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81. 发明申请

WO2010019645A3 MEDICAL DEVICES HAVING ELECTRODEPOSITED CONDUCTIVE POLYMER COATINGS 审中-公开
标题翻译：具有电沉积导电聚合物涂层的医疗设备
公开(公告)号：WO2010019645A3
公开(公告)日：2010-08-05
申请号：PCT/US2009053521
申请日：2009-08-12
申请人： BOSTON SCIENT SCIMED INC , ATANASOSKA LILIANA , CHANDRASEKARAN CHANDRU , WARNER ROBERT W , WEBER JAN
发明人： ATANASOSKA LILIANA , CHANDRASEKARAN CHANDRU , WARNER ROBERT W , WEBER JAN
IPC分类号： A61L31/10
CPC分类号： A61L31/10 , A61L31/14 , C08L101/12
摘要： According to one aspect, the present invention provides implantable or insertable medical devices that comprise a substrate and a coating over the substrate that comprises at least one type of conductive polymer and at least one type of additional polymer.
摘要翻译：根据一个方面，本发明提供了可植入或可插入的医疗装置，其包括基底和在基底上的包括至少一种类型的导电聚合物和至少一种附加聚合物的涂层。

82. 发明申请

WO2009059129A3 ENDOPROSTHESIS WITH POROUS RESERVOIR AND NON-POLYMER DIFFUSION LAYER 审中-公开
标题翻译：具有多孔储层和非聚合物扩散层的内部结构
公开(公告)号：WO2009059129A3
公开(公告)日：2010-06-03
申请号：PCT/US2008081986
申请日：2008-10-31
申请人： BOSTON SCIENT LTD , SCHEUERMANN TORSTEN , WEBER JAN , CLARKE JOHN A
发明人： SCHEUERMANN TORSTEN , WEBER JAN , CLARKE JOHN A
IPC分类号： A61L31/08 , A61L31/14 , A61L31/16
CPC分类号： A61L31/082 , A61L31/146 , A61L31/16 , A61L2300/608 , A61L2420/08
摘要： An endoprosthesis such as a coronary stent includes a porous reservoir of drug, e.g., a porous layer formed of a ceramic and an overlayer formed of ceramic or metal for controlling elution of drug from the reservoir.
摘要翻译：诸如冠状动脉支架的内置假体包括多孔的药物储存器，例如由陶瓷形成的多孔层和由陶瓷或金属形成的覆盖层，用于控制药物从贮存器的洗脱。

83. 发明申请

WO2010040084A2 MEDICAL IMPLANT 审中-公开
标题翻译：医疗植物
公开(公告)号：WO2010040084A2
公开(公告)日：2010-04-08
申请号：PCT/US2009059424
申请日：2009-10-02
申请人： BOSTON SCIENT SCIMED INC , WEBER JAN
发明人： WEBER JAN
IPC分类号： A61L31/02
CPC分类号： A61L31/022 , A61L31/088 , A61L31/148
摘要： A endoprosthesis includes a body comprising a plurality of interconnected struts. The body includes a bioerodible metal. At least a first strut of the plurality of interconnected struts includes a stripe on the surface of the first strut. The stripe including a nitride of the bioerodible metal, a fluoride of the bioerodible metal, or a combination thereof. The stripe runs along the length of the first strut. The stripe is part of a continuous network of stripes on struts adjacent to the first strut.
摘要翻译：内置假体包括包括多个相互连接的支柱的主体。身体包括生物腐蚀性金属。多个相互连接的支柱中的至少第一支柱在第一支柱的表面上包括条纹。该条纹包括生物腐蚀性金属的氮化物，生物腐蚀性金属的氟化物或其组合。条纹沿着第一支柱的长度延伸。条纹是与第一支柱相邻的支柱上的条纹的连续网络的一部分。

84. 发明申请

WO2009012099A3 BORON-ENHANCED SHAPE MEMORY ENDOPROSTHESES 审中-公开
标题翻译： BORON增强形状记忆体内含物
公开(公告)号：WO2009012099A3
公开(公告)日：2010-02-25
申请号：PCT/US2008069536
申请日：2008-07-09
申请人： BOSTON SCIENT LTD , WEBER JAN , O'BRIEN BARRY
发明人： WEBER JAN , O'BRIEN BARRY
IPC分类号： A61L31/02 , A61L31/08 , A61L31/12 , A61L31/14
CPC分类号： A61L31/022 , A61L31/084 , A61L31/088 , A61L31/128 , A61L31/14 , A61L2400/16
摘要： An endoprosthesis comprises a member capable of supporting a body passageway. The member has a surface region overlying a bulk region, and comprises a shape memory alloy and boron. The concentration of boron in the surface region is greater than the concentration of boron in the bulk region.
摘要翻译：内假体包括能够支撑身体通道的构件。该构件具有覆盖块体区域的表面区域，并且包括形状记忆合金和硼。表面区域中硼的浓度大于体积区域中硼的浓度。

