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    • 73. 发明申请
    • THE USE OF BACTERIAL PHAGE ASSOCIATED LYTIC ENZYMES TO PREVENT FOOD POISONING
    • 使用细菌相关的LYTIC ENZYMES预防食物毒素
    • WO2002102405A1
    • 2002-12-27
    • PCT/US2001/042886
    • 2001-11-01
    • NEW HORIZONS DIAGNOSTICS INC.FISCHETTI, VincentLOOMIS, LawrenceTRUDIL, David
    • FISCHETTI, VincentLOOMIS, LawrenceTRUDIL, David
    • A61K38/43
    • A23B7/155A23B4/22A23B5/16A23K20/189A23K30/00A23L3/3463A23L3/3571
    • The present invention discloses a method and composition for the treatment of bacterial contamination of food by the use of a phage associated lysing enzyme, preferably blended with an appropriate carrier. The method for treating food stuffs comprises treating the food stuffs with an anti-infection agent comprising an effective amount of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for the bacteria.. Additionally, chimeric lytic enzymes shuffled lytic enzymes, and holin proteins, either alone or in combination, may be used to treat or prevent bacterial contamination of foodstuffs. The lytic enzyme can be used for the treatment or prevention of various strains of Staphylococcus, Streptococcus, Listeria, Salmonella, E. coli, Campylobacter, Pseudomonas, Brucella, other bacteria, and an,Y combination thereof. Feed for livestock, poultry and beef in slaughterhouses, canned and bottled goods, salad bars, and eggs are just some of the food items that can be treated with at least one lytic enzyme to reduce the risk of food contamination by bacteria.
    • 本发明公开了一种通过使用噬菌体相关的裂解酶处理食物细菌污染的方法和组合物,优选与合适的载体共混。 用于处理食物的方法包括用抗感染剂处理食物,所述抗感染剂包含有效量的由细菌特异性感染的细菌产生的至少一种裂解酶。另外,嵌合裂解酶洗涤裂解酶, 和单独或组合的蛋白质可用于治疗或预防食品的细菌污染。 溶解酶可用于治疗或预防葡萄球菌,链球菌,利斯特氏菌,沙门氏菌,大肠杆菌,弯曲杆菌,假单胞菌,布鲁杆菌,其他细菌及其Y组合的各种菌株。 在屠宰场,罐装和瓶装食品,沙拉吧和鸡蛋中饲养牲畜,家禽和牛肉只是一些可以用至少一种溶解酶处理的食物,以减少细菌食物污染的风险。