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71. 发明申请

WO02070035A3 MULTI-PURPOSE, AUTOMATED BLOOD AND FLUID PROCESSING SYSTEMS AND METHODS 审中-公开
标题翻译：多目的，自动血液和流体加工系统及方法
公开(公告)号：WO02070035A3
公开(公告)日：2003-07-17
申请号：PCT/US0205244
申请日：2002-02-13
申请人： BAXTER INT
发明人： MIN KYUNGYOON , BROWN RICHARD I , VISHNOI ROHIT , ARMER ALAN , WESTBERG TOM
IPC分类号： A61M1/02 , A61M1/34 , A61M1/36 , A61M37/00
CPC分类号： A61M1/3687 , A61M1/262 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/342 , A61M1/3441 , A61M1/3672 , A61M1/3675 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0427 , A61M2205/12
摘要： Automated systems and method for processing blood and other fluids are disclosed. The system and methods utilize a disposable fluid circuit fig. 1 mounted on a re-usable hardware component or module 12. The system withdraws blood from a donor or patient 100, separates the blood into two or more components and further processes or treats the separated component.
摘要翻译：公开了用于处理血液和其它流体的自动化系统和方法。该系统和方法利用一次性流体回路图。该系统安装在可重复使用的硬件部件或模块12上。系统从供体或患者100抽出血液，将血液分离成两个或更多个部件，并进一步处理或处理分离的部件。

72. 发明申请

WO2003049787A1 METHODS AND APPARATUS FOR LEUKOREDUCTION OF RED BLOOD CELLS 审中-公开
标题翻译：红血细胞淋巴细胞的方法和装置
公开(公告)号：WO2003049787A1
公开(公告)日：2003-06-19
申请号：PCT/US2002/039590
申请日：2002-12-10
申请人： GAMBRO, INC.
发明人： GIBBS, Bruce, W. , HERSKOVITS, Jon, D.
IPC分类号： A61M1/02
CPC分类号： A61M1/3633 , A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/0439 , A61M2205/12 , A61M2205/123
摘要： A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell separation and collection procedure. Such procedures involve filtering the separated red blood cells in a diluted state after and/or prior to flushing the filter with storage solution. Storage solution may thus be passed through the leukoreduction filter before, with and/or after the RBCs have been filtered therethrough. The red blood cell collection, filtration and storage assembly is preferably preconnected to a blood component separation disposable assembly, including, for example, a centrifuge vessel and a blood removal/return assembly for removing blood from a donor, passing the blood to the centrifuge vessel for separation of the blood into components for collection and providing for filtration of the separated red blood cell component.
摘要翻译：提供了一种用于红血液收集和过滤的方法和装置，其中红细胞收集组件与红细胞分离和收集程序同时或之后提供白细胞减少过滤。这种方法包括在用储存溶液冲洗过滤器之后和/或之前以稀释状态过滤分离的红细胞。因此，在RBC已经过滤之前，之后和/或之后，储存溶液可以通过白细胞减少滤过器。红细胞收集，过滤和储存组件优选地预先连接到血液成分分离一次性组件，包括例如离心机容器和用于从供体去除血液的除血/返回组件，使血液通过离心机容器用于将血液分离成用于收集的组分并提供用于分离的红细胞组分的过滤。

73. 发明申请

WO2002070062A1 AUTOMATED SYSTEM AND METHOD FOR WITHDRAWING COMPOUNDS FROM BLOOD 审中-公开
标题翻译：自动化系统和从血液中提取化合物的方法
公开(公告)号：WO2002070062A1
公开(公告)日：2002-09-12
申请号：PCT/US2002/005243
申请日：2002-02-13
申请人： BAXTER INTERNATIONAL INC.
发明人： VISHNOI, Rohit , BROWN, Richard, I. , MIN, Kyungyoon , WESTBERG, Tom
IPC分类号： A61M37/00
CPC分类号： A61M1/3693 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/342 , A61M1/3441 , A61M1/3672 , A61M1/3675 , A61M1/3679 , A61M1/3687 , A61M1/3692 , A61M1/3696 , A61M2205/12
摘要： Automated systems (10) and methods for withdrawing a selected compound from blood are disclosed. The systems and methods utilize a disposable fluid circuit (50) mounted on a re-usable hardware component or module (12). The system withdraws blood from a donor or patient, separates the blood into two or more components and further combines the separated component with a solvent so as to remove a compound from the blood component.
摘要翻译：公开了自动化系统（10）和从血液中取出所选化合物的方法。系统和方法利用安装在可重复使用的硬件部件或模块（12）上的一次性流体回路（50）。系统从供体或患者抽出血液，将血液分离成两个或更多个组分，并进一步将分离的组分与溶剂组合，以从血液组分中除去化合物。

