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71. 发明申请

WO2005121799A3 NON-COVALENT COMPLEXES COMPRISING CARBON NANOTUBES 审中-公开
标题翻译：包含碳纳米管的非共价复合物
公开(公告)号：WO2005121799A3
公开(公告)日：2006-04-13
申请号：PCT/EP2005006036
申请日：2005-06-06
申请人： CENTRE NAT RECH SCIENT , UNIV LONDON THE SCHOOL OF PHAR , BIANCO ALBERTO , PANTAROTTO DAVIDE , KOSTARELOS KOSTAS , PRATO MAURIZIO
发明人： BIANCO ALBERTO , PANTAROTTO DAVIDE , KOSTARELOS KOSTAS , PRATO MAURIZIO
IPC分类号： C01B31/02 , C09C1/56 , C12Q1/68 , G01N33/543 , G01N33/551
CPC分类号： C09C1/565 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/174 , C01B2202/02 , C01B2202/06 , C01P2004/13 , C01P2004/133 , C09C1/48 , G01N33/54353 , G01N33/551 , Y10S977/746 , Y10S977/748 , Y10S977/75 , Y10S977/752
摘要： The present invention relates to the use of a carbon nanotube comprising positive and/or negative charges, said charges being carried by at least one charge-carrying group, said chargecarrying group being covalently bound to the surface of said carbon nanotube, for the manufacture of a complex between said carbon nanotube and at least one charged molecule, the bond between the carbon nanotube and the charged molecule being essentially electrostatic, and said charged molecule comprising at least one negative charge if said carbon nanotube comprises positive charges and/or at least one positive charge if said carbon nanotube comprises negative charges.
摘要翻译：本发明涉及包含正电荷和/或负电荷的碳纳米管的用途，所述电荷由至少一个电荷携带基团携带，所述电荷接受基团与所述碳纳米管的表面共价结合，用于制造所述碳纳米管与至少一个带电分子之间的复合物，所述碳纳米管与带电分子之间的键基本上是静电的，并且所述带电分子包含至少一个负电荷，如果所述碳纳米管包含正电荷和/或至少一个如果所述碳纳米管包含负电荷，则为正电荷。

72. 发明申请

WO2005121799A2 NON-COVALENT COMPLEXES COMPRISING CARBON NANOTUBES 审中-公开
标题翻译：包含碳纳米管的非共价复合物
公开(公告)号：WO2005121799A2
公开(公告)日：2005-12-22
申请号：PCT/EP2005/006036
申请日：2005-06-06
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITY OF LONDON, THE SCHOOL OF PHARMACY , BIANCO, Alberto , PANTAROTTO, Davide , KOSTARELOS, Kostas , PRATO, Maurizio
发明人： BIANCO, Alberto , PANTAROTTO, Davide , KOSTARELOS, Kostas , PRATO, Maurizio
IPC分类号： G01N33/551
CPC分类号： C09C1/565 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/174 , C01B2202/02 , C01B2202/06 , C01P2004/13 , C01P2004/133 , C09C1/48 , G01N33/54353 , G01N33/551 , Y10S977/746 , Y10S977/748 , Y10S977/75 , Y10S977/752
摘要： The present invention relates to the use of a carbon nanotube comprising positive and/or negative charges, said charges being carried by at least one charge-carrying group, said chargecarrying group being covalently bound to the surface of said carbon nanotube, for the manufacture of a complex between said carbon nanotube and at least one charged molecule, the bond between the carbon nanotube and the charged molecule being essentially electrostatic, and said charged molecule comprising at least one negative charge if said carbon nanotube comprises positive charges and/or at least one positive charge if said carbon nanotube comprises negative charges.
摘要翻译：本发明涉及包含正和/或负电荷的碳纳米管的用途，所述电荷由至少一个电荷携带基团携带，所述电荷接受基团与所述碳纳米管的表面共价结合，用于制造所述碳纳米管与至少一个带电分子之间的复合物，碳纳米管与带电分子之间的键基本上是静电的，并且所述带电分子包含至少一个负电荷，如果所述碳纳米管包含正电荷和/或至少一个如果所述碳纳米管包含负电荷，则为正电荷。

