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81. 发明申请

WO1996005159A1 BENZENE DERIVATIVES AND LIQUID CRYSTAL MEDIUM 审中-公开
标题翻译：苯系列衍生物液晶媒体INES
公开(公告)号：WO1996005159A1
公开(公告)日：1996-02-22
申请号：PCT/EP1995003045
申请日：1995-07-31
申请人： MERCK PATENT GMBH , TARUMI, Kazuaki , BARTMANN, Ekkehard , REIFFENRATH, Volker , SCHOEN, Sabine , PAULUTH, Detlef , SCHULER, Brigitte , POETSCH, Eike
发明人： MERCK PATENT GMBH
IPC分类号： C07C25/18
CPC分类号： C07C17/263 , C07C25/18 , C07C25/24 , C07C43/225 , C07C2601/14 , C09K19/3001 , C09K19/3003 , C09K19/3028 , C09K19/3098
摘要： A liquid crystal medium based on a mixture of polar compounds with positive dielectric anisotropy is characterised in that it contains one or several compounds having the general formula (I), in which R, A , A , Z , Z , Y, L and m have the meanings given in the first claim.
摘要翻译：本发明涉及一种基于具有正介电各向异性的极性化合物，其特征在于的混合物的液晶介质，它包含通式（I）的一种或多种化合物其中R，A <1>，A <2>，Z <1>，Z <2>，Y，L <1>和m具有权利要求1中给出的含义。

82. 发明申请

WO1995013257A1 2,6-DIFLUOROBENZENES AND THEIR USE IN LIQUID-CRYSTAL MIXTURES 审中-公开
标题翻译： 2,6-二氟苯及它们在的液晶混合物
公开(公告)号：WO1995013257A1
公开(公告)日：1995-05-18
申请号：PCT/EP1994003534
申请日：1994-10-27
申请人： MERCK PATENT GMBH , SCHLOSSER, Hubert , JUNGBAUER, Dietmar
发明人： MERCK PATENT GMBH
IPC分类号： C07C25/02
CPC分类号： C09K19/3001 , C07C17/2635 , C07C17/269 , C07C17/35 , C07C17/354 , C07C25/18 , C07C25/24 , C07C35/21 , C07C43/225 , C07C69/76 , C07C2601/14 , C09K19/0403 , C09K2019/0407
摘要： The invention concerns 2,6-difluorobenzenes of general formula (I) in which the symbols and indices are defined as follows: R is H, a straight-chain or branched-chain alkyl (with or without an asymmetric C-atom) with 1 to 15 C-atoms, whereby one or two non-adjacent CH2 groups may be replaced by -O-, -S-, -CO-, -CO-O-, -O-CO-, -CO-S-, -S-CO-, -O-CO-O-, -CH=CH-, -CC-, cyclopropane-1,2-diyl or -Si(CH3)2- and whereby one or more H-atoms in the alkyl group may be replaced by F, Cl or CN; A , A and A , which may be the same or different are 1,4-phenylene, pyrazine-2,5-diyl, pyridine-2,5-diyl or pyrimidine-2,5-diyl in which one or two H-atoms may be replaced by F, trans-1,4-cyclohexylene, 1,4-cyclohexenylene, (1,3,4)-thiadiazole-2,5-diyl, 1,3-dioxane-2,5-diyl, naphthaline-2,6-diyl, bicyclo[2.2.2]octane-1,4-diyl or 1,3-dioxaborinane-2,5-diyl; M , M and M , which may be the same or different, are -CH2CH2-, -CH=CH-, -CC-, -CH2CH2CH2CH2-, -CH2CH2CH2-O-, -O-CH2CH2CH2-, -CH2CH2CO-O-, -O-CO-CH2CH2-, -CH2-O-, -O-CH2-, -CO-O- or -O-CO-; k, l, m, n, o and p are zero or one, under the condition that the sum k+m+o is greater than zero; with the following provisions: a) when M is -O-CO-, R (-A )k(-M )l(-A )m(-M )n(-A )o is replaced by formulae (II) or (III); b) when M is -CO-O-, R (-A )k(-M )l(-A )m(-M )n(-A )o is replaced by formulae (IV) in which g is 0 or 1 and (V). The compounds of formula (I) are chemically and photochemically stable. They have low melting points and, in general, wide liquid-crystal phases, in particular wide nematic liquid-crystal phases.
摘要翻译： 2,6- difluorobenzenes通式（I）其中符号和指数具有以下含义：R t <1>为H，直链或支链（具有或不具有不对称碳原子）为碳原子数1〜15的烷基，其中一个或两个不相邻的CH 2个基团可以被替换为-O - ， - S - ， - CO - ， - CO-O-，-O-CO - ， - CO-S-，-S-CO - ， - O- CO-O-，-CH = CH-， - CC-，环丙烷-1,2-二基或-Si（CH 3）2 - 可被替换，并且其中被F，Cl的烷基的一个或多个H原子或 CN可以被取代; A <1>，A <2>，A <3>是相同的或不同的1,4-亚苯基，吡嗪-2,5-二基，吡啶-2,5-二基，嘧啶-2,5-二基，其中一个或两个H原子可被F所取代，反式-1,4-亚环己基，1,4-亚环己烯基，（1,3,4-）噻二唑-2,5-二基，1,3-二恶烷2， -1,5-二基，萘-2,6-二基，双环[2.2.2]辛烷-1,4-二基或1,3-二氧杂硼烷-2,5-二基; 中号<1>中，M <2>中，M <3>相同或不同-CH2CH2 - ， - CH = CH - ， - CC-，-CH2CH2CH2CH2-，-CH2CH2CH2 - ， - O-CH 2 CH 2，-CH2CH2CO -O-，-O-CO-CH 2 CH 2 -CH 2 -O-，-O-CH 2 - ， - CO-O-或-O-CO-; K，L，M，N，O，P是0或1，条件是K + M +邻大于零的总和; 具有下列附带条件：一）M <3>是-O-CO-ř删除<1>（ - A <1>）K（-M <1>）升（-A <2>）米（-M <2>）N（-A <3>）o为等于式（II）和（III）; B）和M <3>是-CO-O-省略ř<1>（ - A <1>）K（-M <1>）升（-A <2>）米（-M <2>） N（-A <3>）o为等于式（IV）和（V）。通式（I）的化合物是化学和光化学稳定的。它们的熔点低，一般具有广阔的液晶相insebesondere宽的向列。

