专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明申请

WO2007119987A2 KIT AND METHOD FOR QUANTITATIVELY DETECTING MULTIPLEPATHOGENS WITHOUT GENE AMPLIFICATION 审中-公开
标题翻译：无需基因扩增定量检测多种致病菌的试剂盒和方法
公开(公告)号：WO2007119987A2
公开(公告)日：2007-10-25
申请号：PCT/KR2007/001820
申请日：2007-04-13
申请人： KIM, Jae Man , RO, Eui Chul
发明人： KIM, Jae Man , RO, Eui Chul
IPC分类号： G01N33/53
CPC分类号： G01N33/569 , C12Q1/6837 , G01N2333/01 , G01N2333/08 , C12Q2563/131 , C12Q2561/113 , C12Q2545/114
摘要： A non-amplification multiple quantitative detection kit is characterized in that there are provided a single strand poly nucleotide having a base sequence invented to recognize a specific gene portion of a multilepathogens microorganism to be detected by a fishing probe, and a double strand poly nucleotide indicated with a tag having a base sequence invented to recognize different gene portions which are not duplicated with the recognition portion of the fishing probe in the specific genes of the multilepathogens microorganism to be detected by a reporter probe.
摘要翻译：非扩增多重定量检测试剂盒的特征在于提供了一种单链多核苷酸，其具有发明的碱基序列以识别待由钓鱼探针检测的多器官病原微生物的特定基因部分以及具有标签的双链多核苷酸，所述标签具有发明的碱基序列以识别不同于基因部分，所述基因部分不与钓鱼探针的识别部分在待由报告探针检测的多重病原微生物的特定基因中复制< / p>

62. 发明申请

WO2007108005A1 CHIMERIC TYMOVIRUS-LIKE PARTICLES 审中-公开
标题翻译： CHIMERIC TYMOVIRUS-like颗粒
公开(公告)号：WO2007108005A1
公开(公告)日：2007-09-27
申请号：PCT/IN2006/000342
申请日：2006-09-11
申请人： INDIAN IMMUNOLOGICALS LTD , MASARAPU, Hema , NAGENDRAKUMAR, Singanallur, Balasubramanian , THIAGARAJAN, Dorairajan , SRINIVASAN, Villuppanoor, Alwar
发明人： MASARAPU, Hema , NAGENDRAKUMAR, Singanallur, Balasubramanian , THIAGARAJAN, Dorairajan , SRINIVASAN, Villuppanoor, Alwar
IPC分类号： C12N15/62 , C12N15/41 , C12N15/42 , C12N7/04 , C12N5/10 , G01N33/569
CPC分类号： C12N7/00 , C07K14/005 , C07K2319/00 , C12N2750/14322 , C12N2770/32122 , C12N2770/40022 , C12N2770/40023 , G01N2333/08 , G01N2333/085 , G01N2469/20
摘要： The present disclosure relates to chimeric tymovirus-like particles (TVLPs) comprising a fusion protein that further comprises of a first protein that is a truncated tymovirus coat protein and a second protein. These chimeric TVLPs are useful as antigens. The present disclosure provides a highly efficient means for differentiating Foot and Mouth Disease Virus (FMDV) infected animals from vaccinated animals. The present disclosure further provides a process for the production of chimeric TVLPs and a diagnostic kit for the determination of specific antibodies of FMDV to differentiate FMDV infected from vaccinated animals. The present disclosure also provides the use of the chimeric TVLPs for diagnostic purposes.
摘要翻译：本公开涉及包含融合蛋白的嵌合型病毒样颗粒（TVLP），其还包含第一种蛋白质，其是截短的病毒外壳蛋白和第二种蛋白质。这些嵌合的TVLP可用作抗原。本公开提供了用于区分接种疫苗的动物的口蹄疫病毒（FMDV）感染动物的高效手段。本公开还提供了用于产生嵌合型TVLP的方法和用于测定FMDV的特异性抗体以区分被接种疫苗的动物感染的FMDV的诊断试剂盒。本公开还提供了用于诊断目的的嵌合型TVLP的用途。

