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81. 发明申请

WO2002079441A3 SECRETED PROTEINS 审中-公开
公开(公告)号：WO2002079441A3
公开(公告)日：2002-10-10
申请号：PCT/US2002/009820
申请日：2002-03-29
申请人： INCYTE GENOMICS, INC. , BAUGHN, Mariah, R. , BURFORD, Neil , DING, Li , DUGGAN, Brendan, M. , ELLIOTT, Vicki, S. , FORSYTHE, Ian, J. , GANDHI, Ameena, R. , GIETZEN, Kimberly, J. , GRIFFIN, Jennifer, A. , HE, Ann , HONCHELL, Cynthia, D. , ISON, Craig, H. , LAL, Preeti, G. , LEE, Ernestine, A. , LEE, Sally , LU, Dyung Aina, M. , MASON, Patricia, M. , SANJANWALA, Madhu, M. , SWARNAKAR, Anita , RAMKUMAR, Jayalaxmi , TANG, Y., Tom , THANGAVELU, Kavitha , TRAN, Uyen, K. , WALIA, Narinder, K. , WARREN, Bridget, A. , YAO, Monique, G. , XU, Yuming , YUE, Henry
发明人： BAUGHN, Mariah, R. , BURFORD, Neil , DING, Li , DUGGAN, Brendan, M. , ELLIOTT, Vicki, S. , FORSYTHE, Ian, J. , GANDHI, Ameena, R. , GIETZEN, Kimberly, J. , GRIFFIN, Jennifer, A. , HE, Ann , HONCHELL, Cynthia, D. , ISON, Craig, H. , LAL, Preeti, G. , LEE, Ernestine, A. , LEE, Sally , LU, Dyung Aina, M. , MASON, Patricia, M. , SANJANWALA, Madhu, M. , SWARNAKAR, Anita , RAMKUMAR, Jayalaxmi , TANG, Y., Tom , THANGAVELU, Kavitha , TRAN, Uyen, K. , WALIA, Narinder, K. , WARREN, Bridget, A. , YAO, Monique, G. , XU, Yuming , YUE, Henry
IPC分类号： G01N33/53
摘要： The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.

82. 发明申请

WO2002078420A2 MOLECULES FOR DISEASE DETECTION AND TREATMENT 审中-公开
标题翻译：分子疾病检测和治疗
公开(公告)号：WO2002078420A2
公开(公告)日：2002-10-10
申请号：PCT/US2002/009809
申请日：2002-03-29
申请人： INCYTE GENOMICS, INC. , LU, Dyung, Aina, M. , ARVIZU, Chandra, S. , GANDHI, Ameena, R. , HAFALIA, April, J., A. , DING, Li , LU, Yan , RAMKUMAR, Jayalaxmi , SWARNAKAR, Anita , TANG, Y., Tom , YUE, Henry , TRAN, Bao , LEE, Soo, Y. , WARREN, Bridget, A. , NGUYEN, Danniel, B. , THANGAVELU, Kavitha , YAO, Monique, G. , ELLIOTT, Vicki, S. , BAUGHN, Mariah, R. , EMERLING, Brooke, M. , LAL, Preeti, G. , GIETZEN, Kimberly, J. , BECHA, Shanya, D. , MARQUIS, Joseph, P. , KABLE, Amy, E.
发明人： LU, Dyung, Aina, M. , ARVIZU, Chandra, S. , GANDHI, Ameena, R. , HAFALIA, April, J., A. , DING, Li , LU, Yan , RAMKUMAR, Jayalaxmi , SWARNAKAR, Anita , TANG, Y., Tom , YUE, Henry , TRAN, Bao , LEE, Soo, Y. , WARREN, Bridget, A. , NGUYEN, Danniel, B. , THANGAVELU, Kavitha , YAO, Monique, G. , ELLIOTT, Vicki, S. , BAUGHN, Mariah, R. , EMERLING, Brooke, M. , LAL, Preeti, G. , GIETZEN, Kimberly, J. , BECHA, Shanya, D. , MARQUIS, Joseph, P. , KABLE, Amy, E.
IPC分类号： A61K38/00 , C07K14/47 , C12N5/08 , C12N15/12
CPC分类号： C07K14/47 , A61K38/00 , G01N2500/00
摘要： The invention provides human molecules for disease detection and treatment (MDDT) and polynucleotides which identify and encode MDDT. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of MDDT.
摘要翻译：本发明提供了用于疾病检测和治疗的人分子（MDDT）和鉴定和编码MDDT的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供诊断，治疗或预防与MDDT异常表达相关的疾病的方法。