73. 发明申请

WO2004102152A2 IMPROVED POROUS DEVICE 审中-公开
标题翻译：改进的多孔器件
公开(公告)号：WO2004102152A2
公开(公告)日：2004-11-25
申请号：PCT/US2004/014071
申请日：2004-05-05
申请人： METRIGENIX, INC. , COSSABOON, David , EASTMAN, Eric , CHEEK, Brady , YU, Yung-Yi
发明人： COSSABOON, David , EASTMAN, Eric , CHEEK, Brady , YU, Yung-Yi
IPC分类号： G01N
CPC分类号： G01N33/54373 , G01N33/544 , G01N33/551
摘要： An improved polymer device for conducting a multiplicity of individual and simultaneous binding reactions or performing other separation techniques is described. The apparatus comprises a polymer substrate on which are located discrete and isolated sites for such reactions or separation phenomena. The apparatus is characterized by discrete and isolated regions that extend through said substrate and terminate on a second surface thereof such that when a test sample is allowed to the substrate, it is capable of penetrating through each such region during the course of a reaction. The use of castable polymer techniques improves the manufacturing flexibility and cost over prior materials and fabrication methods and also provides certain improved properties such as lower specific stiffness and ease of lamination or bonding to other elements of a device.
摘要翻译：描述了用于进行多次单独和同时结合反应或执行其它分离技术的改进的聚合物装置。该装置包括聚合物基质，在该基质上分离和分离这些反应或分离现象的位置。该装置的特征在于分离和隔离的区域，其延伸穿过所述衬底并终止在其第二表面上，使得当测试样品被允许到衬底时，其能够在反应过程中穿透每个这样的区域。使用可浇注聚合物技术改善了制造灵活性和成本，而不仅仅是现有的材料和制造方法，并且还提供了某些改进的性能，例如较低的比刚度和易于层压或粘合到装置的其它元件。

74. 发明申请

WO2004048936A2 MICROPOROUS MATERIALS, METHODS, AND ARTICLES FOR LOCALIZING AND QUANTIFYING ANALYTES 审中-公开
标题翻译：用于定位和量化分析物的微孔材料，方法和文章
公开(公告)号：WO2004048936A2
公开(公告)日：2004-06-10
申请号：PCT/US0337598
申请日：2003-11-20
申请人： UNIV UTAH RES FOUND , SMITH ROGER E
发明人： SMITH ROGER E
IPC分类号： B01D67/00 , B01D71/02 , B01J19/00 , B01L3/00 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N21/64 , G01N
CPC分类号： B01D67/0088 , B01D67/0065 , B01D67/0093 , B01D71/022 , B01D71/025 , B01J2219/00286 , B01J2219/00545 , B01J2219/00572 , B01J2219/00641 , B01J2219/00722 , B01J2219/00725 , B01L3/50255 , B01L2300/0829 , B82Y10/00 , B82Y30/00 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N21/6428 , G01N33/551 , Y10T428/249953 , Y10T428/249978 , Y10T428/249986
摘要： Described herein are methods for separating one or more analytes present in a fluid sample. The methods involve passing the fluid through a filter having a microporous material, wherein the analytes are localized near the surface of the microporous material. Additional processing steps such as hybridization and amplification can be performed once the analyte is localized. In one method, once the analyte is localized, the analyte can be detected, counted, and correlated in order to determine the concentration of the analyte in the sample. Modified microporous materials and composite materials are also disclosed that can be used in any of the methods and articles described herein. The composite is composed of a microporous material and a pigment, wherein the pigment is incorporated in the microporous material. The pigments alter the optical properties of the microporous material, which enhances the detection of analyte once it is localized. In a further aspect, various kits and articles such as filtration devices containing any of the microporous materials described herein are provided.
摘要翻译：本文描述了用于分离存在于流体样品中的一种或多种分析物的方法。所述方法包括使流体通过具有微孔材料的过滤器，其中分析物定位在微孔材料的表面附近。一旦分析物被定位，就可以进行其他处理步骤，例如杂交和扩增。在一种方法中，一旦分析物被定位，可以检测，计数和相关分析物，以确定样品中分析物的浓度。还公开了可用于本文所述的任何方法和制品的改性微孔材料和复合材料。复合材料由微孔材料和颜料组成，其中将颜料掺入微孔材料中。颜料改变微孔材料的光学性质，一旦局部化就增强了分析物的检测。在另一方面，提供了各种试剂盒和制品，例如包含本文所述的任何微孔材料的过滤装置。

