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71. 发明申请

WO2006088912A2 MINERAL TECHNOLOGIES (MT) FOR ACUTE HEMOSTASIS AND FOR THE TREATMENT OF ACUTE WOUNDS AND CHRONIC ULCERS 审中-公开
标题翻译：矿物技术（MT）用于急性HEMOSTASIS和治疗急性创伤和慢性ULCER
公开(公告)号：WO2006088912A2
公开(公告)日：2006-08-24
申请号：PCT/US2006005251
申请日：2006-02-15
申请人： UNIV VIRGINIA COMMONWEALTH , DIEGELMANN ROBERT F , WARD KEVIN R , CARR MARCUS E JR , BOWLIN GARY LEE
发明人： DIEGELMANN ROBERT F , WARD KEVIN R , CARR MARCUS E JR , BOWLIN GARY LEE
IPC分类号： A61F13/02
CPC分类号： A61L15/18 , A61L26/0004
摘要： Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when applied to a hemorrhaging wound. Electrospun or electrosprayed materials (e.g. bandages, micron beads, etc.) which include clay minerals, and methods for the treatment of acute hemorrhage, are also provided.
摘要翻译：提供了包含粘土矿物的组合物及其用于促进止血的方法。组合物包括粘土矿物如膨润土，并且当应用于出血伤口时促进凝血。还提供了包括粘土矿物的电纺丝或电喷雾材料（例如绷带，微米珠等）以及用于治疗急性出血的方法。

72. 发明申请

WO2006023481A3 ACOUSTICAL-BASED TISSUE RESUSCITATION 审中-公开
标题翻译：基于声学的组织复原
公开(公告)号：WO2006023481A3
公开(公告)日：2006-05-11
申请号：PCT/US2005029081
申请日：2005-08-16
申请人： UNIV VIRGINIA COMMONWEALTH , WARD KEVIN R , LENHARDT MARTIN L
发明人： WARD KEVIN R , LENHARDT MARTIN L
IPC分类号： A61B5/00
CPC分类号： A61H23/0236 , A61H2201/5005 , A61H2201/5074 , A61H2230/207 , A61H2230/25
摘要： Acoustical-based methods that increase tissue oxygenation, and equipment for carrying out the methods, are provided. The methods involve exposing tissue to low frequency sound in order to increase blood flow in the tissue, and hence oxygenation of the tissue. The methods may be used to treat or prevent disorders related to ischemia and low blood flow, such as shock, stroke and congestive heart failure.
摘要翻译：提供了增加组织氧合的基于声学的方法以及用于实施这些方法的设备。该方法涉及使组织暴露于低频声音以增加组织中的血流量，并因此增加组织的氧合作用。该方法可用于治疗或预防与局部缺血和低血流有关的疾病，例如休克，中风和充血性心力衰竭。

73. 发明申请

WO2005016121A2 METHOD AND APPARATUS FOR MONITORING INTRA OCULAR AND INTRA CRANIAL PRESSURE 审中-公开
标题翻译：用于监测眼内压和内压的方法和装置
公开(公告)号：WO2005016121A2
公开(公告)日：2005-02-24
申请号：PCT/US2004025185
申请日：2004-08-06
申请人： UNIV VIRGINIA COMMONWEALTH , LENHARDT MARTIN L , WARD KEVIN
发明人： LENHARDT MARTIN L , WARD KEVIN
IPC分类号： A61B20060101 , A61B3/16 , A61B5/00 , A61B5/03 , A61B8/08 , A61B
CPC分类号： A61B5/031 , A61B5/6814 , A61B5/6821 , A61B8/0808 , A61B8/4227
摘要： A method and apparatus for measuring acoustic energy applied to the head to detect increases in intra cranial pressure. Acoustic eye patches are applied to a patient's eye or eyelid, and an ultrasonic sweep generator applies an acoustic signal across the patient's skull, the signal being swept across a predetermined range. The eye patches have piezoelectric film sensors for measuring the acoustic signal. In one embodiment the predetermined range is in the ultrasonic band and an analyzer determines from the output of the sensors a resonant frequency and a damping of acoustic amplitude at said resonant frequency, there being a correlation between said damping and intra cranial pressure. In another embodiment the predetermined range includes a range less than 20 kHz and the analyzer determines retinal artery pulsations, with pressure being applied to the eye until the pulsations disappear, such pressure being a measure of intra cranial pressure.
摘要翻译：一种用于测量施加于头部的声能以检测颅内压升高的方法和装置。声眼补片应用于患者的眼睛或眼睑，超声波扫描发生器在患者的颅骨上施加声学信号，该信号被扫过预定范围。眼贴具有用于测量声信号的压电膜传感器。在一个实施例中，预定范围在超声频带中，分析器根据传感器的输出确定谐振频率和在所述共振频率处的声振幅的阻尼，所述阻尼和颅内压之间存在相关性。在另一个实施例中，预定范围包括小于20kHz的范围，并且分析仪确定视网膜动脉脉动，其中施加压力施加到眼睛直到脉动消失，这种压力是颅内压的量度。