83. 发明申请

WO2002077152A1 DEVICE AND METHOD FOR DETECTION OF MULTIPLE ANALYTES 审中-公开
标题翻译：用于检测多个分析仪的装置和方法
公开(公告)号：WO2002077152A1
公开(公告)日：2002-10-03
申请号：PCT/CN2002/000209
申请日：2002-03-28
申请人： GENETECH BIOTECHNOLOGY (SHANGHAI) COMPANY LIMITED , CHEUNG, To , LI, Bin , PENG, Yongji , REN, Yiping , GE, Haipeng , DENG, Fuqiao , DING, Li , LI, Hongmei , CAI, Qifeng , CHEN, Ying
发明人： CHEUNG, To , LI, Bin , PENG, Yongji , REN, Yiping , GE, Haipeng , DENG, Fuqiao , DING, Li , LI, Hongmei , CAI, Qifeng , CHEN, Ying
IPC分类号： C12M1/20
CPC分类号： G01N33/54366 , G01N33/54313
摘要： A device is provided for the detection of multiple analytes in at least one sample. The device contains a solid substrate with a test surface. On the test surface is defined at least one reaction area containing at least one array of discrete test sites. Each of these test sites have a test molecule immobilized on to it, and different test sites may have different test molecules immobilized thereon. A divider is provided for attachment onto the solid substrate. The divider contains a plurality of holes provided on an attachment surface. The attachment surface is complementary to the test surface of the solid device and is adapted for reversible attachment thereto such that when the two parts are attached, each of the holes is adjoined with a portion of the test surface to create a plurality of leak-proof chambers. The test surface within the chamber contains a plurality of test sites exposed within the chambers. Each of the chamber is preferably provided with an opening that is accessible from the exterior such that fluid introduced into the chambers may be contacted with the exposed test sites for testing. In another aspect of the present invention, a method is provided for analysing multiple analytes in the same samples.
摘要翻译：提供了用于在至少一个样品中检测多个分析物的装置。该装置包含具有测试表面的固体基底。在测试表面上限定至少一个包含至少一个离散测试位点阵列的反应区域。这些测试位点中的每一个具有固定在其上的测试分子，并且不同的测试位点可以具有固定在其上的不同测试分子。提供分隔件用于附着到固体基底上。分隔器包括设置在附接表面上的多个孔。附接表面与固体装置的测试表面互补，并且适于可逆地附接到其上，使得当附接两个部分时，每个孔与测试表面的一部分相邻以产生多个防漏室。室内的测试表面包含在室内暴露的多个测试部位。每个室优选地设置有可从外部接近的开口，使得引入室的流体可以与暴露的测试位置接触以进行测试。在本发明的另一方面，提供了一种用于分析相同样品中的多种分析物的方法。

