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    • 83. 发明申请
    • STENTS WITH DRUG DELIVERY COATINGS
    • 与药物输送涂料相提并论
    • WO2006026187A3
    • 2006-05-26
    • PCT/US2005029529
    • 2005-08-18
    • BOSTON SCIENT SCIMED INCWEBER JAN
    • WEBER JAN
    • A61L31/02A61L31/10A61L31/16
    • A61L31/16A61L31/10A61L2300/416A61L2300/624
    • The present invention relates generally to medical devices, preferably a stent, having a drug eluting surface coated or covered with a coating of particles comprising at least an outer layer, an inner layer, and a core comprising a therapeutic agent. Specifically, the invention relates to medical devices having a hydrophilic coating comprising particles with a hydrophilic outer layer, a hydrophobic inner layer, and a core comprising a hydrophobic therapeutic agent, as well as medical devices having a hydrophobic coating comprising particles with a hydrophobic outer layer, a hydrophilic inner layer, and a core comprising a hydrophilic therapeutic agent. The coating, outer layer, and inner layer are preferably biodegradable and capable of providing sustained release of the therapeutic agent over a time period. The invention also relates to methods of making and methods of using the coated or covered medical device.
    • 本发明一般涉及医疗装置,优选支架,其具有用包含至少外层,内层和包含治疗剂的芯的颗粒涂层涂覆或覆盖的药物洗脱表面。 具体地,本发明涉及具有亲水性涂层的医疗装置,其包括具有亲水外层的颗粒,疏水性内层和包含疏水性治疗剂的芯,以及具有疏水性涂层的医疗装置,所述疏水涂层包含具有疏水性外层的颗粒 ,亲水性内层和包含亲水性治疗剂的核心。 涂层,外层和内层优选是可生物降解的并且能够在一段时间内提供治疗剂的持续释放。 本发明还涉及制造方法和使用涂覆或覆盖的医疗装置的方法。