83. 发明申请

WO1995010354A1 EPOXY DERIVATIVES OF POLYACRYLIC AMIDES 审中-公开
标题翻译：聚丙烯酰胺的环氧衍生物
公开(公告)号：WO1995010354A1
公开(公告)日：1995-04-20
申请号：PCT/EP1994003196
申请日：1994-09-24
申请人： MERCK PATENT GMBH , MÜLLER, Egbert
发明人： MERCK PATENT GMBH
IPC分类号： B01J20/32
CPC分类号： B01J20/286 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/327 , B01J20/3274 , B01J20/3278 , B01J20/328 , B01J2220/54
摘要： The invention relates to activated substrate materials containing epoxy-substituted poly(meth)acrylic amides in which: a) the basic substrate contains aliphatic hydroxyl groups; b) the covalently bonded polymers are bonded to the substrate via a final-position monomer unit; c) the polymers contain monomer units of formula (I); d) the monomer units are linearly cross-linked; in formula (I), R , R and R are mutually independently H or CH3; R is H or alkyl with 1-5 C atoms; and n is a whole number between 1 and 5; and their use.
摘要翻译：本发明涉及活化的载体材料中，环氧基取代的聚（甲基）丙烯酰胺包括，其特征在于：a）基材支撑包含脂族羟基基团）的共价键合的聚合物为B经由端子单体与载体结合，c）中的单体单元的聚合物式（I）中，d）的单体单元线性地连接。在式（I）中，R <1>，R <2>和R <3>unagbhängig表示H或CH 3，R <4>是具有1-5个碳原子的氢或烷基，n是1和5之间的整数; 和它们的用途。

