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71. 发明申请

WO2007120477A3 PRODUCTS CONTAINING A PHEROMONE COMPONENT 审中-公开
公开(公告)号：WO2007120477A3
公开(公告)日：2007-10-25
申请号：PCT/US2007/008104
申请日：2007-04-03
申请人： BRAGINSKY, Philip, Y. , MARENBERG, Barry, J. , KATEY, Lang
发明人： BRAGINSKY, Philip, Y. , MARENBERG, Barry, J. , KATEY, Lang
IPC分类号： A01N43/00 , A61K31/33
摘要： Products formulated with and/or coated with a human pheromone substance or component. The products will cause a person coming in contact with the odor or scent that emanates from the products to experience a unique, mood-altering effect which may include libido enhancement. This effect may also be an overall sense of well-being or may be one of heightened sexual attractiveness. The products include hair products, face, body and skin care products, dental products, garments, home products, textiles and paper and sheet products.

72. 发明申请

WO2007001348A3 HETEROARYL-CONTAINING ISOFLAVONES AS AROMATASE INHIBITORS 审中-公开
标题翻译：含杂原子的异黄酮作为芳香化酶抑制剂
公开(公告)号：WO2007001348A3
公开(公告)日：2007-10-04
申请号：PCT/US2005030401
申请日：2005-08-26
申请人： UNIV OHIO STATE RES FOUND , BRUEGGEMEIER ROBERT W , KIM YOUNG-WOO , HACKETT JOHN C
发明人： BRUEGGEMEIER ROBERT W , KIM YOUNG-WOO , HACKETT JOHN C
IPC分类号： A01N43/00 , A61K31/424 , A61K31/497
CPC分类号： C07D311/04 , C07D405/12
摘要： Compounds and methods useful for treating and prevention of cancer, particularly hormone-dependent breast cancer. Provided are compounds of formula I: wherein X is selected from O, N, S, SO, SO 2 , and S(CH 2 ) n , wherein n = 1 - 10; R 1 and R 2 may be the same or different and are selected from H, OH, OCH 3 , OCH 2 CH 3 , OCH 2 C 6 H 5 , NH 2 , NHCH 3 , N(CH 3 ) 2 , CH 3 , CH 2 CH 3 , CH 2 CH 2 CH 3 , CH(CH 3 ) 2 , C(CH 3 ) 3 , NO 2 , F, Cl, Br, CF 3 , SH, SCH 3 , SCH 2 CH 3 , OCOCH 3 , OCOC(CH 3 ) 3 , OCOCH 2 COOH, and CN; and R 3 is a nitrogen-containing heterocyclic ring. Also provided are method for treating or preventing cancer in a subject by administering a therapeutically effective amount of a heteroaryl-containing isoflavone, or a pharmaceutically acceptable salt or prodrug thereof, to a subject in need of treatment. Also provided is a method for the synthesis of 2-substituted isoflavones by first reacting deoxybenzoins with a phase transfer catalyst to provide a 2-(alkylthio)isoflavone; second deprotecting the 2-(alkylthio)isoflavone; and third applying selective debenzylation to form the final compound.
摘要翻译：用于治疗和预防癌症的化合物和方法，特别是激素依赖性乳腺癌。提供了式I的化合物：其中X选自O，N，S，SO，SO 2和S（CH 2）n SUB >，其中n = 1-10; R 1和R 2可以相同或不同，并且选自H，OH，OCH 3，OCH 2， SUB <3>，_{2 6 H _{5 ，NH _{2 ， NHCH <3>，N（CH _{3 ）_{2 ，CH _{3 ，CH _{2 CH _{3 ，CH _{2 CH _{2 CH _{3 ，CH（CH _{3 ） C，CH，SUB，F，Cl，Br，CF _{3， 3，SCH，SCH 3，SCH 2，SCH 3，SCH 3，SCH 3，SCH 3，SCH 3，SCH 3， 3），COCOCH 2，COOH和CN;其中，并且R 3是含氮杂环。还提供了通过向需要治疗的受试者施用治疗有效量的含杂芳基的异黄酮或其药学上可接受的盐或前药来治疗或预防受试者中的癌症的方法。还提供了一种合成2-取代异黄酮的方法，首先使脱氧苯偶姻与相转移催化剂反应以提供2-（烷硫基）异黄酮; 第二步使2-（烷硫基）异黄酮脱保护; 第三次应用选择性去苄基化形成最终化合物。}}}}}}}}}}}}}