74. 发明申请

WO01036022A1 METHODS AND APPARATUS FOR LEUKOREDUCTION OF RED BLOOD CELLS 审中-公开
标题翻译：红血细胞淋巴细胞的方法和装置
公开(公告)号：WO01036022A1
公开(公告)日：2001-05-25
申请号：PCT/US2000/031501
申请日：2000-11-16
IPC分类号： A61M1/02 , A61M1/34 , A61M1/36
CPC分类号： A61M1/0218 , A61M1/0231 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3633 , A61M1/3693 , A61M1/3696 , A61M2202/0429 , A61M2202/0439 , A61M2205/12 , A61M2202/0071
摘要： A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly (2) provides for leukoreduction filtration concurrent with or soon after the red blood cell collection procedure. The procedure preferably involves filtering the separated red blood cells in a high hematocrit (high-crit) state prior to addition of storage solution thereto. Preferably, a storage solution is passed through the leukoreduction filter (960) after the RBCs have been filtered therethrough. The red blood cell collection filtration and storage assembly is preferably preconnected to a blood component separation disposable assembly (6), including, for example, a centrifuge vessel (352) and a blood removal/return assembly (20) for removing blood from a donor (4), passing the blood to the centrifuge vessel (352) for separation of the blood into components for collection and providing for filtration of the separated red blood cell component, as described.
摘要翻译：提供了一种用于红血采集和过滤的方法和装置，其中红细胞收集组件（2）与红细胞收集程序同时或之后提供白细胞减少过滤。该方法优选包括在加入其中的储存溶液之前以高血细胞比容（高暴击）状态过滤分离的红细胞。优选地，在通过其中过滤RBC之后，使储存溶液通过白细胞减退过滤器（960）。红细胞收集过滤和储存组件优选地预先连接到血液成分分离一次性组件（6），其包括例如离心机容器（352）和用于从供体中去除血液的除血/返回组件（20）（4），将血液通入离心机容器（352），以将血液分离成用于收集的组分并提供分离的红细胞组分的过滤，如所述。

75. 发明申请

WO01024848A1 EXTRACORPOREAL BLOOD PROCESSING METHODS AND APPARATUS 审中-公开
标题翻译：超声波血液加工方法和装置
公开(公告)号：WO01024848A1
公开(公告)日：2001-04-12
申请号：PCT/US2000/026738
申请日：2000-09-29
IPC分类号： A61M1/02 , A61M1/30 , A61M1/36
CPC分类号： A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M1/3698
摘要： A preconnected disposable and method for red blood collection is provided wherein the preconnected disposable includes a red blood cell collection assembly comprising a leukoreduction filter and a red blood cell storage bag. Such a red blood cell collection assembly is preferably preconnected to a blood component separation vessel, cassette assembly and a blood removal/return assembly for removing blood from a donor, separating the blood into components for collection and providing for filtration of the separated red blood cell component.
摘要翻译：提供了一种用于红血采集的预先连接的一次性和方法，其中所述预连接的一次性物品包括红细胞收集组件，其包含白细胞减退过滤器和红细胞储存袋。这种红细胞收集组件优选地预先连接到血液成分分离容器，盒组件和用于从供体去除血液的除血/返回组件，将血液分离成用于收集的组分并提供用于分离的红细胞的过滤零件。