84. 发明申请

WO2002070709A2 MOLECULES FOR DISEASE DETECTION AND TREATMENT 审中-公开
标题翻译：疾病检测和治疗分子
公开(公告)号：WO2002070709A2
公开(公告)日：2002-09-12
申请号：PCT/US2002/003709
申请日：2002-02-08
申请人： INCYTE GENOMICS, INC. , LAL, Preeti, G. , BAUGHN, Mariah, R. , YAO, Monique, G. , WALIA, Narinder, K. , ELLIOT, Vicki, S. , XU, Yuming , HONCHELL, Cynthia, D. , YUE, Henry , DING, Li , GIETZEN, Kimberly, J. , ISON, Craig, H. , LU, Dyung, Aina, M. , HAFALIA, April, J., A. , GHANDI, Ameena, R. , THANGAVELU, Kavitha , SANJANWALA, Madhusudan, M. , TANG, Y., Tom , RAMKUMAR, Jayalaxmi , GRIFFIN, Jennifer, A. , SWARNAKER, Anita , AZIMZAI, Yalda , SAPPERSTEIN, Stephanie, K. , BURFORD, Neil , LEE, Ernestine, A. , LU, Yan , TRAN, Uyen, K. , MARQUIS, Joseph, P.
发明人： LAL, Preeti, G. , BAUGHN, Mariah, R. , YAO, Monique, G. , WALIA, Narinder, K. , ELLIOT, Vicki, S. , XU, Yuming , HONCHELL, Cynthia, D. , YUE, Henry , DING, Li , GIETZEN, Kimberly, J. , ISON, Craig, H. , LU, Dyung, Aina, M. , HAFALIA, April, J., A. , GHANDI, Ameena, R. , THANGAVELU, Kavitha , SANJANWALA, Madhusudan, M. , TANG, Y., Tom , RAMKUMAR, Jayalaxmi , GRIFFIN, Jennifer, A. , SWARNAKER, Anita , AZIMZAI, Yalda , SAPPERSTEIN, Stephanie, K. , BURFORD, Neil , LEE, Ernestine, A. , LU, Yan , TRAN, Uyen, K. , MARQUIS, Joseph, P.
IPC分类号： C12N15/12
CPC分类号： C12N9/6421 , A61K38/00 , C07K14/47
摘要： The invention provides full-length human molecules for disease detection and treatment (MDDT) and polynucleotides which identify and encode MDDT. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of MDDT.
摘要翻译：本发明提供用于疾病检测和治疗（MDDT）的全长人分子和鉴定和编码MDDT的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与MDDT的异常表达相关的疾病的方法。

85. 发明申请

WO0190148A8 NEUROTRANSMITTER TRANSPORTERS 审中-公开
标题翻译：神经传递器运输机
公开(公告)号：WO0190148A8
公开(公告)日：2002-07-04
申请号：PCT/US0116283
申请日：2001-05-17
申请人： INCYTE GENOMICS INC , SANJANWALA MADHU S , WALIA NARINDER K , TRIBOULEY CATHERINE M , YUE HENRY , GANDHI AMEENA R , DING LI , YAO MONIQUE G , LAL PREETI , BAUGHN MARIAH R , HAFALIA APRIL , ELLIOTT VICKI S , PATTERSON CHANDRA , RANKUMAR JAYA
发明人： SANJANWALA MADHU S , WALIA NARINDER K , TRIBOULEY CATHERINE M , YUE HENRY , GANDHI AMEENA R , DING LI , YAO MONIQUE G , LAL PREETI , BAUGHN MARIAH R , HAFALIA APRIL , ELLIOTT VICKI S , PATTERSON CHANDRA , RANKUMAR JAYA
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61P3/08 , A61P3/10 , A61P5/00 , A61P7/06 , A61P9/04 , A61P9/06 , A61P9/12 , A61P13/02 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/12 , A61P31/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07K14/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention provides human neurotransmitter transporter (NTT) and polynucleotides which identify and encode NTT. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of NTT.
摘要翻译：本发明提供了人神经递质转运蛋白（NTT）和识别和编码NTT的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与NTT异常表达相关的紊乱的方法。