73. 发明申请

WO2005054224A3 DERIVATIVES OF DIHYDRONEPETALACTONE AND METHOD FOR PREPARATION 审中-公开
标题翻译：二氢萘酮的衍生物及其制备方法
公开(公告)号：WO2005054224A3
公开(公告)日：2007-09-13
申请号：PCT/US2004039511
申请日：2004-11-24
申请人： DU PONT , SCIALDONE MARK
发明人： SCIALDONE MARK
IPC分类号： C07D311/94 , A01N43/00 , A01N43/16 , A61K31/366 , C07D311/02
CPC分类号： A01N43/16 , C07D311/94
摘要： 3-substituted dihydronepetalactone is prepared by deprotonation of nepetalactone and treatment with Grignard reagent to form alkyl and aryl substituted compounds. The compounds so prepared are odorous and have a wide range of utility ranging from insect repellents to fragrance compounds, such as perfumes, among others.
摘要翻译： 3-取代二氢荆芥内酯是通过去甲基内酯进行去质子化并用格氏试剂处理以形成烷基和芳基取代的化合物。如此制备的化合物是气味的，并且具有广泛的用途，从驱虫剂到香料化合物，如香水等。

74. 发明申请

WO2006036711A3 FEATURE ISOLATION FOR FREQUENCY-SHIFTING INTERFEROMETRY 审中-公开
标题翻译：用于频率移位干涉的特征分离
公开(公告)号：WO2006036711A3
公开(公告)日：2007-07-26
申请号：PCT/US2005033884
申请日：2005-09-20
申请人： CORNING INC , KULAWIEC ANDREW W , TRONOLONE MARK J , LEE CHRISTOPHER A
发明人： KULAWIEC ANDREW W , TRONOLONE MARK J , LEE CHRISTOPHER A
IPC分类号： A01N43/00 , A61K31/397
CPC分类号： G01B11/2441
摘要： Frequency-scanning interferometry is used for measuring test objects having multiple surface regions. The regions are distinguished and can be measured based on different measuring criteria. Interference data is gathered for the imageable portion of the test object from a plurality of interference patterns taken over substantially the same imageable portion at different measuring beam frequencies. The interference data is evaluated to determine topographical measures of associated points on the test object. The topographical measures are compared against a benchmark to distinguish between points on the test object that are within a first of the surface regions from points on a boundary separating the first surface region from one or more other surface regions of the imageable portion of the test object. The interference data of points within the first surface region are further evaluated to a higher accuracy.
摘要翻译：频率扫描干涉测量用于测量具有多个表面区域的测试对象。区域是区别的，可以根据不同的测量标准进行测量。从不同测量光束频率的基本上相同的可成像部分上拍摄的多个干涉图案收集测试对象的可成像部分的干扰数据。对干扰数据进行评估，以确定测试对象上相关点的拓扑测量。将地形测量与基准进行比较，以将分离第一表面区域与测试对象的可成像部分的一个或多个其他表面区域的边界上的点之间区分在第一表面区域内的测试对象上的点。进一步对第一表面区域内的点的干涉数据进行更高精度的评估。

75. 发明申请

WO2006102283A3 BETA-LACTAMYLALKANOIC ACIDS FOR TREATING PREMENSTRUAL DISORDERS 审中-公开
公开(公告)号：WO2006102283A3
公开(公告)日：2006-09-28
申请号：PCT/US2006/010143
申请日：2006-03-21
申请人： AZEVAN PHARMACEUTICALS, INC. , KOPPEL, Gary , MILLER, Marvin
发明人： KOPPEL, Gary , MILLER, Marvin
IPC分类号： A01N43/00 , A61K31/397
摘要： 0-lactamyl alkanoic acids are described. Methods for treating various premenstrual disorders using or more β-lactamyl alkanoic acids are also described.

76. 发明申请

WO2005033694A8 NOVEL ANTISENSE OLIGOMERS AND USE THEREOF 审中-公开
标题翻译：新型防伪低聚物及其用途
公开(公告)号：WO2005033694A8
公开(公告)日：2006-05-04
申请号：PCT/BE2004000142
申请日：2004-10-06
申请人： VERBRUGGEN AUGUST , ELEWAUT DIRK , WANG JUN
发明人： VERBRUGGEN AUGUST , ELEWAUT DIRK , WANG JUN
IPC分类号： A61K38/00 , C07H21/00 , C12N15/113 , G01N31/00 , A01N43/00 , A61K31/70 , C07H21/02 , C07H21/04
CPC分类号： C12N15/1138 , A61K38/00 , C07H21/00 , C12N2310/11 , C12N2310/322
摘要： The invention relates to the use of a novel type of antisense oligomers for use in the in vitro or in vivo inhibition of gene expression of a target gene. These oligomers, called exon-bridging oligomers are complementary to those parts of a spliced mRNA which are derived from two adjacent exons in the primary RNA transcript, and are called exon-bridging antisense oligomers. These oligomers have no complimentarity to genomic DNA. These oligomers can be used to performs antisense inhibition with less aspecific binding to genomic DNA. The exon-bridging oligomers are suitable for inhibiting Interleukin1 type I Receptor in, for instance, chondrocytes, and are suitable for the prevention or treatment of osteoarthritis.
摘要翻译：本发明涉及用于靶基因的基因表达的体外或体内抑制的新型反义寡聚体的用途。称为外显子桥接低聚物的这些寡聚体与衍生自初级RNA转录物中的两个相邻外显子的剪接的mRNA的那些部分互补，并被称为外显子桥连反义寡聚体。这些寡聚体对基因组DNA没有补充性。这些寡聚物可用于以较少的与基因组DNA的特异性结合进行反义抑制。外显子桥连寡聚体适用于抑制例如软骨细胞中的白细胞介素1型受体，适用于预防或治疗骨关节炎。

