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    • 81. 发明申请
    • SYSTEM AND METHOD FOR CONTROLLING AND ADJUSTING INTERSTITIAL PHOTODYNAMIC LIGHT THERAPY PARAMETERS
    • 用于控制和调整相互间光化学光照治疗参数的系统和方法
    • WO2008020050A1
    • 2008-02-21
    • PCT/EP2007/058477
    • 2007-08-15
    • SPECTRACURE ABSVANBERG, SuneAXELSSON, JohanSWARTLING, JohannesJOHANSSON, AnnANDERSSON-ENGELS, Stefan
    • SVANBERG, SuneAXELSSON, JohanSWARTLING, JohannesJOHANSSON, AnnANDERSSON-ENGELS, Stefan
    • A61N5/06
    • A61N5/062A61B2017/00022A61B2018/00642A61B2034/105A61N5/0601A61N2005/0612A61N2005/063
    • A method and system for controlling and adjusting light in interstitial photodynamic light therapy (IPDT) in a subject is disclosed. More particularly, a method for controlling the light in interstitial tumor photodynamic light therapy is described using a calculation method for determination of status of tissue during the PDT treatment. The status is used in a feedback loop to control the continued PDT treatment. Methods are disclosed that constitute pre-treatment and realtime dosimetry modules for IPDT on the whole prostate glandular tissue. The method includes reconstruction of the target geometry, optimization of source fiber positions within this geometry, monitoring of the light attenuation during the treatment procedure and updating individual fiber irradiation times to take into account any variation in tissue light transmission. A control device that is arranged to restrict delivery of therapeutic light treatment at least temporary in dependence of at least one attribute of one of photodynamic treatment parameters. In comparison to no treatment feedback, a significant undertreatment of the patient as well as damage to healthy organs at risk are avoided.
    • 公开了一种用于控制和调节受试者中的间质性光动力光疗法(IPDT)中的光的方法和系统。 更具体地,使用用于在PDT处理期间确定组织状态的计算方法来描述用于控制间质肿瘤光动力光疗法中的光的方法。 该状态用于反馈回路以控制持续的PDT治疗。 公开了构成用于IPDT在整个前列腺腺组织上的预处理和实时剂量测定模块的方法。 该方法包括重建目标几何,在该几何中优化源光纤位置,监测处理过程中的光衰减,并更新单个光纤照射时间以考虑到组织光透射中的任何变化。 一种控制装置,其被配置为根据光动力学治疗参数之一的至少一个属性至少临时地限制治疗性光处理的递送。 与没有治疗反馈相比,避免对患者的重大治疗以及处于危险中的健康器官的损害。