85. 发明申请

WO2008083069A3 BIOERODIBLE NANO-FIBROUS AND NANO-POROUS CONDUCTIVE COMPOSITES 审中-公开
标题翻译：可生物降解的纳米纤维和纳米多孔导电复合材料
公开(公告)号：WO2008083069A3
公开(公告)日：2009-07-16
申请号：PCT/US2007088533
申请日：2007-12-21
申请人： BOSTON SCIENT LTD , ATANASOSKA LILIANA , FENG JAMES Q , WEBER JAN , SHIPPY III JAMES LEE
发明人： ATANASOSKA LILIANA , FENG JAMES Q , WEBER JAN , SHIPPY III JAMES LEE
IPC分类号： A61L27/14 , A61L31/10
CPC分类号： A61L27/40 , A61L27/14 , A61L27/50 , A61L27/58 , A61L2400/12
摘要： A bioerodible conductive tissue scaffold that can provide, e.g., improved tissue growth.
摘要翻译：可以提供例如改善的组织生长的生物蚀蚀性导电组织支架。

86. 发明申请

WO2009086325A2 CATHETERS AND MANUFACTURING THEREOF 审中-公开
标题翻译：导管及其制造
公开(公告)号：WO2009086325A2
公开(公告)日：2009-07-09
申请号：PCT/US2008088060
申请日：2008-12-22
申请人： BOSTON SCIENT SCIMED INC , WEBER JAN
发明人： WEBER JAN
IPC分类号： A61F7/12
CPC分类号： A61B18/082 , A61B2017/0046 , A61B2018/00023 , A61M25/00 , A61M25/0009 , B29C47/8895
摘要： A catheter includes a longitudinally extending body having proximal and distal ends and defining at least one lumen that extends longitudinally from the proximal end through the body to the distal end and looping back to the proximal end. A liquid metal, e.g. an alloy of gallium and indium, such as galistan, is disposed in the lumen. In another aspect, a catheter includes a longitudinally extending body defining first and second lumens. An electrically driven device is coupled to a distal end of the body and is in electrical communication with the first and second lumens. A power source is in electrical communication with the first and second lumens and a liquid metal is disposed in the first and second lumens to provide an electrical conduit between the power source and electrically driven device. Each lumen may loop from a proximal end of the body to the distal end back to the proximal end.
摘要翻译：导管包括纵向延伸的本体，其具有近端和远端并且限定至少一个内腔，该内腔从近端通过主体纵向延伸到远端并环绕回近端。液态金属，例如镓和铟的合金如galistan被设置在管腔中。在另一方面，导管包括限定第一和第二腔的纵向延伸体。电驱动装置联接到主体的远端并且与第一和第二管腔电连通。电源与第一和第二管腔电连通，并且液体金属设置在第一和第二管腔中，以在电源和电驱动装置之间提供电导管。每个内腔可以从主体的近端回到远端回到近端。

87. 发明申请

WO2008063539A3 STENT WITH DIFFERENTIAL TIMING OF ABLUMINAL AND LUMINAL RELEASE OF A THERAPEUTIC AGENT 审中-公开
标题翻译：治疗药物的尿素和尿素释放的差异时间
公开(公告)号：WO2008063539A3
公开(公告)日：2009-05-14
申请号：PCT/US2007024012
申请日：2007-11-15
申请人： BOSTON SCIENT LTD , SHIPPY JAMES LEE , ROBERTSON KIMBERLY A , WEBER JAN
发明人： SHIPPY JAMES LEE , ROBERTSON KIMBERLY A , WEBER JAN
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91575 , A61F2230/0013 , A61L31/10 , A61L31/16 , A61L2300/00 , A61L2300/608 , A61L2420/08
摘要： The invention relates generally to a medical device that is useful for delivering a therapeutic agent to the body tissue of a patient, and the method for making such a medica device. More particularly, the invention is directed to a stent having a tubular sidewall wit first coating composition on at least the luminal surface and/or abluminal surface, and a second coating composition disposed on at least a portion of the first coating composition comprising a low diffusivity biodegradable polymer.
摘要翻译：本发明一般涉及可用于将治疗剂递送到患者的身体组织的医疗装置以及用于制造这种药物装置的方法。更具体地，本发明涉及一种具有管状侧壁的支架，其具有在至少腔管表面和/或外侧表面上的第一涂层组合物，以及设置在第一涂层组合物的至少一部分上的第二涂层组合物，其包含低扩散率可生物降解的聚合物。

