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71. 发明申请

WO1998023638A2 COMPLEMENT INHIBITOR 审中-公开
标题翻译：补充抑制剂
公开(公告)号：WO1998023638A2
公开(公告)日：1998-06-04
申请号：PCT/GB1997003275
申请日：1997-11-28
申请人： UNIVERSITY OF LEICESTER , SCHWAEBLE, Wilhelm , SIM, Robert, Braidwood
发明人： UNIVERSITY OF LEICESTER
IPC分类号： C07K14/00
CPC分类号： C07K14/472 , A61K38/00
摘要： The present invention concerns regulation of complement activation, in particular the fluid phase regulation of complement activation, and provides molecules comprising at least complement control protein modules 1-4 of complement factor H, DNA molecules encoding same, their use in the manufacture of a medicament for inhibiting complement activation and methods of same, together with DNA sequences encoding rat FH 4.3 and 1.0 kb mRNA.
摘要翻译：本发明涉及补体激活的调节，特别是补体激活的流体相调节，并且提供至少包含补体因子H的补体对照蛋白模块1-4，编码相同因子的DNA分子，它们在制备药物中的用途用于抑制补体活化及其方法，以及编码大鼠FH 4.3和1.0kb mRNA的DNA序列。

72. 发明申请

WO1997014061A1 DETECTOR AND METHOD FOR AUTORADIOGRAPHY 审中-公开
标题翻译：检测器和自动方法
公开(公告)号：WO1997014061A1
公开(公告)日：1997-04-17
申请号：PCT/GB1996002238
申请日：1996-09-10
申请人： UNIVERSITY OF LEICESTER , FRASER, George, William , LEES, John, Ernest
发明人： UNIVERSITY OF LEICESTER
IPC分类号： G01T01/28
CPC分类号： G01T1/28 , G01T1/2942
摘要： There is disclosed a detector for autoradiography, the detector comprising a substantially radioisotope free microchannel plate (MCP) detector, the dimensions of the active area of said detector being substantially comparable with, or greater than, the working field of the autoradiography sample; and MCP signal collection means.
摘要翻译：公开了一种用于放射自显影的检测器，该检测器包括基本上无放射性同位素的微通道板（MCP）检测器，所述检测器的有效面积的尺寸基本上与放射自显影样品的工作场相当或大于; 和MCP信号采集装置。

73. 发明申请

WO1993005164A1 CALLUS-SPECIFIC PROMOTERS 审中-公开
标题翻译：电话特价促销
公开(公告)号：WO1993005164A1
公开(公告)日：1993-03-18
申请号：PCT/GB1992001602
申请日：1992-09-02
申请人： THE UNIVERSITY OF LEICESTER , DRAPER, John
发明人： THE UNIVERSITY OF LEICESTER
IPC分类号： C12N15/82
CPC分类号： C07K14/415 , C12N15/8222 , C12N15/8223
摘要： A marker gene for use in the genetic transformation of plants is driven by a promoter which is capable of acting as a callus-specific promoter, for example in monocotyledonous plants. A suitable promoter naturally drives the expression of a gene encoding a predicted 16.92 kDa protein after wounding and/or callus formation in Asparagus officinalis or an equivalent protein in other members of Liliaceae or Amaryllidaceae. A preferred embodiment is designated the AoPR1 promoter. Under the control of a promoter of the invention, the marker gene (which may for example be an antibiotic- or herbicide-resistance gene) is expressed strongly in wounded tissues and cells and cultured explants, but not constitutively throughout the whole plant. Such promoters may also be used to drive expression of genes in plant tissue culture.
摘要翻译：用于植物遗传转化的标记基因由能够作为愈伤组织特异性启动子的启动子驱动，例如在单子叶植物中。合适的启动子自然地驱动编码在芦笋中的伤口和/或愈伤组织形成之后的预测的16.92kDa蛋白质的基因的表达或百合科或芳樟科的其他成员中的等同蛋白质的表达。优选的实施方案指定为AoPR1启动子。在本发明的启动子的控制下，标记基因（其可以是例如抗生素或除草剂抗性基因）在受伤的组织和细胞和培养的外植体中强烈表达，但不整体在整个植物中表达。此类启动子也可用于驱动植物组织培养中基因的表达。