74. 发明申请

WO2004060269A3 MDA-7 AND FREE RADICALS IN THE TREATMENT OF CANCER 审中-公开
标题翻译： MDA-7和自由基在治疗癌症中的作用
公开(公告)号：WO2004060269A3
公开(公告)日：2004-10-14
申请号：PCT/US0328512
申请日：2003-09-09
申请人： UNIV COLUMBIA , UNIV VIRGINIA COMMONWEALTH , FISHER PAUL B , GOPALKRISHNAN RAHUL , LEBEDEVA IRINA , GRANT STEVEN , YACOUB ADLY , DENT PAUL
发明人： FISHER PAUL B , GOPALKRISHNAN RAHUL , LEBEDEVA IRINA , GRANT STEVEN , YACOUB ADLY , DENT PAUL
IPC分类号： A61K38/17 , A61K48/00 , C07K14/47 , C12N15/861 , A01N37/18 , A01N43/04 , C07H21/04 , C07K1/00 , C12N15/00 , C12N15/63
CPC分类号： C12N15/86 , A61K38/1709 , A61K48/00 , C07K14/47 , C07K2319/23 , C12N2710/10343 , C12N2810/00
摘要： The present invention relates to methods of treating a cancer in a subject comprising generating within one or more cancer cells of a subject an effective amount of MDA-7 and an effective amount of one or more free radicals. The present invention further relates to methods of inhibiting proliferation or promoting death in a cancer cell of a subject comprising generating within one or more cancer cells of a subject an effective amount of MDA-7 and an effective amount of one or more free radicals. Generation of an effective amount of MDA-7 can occur by administering to the cancer cell an effective amount of an mda-7 nucleic acid, MDA-7 protein, functional equivalents of either of these molecules, by upregulation of the endogenous mda-7 gene, or by stabilization of the mda-7 mRNA. Generation of one or more free radicals in a cancer cell can occur by exposing the cancer cell to an effective amount of ionizing radiation, a free radical, a generator of a free radical, a ROS, a generator of a ROS, or a disruptor of mitochondrial membrane potential.
摘要翻译：本发明涉及治疗受试者的癌症的方法，其包括在受试者的一个或多个癌细胞内产生有效量的MDA-7和有效量的一种或多种自由基。本发明进一步涉及抑制受试者癌细胞增殖或促进死亡的方法，包括在受试者的一个或多个癌细胞内产生有效量的MDA-7和有效量的一种或多种自由基。通过向癌细胞施用有效量的mda-7核酸，MDA-7蛋白，这些分子中的任一个的功能等价物，通过上调内源性mda-7基因，可以产生有效量的MDA-7 ，或通过稳定mda-7 mRNA。通过将癌细胞暴露于有效量的电离辐射，自由基，自由基的生成物，ROS，ROS的生成物或干扰物的干扰物，可以发生癌细胞中的一种或多种自由基线粒体膜电位。

