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61. 发明申请

WO2011142836A9 ASSAYS FOR THE DETECTION OF GENOTYPE, MUTATIONS, AND/OR ANEUPLOIDY 审中-公开
标题翻译：用于检测基因型，突变和/或缺失的测定
公开(公告)号：WO2011142836A9
公开(公告)日：2012-01-05
申请号：PCT/US2011000887
申请日：2011-05-16
申请人： FLUIDIGM CORP , JONES ROBERT C , LIVAK KENNETH J , MAY ANDREW , MIR ALAIN , PIEPRZYK MARTIN , QIN JIAN , RAMAKRISHNAN RAMESH , SPURGEON SANDRA , WANG JUN , ZIMMERMANN BERNHARD G
发明人： JONES ROBERT C , LIVAK KENNETH J , MAY ANDREW , MIR ALAIN , PIEPRZYK MARTIN , QIN JIAN , RAMAKRISHNAN RAMESH , SPURGEON SANDRA , WANG JUN , ZIMMERMANN BERNHARD G
IPC分类号： C12Q1/68 , G01N33/52 , G06F19/18
CPC分类号： C12Q1/6851 , C12Q1/6855 , C12Q1/6858 , G01N33/542 , G01N33/582 , G01N33/6893 , G01N2800/368 , C12Q2521/301 , C12Q2521/501 , C12Q2525/155 , C12Q2535/131 , C12Q2537/143 , C12Q2537/16 , C12Q2563/173
摘要： The present invention provides amplification-based methods for detection of genotype, mutations, and/or aneuploidy. These methods have broad applicability, but are particularly well-suited to detecting and quantifying target nucleic acids in free fetal DNA present in a maternal bodily fluid sample.
摘要翻译：本发明提供了用于检测基因型，突变和/或非整倍性的基于扩增的方法。这些方法具有广泛的适用性，但特别适合于检测和定量存在于母体液样品中的游离胎儿DNA中的靶核酸。

62. 发明申请

WO2009076007A3 METHOD AND SYSTEM FOR MANAGING COMMUNICATION BETWEEN A BASE STATION AND SUBSCRIBER STATIONS 审中-公开
标题翻译：用于管理基站与订户站之间的通信的方法和系统
公开(公告)号：WO2009076007A3
公开(公告)日：2009-07-30
申请号：PCT/US2008083821
申请日：2008-11-17
申请人： MOTOROLA INC , VAIDYA SAMIR S , RASQUINHA KALVYN T , WANG JUN
发明人： VAIDYA SAMIR S , RASQUINHA KALVYN T , WANG JUN
IPC分类号： H04W72/12 , H04W16/12 , H04W28/10
CPC分类号： H04W56/009 , H04W72/1263
摘要： A method and system for managing a communication between a base station (102) and plurality of subscriber stations (104, 106, 108 and 110) is disclosed. The method includes determining (504) whether a Round Trip Delay (RTD) component is greater than the duration of a data slot for at least one subscriber station of the plurality of subscriber stations. The RTD component is a part of a Transmit/receive Transition Gap (TTG) of the base station. The method also includes scheduling (506) the data slot for the at least one subscriber station using the RTD component of the base station when the duration of the RTD component is greater than the duration of the data slot for the at least one subscriber station.
摘要翻译：公开了一种用于管理基站（102）和多个用户站（104,106,108和110）之间的通信的方法和系统。该方法包括确定（504）往返延迟（RTD）分量是否大于多个用户站中的至少一个用户台的数据时隙的持续时间。 RTD组件是基站的发送/接收转换间隙（TTG）的一部分。该方法还包括当RTD分量的持续时间大于至少一个用户台的数据时隙的持续时间时，使用基站的RTD分量调度（506）至少一个用户台的数据时隙。

63. 发明申请

WO2008156873A3 APOA-1 PEPTIDE MIMETICS 审中-公开
标题翻译： APOA-1肽类物质
公开(公告)号：WO2008156873A3
公开(公告)日：2009-04-09
申请号：PCT/US2008007855
申请日：2008-06-18
申请人： MERCK & CO INC , ANGELETTI P IST RICHERCHE BIO , BIANCHI ELISABETTA , PESSI ANTONELLO , INGENITO RAFFAELE , WANG JUN , CARBALLO-JANE ESTER , CHANG CHING H
发明人： BIANCHI ELISABETTA , PESSI ANTONELLO , INGENITO RAFFAELE , WANG JUN , CARBALLO-JANE ESTER , CHANG CHING H
IPC分类号： C07K14/775
CPC分类号： C07K14/775 , A61K38/00
摘要： The invention relates to peptide mimetics for treating disorders associated with hypercholesterolemia and cardiovascular disease. In particular, the invention relates to peptides that mimic the activity of apolipoprotein A-I (Apo AI).
摘要翻译：本发明涉及用于治疗与高胆固醇血症和心血管疾病相关的疾病的肽模拟物。特别地，本发明涉及模拟载脂蛋白A-1（Apo AI）的活性的肽。