74. 发明申请

WO1992007284A1 DIRECT DIGITAL POSITION READOUT TRANSDUCER 审中-公开
标题翻译：直接数字位置读出传感器
公开(公告)号：WO1992007284A1
公开(公告)日：1992-04-30
申请号：PCT/GB1991001773
申请日：1991-10-11
申请人： UNIVERSITY OF LEICESTER , FRASER, George, William
发明人： UNIVERSITY OF LEICESTER
IPC分类号： G01T01/29
CPC分类号： G01T1/2957
摘要： There is disclosed a direct digital position readout transducer for a 2 x 2 array of positions, adapted to assign coordinates uniquely to each of the 2 positions of the array, comprising readout elements arranged in m + n layers parallel to the array each ith layer (i = 1 to m) having 2 and each jth layer (j = 1 to n) having 2 readout elements, the elements of each layer occupying half of the 2 positions in that layer corresponding to the positions in the array and the ith and jth layers respectively assigning a "1" or a "0" to the ith and jth significant bits of the binary coordinates according as a signal incident at a position affects or does not affect a readout element in the ith and jth layer and the elements being so patterned within the layers as to yield thereby unique binary coordinate codes to the positions.
摘要翻译：公开了一种用于2×m 2 阵列阵列的直接数字位置读出换能器，其适于为阵列的2 个位置中的每一个独立地分配坐标，包括以m为单位布置的读出元件 + n个层与平行于阵列的每个第i层（i = 1到m）和具有2个读出元件的第j层（j = 1到n）的第i层（i = 1到m），每层的元素占据了该层中的2

75. 发明申请

WO2020065302A8 THERAPEUTIC BACTERIOPHAGES 审中-公开
公开(公告)号：WO2020065302A8
公开(公告)日：2020-04-02
申请号：PCT/GB2019/052695
申请日：2019-09-24
申请人： UNIVERSITY OF LEICESTER
发明人： CLOKIE, Martha , THANKI, Anisha
IPC分类号： A61K35/76 , C12N7/00 , C12N9/36
摘要： There is provided a bacteriophage of the Myoviridae family, comprising a genome of circularly permuted double-stranded DNA at a length of 200kbp or more; characterised in that the phage has any one or more of the following features: a) does not have a holin gene; and/or b) binds to the Salmonella lipopolysaccharide; and/or c) has only one tail fibre protein; and d) has a sequence with at least 95% sequence identity to SEQ ID NO. 7 and/or a sequence with at least 80% sequence identity to SEQ ID NO.8. Suitably, the bacteriophage may be used to treat salmonella, in particular in the treatment of salmonella in pigs and fowl.

76. 发明申请

WO2019102186A1 KYNURENINE 3-MONOOXYGENASE (KMO) INHIBITORS, AND USES AND COMPOSITIONS THEREOF 审中-公开
公开(公告)号：WO2019102186A1
公开(公告)日：2019-05-31
申请号：PCT/GB2018/053352
申请日：2018-11-20
申请人： UNIVERSITY OF LEICESTER , UNIVERSITY OF MANCHESTER
发明人： SCRUTTON, Nigel , GIORGINI, Flaviano
IPC分类号： C07D413/06 , A61K31/538 , C07D265/36 , A61P25/00
CPC分类号： C07D265/36 , A61P25/00 , C07D413/06
摘要： There is provided compounds of formula (I) or pharmaceutically-acceptable salts thereof, wherein: L, X, R 1 , R 2 and n have meanings provided in the description, which compounds are useful in the treatment of neurodegenerative and neuroinflammatory diseases.

77. 发明申请

WO2018026722A1 COMPOSITIONS AND METHODS OF INHIBITING MASP-3 FOR THE TREATMENT OF VARIOUS DISEASES AND DISORDERS 审中-公开
标题翻译：抑制MASP-3治疗各种疾病和病症的组合物和方法
公开(公告)号：WO2018026722A1
公开(公告)日：2018-02-08
申请号：PCT/US2017/044714
申请日：2017-07-31
申请人： OMEROS CORPORATION , UNIVERSITY OF LEICESTER , CUMMINGS, W., Jason , DEMOPULOS, Gregory, A. , DUDLER, Thomas , SCHWAEBLE, Hans-Wilhelm , TJOELKER, Larry, W. , WOOD, Christi, L. , YABUKI, Munehisa
发明人： CUMMINGS, W., Jason , DEMOPULOS, Gregory, A. , DUDLER, Thomas , SCHWAEBLE, Hans-Wilhelm , TJOELKER, Larry, W. , WOOD, Christi, L. , YABUKI, Munehisa
IPC分类号： A61K39/395 , A61K45/06 , C07K16/40
摘要： The present invention relates to MASP-3 inhibitory antibodies and compositions comprising such antibodies for use in inhibiting the adverse effects of MASP-3 dependent complement activation.
摘要翻译：本发明涉及MASP-3抑制性抗体和包含此类抗体的组合物，其用于抑制MASP-3依赖性补体活化的不利影响。