76. 发明申请

WO01017649A1 BLOOD PROCESSING PROCEDURES WITH RELATED SENSING PROCEDURES 审中-公开
标题翻译：血液加工程序与相关感染程序
公开(公告)号：WO01017649A1
公开(公告)日：2001-03-15
申请号：PCT/US2000/023691
申请日：2000-08-29
IPC分类号： G01N33/48 , A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D17/038 , B01D17/12 , B04B5/00 , G01N21/27 , G01N21/53 , G01N33/483 , G01N33/49 , G01N35/00 , G01N35/08
CPC分类号： G01N21/31 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3393 , B01D17/0217
摘要： Systems and related methods for sensing the presence of targeted cellular blood species during extracorporeal blood separation and processing which use a centrifuge station (20) and a pump and valve station (30). The systems and methods tailor sensing parameters to the particular objectives of particular procedures selected to be accomplished. Different cellular blood species are targeted for detection for different selected blood processing procedures by the centrifuge station (20) and pump and valve station (30). The systems and methods differentiate among different cellular blood species for detection, according to the blood processing procedures selected.
摘要翻译：用于感测在使用离心机（20）和泵和阀站（30）的体外血液分离和处理期间存在目标细胞血液种类的系统和相关方法。系统和方法根据选定要完成的特定程序的特定目标来定制传感参数。不同的细胞血液物种被靶向用于通过离心机站（20）和泵和阀站（30）检测不同的选择的血液处理程序。根据所选择的血液处理程序，系统和方法区分不同细胞血液进行检测。

77. 发明申请

WO0021590A8 AUTOMATIC WHOLE BLOOD COLLECTION SYSTEM 审中-公开
标题翻译：自动全血采集系统
公开(公告)号：WO0021590A8
公开(公告)日：2000-09-21
申请号：PCT/US9923951
申请日：1999-10-14
申请人： HAEMONETICS CORP
发明人： GILCHER RONALD O , CHAMMAS JACQUES , MEDBERRY JOSEPH M , STACEY GARY R
IPC分类号： A61B5/15 , A61J1/14 , A61J3/00 , A61M1/02 , A61M1/30 , A61M1/36 , F04B43/12 , A61M1/34
CPC分类号： F04B43/1292 , A61M1/0272 , A61M1/1039 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3672 , A61M2205/6072
摘要： A whole blood collection system includes an automated pump/control unit and an accompanying disposable blood set. When combined and connected to a source of anticoagulant, these elements allow automatic priming of the blood set with anticoagulant and automatic collection of anticoagulated blood product according to three different collection modes. The unit's pump and the blood set are specially designed to cooperate during the collection process to assure that the collected product has a precise blood to anticoagulant ratio. During the collection procedure, the pump/control unit automatically collects data relating to the procedure. Additional data specifically identifying components of the blood set, such as the blood collection bag, along with identification data on the donor's registration form may be scanned into the pump/controller unit by a scanner associated with the unit; this facilitates positive sample identification and tracking. At the end of the procedure, a printer in the pump/controller unit automatically prints out this information so that a detailed record is immediately available about the collected blood product, the procedure for collecting it and the source of the product.
摘要翻译：全血采集系统包括自动化泵/控制单元和伴随的一次性血液装置。当组合并连接到抗凝血剂来源时，这些元件允许根据三种不同的收集模式用抗凝剂自动引发血液凝集物并自动收集抗凝血液制品。设备的泵和血液装置是专门设计在收集过程中配合，以确保收集的产品具有精确的血液和抗凝血比例。在收集过程中，泵/控制单元自动收集有关过程的数据。可以通过与该单元相关联的扫描仪将与血液集合的组分（例如采集袋）一起的附加数据连同供体登记表上的识别数据一起扫描到泵/控制器单元中; 这有助于正面的样品识别和跟踪。在程序结束时，泵/控制器单元中的打印机自动打印出该信息，以便立即获得关于收集的血液制品，收集的程序和产品来源的详细记录。

78. 发明申请

WO99011305A1 EXTRACORPOREAL BLOOD PROCESSING METHODS AND APPARATUS 审中-公开
标题翻译：超声波血液加工方法和装置
公开(公告)号：WO99011305A1
公开(公告)日：1999-03-11
申请号：PCT/US1998/018352
申请日：1998-09-02
IPC分类号： A61M1/36
CPC分类号： A61M1/3693 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3692 , A61M1/3696
摘要： Improved extracorporeal blood processing methods and apparatus are disclosed. In one aspect of the invention, an extracorporeal method for the collection of platelets and red blood cells, and if desired plasma, is provided, wherein the collection of platelets and red blood cells may occur in differing time periods utilizing the same blood processing vessel. The flow of blood to the blood processing vessel and return of uncollected blood components may be provided via a single needle, wherein blood is removed and returned to a donor/patient during alternating blood removal and blood return submodes. Prior to red blood cell collection, a set-up phase may be carried out during which a predetermined hematocrit and AC ratio is established.
摘要翻译：公开了改进的体外血液处理方法和装置。在本发明的一个方面，提供了用于收集血小板和红细胞以及如果需要的血浆的体外方法，其中血小板和红细胞的收集可以在不同的时间段内使用相同的血液处理容器进行。可以通过单个针提供血液加工血液到血液处理容器的流动并返回未收集的血液成分，其中在交替的血液清除和血液回流子模式期间，血液被移除并返回给供体/患者。在红细胞收集之前，可以进行建立阶段，在此期间建立预定的血细胞比容和AC比。