84. 发明申请

WO1995009827A1 3,4-DIFLUOROBENZENES AND THEIR USE IN LIQUID-CRYSTAL MIXTURES 审中-公开
标题翻译： 3,4-二氟苯及它们在的液晶混合物
公开(公告)号：WO1995009827A1
公开(公告)日：1995-04-13
申请号：PCT/EP1994003125
申请日：1994-09-19
申请人： MERCK PATENT GMBH , SCHLOSSER, Hubert , JUNGBAUER, Dietmar
发明人： MERCK PATENT GMBH
IPC分类号： C07C43/225
CPC分类号： C09K19/3066 , C07C43/225 , C07C2601/14 , C09K19/0403 , C09K2019/0407
摘要： Described are 3,4-difluorobenzenes of formula (I) in which the symbols and indices have the following meanings: R is H, a straight-chain or branched-chain alkyl (with or without an asymmetric C-atom) with 1 to 15 C-atoms, whereby one or two non-adjacent -CH2- groups may be replaced by -O-, -CH=CH-, -CC-, cyclopropane-1,2-diyl or -Si(CH3)2- and one or more H-Atoms in the alkyl group may be substituted by F; A , A and A which may be the same or different, are 1,4-phenylene, pyridine-2,5-diyl, pyrimidine-2,5-diyl in which one or more H-atoms may be replaced by F, trans 1,4-cyclohexylene, 1,3-dioxane-2,5-diyl or naphthalene-2,6-diyl; M and M , which may be the same or different, are -CH2CH2-, -CH=CH-, -CC-, -CH2CH2CH2CH2-, -CH2CH2CH2-O-, -O-CH2CH2CH2-, -CH2CH2-CO-O-, -O-CO-CH2CH2-, -CH2-O-, -O-CH2, -CO-O- or -O-CO-; X is -CH2-O- or -O-CH2-; k, l, m, n, o and p are zero or one, under the condition that k+m+o is greater than zero. The compounds described have particularly low melting points. In mixtures, they improve the properties e.g. reducing the glass-transition temperature. This makes for a low viscosity and a low temperature dependence of the viscosity.
摘要翻译：（I），其中符号和指数具有以下含义的式3,4-二氟苯衍生物，R <1>为H，直链或支链（具有或不具有不对称碳原子），具有1至15个碳原子，其中烷基被-O - ， - CH CH - ， - CC-，环丙烷-1,2-二基或-Si（CH 3）2 =一个或两个非相邻-CH 2 - 基团可以被取代，并且其中一个或多个所述烷基可被F取代的H原子; A <1>，A <2>，A <3>相同或不同的1,4-亚苯基，吡啶-2,5-二基，嘧啶-2,5-二基，其中一个或两个H原子被F取代可更换，反式-1,4-亚环己基，1,3-二恶烷-2,5-二基或萘-2,6-二基; 中号<1>中，M <2>是相同的或不同的-CH 2 CH 2 - ， - CH = CH - ， - CC-，-CH2CH2CH2CH2-，-CH2CH2CH2 - ， - O-CH 2 CH 2，-CH 2 CH 2 CO-O- ，-O-CO-CH 2 CH 2 -CH 2 -O-，-O-CH 2 - ， - CO-O-或-O-CO-; X是-CH2-O-或-O-CH 2 - ; K，L，M，N，O，P是0或1，条件是K + M + O的总和是大于零。该新型物质通过特别低的熔点表征。在混合物中，它们具有有利的效果，例如降低玻璃化转变温度。这是一个低粘度和它们的低温度依赖性良好。

