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81. 发明申请

WO1995017600A1 PERISTALTIC PUMP TUBE CASSETTE WITH ANGLE PUMP TUBE PORTS 审中-公开
标题翻译：具有角度泵管端口的PERISTALTIC PUMP TASTERS CASSETTE
公开(公告)号：WO1995017600A1
公开(公告)日：1995-06-29
申请号：PCT/US1994002899
申请日：1994-03-17
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , CHAPMAN, Arthur, S. , DENNEHEY, T., Michael , BROWN, Richard, I. , WILLIAMSON, Warren, P.
IPC分类号： F04B43/08
CPC分类号： A61M1/3693 , A61M1/30 , A61M1/303 , A61M1/3696 , A61M2205/12 , F02B2075/025 , F04B43/1253
摘要： A peristaltic pump tube holder (22A/B/C) has a body (110) having first and second pump ports extending outside of it. The pump ports extend at an acute angle to receive a flexible tubing loop (134/136) and orient the tubing loop for engagement with an external pump rotor (292).
摘要翻译：蠕动泵管座（22A / B / C）具有主体（110），其具有在其外部延伸的第一和第二泵口。泵口以锐角延伸，以接收柔性油管回路（134/136），并定向油管回路以与外部泵转子（292）接合。

82. 发明申请

WO1995017599A1 PERISTALTIC PUMP MODULE HAVING JAWS FOR GRIPPING A PERISTALTIC PUMP TUBE CASSETTE 审中-公开
标题翻译：具有蠕动泵的超声波泵模块
公开(公告)号：WO1995017599A1
公开(公告)日：1995-06-29
申请号：PCT/US1994002898
申请日：1994-03-17
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , DIPERNA, Paul , WEST, Richard, L.
IPC分类号： F04B43/08
CPC分类号： F04B43/1253 , A61M1/30 , A61M1/303 , A61M1/3693 , A61M1/3696 , A61M2205/12 , F02B2075/025
摘要： A peristaltic pumping apparatus includes a peristaltic pump rotor (298) and pump race (296). A pump tube holder (250) includes a body for supporting a flexible tubing loop (134, 136) in an erect, outwardly bowed position for placement within the pump race and for removal from the pump race. A surface juxtaposed the peristaltic pump rotor and race carries a gripping jaw assembly (270). The gripping jaw assembly opens to receive the pump tube holder body as the body is moved toward the pump rotor to place the tubing loop within the pump race. The gripping jaw assembly closes to secure the pump tube holder body on the surface in an orientation in which the tubing loop lies within the pump race for engagement with the peristaltic pump rotor.
摘要翻译：蠕动泵送装置包括蠕动泵转子（298）和泵座（296）。泵管保持器（250）包括用于支撑处于直立的向外弯曲位置的柔性管道回路（134,136）的主体，用于放置在泵座内并用于从泵座移除。蠕动泵转子和座圈并列的表面携带夹爪组件（270）。当主体朝向泵转子移动以将管道环放置在泵座内时，夹爪组件打开以接收泵管保持器本体。夹紧爪组件关闭以将泵管保持器本体固定在表面上的管路环位于泵座内的方向上，以与蠕动泵转子接合。

83. 发明申请

WO1995013837A1 PERISTALTIC PUMPING ASSEMBLY 审中-公开
标题翻译：超声波泵送装置
公开(公告)号：WO1995013837A1
公开(公告)日：1995-05-26
申请号：PCT/US1994013320
申请日：1994-11-16
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , CHAPMAN, Arthur, S. , TSUJI, Tsuyoshi
IPC分类号： A61M01/00
CPC分类号： F04B43/1292 , A61M1/30 , A61M1/302 , A61M1/303
摘要： A compact pump assembly includes a plurality of axially aligned peristaltic pumps (112-118) for activating the flow of liquids through the conduits (44). A housing containing the pumps is provided with a removable cover (14) for retaining the pumps in the housing when the cover is closed, and for permitting removal of the pumps when the cover is opened. A reversible motor (132, 134) is mounted outside of the housing for driving each of the pumps. The pumps may be independently inactivated by individual release mechanisms provided on the common closure cover.
摘要翻译：紧凑的泵组件包括多个轴向排列的蠕动泵（112-118），用于启动通过导管（44）的液体流。包含泵的壳体设置有可拆卸盖（14），用于当盖关闭时将泵保持在壳体中，并且用于当盖打开时允许泵移除。可逆电动机（132,134）安装在壳体的外部，用于驱动每个泵。泵可以通过设置在公共封盖上的各个释放机构独立地灭活。