64. 发明申请

WO2007047547A3 ABRASIVE PARTICULATE MATERIAL, AND METHOD OF PLANARIZING A WORKPIECE USING THE ABRASIVE PARTICULATE MATERIAL 审中-公开
标题翻译：磨料颗粒材料和使用磨料颗粒材料平整工件的方法
公开(公告)号：WO2007047547A3
公开(公告)日：2007-06-14
申请号：PCT/US2006040295
申请日：2006-10-13
申请人： SAINT GOBAIN CERAMICS , HAERLE ANDREW G , WANG JUN
发明人： HAERLE ANDREW G , WANG JUN
IPC分类号： C09K3/14 , C01F7/02 , C09G1/02
CPC分类号： C09K3/1463 , B82Y30/00 , C01F7/02 , C01P2002/02 , C01P2004/10 , C01P2004/20 , C01P2004/54 , C01P2004/62 , C01P2004/64 , C01P2006/10 , C01P2006/12 , C09K3/1409
摘要： An abrasive particulate material is disclosed that includes alumina particles. The alumina particles include a transition alumina and at least 5.0wt% of an amorphous phase. The transition alumina particles also have a density not greater than about 3.20g/cm 3
摘要翻译：公开了一种包括氧化铝颗粒的磨料颗粒材料。氧化铝颗粒包括过渡氧化铝和至少5.0wt％的非晶相。过渡氧化铝颗粒也具有不大于约3.20g / cm 3的密度

65. 发明申请

WO2005033694A8 NOVEL ANTISENSE OLIGOMERS AND USE THEREOF 审中-公开
标题翻译：新型防伪低聚物及其用途
公开(公告)号：WO2005033694A8
公开(公告)日：2006-05-04
申请号：PCT/BE2004000142
申请日：2004-10-06
申请人： VERBRUGGEN AUGUST , ELEWAUT DIRK , WANG JUN
发明人： VERBRUGGEN AUGUST , ELEWAUT DIRK , WANG JUN
IPC分类号： A61K38/00 , C07H21/00 , C12N15/113 , G01N31/00 , A01N43/00 , A61K31/70 , C07H21/02 , C07H21/04
CPC分类号： C12N15/1138 , A61K38/00 , C07H21/00 , C12N2310/11 , C12N2310/322
摘要： The invention relates to the use of a novel type of antisense oligomers for use in the in vitro or in vivo inhibition of gene expression of a target gene. These oligomers, called exon-bridging oligomers are complementary to those parts of a spliced mRNA which are derived from two adjacent exons in the primary RNA transcript, and are called exon-bridging antisense oligomers. These oligomers have no complimentarity to genomic DNA. These oligomers can be used to performs antisense inhibition with less aspecific binding to genomic DNA. The exon-bridging oligomers are suitable for inhibiting Interleukin1 type I Receptor in, for instance, chondrocytes, and are suitable for the prevention or treatment of osteoarthritis.
摘要翻译：本发明涉及用于靶基因的基因表达的体外或体内抑制的新型反义寡聚体的用途。称为外显子桥接低聚物的这些寡聚体与衍生自初级RNA转录物中的两个相邻外显子的剪接的mRNA的那些部分互补，并被称为外显子桥连反义寡聚体。这些寡聚体对基因组DNA没有补充性。这些寡聚物可用于以较少的与基因组DNA的特异性结合进行反义抑制。外显子桥连寡聚体适用于抑制例如软骨细胞中的白细胞介素1型受体，适用于预防或治疗骨关节炎。

66. 发明申请

WO2005009391A3 ANTIBIOTIC COMPOUND 审中-公开
标题翻译：抗生素化合物
公开(公告)号：WO2005009391A3
公开(公告)日：2005-10-20
申请号：PCT/US2004023780
申请日：2004-07-20
申请人： MERCK & CO INC , MERCK SHARP & DOHME DE ESPANA , SINGH SHEO BUX , WANG JUN , BASILIO ANGELA , GENILLOUD OLGA , HERNANDEZ PILAR , TORMO JOSE RUBEN
发明人： SINGH SHEO BUX , WANG JUN , BASILIO ANGELA , GENILLOUD OLGA , HERNANDEZ PILAR , TORMO JOSE RUBEN
IPC分类号： A61K20060101 , A61K31/352 , A61K35/74 , C07D311/94 , C07D311/96 , C07D493/08 , C12P17/08 , C12R1/465
CPC分类号： C12R1/465 , C07D493/08 , C12P17/06
摘要： Fermentation of a nutrient medium with a eubacterium Streptomyces sp. yields a novel antibacterial compound of structure (I).
摘要翻译：用链霉菌（Streptomyces sp。）发酵营养培养基产生结构（I）的新型抗菌化合物。