75. 发明申请

WO03102578B1 HIGH THROUGHPUT CELLULAR RESPONSE ASSAY USING MICROARRAYS 审中-公开
标题翻译：使用微阵列的高通量细胞响应测定
公开(公告)号：WO03102578B1
公开(公告)日：2004-04-08
申请号：PCT/EP0305798
申请日：2003-06-03
申请人： PAMGENE BV , VAN DAMME HENDRIK SIBOLT , BLOK HERMAN JACOBUS , HILHORST MARIA HELENA , INGHAM COLIN JOHN
发明人： VAN DAMME HENDRIK SIBOLT , BLOK HERMAN JACOBUS , HILHORST MARIA HELENA , INGHAM COLIN JOHN
IPC分类号： B01J19/00 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/02 , C12Q1/68 , C40B30/04 , C40B60/14 , G01N33/15 , G01N33/50 , G01N33/551 , G01N33/569 , G01N33/68 , G01N37/00
CPC分类号： C40B30/04 , B01J2219/00286 , B01J2219/00378 , B01J2219/00527 , B01J2219/00659 , B01J2219/00702 , B01J2219/00743 , C40B60/14 , G01N33/5008 , G01N33/5023 , G01N33/5026 , G01N33/551 , G01N33/56911 , G01N33/6854 , G01N2500/20
摘要： The present invention relates to methods for screening of cellular responses of cellular components comprising:(a) providing cellular components on the surface of a substrate, said substrate having immobilized thereon an array of detector molecules;(b) delivering test compounds to positions on the substrate corresponding to the arrayed detector molecules on the surface of said solid substrate;(c) incubating said test compounds with said cellular components on the surface of the solid support, under conditions allowing the induction of cellular responses;(d) assaying said cellular responses; and,identifying and characterizing the cellular responses induced by said test compounds. The present invention further relates to the uses of said methods as well as microarrays and kits for carrying out said methods.
摘要翻译：本发明涉及筛选细胞成分的细胞反应的方法，包括：（a）在基质的表面上提供细胞组分，所述底物固定有一组检测分子;（b）将测试化合物递送到（c）在允许诱导细胞反应的条件下，将所述测试化合物与固体支持物表面上的所述细胞组分一起温育;（d）测定所述细胞反应 ; 以及鉴定和表征由所述测试化合物诱导的细胞应答。本发明还涉及所述方法的用途以及用于实施所述方法的微阵列和试剂盒。

76. 发明申请

WO2004024428A1 CARBON NANOTUBES: HIGH SOLIDS DISPERSIONS AND NEMATIC GELS THEREOF 审中-公开
标题翻译：碳纳米管：高固体分散体及其固体凝胶
公开(公告)号：WO2004024428A1
公开(公告)日：2004-03-25
申请号：PCT/US2003/016086
申请日：2003-05-21
申请人： THE TRUSTEES OF THE UNIVERSITY PENNSYLVANIA , YODH, Arjun, G. , ISLAM, Mohammad, F , ALI, Ahmed, M. Alsayed
发明人： YODH, Arjun, G. , ISLAM, Mohammad, F , ALI, Ahmed, M. Alsayed
IPC分类号： B29C71/00
CPC分类号： C04B35/62625 , B82Y10/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B32/168 , C01B32/174 , C01B2202/02 , C04B35/117 , C04B35/14 , C04B35/46 , C04B35/624 , C04B35/6263 , C04B35/63 , C04B35/632 , C04B2235/444 , C04B2235/448 , C04B2235/483 , C04B2235/526 , C04B2235/5264 , C04B2235/5288 , C08K7/24 , G01N33/551 , Y10T428/24612 , Y10T428/24802 , Y10T428/249921
摘要： Disclosed are high weight fraction carbon nanotube dispersions including an aqueous medium, carbon nanotubes, and at least one surfactant, the surfactant having an aromatic group, an alkyl group having from about 4 to about 30 carbon atoms, and a charged head group. Also disclosed are ultrasonication processes capable of providing stable dispersions of carbon nanotubes having reduced breakage of the carbon nanotubes. The preparation of nematic nanotube gels from the carbon nanotube dispersions are also disclosed. A variety of uses and applications of the carbon nanotube dispersions and nematic nanotube gels are provided.
摘要翻译：公开了包括水性介质，碳纳米管和至少一种表面活性剂的高重量级碳纳米管分散体，表面活性剂具有芳基，具有约4至约30个碳原子的烷基和带电头基。还公开了能够提供具有降低的碳纳米管断裂的碳纳米管的稳定分散体的超声波处理方法。还公开了从碳纳米管分散体制备向列型纳米管凝胶。提供了碳纳米管分散体和向列型纳米管凝胶的各种用途和应用。