75. 发明申请

WO2004050030A3 ANTI-SICKLING AGENTS 审中-公开
标题翻译：防蛀剂
公开(公告)号：WO2004050030A3
公开(公告)日：2004-07-29
申请号：PCT/US0338264
申请日：2003-12-03
申请人： UNIV VIRGINIA COMMONWEALTH
发明人： SAFO MARTIN K , DANSO-DANQUAH RICHMOND , NOKURI SAMUEL , MUSAYEV FAIK N , JOSHI GAJANAN S , BURNETT JAMES C , ABRAHAM DONALD J
IPC分类号： A61K31/34 , A61K31/381 , A61K31/40 , A61K31/401 , A61K31/66 , C07D207/30 , C07D417/04 , C07D307/34
CPC分类号： C07D417/04 , A61K31/34 , A61K31/381 , A61K31/40 , A61K31/401 , A61K31/66 , C07D307/48 , C07D333/22 , C07D333/26 , Y02P20/55
摘要： The provides compounds for the treatment of sickle-cell disease. In particular, the invention provides 5-membered heterocyclic anti-sickling agents that are highly effective and nontoxic, and methods for their use. The compounds include analogues and derivatives of naturally occurring 5-hydroxymethyl-2-furfuraldehyde, 5-Ethyl-2-furfuraldehyde, 5-Methyl-2furfuraldehyde, and 2-furfuraldehyde, and prodrug forms of the compound.
摘要翻译：提供治疗镰状细胞病的化合物。特别地，本发明提供了高效无毒的5元杂环抗镰刀剂及其使用方法。该化合物包括天然存在的5-羟甲基-2-糠醛，5-乙基-2-糠醛，5-甲基-2糠醛和2-糠醛的类似物和衍生物，以及该化合物的前药形式。

76. 发明申请

WO0232397A9 ELECTROPROCESSING IN DRUG DELIVERY AND CELL ENCAPSULATION 审中-公开
标题翻译：在药物递送和细胞包封中的电子加工
公开(公告)号：WO0232397A9
公开(公告)日：2002-10-24
申请号：PCT/US0132301
申请日：2001-10-18
申请人： UNIV VIRGINIA COMMONWEALTH , SIMPSON DAVID G , BOWLIN GARY L , WNEK GARY E
发明人： SIMPSON DAVID G , BOWLIN GARY L , WNEK GARY E
IPC分类号： A61K9/00 , A61K31/65 , A61K35/12 , A61K38/22 , A61K41/00 , A61K45/00 , A61K47/16 , A61K47/26 , A61K47/30 , A61K47/42 , A61L15/32 , A61L27/22 , A61L27/24 , A61L27/26 , A61L27/38 , A61L31/04 , A61P3/10 , A61P17/02 , A61P19/00 , A61P31/04 , A61P43/00 , B29C41/00 , B29C67/00 , C07K14/75 , C07K14/78 , C12N5/00 , C12N5/06 , C12Q1/02
CPC分类号： C12N5/0068 , A61K2035/126 , A61L15/32 , A61L27/225 , A61L27/24 , A61L27/26 , A61L27/38 , A61L27/3847 , A61L31/041 , A61L2400/04 , B29C41/006 , B29C67/0007 , C07K14/75 , C07K14/78 , C12N5/0012 , C12N2533/40 , C12N2533/54 , C12N2533/56 , D01D5/0007 , D01F1/10 , C08L89/00
摘要： The invention is directed to novel compositions comprising an electroprocessed material and a substance, their formation and use. The electroprocessed material can, for example, be one or more natural materials, one or more synthetic materials, or a combination thereof. The substance can be one or more therapeutic or cosmetic substances or other compounds, molecules, cells, vesicles. The compositions can be used in substance delivery, including drug delivery within an organism by, for example, releasing substances or containing cells that release substances. The compositions can be used for other purposes, such as prostheses or similar implants.
摘要翻译：本发明涉及包含电处理材料和物质的新型组合物，它们的形成和用途。电处理材料可以例如是一种或多种天然材料，一种或多种合成材料或其组合。该物质可以是一种或多种治疗或美容物质或其他化合物，分子，细胞，囊泡。该组合物可用于物质递送，包括通过例如释放物质或含有释放物质的细胞在生物体内递送药物。该组合物可以用于其他目的，例如假体或类似的植入物。