79. 发明申请

WO9622117A3 ON-LINE DRUG DELIVERY SYSTEM IN EXTRACORPOREAL THEON-LINE DRUG DELIVERY SYSTEM IN EXTRACORPOREAL THERAPY RAPY 审中-公开
标题翻译：在线药物递送系统在离线药物递送系统在超临界治疗RAPY
公开(公告)号：WO9622117A3
公开(公告)日：1996-11-07
申请号：PCT/US9600458
申请日：1996-01-16
申请人： JOHNSON & JOHNSON CORP , BRIGGS DENNIS A , LEE KYU H , GARRO JOSEPH JR
发明人： BRIGGS DENNIS A , LEE KYU H , GARRO JOSEPH JR
IPC分类号： A61M1/00 , A61M1/16 , A61M1/30 , A61M1/36 , A61M5/145 , B01F5/06 , G01M3/18
CPC分类号： B01F5/0682 , A61M1/0021 , A61M1/1692 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/304 , A61M1/308 , A61M1/3626 , A61M1/3681 , A61M1/3683 , A61M1/3693 , A61M1/3696 , A61M5/1456 , A61M2205/3386 , A61M2205/50 , B01F5/0694 , G01M3/186
摘要： A preferred patient blood treatment system and method for the photoactivation of reagents in contact with a patient's blood achieves a well-mixed and accurate drug concentration in extracorporeal therapy. The preferred drug delivery system of the present invention comprises specially designed components and a microprocessor control system including a syringe pump, drug mixer and a reaction chamber, whereby the microprocessor control system monitors patient blood flow and regulates the system components to deliver the desired drug concentration to the reaction chamber maximizing the effectiveness of extracorporeal therapy.
摘要翻译：用于与患者血液接触的试剂的光活化的优选的患者血液处理系统和方法在体外疗法中实现良好混合且准确的药物浓度。本发明优选的药物输送系统包括特别设计的组件和包括注射泵，药物混合器和反应室的微处理器控制系统，由此微处理器控制系统监测患者的血流量并调节系统组分以递送所需的药物浓度对反应室最大化体外疗法的有效性。

80. 发明申请

WO1995017604A1 PERISTALTIC PUMP TUBE HOLDER WITH PUMP TUBE SHIELD AND COVER 审中-公开
标题翻译：超声波泵管与泵管屏蔽和盖子
公开(公告)号：WO1995017604A1
公开(公告)日：1995-06-29
申请号：PCT/US1994002907
申请日：1994-03-17
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , GIESLER, Richard, C. , MILES, Myra, P. , LOVELACE, Susan, L.
IPC分类号： F04B43/08
CPC分类号： F04B43/1253 , A61M1/30 , A61M1/303 , A61M1/3693 , A61M1/3696 , A61M2205/12 , F02B2075/025
摘要： A peristaltic pump tube holder includes a body (110) that supports a flexible tubing loop (134/136) in an erect, outwardly bowed position extending from the body for engagement with a peristaltic pump rotor (292). The holder also includes a receptacle (26) carrying the body. The receptacle (26) also includes a wall forming a chamber (152 A/B/C) that covers the flexible tubing loop and at least partially shields it from contact. The chamber further serves, during engagement between the tubing loop (134/136) and a peristaltic pump rotor (292), as a cover for the peristaltic pump rotor.
摘要翻译：蠕动泵管保持器包括主体（110），该主体（110）支撑柔性管道回路（134/136），其处于从主体延伸的直立的向外弯曲位置，用于与蠕动泵转子（292）接合。支架还包括承载本体的容器（26）。容器（26）还包括形成腔室（152A / B / C）的壁，其覆盖柔性管道环并且至少部分地将其遮蔽而不接触。在该管路回路（134/136）和蠕动泵转子（292）之间的接合期间，该腔室还用作蠕动泵转子的盖子。

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