86. 发明申请

WO0246385A2 ENZYMES 审中-公开
标题翻译：酶
公开(公告)号：WO0246385A2
公开(公告)日：2002-06-13
申请号：PCT/US0147432
申请日：2001-12-04
申请人： INCYTE GENOMICS INC , TANG Y TOM , GRIFFIN JENNIFER A , YUE HENRY , LEE ERNESTINE A , BAUGHN MARIAH R , DUGGAN BRENDAN M , WALIA NARINDER K , LEE SALLY , RAMKUMAR JAYALAXMI , WARREN BRIDGET A , GANDHI AMEENA R , LU DYUNG AINA M , LU YAN , YAO MONIQUE G , DING LI , TRIBOULEY CATHERINE M , SANJANWALA MADHU M , ARVIZU CHANDRA , HILLMAN JENNIFER L
发明人： TANG Y TOM , GRIFFIN JENNIFER A , YUE HENRY , LEE ERNESTINE A , BAUGHN MARIAH R , DUGGAN BRENDAN M , WALIA NARINDER K , LEE SALLY , RAMKUMAR JAYALAXMI , WARREN BRIDGET A , GANDHI AMEENA R , LU DYUNG AINA M , LU YAN , YAO MONIQUE G , DING LI , TRIBOULEY CATHERINE M , SANJANWALA MADHU M , ARVIZU CHANDRA , HILLMAN JENNIFER L
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61K49/00 , A61P1/00 , A61P9/00 , A61P11/00 , A61P15/00 , A61P25/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/88 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N37/00
CPC分类号： C12N9/88 , A01K2217/05
摘要： The invention provides human enzymes (NZMS) and polynucleotides which identify and encode NZMS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of NZMS.
摘要翻译：本发明提供了识别和编码NZMS的人类酶（NZMS）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与NZMS的异常表达相关的紊乱的方法。

87. 发明申请

WO0129875A3 METHODS AND APPARATUS FOR DRIVING A QUADRUPOLE ION TRAP DEVICE 审中-公开
标题翻译：驱动四极离子捕获装置的方法和装置
公开(公告)号：WO0129875A3
公开(公告)日：2002-05-02
申请号：PCT/GB0003964
申请日：2000-10-16
申请人： SHIMADZU RES LAB EUROPE LTD , DING LI , NUTTALL JAMES EDWARD
发明人： DING LI , NUTTALL JAMES EDWARD
IPC分类号： G01N27/62 , H01J49/02 , H01J49/42
CPC分类号： H01J49/427 , H01J49/022 , H01J49/4295
摘要： A digital drive apparatus (Fig. 3) for quadrupole device such as a quadrupole ion trap has a digital signal generator (11, 13, 14; 24, 25, 26) and a switching arrangement (16, 17) which alternately switches between high and low voltage levels (V1, V2) to generate a rectangular wave drive voltage. A dipole excitation voltage is also supplied to the quadrupole device to excite resonant oscillatory motion of ions.
摘要翻译：用于诸如四极离子阱的四极装置的数字驱动装置（图3）具有数字信号发生器（11,13,14; 24,25,26）和切换装置（16,17），其交替地在高和低电压电平（V1，V2）以产生矩形波驱动电压。也向四极装置提供偶极激发电压以激发离子的共振振荡运动。

88. 发明申请

WO0218581A2 G-PROTEIN COUPLED RECEPTORS 审中-公开
标题翻译： G蛋白偶联受体
公开(公告)号：WO0218581A2
公开(公告)日：2002-03-07
申请号：PCT/US0127058
申请日：2001-08-30
申请人： INCYTE GENOMICS INC , LEE ERNESTINE A , BAUGHN MARIAH R , KALLICK DEBORAH A , DING LI , TRIBOULEY CATHERINE M , PATTERSON CHANDRA , AZIMZAI YALDA , GRAUL RICHARD C , KHAN FARRAH A , NGUYEN DANNIEL B , KEARNEY LIAM , AU YOUNG JANICE
发明人： LEE ERNESTINE A , BAUGHN MARIAH R , KALLICK DEBORAH A , DING LI , TRIBOULEY CATHERINE M , PATTERSON CHANDRA , AZIMZAI YALDA , GRAUL RICHARD C , KHAN FARRAH A , NGUYEN DANNIEL B , KEARNEY LIAM , AU-YOUNG JANICE
IPC分类号： G01N33/50 , A61K38/00 , A61K38/17 , A61K45/00 , A61P9/00 , A61P25/00 , A61P31/12 , A61P35/00 , A61P37/00 , C07K14/705 , C07K16/28 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C12N15/00
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00 , C07K16/28 , G01N33/566 , G01N2500/04
摘要： The invention provides human G-protein coupled receptors (GCREC) and polynucleotides which identify and encode GCREC. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of GCREC.
摘要翻译：本发明提供了鉴定和编码GCREC的人G蛋白偶联受体（GCREC）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了用于诊断，治疗或预防与GCREC的异常表达相关的病症的方法。