85. 发明申请

WO1995002820A1 STATIONARY PHASES FOR USE IN HYDROPHOBIC INTERACTION CHROMATOGRAPHY 审中-公开
标题翻译：切割材料的疏水层析
公开(公告)号：WO1995002820A1
公开(公告)日：1995-01-26
申请号：PCT/EP1994002182
申请日：1994-07-04
申请人： MERCK PATENT GMBH , MÜLLER, Egbert
发明人： MERCK PATENT GMBH
IPC分类号： G01N30/48
CPC分类号： B01D15/327 , B01J20/286 , B01J20/287 , B01J20/321 , B01J20/3217 , B01J20/327 , B01J20/3278 , B01J20/328 , B01J2220/54 , B01J2220/58
摘要： The invention concerns stationary phases for use in hydrophobic interaction chromatography, the stationary phases being based on hydroxy-group-containing support materials on whose surfaces polymers are covalently bound. The stationary phases are characterized in that: a) the support material contains aliphatic hydroxy groups; b) the polymers are covalently bound to the support material through a terminal monomer unit; c) the polymers contains monomer units of formula (II) in which R , R and R , independently of each other, are H or CH3, R is H, C1-C5 alkyl or C6-C12 aryl, n is a whole number between 1 and 5, one X group is OH and the other X group is Z-R , Z is O or NH and R is C1-C20 alkyl, C6-C25 aryl; C7-C25 alkylaryl or C7-C25 arylalkyl which may be substituted with one or more nitrile or C1-C5 alkoxy groups and in which one or more non-adjacent CH2 groups may be replaced by NH or O or one or more CH groups may be replaced by N or R is -[(CH2)m-O-]o-R in which m is 2 or 3, o is a whole number between 1 and 200 and R is H or C1-C5 alkyl; d) the monomer units are linked together linearly. The invention also concerns methods of preparing such stationary phases and their use in the chromatographic separation of mixtures of substances.
摘要翻译：分离材料基于含羟基的基疏水层析上其表面的聚合物共价键合，其特征在于在支持a）基材支撑包含脂族羟基基团）的共价键合的聚合物经由末端单体单元结合到基体支承B，C）含有式（II）的单体单元的聚合物，d）中的单体单元线性地连接，其中，R <1>，R <2>和R <3>独立地是H或CH 3，R <4>为H，C1-C5烷基或C 6 -C 12 - 芳基，n是1和5之间的整数，一个基团，X为OH，而另一个基团X ZR <5>中，Z是O或NH且R <5> C1-C20烷基，C6-C25芳基， C7-C25烷芳基或C7-C25芳烷基，其可被衍生化或多次腈或C1-C5烷氧基，其中一个或多个不相邻的CH 2个基团被NH或O或其他一个或多个CH 基团可以被N代替，或者R <5> - [（CH 2）Mo]的 O-R <6>，其中m是2或3，o为1至200和R之间的整数<6>为H或C1-C5烷基。本发明进一步涉及用于制备这些分离材料以及它们用于物质混合物的色谱分离的用途。

86. 发明申请

WO1994026379A1 METHOD AND SUPPORT MATERIAL FOR GEL-PERMEATION CHROMATOGRAPHY 审中-公开
标题翻译： METHOD AND CARRIER为凝胶渗透色谱法
公开(公告)号：WO1994026379A1
公开(公告)日：1994-11-24
申请号：PCT/EP1994001378
申请日：1994-04-30
申请人： MERCK PATENT GMBH , MÜLLER, Werner
发明人： MERCK PATENT GMBH
IPC分类号： B01D15/08
CPC分类号： B01D15/34 , B01J20/3204 , B01J20/3219 , B01J20/327 , B01J20/3276 , B01J20/3278
摘要： The invention concerns an improved gel-permeation chromatography method and support materials for the method. In the method, the support material used includes linear polymers made from water-soluble vinyl monomers which are grafted on aliphatic hydroxyl groups on the support and are covalently bonded to the support by a terminal monomer unit.

87. 发明申请

WO1994019687A1 SEPARATOR 审中-公开
标题翻译：脱模剂
公开(公告)号：WO1994019687A1
公开(公告)日：1994-09-01
申请号：PCT/EP1994000488
申请日：1994-02-18
申请人： MERCK PATENT GMBH , CABRERA, Karin , SÄTTLER, Günther , WIELAND, Gerhard
发明人： MERCK PATENT GMBH
IPC分类号： G01N30/48
CPC分类号： B01J20/28042 , B01D15/08 , B01J20/281 , B01J2220/54 , G01N30/48 , G01N2030/528
摘要： Porous ceramic shaped bodies are used as a substance separating medium, in particular as a stationary phase for chromatography. Also disclosed are surface-modified porous ceramic shaped bodies, as well as chromatography columns and cartridges containing the porous ceramic shaped bodies as stationary phase.