77. 发明申请

WO0224053A3 MONITORING CENTRAL VENOUS PRESSURES AND INTRAVASCULAR VOLUME 审中-公开
标题翻译：监测中心静脉压和血管内容积
公开(公告)号：WO0224053A3
公开(公告)日：2002-07-04
申请号：PCT/US0129582
申请日：2001-09-21
申请人： UNIV VIRGINIA COMMONWEALTH , WARD KEVIN R , BARBEE ROBERT W , IVATURY RAO R , SPIESS BRUCE D , ARROWOOD JAMES A
发明人： WARD KEVIN R , BARBEE ROBERT W , IVATURY RAO R , SPIESS BRUCE D , ARROWOOD JAMES A
IPC分类号： A61B5/00 , A61B5/022 , A61B5/05 , A61B5/103
CPC分类号： A61B5/412 , A61B5/0059 , A61B5/022 , A61B5/05 , A61B5/1073
摘要： Central Venous Pressure (CVP) is non-invasively determined with accuracy comparable to invasive measurement techniques. To do so, curves are plotted based on non-invasively determined patient information obtained by applying a controllable variable (pressure) to a vein of interest at a non-distal point and taking certain measurements (such as pressure and volume measurements) from the patient. An example of a controllable variable is voltage applied in incremental inflation/deflation of a vascular cuff (1). A curve is plotted based on datapoints (such as a volume increase curve or a volume decline curve). Pertinent, accurate CVP and/or blood volume information is obtained from the slope of the non-invasive-based curve. Accurate CVP information is provided without the risks and disadvantages of invasive measurements.
摘要翻译：中心静脉压（CVP）以非侵入式方式确定，准确度与侵入式测量技术相当。为此，基于非侵入式确定的患者信息绘制曲线，所述患者信息通过将可控变量（压力）应用于非远侧点处的感兴趣静脉并从患者获取某些测量结果（诸如压力和体积测量结果）。可控变量的一个例子是在血管套囊（1）的增量膨胀/收缩中施加的电压。基于数据点绘制曲线（如体积增加曲线或体积减小曲线）。相关的，准确的CVP和/或血量信息是从非侵入性曲线的斜率获得的。提供准确的CVP信息，没有有创测量的风险和缺点。

78. 发明申请

WO0040203A3 POLYMERIC DELIVERY AGENTS AND DELIVERY AGENT COMPOUNDS 审中-公开
标题翻译：聚合物输送剂和输送剂化合物
公开(公告)号：WO0040203A3
公开(公告)日：2000-12-14
申请号：PCT/US0000476
申请日：2000-01-07
申请人： EMISPHERE TECH INC , UNIV VIRGINIA COMMONWEALTH , MILSTEIN SAM J , BARANTSEVITCH EUGENE N , WANG NAI FANG , LIAO JUN , SMART JOHN E , CONTICELLO RICHARD D , OTTENBRITE RAPHAEL M
发明人： MILSTEIN SAM J , BARANTSEVITCH EUGENE N , WANG NAI FANG , LIAO JUN , SMART JOHN E , CONTICELLO RICHARD D , OTTENBRITE RAPHAEL M
IPC分类号： A61K9/00 , A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , A61K47/10 , A61K47/32 , A61K47/48 , C08F8/30 , C08G65/329 , C08G65/333 , A01N25/00 , A01N37/18 , A01N43/04 , A61K9/50 , A61K38/00
CPC分类号： C08G65/33396 , A61K9/0019 , A61K38/27 , A61K38/29 , A61K47/10 , A61K47/32 , A61K47/56 , A61K47/60 , C08F8/30 , C08G65/329 , C08L2203/02
摘要： Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译：提供了可用于递送活性剂的聚合物递送剂，递送剂化合物和包含它们的组合物。还提供给药方法和制剂。