89. 发明申请

WO2002004619A3 DEHYDROQUINAT DEHYDRATASE/SHIKIMAT DEHYDROGENASE ALS HERBIZIDES TARGET 审中-公开
公开(公告)号：WO2002004619A3
公开(公告)日：2002-01-17
申请号：PCT/EP2001/007763
申请日：2001-07-06
申请人： BASF AKTIENGESELLSCHAFT , FREUND, Annette , SONNEWALD, Uwe , DING, Li
发明人： FREUND, Annette , SONNEWALD, Uwe , DING, Li
IPC分类号： C12N15/11
摘要： Die vorliegende Erfindung betrifft die Verwendung von Nukleinsäuresequenzen codierend für ein Polypeptid mit Dehydroquinat Dehydratase/Shikimat Dehydrogenase Aktivität zur Herstellung eines Testsystems zum Auffinden von Inhibitoren der Dehydroquinat Dehydratase/Shikimat Dehydrogenase. Erstmals wurde mit Hilfe der Antisense-Technologie gezeigt, daß Dehydroquinat Dehydratase/Shikimat Dehydrogenase ein Herbizides Target darstellt. Desweiteren betrifft die Anmeldung die Herstellung transgener Pflanzen enthaltend eine Nukleinsäuresequenz codierend für ein Polypeptid mit Dehydroquinat Dehydratase/Shikimat Dehydrogenase (E.C. 4.2.1.10/E.C. 1.1.1.25) Aktivität gekennzeichnet durch eine erhöhte Biomasseproduktion oder/und einen erhöhten Gehalt an aromatischen Aminosäuren im Vergleich mit einer nicht transgenen Pflanze.

90. 发明申请

WO0198323A2 MULTI-MODE DIRECTI MEMORY ACCESS CONTROLLER AND METHOD 审中-公开
标题翻译：多模式直接存储器访问控制器和方法
公开(公告)号：WO0198323A2
公开(公告)日：2001-12-27
申请号：PCT/US0119354
申请日：2001-06-15
申请人： INCYTE GENOMICS INC , LAL PREETI , GRAUL RICHARD , HAFALIA APRIL J A , WALIA NARINDER K , THORNTON MICHAEL , NGUYEN DANNIEL B , LU YAN , GANDHI AMEENA R , PATTERSON CHANDRA , KALLILCK DEBORAH A , BAUGHN MARIAH R , RAMKUMAR JAYALAXMI , TRIBOULEY CATHERINE M , LEE ERNESTINE A , DING LI , BURFORD NEIL , YAO MONIQUE G , YANG JUNMING , GRIFFIN JENNIFER A
发明人： LAL PREETI , GRAUL RICHARD , HAFALIA APRIL J A , WALIA NARINDER K , THORNTON MICHAEL , NGUYEN DANNIEL B , LU YAN , GANDHI AMEENA R , PATTERSON CHANDRA , KALLILCK DEBORAH A , BAUGHN MARIAH R , RAMKUMAR JAYALAXMI , TRIBOULEY CATHERINE M , LEE ERNESTINE A , DING LI , BURFORD NEIL , YAO MONIQUE G , YANG JUNMING , GRIFFIN JENNIFER A
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61P1/00 , A61P1/16 , A61P3/04 , A61P3/10 , A61P7/00 , A61P7/04 , A61P7/06 , A61P9/00 , A61P9/10 , A61P9/14 , A61P11/00 , A61P13/12 , A61P17/06 , A61P17/12 , A61P19/00 , A61P19/02 , A61P19/06 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P35/02 , A61P37/02 , C07K1/14 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07K
CPC分类号： C07K14/705 , A61K38/00 , G01N2333/4719 , Y10T436/143333
摘要： The invention provides human G-protein coupled receptors (GCREC) and polynucleotides which identify and encode GCREC. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of GCREC.
摘要翻译：本发明提供鉴定和编码GCREC的人G-蛋白偶联受体（GCREC）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与GCREC的异常表达相关的障碍的方法。

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