及使用该宿主生产脂肪酶的方法细胞。

2. 发明申请

WO2017060318A3 KAURENOIC ACID HYDROXYLASES 审中-公开
标题翻译： KAURENOIC ACID HYDROXYLESES
公开(公告)号：WO2017060318A3
公开(公告)日：2017-06-08
申请号：PCT/EP2016073818
申请日：2016-10-05
申请人： DSM IP ASSETS BV
发明人： VAN LEEUWEN JOHANNES GUSTAAF ERNST , ZWARTJENS PRISCILLA , BOER VIKTOR MARIUS
IPC分类号： C12N9/02
CPC分类号： C12N9/0073 , C12Y114/13079
摘要： The present invention relates a variant polypeptide having kaurenoic acid 13-hydroxylase activity, which variant polypeptide comprises an amino acid sequence which, when aligned with a kaurenoic acid 13-hydroxylase comprising the sequence set out in SEQ ID NO: 1, comprises at least one substitution of an amino acid residue corresponding to any of amino acids 72, 85, 108, 127, 129, 141, 172, 195, 196, 197, 199, 226, 236, 291, 302, 361 or 464, said positions being defined with reference to SEQ ID NO: 1 and wherein the variant has one or more modified properties as compared with a reference polypeptide having kaurenoic acid 13-hydroxylase activity. A variant polypeptide of the invention may be used in a recombinant host for the production of steviol or a steviol glycoside.
摘要翻译：本发明涉及具有kaurenoic酸13-羟化酶活性的变体多肽，所述变体多肽包含氨基酸序列，所述氨基酸序列在与包含SEQ ID NO：1中所示序列的海人酸13-羟化酶比对时包含至少一个取代对应于任何氨基酸72,85,108,127,129,141,172,195,196,197,199,226,236,291,302,361或464的氨基酸残基，所述位置被定义为参考SEQ ID NO：1，并且其中所述变体与具有kaurenoic acid 13-羟化酶活性的参考多肽相比具有一个或多个修饰的性质。本发明的变体多肽可以在重组宿主中用于生产甜菊醇或甜菊醇糖苷。

3. 发明申请

WO2017037304A3 AN ASSEMBLY SYSTEM FOR A EUKARYOTIC CELL 审中-公开
标题翻译：真核细胞组装系统
公开(公告)号：WO2017037304A3
公开(公告)日：2017-06-01
申请号：PCT/EP2016081240
申请日：2016-12-15
申请人： DSM IP ASSETS BV
发明人： ROUBOS JOHANNES ANDRIES , VERWAAL RENÉ , GIELESEN BIANCA ELISABETH MARIA , VONK BRENDA
IPC分类号： C12N15/10 , C12N15/113
CPC分类号： C12N15/102 , C12N15/111 , C12N2310/20 , C12Q2521/301
摘要： The present invention is based on the adavantageous use of single-stranded oligonucleotides in the in vivo (within a cell) assembly of double-stranded oligonucleotides into a single double-stranded nucleic acid construct. The present invention relates to the use of at least a first and a second single-stranded oligonucleotide in the assembly within a cell of at least two double-stranded nucleic acid molecules into a single double-stranded nucleic acid construct of pre-determined sequence, wherein the first and second single-stranded oligonucleotide are essentially complementary to each other.
摘要翻译：本发明基于单链寡核苷酸在双链寡核苷酸体内（在细胞内）装配成单个双链核酸构建体的有利应用。本发明涉及至少第一和第二单链寡核苷酸在细胞内在至少两个双链核酸分子的装配中用于预定序列的单个双链核酸构建体的用途，其中所述第一和第二单链寡核苷酸彼此基本互补。