88. 发明申请

WO1994018285A1 INDAN DERIVATES 审中-公开
标题翻译：茚满衍生物
公开(公告)号：WO1994018285A1
公开(公告)日：1994-08-18
申请号：PCT/EP1994000354
申请日：1994-02-08
申请人： MERCK PATENT GMBH , EIDENSCHINK, Rudolf
发明人： MERCK PATENT GMBH
IPC分类号： C09K19/32
CPC分类号： C07C25/22 , C07C13/465 , C07C43/192 , C07C255/52 , C07C2601/14 , C07C2602/06 , C07C2602/08 , C09K19/32 , C09K2019/327
摘要： Indan derivates have formula (I), in which X and X independently represent H, F, Cl, CF3, CN, OCF3, OCF2H, alkyl or alkoxy having each up to 5 carbon atoms, P-Q is a simple or double bond and MG is a mesogenic group. Also disclosed is their use as components of liquid crystal media for electrooptical displays.

89. 发明申请

WO1994006929A1 SMALL CELL LUNG CARCINOMA SPECIFIC ANTIBODY AND ANTIGEN 审中-公开
标题翻译：小细胞肺癌特异性抗体和抗原
公开(公告)号：WO1994006929A1
公开(公告)日：1994-03-31
申请号：PCT/EP1993002042
申请日：1993-07-30
申请人： MERCK PATENT GMBH , STAHEL, Rolf
发明人： MERCK PATENT GMBH
IPC分类号： C12P21/08
CPC分类号： C07K16/3023 , A61K38/00 , C07K16/2803 , Y10S436/813
摘要： The invention relates to a novel epitope of 180,000 daltons for the NCAM antigen and a monoclonal antibody, SEN7, directed against this antigen, and their use in diagnosis and therapy of small-cell carcinoma of the lung. The antibody SEN7 reacts significantly more selectively than previously known antibodies with cells of small-cell carcinoma of the lung, and binds with high avidity. In particular, no reaction occurs with leucocytes or healthy kidney or lung epithelial cells. The novel antigen is dominantly expressed by cells of small-cell carcinoma of the lung with a high copy number.
摘要翻译：本发明涉及用于NCAM抗原的180,000道尔顿的新表位和针对该抗原的单克隆抗体SEN7，以及它们在诊断和治疗小细胞肺癌中的用途。抗体SEN7比以前已知的具有肺细胞癌细胞的抗体显着更有选择性地反应，并以高亲合力结合。特别是，白细胞或健康的肾或肺上皮细胞无反应。新型抗原主要由具有高拷贝数的肺小细胞癌细胞表达。

90. 发明申请

WO1994004958A1 PAPER WHITE PDLC SYSTEM 审中-公开
标题翻译：纸白色PDLC系统
公开(公告)号：WO1994004958A1
公开(公告)日：1994-03-03
申请号：PCT/EP1993002145
申请日：1993-08-12
申请人： MERCK PATENT GMBH , COATES, David , NOLAN, Patrick , GINTER, Ewald
发明人： MERCK PATENT GMBH
IPC分类号： G02F01/1333
CPC分类号： G02F1/1334 , C09K19/544
摘要： The invention relates to a paper white PDLC system which between 2 electrode layers contains a PDLC film comprising a liquid crystal mixture forming microdroplets in an optically isotropic, transparent polymer matrix; in which one of the refractive indices of the liquid crystal mixture is matched to the refractive index of the polymer matrix nM; the transmission of which can be varied by applying an electrical voltage, characterized in that the PDLC film exhibits the following properties: ]n(OVERSCORE)-nM] >= 0.05 wherein n(OVERSCORE) is the mean refractive index of the liquid crystal mixture defined via n(OVERSCORE)2 = 1/3(me2+2no2); mean droplet diameter = 20 %.
摘要翻译：本发明涉及一种白色PDLC系统，其在2个电极层之间包含包含在光学各向同性的透明聚合物基质中形成微滴的液晶混合物的PDLC膜; 其中液晶混合物的折射率之一与聚合物基体的折射率nM匹配; 其透射率可以通过施加电压而变化，其特征在于PDLC膜具有以下性质：其中n（OVERSCORE）是液晶混合物的平均折射率通过n（OVERSCORE）2 = 1/3（me2 + 2no2）定义; 平均液滴直径<= 2（my）m; PDLC膜5（my）m <= d <= 75（my）m; 反向散射度> = 20％。

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