88. 发明申请

WO2007098330A3 MEDICAL BALLOONS AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：医用气球及其制造方法
公开(公告)号：WO2007098330A3
公开(公告)日：2008-07-17
申请号：PCT/US2007062042
申请日：2007-02-13
申请人： BOSTON SCIENT SCIMED INC , WEBER JAN , ATANASOSKA LILIANA , KONDYURIN ALEXEY
发明人： WEBER JAN , ATANASOSKA LILIANA , KONDYURIN ALEXEY
IPC分类号： A61L27/30 , A61L31/08
CPC分类号： A61L31/084 , A61L27/303
摘要： Medical balloons are provided that have enhanced properties, such as enhanced puncture and scratch resistance.
摘要翻译：提供具有增强性能的医疗气球，例如增强穿刺和耐划伤性。

89. 发明申请

WO2007078516A3 MEDICAL DEVICES HAVING MULTIPLE CHARGED LAYERS 审中-公开
标题翻译：具有多个充电层的医疗器械
公开(公告)号：WO2007078516A3
公开(公告)日：2008-05-15
申请号：PCT/US2006046325
申请日：2006-12-04
申请人： BOSTON SCIENT SCIMED INC , ATANASOSKA LILIANA , WEBER JAN , SHIPPY JAMES LEE
发明人： ATANASOSKA LILIANA , WEBER JAN , SHIPPY JAMES LEE
IPC分类号： A61L27/28 , A61L15/46 , A61L27/54 , A61L31/08 , A61L31/16
CPC分类号： A61L15/46 , A61F2/0077 , A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2210/0076 , A61F2230/0054 , A61F2310/00574 , A61F2310/00592 , A61F2310/0097 , A61L27/28 , A61L27/54 , A61L31/08 , A61L31/16 , A61L2300/61 , A61L2400/12 , A61L2420/04
摘要： According to an aspect of the present invention, medical devices are provided, which are adapted for implantation or insertion into a subject and which include at least one multilayer region that contains multiple charged layers of alternating charge. The multiple charged layers, in turn, include the following: (i) at least one charged block copolymer (e.g., a charged block copolymer that contains one or more polyelectrolyte blocks) and (ii) at least one charged therapeutic agent (e.g., a charged therapeutic agent that contains one or more polyelectrolyte blocks).
摘要翻译：根据本发明的一个方面，提供了适于植入或插入到受试者中并且包括至少一个多层区域的医疗装置，所述至少一个多层区域包含交替充电的多个带电层。多个带电层又包括以下：（i）至少一个带电荷的嵌段共聚物（例如，含有一个或多个聚电解质嵌段的带电嵌段共聚物）和（ii）至少一个带电荷的治疗剂（例如，含有一种或多种聚电解质块的电荷治疗剂）。

90. 发明申请

WO2008033711A3 MEDICAL DEVICES WITH DRUG-ELUTING COATING 审中-公开
标题翻译：具有药液涂层的医疗装置
公开(公告)号：WO2008033711A3
公开(公告)日：2008-05-08
申请号：PCT/US2007077711
申请日：2007-09-06
申请人： BOSTON SCIENT SCIMED INC , WEBER JAN , MILLER MATTHEW
发明人： WEBER JAN , MILLER MATTHEW
IPC分类号： A61F2/00 , A61F2/82 , A61L31/08 , B23K26/38
CPC分类号： A61F2/06 , A61F2/82 , A61F2/91 , A61F2002/30322 , A61F2210/0076 , A61F2230/0054 , A61F2250/0026 , A61F2250/0056 , A61F2250/0068 , A61F2310/00389 , A61L31/082 , A61L31/10 , A61L31/16 , A61L2300/608 , Y10T29/49826
摘要： Medical devices, such as endoprostheses, and methods of making the devices are described. In one embodiment, a medical device having a body of interconnected bands and connectors forming an elongated tubular structure having an inner luminal wall surface, an outer abluminal wall surface and a side wall surface, and defining a central lumen or passageway, wherein said inner luminal wall surface and side wall surface of the bands and connectors form transverse passageways through the elongated tubular structure is described. One or more wall surfaces of the tubular structure can bear a coating whose selected regions define at least one depression. The coating can further include at least one biologically active substance.
摘要翻译：描述医疗装置，例如内用假体，以及制造装置的方法。在一个实施例中，具有相互连接的条带和连接器形成具有内腔壁表面，外腔外壁面和侧壁表面，一个细长的管状结构的主体并限定了中心内腔或通道内的医疗装置，其中所述内部管腔描述了带和连接器的壁表面和侧壁表面通过细长管状结构形成横向通道。管状结构的一个或多个壁表面可以承受其选定区域限定至少一个凹陷的涂层。该涂层可进一步包括至少一种生物活性物质。

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