63. 发明申请

WO2007013089A1 DEVELOPMENT OF DIAGNOSTIC KIT AGAINST THE RECOMBINANT COAT PROTEIN OF PRUNUS NECROTIC RINGSPOT VIRUS 审中-公开
标题翻译：针对PRUNUS NECROTIC RINGSPOT病毒的重组蛋白质蛋白质的诊断试剂盒的开发
公开(公告)号：WO2007013089A1
公开(公告)日：2007-02-01
申请号：PCT/IN2005/000390
申请日：2005-11-29
申请人： COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH , KULSHRESHTHA, Saurabh , HALLAN, Vipin , RAIKHY, Gaurav , ZAIDI, Aijaz, Asghar
发明人： KULSHRESHTHA, Saurabh , HALLAN, Vipin , RAIKHY, Gaurav , ZAIDI, Aijaz, Asghar
IPC分类号： C12Q1/70 , G01N33/569
CPC分类号： G01N33/56983 , C12Q1/701 , G01N2333/08
摘要： The present invention deals with a set of primers of sequence ID 1: upstream primer AACTGCAGATGGTTTGCCGAATTTGCAA and sequence ID 2: downstream primer GCTCTAGACTAGATCTCAAGCAGGTC useful for detection of Prunus necrotic ringspot virus in plants. It also relates to a method for detection of Prunus necrotic ringspot virus in plants by using said primers. Further the invention also relates to a diagnostic kit useful for detection of coat protein of Prunus necrotic ringspot in plants.
摘要翻译：本发明涉及序列ID 1的引物：上游引物AACTGCAGATGGTTTGCCGAATTTGCAA和序列ID2：下游引物GCTCTAGACTAGATCTCAAGCAGGTC的引物，其用于检测植物中的李属坏死环斑病毒。它还涉及通过使用所述引物在植物中检测李属坏死性环斑病毒的方法。此外，本发明还涉及用于检测植物中杏仁坏死环斑的外壳蛋白的诊断试剂盒。

64. 发明申请

WO2006093797A2 METHOD AND KIT FOR DETECTING PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS 审中-公开
标题翻译：检测磷酸盐生殖和呼吸道综合症病毒的方法和工具包
公开(公告)号：WO2006093797A2
公开(公告)日：2006-09-08
申请号：PCT/US2006/006441
申请日：2006-02-24
申请人： MJ BIOLOGICS, INC. , JUNG, Dong-Hyuk
发明人： JUNG, Dong-Hyuk
CPC分类号： G01N33/56983 , C12Q1/701 , G01N2333/08 , G01N2469/20
摘要： The invention provides methods, devices, and kits for the detection of a class of porcine reproductive and respiratory syndrome (PRRS) virus, or PRRSV, in a biological fluid. The invention is based in part on an agent which binds the nucleocapsid (N) protein of PRRSV. The agent may be an antibody that binds the N protein with specificity. Compositions and devices comprising the binding agent, as well as methods of using it are also provided. Also provided are methods of preparing devices and kits for the practice of the methods.
摘要翻译：本发明提供了用于在生物流体中检测一类猪繁殖与呼吸综合征（PRRS）病毒或PRRSV的方法，装置和试剂盒。本发明部分基于结合PRRSV的核壳（N）蛋白的试剂。该试剂可以是以特异性结合N蛋白的抗体。还提供了包含结合剂的组合物和装置，以及使用它们的方法。还提供了用于实施该方法的装置和试剂盒的制备方法。