4. 发明申请

WO2016110453A8 A CRISPR-CAS SYSTEM FOR A FILAMENTOUS FUNGAL HOST CELL 审中-公开
标题翻译：用于FILAMENTOUS FUNGAL HOST细胞的CRISPR-CAS系统
公开(公告)号：WO2016110453A8
公开(公告)日：2016-12-22
申请号：PCT/EP2016000029
申请日：2016-01-06
申请人： DSM IP ASSETS BV , UNIV GRONINGEN
发明人： MEIJRINK BERNARD , VERWAAL RENÉ , GIELESEN BIANCA ELISABETH MARIA , ROUBOS JOHANNES ANDRIES , NYGÅRD YVONNE IRENE , BOVENBERG ROELOF ARIJ LANS , DRIESSEN ARNOLD JACOB MATHIEU , POHL CARSTEN
IPC分类号： C12N15/90
CPC分类号： C12N15/902 , C12N15/102 , C12N15/111 , C12N15/905 , C12N2310/10 , C12N2310/20
摘要： The present invention relates to the field of molecular biology and cell biology. More specifically, the present invention relates to a CRISPR-CAS system for a filamentous fungal host cell.
摘要翻译：本发明涉及分子生物学和细胞生物学领域。更具体地，本发明涉及用于丝状真菌宿主细胞的CRISPR-CAS系统。

5. 发明申请

WO2016113637A3 LIGHTWEIGHT LAMINATES AND PLATE-CARRIER VESTS AND OTHER ARTICLES OF MANUFACTURE THEREFROM 审中-公开
标题翻译：轻量层压板和载板测试架及其他制造品
公开(公告)号：WO2016113637A3
公开(公告)日：2016-09-09
申请号：PCT/IB2016000568
申请日：2016-01-08
申请人： DSM IP ASSETS BV
发明人： DOWNS ROLAND JOSEPH , ADAMS CHRISTOPHER MICHAEL , MCDANIELS KEITH JOEL
IPC分类号： B32B5/08 , B32B5/12 , B32B27/32
CPC分类号： B32B5/08 , B32B5/024 , B32B5/12 , B32B27/32 , B32B27/34 , B32B2255/02 , B32B2255/26 , B32B2262/0253 , B32B2323/043 , B32B2571/02 , F41H1/02 , F41H5/0478
摘要： A lightweight laminate comprises: (a) a first outer layer; (b) at least one internal reinforcing layer; (c) optionally, one or more intervening film layers; and (d) a second outer layer, wherein the at least one internal reinforcing layer is disposed between first and second outer layers, and wherein the second outer layer is saturated, partially saturated and coated, or partially coated with a wet-out resin. Reinforcing layers can comprise unitape further comprising parallel monofilaments embedded in resin. An article of manufacture, such as MOLLE, a plate-carrier, or other military, law enforcement, or recreational apparel or gear comprises the lightweight laminate.
摘要翻译：轻质层压材料包括：（a）第一外层; （b）至少一个内部增强层; （c）任选地，一个或多个中间膜层; 和（d）第二外层，其中所述至少一个内增强层设置在第一外层和第二外层之间，并且其中所述第二外层是饱和的，部分饱和的并涂覆或部分涂覆有浸润树脂。增强层可以包括进一步包含嵌入树脂中的平行单丝的单节段。诸如MOLLE，板载体或其他军事，执法或休闲服饰或装备的制造品包括轻质层压板。