84. 发明申请

WO1995003112A1 SYSTEMS AND METHODS FOR COLLECTING BLOOD COMPONENTS 审中-公开
标题翻译：用于收集血液成分的系统和方法
公开(公告)号：WO1995003112A1
公开(公告)日：1995-02-02
申请号：PCT/US1994001905
申请日：1994-02-14
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , BROWN, Richard, I.
IPC分类号： B01D37/00
CPC分类号： B04B13/00 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/3693 , A61M1/3696 , A61M2202/0427 , B01D17/0217 , B01D21/2405 , B01D21/245 , B01D21/26 , B01D21/262 , B01D21/34 , B01D2221/08 , B01D2221/10 , B04B5/0442 , A61M2202/0071
摘要： Systems and methods for collecting cellular-rich concentrates of blood are disclosed. Blood from donor (78) is mixed with anticoagulant (90) and conveyed to a first separation device (12) for separating an anticoagulated cellular suspension from blood. The anticoagulated cellular suspension is conveyed to a second separation device (14) for removing leukocytes. Leukocyte-depleted cellular suspension is conveyed to a third separation device (16) for concentrating the leukocyte-depleted cellular suspension into a cellular-rich concentrate and a cellular-poor component and a portion of the cellular-poor component is returned to the donor (78). A controller (88) is used to control the process including monitoring the rate at which anticoagulant carried in the cellular-poor component is being infused with the returned cellular-poor component into the donor (78).
摘要翻译：公开了收集富含细胞的血液浓缩物的系统和方法。来自供体（78）的血液与抗凝血剂（90）混合并输送到第一分离装置（12）以将抗凝细胞悬浮液与血液分离。将抗凝细胞悬浮液输送到用于去除白细胞的第二分离装置（14）。将白细胞贫乏的细胞悬浮液输送到第三分离装置（16），用于将白细胞贫乏的细胞悬浮液浓缩成富含细胞的浓缩物和贫乏细胞的组分，并将一部分贫细胞组分返回给供体（ 78）。控制器（88）用于控制该过程，包括监测在将细胞贫乏成分中携带的抗凝血剂与所返回的细胞贫乏成分注入供体（78）中的速率。

85. 发明申请

WO1995003108A1 SYSTEMS AND METHODS FOR RESUSPENDING CELLULAR-RICH CONCENTRATES 审中-公开
标题翻译：恢复细胞浓度的系统和方法
公开(公告)号：WO1995003108A1
公开(公告)日：1995-02-02
申请号：PCT/US1994001907
申请日：1994-02-14
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , BROWN, Richard, I.
IPC分类号： B01D21/26
CPC分类号： B04B5/0442 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/3693 , A61M1/3696 , A61M2202/0427 , B01D21/262 , B01D21/302 , B01D2221/08 , B01D2221/10 , B04B2005/045 , A61M2202/0071
摘要： Systems and methods for resuspending cellular-rich concentrates of blood are disclosed. Systems include first compartment (24) including a blood inlet port (40) and a plasma-rich platelets (PRP) collection port (38) and a red blood cell collection port (42), and second compartment (26) including a platelet-poor plasma (PPP) collection port (44) and a leukocyte-depleted PRP (LDPRP) inlet port (46), and a separation element (14). In resuspension mode, a volume of retained PPP is returned through the PPP collection port (44) into the second compartment (26) to mix with and resuspend leukocyte-depleted platelet concentrate (LDPC) in the second compartment (26). During the resuspension period, a rotor (28) slowly oscillates the second compartment (26) first in one rotational direction and then in an opposite rotational direction. The oscillation creates variable agitation forces that aid the mixing and resuspension process within the second compartment (26).
摘要翻译：公开了用于重悬细胞富集的血液浓缩物的系统和方法。系统包括包括血液入口（40）和富血小板血浆（PRP）收集口（38）和红细胞收集口（42）的第一隔室（24），以及包括血小板 - 贫血血浆（PPP）收集口（44）和白细胞贫乏的PRP（LDPRP）入口（46）和分离元件（14）。在再悬浮模式中，通过PPP收集端口（44）将一定量的保留的PPP返回到第二隔室（26），以将第二隔室（26）中的白细胞贫乏的血小板浓缩物（LDPC）混合并重新悬浮。在再悬浮期间，转子（28）首先在一个旋转方向上然后以相反的旋转方向缓慢振荡第二隔室（26）。振荡产生可变搅拌力，其有助于在第二隔室（26）内的混合和再悬浮过程。