65. 发明申请

WO03101176A8 METHOD, COMPOSITION AND KIT FOR ANTIGENIC BINDING OF NORWALK-LIKE VIRUSES 审中-公开
标题翻译：用于诺瓦克样病毒的抗原结合的方法，组合物和试剂盒
公开(公告)号：WO03101176A8
公开(公告)日：2005-11-10
申请号：PCT/US0317247
申请日：2003-06-02
申请人： CHILDRENS HOSP MEDICAL CENTER , JIANG XI , LE PENDU JACQUES
发明人： JIANG XI , LE PENDU JACQUES
IPC分类号： A61K31/70 , C12N15/33 , G01N33/569 , C12Q1/70 , A61K39/12
CPC分类号： G01N33/56983 , A61K31/70 , G01N33/80 , G01N2333/08 , G01N2469/10 , G01N2500/02
摘要： A method for detecting a Norwalk-Like Virus (NLV) in a biological sample, comprising the steps of: obtaining a biological sample suspected of containing a NLV; contacting the biological sample with at least one human histo-blood group antigen to allow formation of a complex of the NLV with the antigen; and detecting the antigen NLV complex. The antigen-NLV complex can be detected by contacting the NLV-antigen complex with a NLV antibody that binds at an epitope of the NLV, and detecting the NLV antibody. The invention also includes a method for identifying compounds, and the compounds, that can inhibit the binding between a Norwalk-Like Virus (NLV) and a histo-blood group antigen. The method includes the steps of contacting the NLV target with a compound; subsequently contacting the NLV with a standard compound that is known to be bound at a determinant binding site of the NLV; and determining whether the binding of the standard compound is decreased in the presence of the test compound, the decrease in binding being an indication that the test compound inhibits the binding activity of the NLV with the standard compound. In preferred embodiments, the standard compound is a histo-blood group antigen.
摘要翻译：一种用于检测生物样品中诺沃克样病毒（NLV）的方法，包括以下步骤：获得怀疑含有NLV的生物样品; 使生物样品与至少一种人类组织血型抗原接触以允许形成NLV与抗原的复合物; 并检测抗原NLV复合物。可以通过将NLV抗原复合物与结合NLV表位的NLV抗体接触并检测NLV抗体来检测抗原NLV复合物。本发明还包括鉴定可抑制诺瓦克样病毒（NLV）与组织血型抗原之间的结合的化合物和化合物的方法。该方法包括使NLV靶与化合物接触的步骤; 随后使NLV与已知结合于NLV的决定簇结合位点的标准化合物接触; 并确定在测试化合物存在下标准化合物的结合是否降低，结合的降低表明测试化合物抑制NLV与标准化合物的结合活性。在优选的实施方案中，标准化合物是组织血型抗原。

66. 发明申请

WO1997031651A1 PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VACCINE 审中-公开
标题翻译： PORCINE生殖和呼吸综合征疫苗
公开(公告)号：WO1997031651A1
公开(公告)日：1997-09-04
申请号：PCT/US1997002562
申请日：1997-02-26
申请人： SCHERING CORPORATION
发明人： SCHERING CORPORATION , HESSE, Richard, A.
IPC分类号： A61K39/12
CPC分类号： G01N33/56983 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C07K16/08 , C12N2770/10034 , G01N2333/08
摘要： The invention discloses a vaccine and methods for the treatment of porcine reproductive and respiratory syndrome. The vaccine is derived from the viral agent NEB-1-P94, deposited at the American Type Culture Collection under accession number VR-2525. Further, the invention discloses a vaccine virus with phenotypic characteristics which can be distinguished from wild type PRRS virus.
摘要翻译：本发明公开了一种用于治疗猪繁殖与呼吸综合症的疫苗和方法。疫苗来源于保藏在美国典型培养物保藏中心的登录号VR-2525的病毒剂NEB-1-P94。此外，本发明公开了具有表型特征的疫苗病毒，其可与野生型PRRS病毒区分开。