77. 发明申请

WO2006024523A1 PHTHALAMIDE DERIVATIVES FOR USE AS INSECTICIDES 审中-公开
标题翻译：用作杀虫剂的苯甲酰胺衍生物
公开(公告)号：WO2006024523A1
公开(公告)日：2006-03-09
申请号：PCT/EP2005/009392
申请日：2005-08-31
申请人： SYNGENTA PARTICIPATION AG , O'SULLIVAN, Anthony, Cornelius , LUTZ, William , JEANGUENAT, André , ROBSON, Michael, J. , SMITH, Steve
发明人： O'SULLIVAN, Anthony, Cornelius , LUTZ, William , JEANGUENAT, André , ROBSON, Michael, J. , SMITH, Steve
IPC分类号： C07C233/66 , C07D213/40 , C07D213/61 , C07D307/52 , C07D333/20 , A01N37/22 , A01N43/00
CPC分类号： C07D241/12 , C07C233/65 , C07C233/66 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2602/20 , C07C2602/42 , C07D213/40 , C07D213/61 , C07D239/26 , C07D249/06 , C07D249/08 , C07D251/16 , C07D277/28 , C07D307/52 , C07D333/20
摘要： Compounds of formula (I), wherein the substituents are as defined in claim (1), and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula (I) can be used as agrochemical active ingredients and can be prepared in a manner known per se.
摘要翻译：式（I）化合物，其中取代基如权利要求（1）中所定义，以及式（I）化合物的农业化学上可接受的盐和所有立体异构体和互变异构形式可用作农业化学活性成分，并且可以制备为本身已知的方式。

78. 发明申请

WO2005084439A1 2-PYRIDINYL[7-(SUBSTITUTED-PYRIDIN-4-YL) PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]METHANONES 审中-公开
标题翻译： 2-吡啶基[7-（取代的吡啶-4-基）吡唑并[1,5-A]嘧啶-3-基]甲烷
公开(公告)号：WO2005084439A1
公开(公告)日：2005-09-15
申请号：PCT/US2005/007238
申请日：2005-03-02
申请人： DOV PHARMACEUTICAL, INC. , SKOLNICK, Phil
发明人： SKOLNICK, Phil
IPC分类号： A01N43/00
CPC分类号： C07D487/04
摘要： The present invention provides novel 2-pyridinyl[7(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones with at least one substituent on the 4-pyridinyl ring having the chemical structure of formula (I): The invention further provides compositions and methods employing the novel 2-pyridinyl[7-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones of formula: (I) in to modulate GABA and GABA receptor physiology to elicit therapeutic responses in mammalian subjects to alleviate neurological or psychiatric disorders, including stroke, head trauma, epilepsy, pain, migraine, mood disorders, anxiety, post traumatic stress disorder, obsessive compulsive disorders, mania, bipolar disorders, schizophrenia, seizures, convulsions, tinnitus, neurodegenerative disorders including Alzheimer's disease, amyotrophic lateral sclerosis and Parkinson's disease, Huntington's chorea, depression, bipolar disorders, mania, trigeminal and other neuralgia, neuropathic pain, hypertension, cerebral ischemia, cardiac arrhythmia, myotonia, substance abuse, myoclonus, essential tremor, dyskinesia and other movement disorders, neonatal cerebral hemorrhage, and spasticity, as well as other psychiatric and neurological disorders mediated by GABA and/or GABA receptors.
摘要翻译：本发明提供了具有式（III）化学结构的4-吡啶基环上具有至少一个取代基的新的2-吡啶基[7（吡啶-4-基）吡唑并[1,5-a]嘧啶-3-基] I）：本发明还提供了使用式（I）的新型2-吡啶基[7-（吡啶-4-基）吡唑并[1,5-a]嘧啶-3-基]甲酮调节的组合物和方法 GABA和GABA受体生理学，以在哺乳动物受试者中引发治疗反应以减轻神经或精神疾病，包括中风，头部创伤，癫痫，疼痛，偏头痛，情绪障碍，焦虑，创伤后应激障碍，强迫症，躁狂症，双相情感障碍，精神分裂症，癫痫发作，抽搐，耳鸣，包括阿尔茨海默病，肌萎缩性侧索硬化和帕金森病，亨廷顿氏舞蹈病，抑郁症，双相情感障碍，躁狂症，三叉神经痛和其他神经痛的神经变性疾病，神经性疼痛，高血压，脑缺血， ardiac心律不齐，肌强直，药物滥用，肌阵挛，原发性震颤，运动障碍和其他运动障碍，新生儿脑出血和痉挛状态，以及由GABA和/或GABA受体介导的其他精神和神经障碍。