86. 发明申请

WO1994019031A1 APHERESIS SYSTEM INCORPORATING ALTERNATIVE SITE FOR ANTICOAGULANT ADDITION 审中-公开
标题翻译：加入反刍动物添加剂的替代品系统的APHERESIS系统
公开(公告)号：WO1994019031A1
公开(公告)日：1994-09-01
申请号：PCT/US1994001630
申请日：1994-02-17
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , SCHOENDORFER, Donald, W.
IPC分类号： A61M01/36
CPC分类号： A61M1/3672 , A61M1/30 , A61M1/303 , A61M1/3673
摘要： An extracorporeal blood processing method and system (14) wherein blood is extracted from a mammalian subject through a blood withdrawal tube (16) having a blood pump (18), such as a peristaltic pump, positioned thereon. A "distal segment" of the blood withdrawal tube (16) extends from the mammalian subject to the inlet side of withdrawal pump (18). A "proximal segment" of the blood withdrawal tube (16) extends from the outlet side of the blood pump (18) to an extracorporeal blood processing apparatus (14). An anticoagulant feed tube (24) is connected to the "proximal segment" of the blood withdrawal tube (16) such that a flow of anticoagulant solution may be combined with blood exiting the outlet of said blood pump (18) and passing through the "proximal segment" of said blood withdrawal tubing (16).
摘要翻译：一种体外血液处理方法和系统（14），其中通过具有定位在其上的具有诸如蠕动泵的血液泵（18）的抽血管（16）从哺乳动物受试者中提取血液。抽血管（16）的“远端”部分从哺乳动物受试者延伸到抽取泵（18）的入口侧。抽血管（16）的“近端”部分从血液泵（18）的出口侧延伸到体外血液处理装置（14）。抗凝剂供给管（24）连接到抽血管（16）的“近端段”，使得抗凝血剂溶液流可以与离开血泵（18）的出口的血液结合并通过“ 所述抽血管（16）的近端段“。

87. 发明申请

WO1993024157A1 APPARATUS AND METHODS FOR GENERATING LEUKOCYTE FREE PLATELET CONCENTRATE _________________________________________________________ 审中-公开
标题翻译：用于产生无铅离子浓度的装置和方法_________________________________________________________
公开(公告)号：WO1993024157A1
公开(公告)日：1993-12-09
申请号：PCT/US1993005149
申请日：1993-05-28
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , DENIEGA, Jose, C. , DUFF, Daniel, H. , SCHOENDORFER, Donald, W. , MILLER, William, R.
IPC分类号： A61M01/34
CPC分类号： A61M1/30 , A61M1/262 , A61M1/265 , A61M1/302 , A61M1/303 , A61M1/3603 , A61M1/3693 , A61M2202/0427 , A61M2202/0439 , A61M2202/005 , A61M2202/0042
摘要： Methods and devices for separating leukocytes from a leukocyte contaminated blood fraction by use of a rotating membrane filter apparatus (60). The invention includes methods/devices for preparing substantially leukocyte free platelet concentrate for therapeutic use. The devices of the invention include a rotating membrane filter apparatus (60) for leukocyte separation as well as tubing harness/component systems (Figs. 2a, 2b, 2c) useable in connection with automated apheresis instruments.
摘要翻译：通过使用旋转的膜过滤装置（60）将白细胞与白细胞污染的血液分数分离的方法和装置。本发明包括用于制备基本上无白血球的血小板浓缩物用于治疗用途的方法/装置。本发明的装置包括用于白细胞分离的旋转膜过滤装置（60）以及可用于与自动分离装置结合使用的管线束/部件系统（图2a，2b，2c）。