67. 发明申请

WO1995002824A1 METHOD AND KIT FOR THE QUANTITATIVE DETERMINATION OF HUMAN THYROID PEROXIDASE 审中-公开
标题翻译：人THYROID过氧化物定量测定的方法和工具包
公开(公告)号：WO1995002824A1
公开(公告)日：1995-01-26
申请号：PCT/EP1994001771
申请日：1994-05-31
申请人： HENNING BERLIN ANLAGEN GMBH , WECKERMANN, Renate , BERGMANN, Andreas
发明人： HENNING BERLIN ANLAGEN GMBH
IPC分类号： G01N33/573
CPC分类号： G01N33/573 , G01N33/564 , G01N33/57488 , G01N2333/08
摘要： Method for the quantitative determination of human thyroid peroxidase (hTPO) in biological fluids, culture media, tissue extracts and fluids containing highly purified natural hTPO or recombinant hTPO, in which the determination is carried out as a sandwich assay known per se, using a first monoclonal antibody against hTPO and at least one further monoclonal antibody against hTPO (MAB1, MAB2), of which the former (MAB1) recognises hTPO in a region which is sensitive to denaturing and is involved in the binding of the autoantibodies against hTPO and in enzyme inhibition, while the one or more further antibodies (MAB2) recognises hTPO in a region whose binding properties are not essentially impaired by denaturing of hTPO.
摘要翻译：用于定量测定生物流体，培养基，组织提取物和含有高度纯化的天然hTPO或重组hTPO的液体中的人类甲状腺过氧化物酶（hTPO）的方法，其中测定作为本身已知的夹心测定，使用第一针对hTPO的单克隆抗体和至少一种针对hTPO（MAB1，MAB2）的另外的单克隆抗体，其前者（MAB1）在对变性敏感并参与自身抗体与hTPO和酶结合的区域中识别hTPO 而一个或多个其他抗体（MAB2）在其结合特性基本上不受hTPO变性影响的区域中识别hTPO。

68. 发明申请

WO2017139587A2 ANTI-DENGUE VIRUS NS1 PROTEIN MONOCLONAL ANTIBODIES 审中-公开
标题翻译：登革病毒NS1蛋白单克隆抗体
公开(公告)号：WO2017139587A2
公开(公告)日：2017-08-17
申请号：PCT/US2017/017385
申请日：2017-02-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： BOSCH, Irene , SCHIFFERLI-HAMAD, Kimberly , MARQUEZ-GOMEZ, Jose , DE PUIG, Helena , GEHRKE, Lee
IPC分类号： C07K16/10 , G01N33/569
CPC分类号： C07K16/10 , A61K2039/505 , C07K16/1081 , C07K2317/34 , C07K2317/92 , G01N33/56983 , G01N2333/08 , G01N2469/10 , Y02A50/53
摘要： The present invention provides matched antibody pairs for the specific detection of one or more of the four dengue virus serotypes in a biological sample that may contain one or more of such dengue virus serotypes. Each matched antibody pair is capable of detecting not more than one serotype of dengue virus NS1 protein that may be present in the sample and will not cross react with other serotypes that may be present in the sample. Multiple matched pairs may be used to detect one or more dengue virus serotypes that may be present in a sample. Such matched pair antibodies, facilitate the development of confirmatory in vitro diagnostic tests such as sandwich immunoassays, that detect and distinguish the presence of one or more dengue virus serotypes in a biological sample, preferably a sample derived from human subject. The invention also provides kits comprising the matched antibody pairs of the invention and methods for using the kits for immunoassays for the specific detection of one or more serotypes of dengue virus in a patient population. The present invention also provides monoclonal antibodies specific for the NS1 protein of dengue virus and therapeutic compositions and methods for treating dengue virus infection.
摘要翻译：本发明提供了用于对可能含有一种或多种登革病毒血清型的生物样品中的四种登革病毒血清型中的一种或多种进行特异性检测的匹配抗体对。每个匹配的抗体对能够检测出样品中可能存在的登革热病毒NS1蛋白不超过一种血清型，并且不会与可能存在于样品中的其他血清型交叉反应。多个匹配的对可以用于检测样品中可能存在的一种或多种登革病毒血清型。这种匹配的抗体有助于开发验证性体外诊断测试，例如夹心免疫测定法，其检测和区分生物样品中一种或多种登革病毒血清型的存在，所述生物样品优选来源于人的样品学科。本发明还提供了包含本发明的匹配抗体对的试剂盒以及使用该试剂盒进行免疫测定以特异性检测患者群体中的一种或多种登革病毒血清型的方法。本发明还提供了对登革热病毒NS1蛋白具有特异性的单克隆抗体，以及治疗登革热病毒感染的治疗组合物和方法。

