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    • 9. 发明申请
    • METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF MUSCULOSKELETAL DISORDERS AND SYMPTOMS ASSOCIATED THEREWITH
    • 方法,组合物和用于治疗关节炎的症状和症状
    • WO2007089617A3
    • 2008-06-12
    • PCT/US2007002224
    • 2007-01-25
    • COMBINATORX INCLESSEM JAN NZHANG YANZHEN
    • LESSEM JAN NZHANG YANZHEN
    • G06F15/18
    • A61K31/519A61K31/505A61K31/573A61K2300/00
    • The invention features methods, compositions, and kits for treating a musculoskeletal disorder, e.g., osteoarthritis, or pain, fatigue, tenderness, impairment in mobility, soft tissue swelling, or bony swelling associated therewith, by administering to a patient diagnosed with or at risk of developing such pain, fatigue, tenderness, impairment in mobility, soft tissue swelling, or bony swelling a tetra-substituted pyrimidopyrimidine, e.g., dipyridamole, or an adenosine activity upregulator, in combination with one or more additional agents. The invention further features methods, compositions, and kits for treating a patient diagnosed with or at risk of developing a musculoskeletal disorder by administering to the patient a tetra-substituted pyrimidopyrimidine or an adenosine activity upregulator in combination with one or more additional agents.
    • 本发明的特征在于通过对被诊断患有或处于危险中的患者施用治疗肌肉骨骼疾病例如骨关节炎或疼痛,疲劳,触痛,移动性损伤,软组织肿胀或与之相关的骨肿胀的方法,组合物和试剂盒 与一种或多种另外的试剂组合,发展出这种疼痛,疲劳,触痛,运动障碍,软组织肿胀或四肢取向的嘧啶并嘧啶(例如双嘧达莫或腺苷活性上调)的肿胀。 本发明还涉及用于治疗诊断患有或处于发展肌肉骨骼疾病的风险中的患者的方法,组合物和试剂盒,其通过向患者施用四取代的嘧啶并嘧啶或腺苷活性上调与一种或多种其它试剂的组合。