88. 发明申请

WO1991019561A1 METHOD AND APPARATUS FOR ADMINISTRATION OF ANTICOAGULANT TO RED CELL SUSPENSION OUTPUT OF A BLOOD SEPARATOR 审中-公开
标题翻译：抗血清对血液分离器红细胞悬浮液输出的方法和装置
公开(公告)号：WO1991019561A1
公开(公告)日：1991-12-26
申请号：PCT/US1991004192
申请日：1991-06-12
申请人： BAXTER INTERNATIONAL, INC.
发明人： BAXTER INTERNATIONAL, INC. , SCHOENDORFER, Donald, W.
IPC分类号： B01D61/16
CPC分类号： A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3672
摘要： Method and apparatus for machine separation of blood and blood components that utilizes improved administration of anticoagulant to the red cell suspension output. Anticoagulant (20) is added to incoming whole blood (13) in an amount sufficient to prevent clotting of the whole blood in the flow path upstream of the blood component separator (46), but in an amount insufficient to prevent clotting of the red cell suspension created by the separator. Anticoagulant (20) is added to the red cell suspension downstream (50) of the separator (46) in order to prevent clotting. By adding an additional aliquot of anticoagulant to the red cell suspension, the amount of anticoagulant added to whole blood before separation can be reduced or eliminated, resulting in an increase in platelet yield during the blood component separation step.

89. 发明申请

WO1991019554A1 AUTOMATED BLOOD COMPONENT SEPARATION PROCEDURE AND APPARATUS PROMOTING DIFFERENT FUNCTIONAL CHARACTERISTICS IN MULTIPLE BLOOD COMPONENTS 审中-公开
标题翻译：自动血液成分分离程序和装置促进多种血液成分中的不同功能特征
公开(公告)号：WO1991019554A1
公开(公告)日：1991-12-26
申请号：PCT/US1991004193
申请日：1991-06-12
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , HWANG, Yean, Yow , RITCHEY, Brian , SCHOENDORFER, Donald, W.
IPC分类号： B01D21/30
CPC分类号： A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3646 , A61M1/3672 , A61M1/3693 , A61M1/3696 , A61M2202/0427
摘要： Method and apparatus are provided for machine separation of blood into blood components, wherein a preselected fluid such as anticoagulant is added to at least two different locations (16, 112) through the fluid flow path of the set (10), in order to promote the different functional characteristics in different blood components. The method results in reduced incidence of citrate reaction in the blood donor and increased platelet yield in platelet rich plasma (60) collected during the procedure.
摘要翻译：在第一次操作中，将全血分离成分离器（46）中的组分以产生富含血小板的血浆，其中少量抗凝血剂足以防止凝血。在全血流已经停止之后，进一步的抗凝血剂通过分离器（46），从而为富含血小板的血浆添加更多抗凝血剂以促进储存。这允许在分离器中获得更高的血小板产量。

90. 发明申请

WO1989004709A1 APPARATUS AND METHODS FOR GENERATING PLATELET CONCENTRATE 审中-公开
标题翻译：用于产生浓度的装置和方法
公开(公告)号：WO1989004709A1
公开(公告)日：1989-06-01
申请号：PCT/US1988004191
申请日：1988-11-22
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , SCHONEDORFER, Donald, W.
IPC分类号： B01D33/02
CPC分类号： A61M1/3693 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3696 , A61M2202/0427 , A61M2205/12
摘要： A tubing or harness set (10) is provided having first and second portions sequentially applicable to a microprocessor-controlled hemapheresis instrument (H) for generating platelet concentrate. The first portion includes a reservoir (22) having dual compartments (24, 26) and a separator (46). The instrument (H) and the first portion of the harness set alternately collect whole blood from the donor and reinfuse packed cells into the donor while simultaneously continuously separating whole blood into packed cells and platelet-rich plasma. Upon collection of a predetermined quantity of platelet-rich plasma, the donor is disconnected from the phlebotomy needle (12) of the harness (10), the first harness portion is removed from the instrument (H) and the second harness portion is applied to the instrument (H). The second harness portion includes a separator (62) for receiving platelet-rich plasma from the collection container (60) of the first harness portion and separating such plasma into platelet concentrate and platelet-depleted plasma.
摘要翻译：提供了一种管道或线束组，其具有顺序地应用于用于产生血小板浓缩物的微处理器控制的血液净化仪器的第一和第二部分。第一部分包括具有双隔室和分离器的储存器。仪器和线束组的第一部分交替地从供体中收集全血并将填充的细胞再融化到供体中，同时将全血连续分离成填充细胞和富血小板血浆。在收集预定量的富含血小板的等离子体后，供体从线束的静脉注射针断开，第一束带部分从仪器上移除，第二束带部分被施加到仪器上。第二束带部分包括用于从第一束带部分的收集容器接收富含血小板血浆的分离器，并将这种血浆分离成血小板浓缩物和血小板贫化血浆。

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