78. 发明申请

WO2017173290A1 METHODS FOR INHIBITING ANGIOGENESIS IN A SUBJECT IN NEED THEREOF 审中-公开
标题翻译：用于在其需要的受试者中抑制血管生成的方法
公开(公告)号：WO2017173290A1
公开(公告)日：2017-10-05
申请号：PCT/US2017/025411
申请日：2017-03-31
申请人： OMEROS CORPORATION , UNIVERSITY OF LEICESTER , DEMOPULOS, Gregory, A. , SCHWAEBLE, Hans-Wilhelm , DUDLER, Thomas , TJOELKER, Larry
发明人： DEMOPULOS, Gregory, A. , SCHWAEBLE, Hans-Wilhelm , DUDLER, Thomas , TJOELKER, Larry
IPC分类号： A61K39/395 , A61P7/00 , A61P27/02 , C07K16/40
摘要： In one aspect, the present invention provides methods for preventing, treating, reverting and/or delaying angiogenesis in a mammalian subject suffering from, or at risk for developing, an angiogenesis-dependent disease or condition, comprising administering to the subject an amount of a MASP-2 inhibitory agent effective to inhibit angiogenesis. In some embodiments of these aspects of the invention, the MASP-2 inhibitory agent is a MASP-2 antibody or fragment thereof.
摘要翻译：在一个方面，本发明提供了用于预防，治疗，恢复和/或延迟哺乳动物受试者患血管生成依赖性疾病或病症或处于形成血管生成依赖性疾病或病症风险中的血管生成的方法，其包括给受试者施用有效抑制血管生成的量的MASP-2抑制剂。在本发明这些方面的一些实施方案中，MASP-2抑制剂是MASP-2抗体或其片段。

79. 发明申请

WO2017083371A1 METHODS FOR TREATING CONDITIONS ASSOCIATED WITH MASP-2 DEPENDENT COMPLEMENT ACTIVATION 审中-公开
标题翻译：治疗与MASP-2依赖性补体活化有关的病症的方法
公开(公告)号：WO2017083371A1
公开(公告)日：2017-05-18
申请号：PCT/US2016/061113
申请日：2016-11-09
申请人： OMEROS CORPORATION , UNIVERSITY OF LEICESTER , DEMOPULOS, Gregory, A. , DUDLER, Thomas , SCHWAEBLE, Hans-Wilhelm
发明人： DEMOPULOS, Gregory, A. , DUDLER, Thomas , SCHWAEBLE, Hans-Wilhelm
IPC分类号： A61K39/00 , A61K39/395 , A61P7/02 , A61P37/02 , C07K16/40
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12Y304/21104
摘要： In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a human subject suffering from TMA associated with hematopoietic stem cell transplant. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.
摘要翻译：在一个方面，本发明提供了抑制患有与造血干细胞移植相关的TMA的人类受试者中MASP-2依赖性补体活化作用的方法。该方法包括向有需要的受试者施用有效抑制MASP-2依赖性补体活化的量的MASP-2抑制剂的步骤。

80. 发明申请

WO2016193676A1 IMPROVEMENTS IN AND RELATING TO NUCLEIC ACID PROBES AND HYBRIDISATION METHODS 审中-公开
标题翻译：改进和相关的核酸探针和杂交方法
公开(公告)号：WO2016193676A1
公开(公告)日：2016-12-08
申请号：PCT/GB2016/051531
申请日：2016-05-26
申请人： UNIVERSITY OF LEICESTER
发明人： CAUSEY-FREEMAN, Peter , BROOKES, Anthony
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6841 , C12Q2537/163 , C12Q2561/108 , C12Q2563/107 , C12Q2563/125 , C12Q2563/131
摘要： The invention provides a method of nucleic acid sequence hybridisation comprising the steps of: a) hybridising one or more samples comprising nucleic acids containing a region of interest with at least one probe nucleic acid sequence; and b) adding to the samples a non-deoxy ribonucleic acid molecule, before or during step a). and use of non-deoxy ribonucleic molecules to block or mask a surface or to block or mask repetitive DNA sequences.
摘要翻译：本发明提供核酸序列杂交的方法，其包括以下步骤：a）将包含含有目的区域的核酸的一种或多种样品与至少一种探针核酸序列杂交; 和b）在步骤a）之前或期间向样品中加入非脱氧核糖核酸分子。以及使用非脱氧核糖核酸分子来阻断或掩蔽表面或阻断或掩盖重复的DNA序列。

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