77. 发明申请

WO2003083478A1 ポリエチレングリコール化ナノ粒子を担持するバイオセンサーチップ表面审中-公开
标题翻译：生物传感器表面携带聚乙烯甘油化纳米粒子
公开(公告)号：WO2003083478A1
公开(公告)日：2003-10-09
申请号：PCT/JP2003/003504
申请日：2003-03-24
申请人：科学技術振興事業団 , 片岡一則 , 長崎幸夫 , 大塚英典 , 内田勝美 , 石井武彦 , 鈴木祐子 , 秋山好嗣 , 高江誓詞
发明人：片岡一則 , 長崎幸夫 , 大塚英典 , 内田勝美 , 石井武彦 , 鈴木祐子 , 秋山好嗣 , 高江誓詞
IPC分类号： G01N33/543
CPC分类号： G01N33/54346 , B82Y15/00 , B82Y30/00 , G01N33/54393 , G01N33/551 , G01N33/553
摘要：生物学的試料における夾雑物、例えば、タンパク質等の非特異的吸着を抑制した高感度バイオアッセイセンサー系が提供される。センサー材料と共通する金属、半導体を内包するポリエチレン化粒子を増幅に用いる。
摘要翻译：旨在提供一种高度灵敏的生物测定传感器系统，其中防止生物样品中杂质如蛋白质的非特异性吸附。在该系统中，使用具有金属的聚乙烯颗粒的放大和用于封装在其中的传感器材料共有的半导体。

78. 发明申请

WO2003021268A1 ADDRESSABLE CONCENTRATORS 审中-公开
标题翻译：可达到的浓度
公开(公告)号：WO2003021268A1
公开(公告)日：2003-03-13
申请号：PCT/US2002/026927
申请日：2002-08-22
申请人： HRL LABORATORIES, LLC , CHOW, David , BREWER, Peter, D.
发明人： CHOW, David , BREWER, Peter, D.
IPC分类号： G01N33/543
CPC分类号： G01N33/543 , G01N33/54366 , G01N33/5438 , G01N33/551
摘要： A concentrator for detecting biological and/or chemical materials in an environment. The concentrator comprises an engineered superlattice structure having alternating layers of binary and ternary group III-group V, or group IV-group IV semiconducting materials. A method for detecting biological and/or chemical materials in an environment using the concentrator. The method comprising exposing the concentrator to the biological and/or chemical materials in an environment and activating the superlattice structure optically or electrically followed by the detection of the biological and/or chemical materials.
摘要翻译：用于在环境中检测生物和/或化学物质的浓缩器。集中器包括具有二元和三元组III族V族或IV族IV族半导体材料的交替层的工程超晶格结构。一种使用该浓缩器检测环境中生物和/或化学物质的方法。该方法包括在环境中将浓缩器暴露于生物和/或化学材料，并光学地或电地激活超晶格结构，然后检测生物和/或化学材料。