6. 发明申请

WO2016062579A8 PROCESS FOR PREPARING A POLYAMIDE, A NYLON SALT TO BE USED THEREIN AND A PROCESS FOR MAKING THE SALT 审中-公开
标题翻译：制备聚酰胺，要使用的尼龙盐和制备盐的方法
公开(公告)号：WO2016062579A8
公开(公告)日：2016-08-25
申请号：PCT/EP2015073639
申请日：2015-07-29
申请人： DSM IP ASSETS BV
发明人： LAARHOVEN VAN BAS , STOELWINDER CHRISTIAAN JOHANNES CORNELIS , HELMSING MARK
IPC分类号： C08G69/26 , C08G69/28 , C08G69/30
CPC分类号： C08G69/30 , B01J2/04 , C07C51/412 , C07C209/68 , C08G69/26 , C08G69/265 , C08G69/28 , C08J3/12 , C08J2377/06
摘要： The present invention relates to a process for preparing a polyamide, a polyamide material obtainable by the said process, a nylon salt to be used therein, and a process for making the nylon salt. The process for preparing the polyamide is a direct solid state polymerization process. The salt used herein is a granulate material, prepared by a process, comprising spraying an aqueous solution comprising a diamine and a dicarboxylic acid dissolved in an aqueous medium, or an aqueous slurry comprising a diammonium dicarboxylate salt dispersed in an aqueous medium directly obtained from such an aqueous solution, onto or in a fluidized bed of diammonium dicarboxylate salt particles, while evaporating the aqueous medium, thereby forming a granulate salt material.
摘要翻译：本发明涉及一种制备聚酰胺的方法，通过所述方法得到的聚酰胺材料，其中使用的尼龙盐以及制备尼龙盐的方法。制备聚酰胺的方法是直接固态聚合方法。本文使用的盐是通过一种方法制备的颗粒材料，其包括喷雾包含溶解在水性介质中的二胺和二羧酸的水溶液，或包含分散在直接从其获得的水性介质中的二羧酸二铵盐的水性浆料水溶液，在二羧酸二铵盐颗粒的流化床上或其中，同时蒸发水性介质，从而形成颗粒盐材料。

7. 发明申请

WO2015185592A3 PROLINE-SPECIFIC ENDOPROTEASE AND USE THEREOF 审中-公开
标题翻译：特异性内切酶及其用途
公开(公告)号：WO2015185592A3
公开(公告)日：2016-02-11
申请号：PCT/EP2015062327
申请日：2015-06-03
申请人： DSM IP ASSETS BV
发明人： LAAN VAN DER JAN METSKE , VONDERVOORT VAN DE PETER JOZEF IDA , CHRISTIS CHANTAL , SPAANS MARTINE , BRUINE-PAULUS DE ANGELA
IPC分类号： C12N9/62
CPC分类号： C12N9/62 , C12C11/00 , C12Y304/21026
摘要： The present invention relates to a polypeptide having proline-specific endoprotease activity, wherein the polypeptide has less than 70% residual activity when the polypeptide has been kept at a temperature of 65°C for 15 min. The invention further relates to a polypeptide having proline-specific endoprotease activity comprising an amino acid sequence according to SEQ ID NO: 1, wherein SEQ ID NO: 1 comprises at least one amino acid substitution selected from the group consisting of M144L, S398F, V460A, I204F, Y205N, F279S, F263Y, P377A, L470P, and P477A, a nucleic acid encoding a polypeptide having proline-specific endoprotease activity, a method of making a variant polypeptide having proline-specific endoprotease activity, a recombinant host cell and a method of producing the polypeptide and a process for the preparation of a food or feed product wherein the polypeptide is used.
摘要翻译：本发明涉及具有脯氨酸特异性内切蛋白酶活性的多肽，其中当多肽已经在65℃的温度下保持15分钟时，多肽具有小于70％的残留活性。本发明还涉及具有脯氨酸特异性内切蛋白酶活性的多肽，其包含根据SEQ ID NO：1的氨基酸序列，其中SEQ ID NO：1包含至少一个选自M144L，S398F，V460A的氨基酸取代，I204F，Y205N，F279S，F263Y，P377A，L470P和P477A，编码具有脯氨酸特异性内切蛋白酶活性的多肽的核酸，制备具有脯氨酸特异性内切蛋白酶活性的变体多肽的方法，重组宿主细胞和方法以及制备其中使用多肽的食品或饲料产品的方法。