69. 发明申请

WO2017096468A1 APTAMERS, NUCLEIC ACID MOLECULES, POLYNUCLEOTIDES, SYNTHETIC ANTIBODIES COMPOSITIONS FOR DETECTING PRRS VIRUSES AND TREATING PRRS VIRUS INFECTION 审中-公开
标题翻译：用于检测PRRS病毒和治疗PRRS病毒感染的APTAMERS，核酸分子，多核苷酸，合成抗体组合物
公开(公告)号：WO2017096468A1
公开(公告)日：2017-06-15
申请号：PCT/CA2016/051411
申请日：2016-12-01
申请人： AEROVIRUS TECHNOLOGIES INC.
发明人： MARCHAND, Norman , CALTAGIRONE, G. Thomas , LIAO, Albert
IPC分类号： C12N15/115 , A61K31/7088 , A61K31/711 , A61K47/61 , A61P31/14 , C07H21/04 , C12Q1/68 , C12Q1/70 , C40B30/04 , G01N33/569 , C07K14/08
CPC分类号： A61K31/7088 , A61K31/711 , C07K16/10 , C12N15/115 , C12N2310/16 , C12Q1/68 , C12Q1/70 , G01N33/5308 , G01N2333/08
摘要： Aptamers, polynucleotides which participate in preventing the Porcine Respiratory and Reproductive Syndrome virus (PRRSV) infection of cells, and nucleic acid molecules, which include a polynucleotide sequence capable of specifically binding the polypeptides domain of the PRRSV that controls infection, constitute the core of the present invention. Also provided are methods of using such nucleic acid molecules, polynucleotides and synthetic antibodies directed against these, for detection, treating and neutralization of PRRSV infection.
摘要翻译：适体，参与预防细胞的猪呼吸和繁殖综合症病毒（PRRSV）感染的多核苷酸，以及核酸分子，其包括能够特异性结合PRRSV多肽结构域的多核苷酸序列，控制感染，构成了本发明的核心。还提供了使用这些核酸分子，多核苷酸和针对它们的合成抗体来检测，治疗和中和PRRSV感染的方法。

70. 发明申请

WO2017079314A2 SINGLE DOMAIN ANTIBODIES DIRECTED AGAINST INTRACELLULAR ANTIGENS 审中-公开
标题翻译：单个抗体针对细胞内抗原
公开(公告)号：WO2017079314A2
公开(公告)日：2017-05-11
申请号：PCT/US2016/060134
申请日：2016-11-02
申请人： SINGH BIOTECHNOLOGY, LLC
发明人： SINGH, Sunanda
IPC分类号： C07K16/10 , A61K39/42
CPC分类号： A61K45/06 , A61K39/42 , A61K2039/505 , C07K16/1045 , C07K16/40 , C07K2317/22 , C07K2317/34 , C07K2317/569 , C07K2317/92 , G01N33/56983 , G01N33/573 , G01N2333/08 , G01N2333/9128 , G01N2469/10
摘要： This invention provides compositions and methods to treat a condition or disease without the use of exogenous targeting sequences or chemical compositions. The present invention relates to single-domain antibodies (sdAbs), proteins and polypeptides comprising the sdAbs that are directed against targets that cause a condition or disease. The invention also includes nucleic acids encoding the sdAbs, proteins and polypeptides, and compositions comprising the sdAbs. The invention includes the use of the compositions, sdAbs, and nucleic acids encoding the sdAbs for prophylactic, therapeutic or diagnostic purposes.
摘要翻译：本发明提供了在不使用外源靶向序列或化学组合物的情况下治疗病症或疾病的组合物和方法。本发明涉及针对导致病症或疾病的靶标的单域抗体（sdAb），包含sdAb的蛋白质和多肽。本发明还包括编码sdAb的核酸，蛋白质和多肽以及包含sdAb的组合物。本发明包括组合物，sdAb和编码sdAb的核酸用于预防，治疗或诊断目的的用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式