79. 发明申请

WO2004052919A2 PEPTIDE DEFORMYLASE INHIBITORS 审中-公开
公开(公告)号：WO2004052919A2
公开(公告)日：2004-06-24
申请号：PCT/US0339528
申请日：2003-12-11
申请人： SMITHKLINE BEECHAM CORP , LEE JINHWA , CHRISTENSEN SIEGFRIED B IV
发明人： LEE JINHWA , CHRISTENSEN SIEGFRIED B IV
IPC分类号： A01N43/00 , A01N47/10 , A61K38/00 , C07C233/00 , C07C259/06 , C07D215/48 , C07D307/68 , C07D307/85 , C07D317/68 , C07D319/18 , C07D321/10 , C07D471/04 , C07K20060101 , C07K1/00 , C07K
CPC分类号： C07D471/04 , C07C259/06 , C07D215/48 , C07D307/68 , C07D307/85 , C07D317/68 , C07D319/18 , C07D321/10
摘要： Novel PDF inhibitors and novel methods for their use are provided.

80. 发明申请

WO03041728A9 NOVEL PHENYL-PROPARGYLETHER DERIVATIVES 审中-公开
标题翻译：新的苯基 - 丙酰基酯衍生物
公开(公告)号：WO03041728A9
公开(公告)日：2004-04-22
申请号：PCT/EP0212848
申请日：2002-11-15
申请人： SYNGENTA PARTICIPATIONS AG , ZELLER MARTIN , LAMBERTH CLEMENS
发明人： ZELLER MARTIN , LAMBERTH CLEMENS
IPC分类号： C07D239/36 , A01N37/18 , A01N37/36 , A61P17/00 , C07B53/00 , C07C231/12 , C07C235/08 , C07C255/16 , C07D213/56 , C07D213/61 , C07D215/12 , C07D215/14 , C07D239/26 , C07D241/42 , C07D261/08 , C07D277/64 , C07D307/54 , C07D307/78 , C07D307/79 , C07D317/60 , C07D319/18 , C07D333/24 , C07D333/28 , C07D333/54 , C07D333/60 , C07C235/34 , A01N43/00 , C07C323/52
CPC分类号： C07D239/26 , A01N37/36 , C07C2601/02 , C07C2602/08 , C07C2602/10 , C07C2603/18 , C07D213/56 , C07D213/61 , C07D215/12 , C07D241/42 , C07D261/08 , C07D277/64 , C07D307/54 , C07D307/79 , C07D317/60 , C07D319/18 , C07D333/24 , C07D333/28 , C07D333/54 , C07D333/60
摘要： The invention relates to phenyl-propargylether derivatives of the general formula I including the optical isomers thereof and mixtures of such osimers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3 are each independently hydrogen or alkyl, R4 is alkyl, alkenal or alkynyl, R5, R6, R7, and R8 are each independently hydrogen or alkal, R9 is hydrogen, optionally substituted alkyl, optionnaly substituted alkenyl or optionally substituted alkynyl, R10 is optionally substituted aryl or optionaly substituted heteroaryl, and Z is optionally substituted aryloxy, optionally substituted alkoxy, optionally substituted alkenyloxy or optionally substituted alkynyloxy. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.
摘要翻译：本发明涉及通式I的苯基 - 炔丙基醚衍生物，包括其光学异构体和此类反应剂的混合物，其中R 1为氢，烷基，环烷基或任选取代的芳基，R 2和R 3各自独立地为氢或烷基，R 4为烷基，烯醛或炔基，R 5，R 6，R 7和R 8各自独立地为氢或碱，R 9为氢，任选取代的烷基，任选取代的烯基或任选取代的炔基，R 10为任选取代的芳基或任选取代的杂芳基，取代的芳氧基，任选取代的烷氧基，任选取代的烯氧基或任选取代的炔氧基。这些化合物具有有用的植物保护特性，并且可以有利地用于农业实践中以控制或防止植物病原微生物特别是真菌侵染植物。

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