8. 发明申请

WO2015163945A8 DEVELOPMENT OF MOLECULAR BIOLOGY TOOLS FOR BASIDIOMYCETE 'RED' YEAST, SPORIDIOBOLUS PARAROSEUS ENGINEERING 审中-公开
标题翻译：基因工程“红”，分枝杆菌共生植物分子生物工程的开发
公开(公告)号：WO2015163945A8
公开(公告)日：2015-12-23
申请号：PCT/US2014071165
申请日：2014-12-18
申请人： DSM IP ASSETS BV , APT KIRK , BURJA ADAM , HANSEN JON , SIMPSON DAVID , ZIRKLE ROSS
发明人： APT KIRK , BURJA ADAM , HANSEN JON , SIMPSON DAVID , ZIRKLE ROSS
IPC分类号： C12N1/02 , C12N1/16 , C12N15/64 , C12N15/81 , C12P7/64
CPC分类号： C12N15/815 , C12N15/04 , C12P7/64 , C12P21/02
摘要： A molecular biology toolkit including tools, systems, methods, and protocols for the metabolic engineering of Urediniomycetes, specifically Sporidiobolus pararoseus. These molecular biology tools inchides extraction of genetic material such as RNA, DNA, and protein; transformation including chromosomal integration, gene targeting, and homologous recombination; and expression of both homologous and heterologous genes.
摘要翻译：分子生物学工具包，包括Urediniomycetes，特别是Sporidiobolus pararoseus的代谢工程的工具，系统，方法和方案。这些分子生物学工具可以提取遗传物质，如RNA，DNA和蛋白质; 转化包括染色体整合，基因靶向和同源重组; 和同源基因和异源基因的表达。

9. 发明申请

WO2015116781A3 PROMOTERS SUITABLE FOR HETEROLOGOUS GENE EXPRESSION IN YEAST 审中-公开
标题翻译：适用于酵母异源基因表达的启动子
公开(公告)号：WO2015116781A3
公开(公告)日：2015-11-19
申请号：PCT/US2015013453
申请日：2015-01-29
申请人： DSM IP ASSETS BV , MC GRATH JESSICA LEIGH , CHEVREUX BASTIEN , YORGEY PETER SCOTT
发明人： MC GRATH JESSICA LEIGH , CHEVREUX BASTIEN , YORGEY PETER SCOTT
IPC分类号： C12N15/64 , C12N15/81
CPC分类号： C07K14/39 , C12N15/815 , C12P1/02 , C12P21/02 , C12P23/00
摘要： The present invention relates to the use of novel promoters for heterologous gene expression, preferably for expression of genes in organisms of the genus Yarrowia, to the genetically modified organisms of the genus Yarrowia, and to a process for producing biosynthetic products by cultivating the genetically modified organisms.
摘要翻译：本发明涉及用于异源基因表达，优选用于在耶氏酵母属（Yarrowia）的生物体中表达基因的新型启动子，至耶氏酵母属（Yarrowia）的基因修饰生物体的用途，以及通过培养基因修饰生物。

10. 发明申请

WO2015055562A8 METHOD FOR PREPARING OIL FROM GRAIN MATERIAL 审中-公开
标题翻译：从颗粒材料制备油的方法
公开(公告)号：WO2015055562A8
公开(公告)日：2015-11-19
申请号：PCT/EP2014071853
申请日：2014-10-13
申请人： DSM IP ASSETS BV
发明人： KUMAR MANOJ , SMITH DREW , CUMMINGS MARSHA ANNE
IPC分类号： A23K1/06 , A23D9/00 , A23K1/00 , A23K1/16 , A23K1/165 , C11B1/00
CPC分类号： C11B13/00 , A23D9/02 , A23K10/38 , A23K20/158 , C11B1/025 , C11B1/10 , Y02P60/873 , Y02W30/74
摘要： The present invention relates to a process for preparing an oil composition from a grain material comprising incubating the grain material with a proline-specific endoprotease and preparing the oil composition. The process may be applied in an ethanol fermentation process.
摘要翻译：本发明涉及从颗粒材料制备油组合物的方法，包括将谷物物质与脯氨酸特异性内切蛋白酶一起孵育并制备油组合物。该方法可以应用于乙醇发酵过程中。

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