79. 发明申请

WO0007440A9 METHODS AND APPARATUS FOR ALERTING AND/OR REPELLING BIRDS AND OTHER ANIMALS 审中-公开
标题翻译：用于改变和/或驱赶鸟类和其它动物的方法和设备
公开(公告)号：WO0007440A9
公开(公告)日：2000-08-24
申请号：PCT/US9917827
申请日：1999-08-06
申请人： UNIV VIRGINIA COMMONWEALTH
发明人： LENHARDT MARTIN L , OCHS ALFRED L
IPC分类号： A01M29/16 , A01M29/18 , A01M29/22 , A01M29/24 , A01M29/26 , H04B1/02 , A01K15/04 , G01S13/93 , G08B23/00
CPC分类号： A01M29/24 , A01M29/16 , A01M29/18 , A01M29/22 , A01M29/26 , Y02B10/30 , Y10S119/908
摘要： An external stimuli is provided that alerts animals to danger and/or repels the animals from certain areas. More specifically, the system and method of the present invention uses an external stimuli, such as, for example, pulsing microwaves, vibration or supersonic sound waves (6), in order to alert birds (10) or other animals of danger and/or repel these same birds (10) or animals from specific areas. These produced external stimuli may provide a reversible unpleasant sensation to the birds (10) and other animals so that they will not only be repelled from a specific area, such as an airport, but they will also avoid returning to such area. One such unpleasant sensation that is virtually harmless to the birds (10) and other animals is the sensation of dizziness.
摘要翻译：提供外部刺激提醒动物危险和/或排斥某些地区的动物。更具体地说，本发明的系统和方法使用外部刺激，例如脉冲微波，振动或超声波声波（6），以便警告鸟类（10）或其他动物危险和/或击退这些相同的鸟类（10）或特定区域的动物。这些产生的外部刺激可能给鸟类（10）和其他动物带来可逆的不愉快感觉，使得它们不仅会从机场等特定区域被排斥，而且它们也将避免返回到这样的区域。对鸟类（10）和其他动物几乎无害的这种不愉快的感觉是头晕的感觉。

80. 发明申请

WO2014197598A3 TRIPARTITE CANCER THERANOSTIC NUCLEIC ACID CONSTRUCTS 审中-公开
标题翻译：三磷酸核苷酸核酸结构
公开(公告)号：WO2014197598A3
公开(公告)日：2015-06-04
申请号：PCT/US2014040912
申请日：2014-06-04
申请人： UNIV JOHNS HOPKINS , UNIV VIRGINIA COMMONWEALTH
发明人： FISHER PAUL B , DAS SWADESH K , MENEZES MITCHELL E , SARKAR DEVANAND , POMPER MARTIN G
IPC分类号： A61K48/00
CPC分类号： A61K48/0058 , A61K9/0019 , A61K38/20 , A61K41/0028 , A61K41/0033 , A61K49/0013 , A61K49/0045 , A61K49/0054 , A61K51/00 , A61K51/0491 , C12N7/00 , C12N15/86 , C12N15/87 , C12N2710/10043 , C12N2710/10343 , C12N2710/16143 , C12N2710/16171 , C12N2830/008 , C12Q1/6897
摘要： The presently disclosed subject matter generally relates to genetic constructs and methods for their use in cancer imaging, cancer treatment, and combined imaging and treatment protocols. In particular, the presently disclosed subject matter relates to tripartite cancer theranostic nucleic acid constructs that permit simultaneous cancer specific viral replication, expression of a diagnostic gene product, and expression of a therapeutic gene.
摘要翻译：目前公开的主题通常涉及其用于癌症成像，癌症治疗和组合成像和治疗方案中的遗传构建体和方法。特别地，目前公开的主题涉及允许同时进行癌症特异性病毒复制，诊断基因产物的表达和治疗基因表达的三方式癌症核糖核酸构建体。

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