79. 发明申请

WO02090945A3 METHOD OF PERFORMING AN ASSAY, APPARATUS THEREFOR, AND A METHOD OF MANUFACTURING AND APPARATUS 审中-公开
标题翻译：一种测定方法，其装置及其制造方法及装置
公开(公告)号：WO02090945A3
公开(公告)日：2003-01-03
申请号：PCT/NL0200287
申请日：2002-05-02
申请人： UNIV DELFT TECH , IORDANOV VENTZESLAV PETROV , SARRO PASQUALINA MARIA , WOLFFENBUTTEL REINOUD FELIX , VELLEKOOP MICHAEL JOHANNES
发明人： IORDANOV VENTZESLAV PETROV , SARRO PASQUALINA MARIA , WOLFFENBUTTEL REINOUD FELIX , VELLEKOOP MICHAEL JOHANNES
IPC分类号： C12Q1/26 , C12Q1/32 , C12Q1/48 , G01N21/03 , G01N21/25 , G01N21/64 , G01N21/78 , G01N33/551 , G01N33/552 , G01N33/553 , G02B5/20 , C12Q1/68
CPC分类号： G01N21/6452 , C12Q1/26 , C12Q1/32 , C12Q1/485 , G01N21/0303 , G01N21/6428 , G01N33/551 , G01N33/552 , G01N33/553 , G01N2021/6471 , G01N2021/6482 , G01N2201/0446 , G02B5/207 , G02B5/208
摘要： The invention relates to a method of performing a fluorescence assay. According to the invention a filter is integrated with at least one component chosen from i) a body comprising a well, wherein the well in which the assay is being performed is exposed to excitation light in such a manner that the filter is positioned between the light-sensitive element and the excitation light source, and ii) a light-sensitive element, wherein the filter is applied at least at the light-sensitive side of the surface of the light-sensitive element, and any light that may be emitted is detected by means of the light-sensitive element. The invention also relates to an apparatus suitable for carrying out the method, as well as a method for its manufacture.
摘要翻译：本发明涉及进行荧光测定的方法。根据本发明，过滤器与至少一种选自i）包括井的主体的组件整合在一起，其中将进行测定的井暴露于激发光，使得过滤器位于光感光元件和激发光源，以及ii）感光元件，其中至少在感光元件的表面的感光侧施加滤光片，并且检测到可能发射的任何光借助于光敏元件。本发明还涉及一种适于实施该方法的装置及其制造方法。

80. 发明申请

WO2002095408A1 生理活性物質固定化担体及びその製造方法、固定化生理活性物質、試料中の対象成分分析方法、並びに試料中の対象成分分析用キット审中-公开
标题翻译：生产支持生物活性物质的方法及其生产方法，固定生理活性物质，样品中分析成分的方法和试剂盒中分析成分的方法
公开(公告)号：WO2002095408A1
公开(公告)日：2002-11-28
申请号：PCT/JP2002/004661
申请日：2002-05-14
申请人：東洋鋼鈑株式会社 , 和光純薬工業株式会社 , 丹花通文 , 岡村浩 , 高木研一 , 天野誠 , 黒澤竜雄
发明人：丹花通文 , 岡村浩 , 高木研一 , 天野誠 , 黒澤竜雄
IPC分类号： G01N33/551
CPC分类号： G01N33/553 , G01N33/551
摘要： It is intended to provide a support showing a high immobilization efficiency on which a physiologically active substance can be immobilized at a high density; a method of efficiently analyzing a biological component by using the immobilization support; and a kit for the analysis. A support for immobilizing a physiologically active substance which comprises a support having a carbon, metallic or a semi−metallic carbon compound layer carrying the physiologically active substance formed on the surface thereof; a process for producing the support for immobilizing a physiologically active substance characterized by bringing a support having a carbon, metallic or a semi−metallic carbon compound layer having functional group into contact with the physiologically active substance; a method of analyzing a component in a sample by using the support; and a kit for analyzing a component in a sample which contains the above support.
摘要翻译：旨在提供显示高固定效率的载体，其上可以高密度固定生理活性物质; 通过使用所述固定支持体有效地分析生物成分的方法; 和一个用于分析的工具箱。用于固定生物活性物质的载体，其包含具有形成在其表面上的生理活性物质的碳，金属或半金属碳化合物层的载体; 一种生产用于固定生理活性物质的载体的方法，其特征在于使带有具有官能团的碳，金属或半金属碳化合物层的载体与生理活性物质接触; 通过使用所述支持体分析样品中的成分的方法; 以及用于分析包含上述支持物的样品中的组分的试剂盒。

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