67. 发明申请

WO2005081066A8 RECTANGULAR CONTACT LITHOGRAPHY FOR CIRCUIT PERFORMANCE IMPROVEMENT 审中-公开
标题翻译：矩形接触光刻改善电路性能
公开(公告)号：WO2005081066A8
公开(公告)日：2005-10-13
申请号：PCT/CN2005000223
申请日：2005-02-24
申请人： UNIV HONG KONG , WANG JUN , WONG ALFRED K K , LAM EDMUND Y
发明人： WANG JUN , WONG ALFRED K K , LAM EDMUND Y
IPC分类号： G03F1/14 , G03F7/20 , G03F9/00 , H01L21/00
CPC分类号： G03F7/70283 , G03F1/70 , G03F7/70466
摘要： An optical lithography method is disclosed that uses double exposure of a reusable a chromeless alternating phase-shifting template mask and a binary trim mask to fabricate regularly-placed rectangular contacts in standard cells of application-specific integrated circuits (ASICs). A first exposure of the reusable chromeless alternating phase-shifting template ask forms periodic dark lines on a wafer and a second exposure of binary tri mask remove the unwanted part of the dark lines and the small cuts of the dark lines left form the rectangular-placed contacts. All contacts are placed regularly in one direction while randomly in the perpendicular direction. The method of the invention can be used in the fabrication of standard cells in application-specific integrated circuits (ASICs) to decrease circuit area an improve circuit performance.
摘要翻译：公开了一种光学光刻方法，其使用可重复使用的无铬交替相移模板掩模和二进制修整掩模的双重曝光来制造专用集成电路（ASIC）的标准单元中的规则放置的矩形触点。可重复使用的无铬交替移相模板问的第一次曝光在晶圆上形成周期性的黑线，并且二元三掩模的第二次曝光去除不需要的部分黑线和剩余的黑线的小切割形成矩形放置联系人。所有触点均按照一个方向定期放置，同时在垂直方向随机放置。本发明的方法可用于在专用集成电路（ASIC）中制造标准单元以减小电路面积和提高电路性能。

68. 发明申请

WO2009067355A3 TECHNIQUES FOR IMPROVING CHANNEL QUALITY ESTIMATES IN WIRELESS COMMUNICATION SYSTEMS 审中-公开
标题翻译：在无线通信系统中提高通道质量估计的技术
公开(公告)号：WO2009067355A3
公开(公告)日：2010-07-08
申请号：PCT/US2008083094
申请日：2008-11-11
申请人： MOTOROLA INC , BARVE SATYEN D , NUNSAVATHU ARAVIND N , WANG JUN
发明人： BARVE SATYEN D , NUNSAVATHU ARAVIND N , WANG JUN
IPC分类号： H04W28/16 , H04W72/08 , H04W92/10
CPC分类号： H04L1/0026 , H04B17/336 , H04L1/0033
摘要： A technique for operating a wireless communication device includes determining (106) mobility of a subscriber station (304). A channel quality indicator averaging parameter is then adjusted (108) based on the mobility of the subscriber station.
摘要翻译：一种用于操作无线通信设备的技术包括确定（106）用户站（304）的移动性。然后基于用户台的移动性来调整（108）信道质量指标平均参数。

69. 发明申请

WO2010005674A3 MECHANISM FOR MAXIMIZING UPLINK BANDWIDTH BY OVERLAPPING CONTROL REGIONS IN WIMAX SYSTEM 审中-公开
标题翻译：通过WIMAX系统中重叠控制区域最大化上行链带宽度的机制
公开(公告)号：WO2010005674A3
公开(公告)日：2010-04-22
申请号：PCT/US2009047069
申请日：2009-06-11
申请人： MOTOROLA INC , MU CHEN , KUMAR PRACHI P , VUONG NGHIA T , WANG JUN
发明人： MU CHEN , KUMAR PRACHI P , VUONG NGHIA T , WANG JUN
IPC分类号： H04L1/18 , H04L29/02
CPC分类号： H04L1/1854 , H04L1/0026 , H04L1/1671
摘要： A method and system for allocating an uplink control region (201) to both HARQ ACKCH and CQICH in order to maximize uplink bandwidth for data transfer in a communication network. A control region scheduling (CRS) utility (110) assigns (402) a higher priority to HARQ ACKCH relative to CQICH. When both HARQ ACKCH and CQICH are to be allocated for a subscriber (101-103) in the same region (201) in the same frame (200), HARQ ACKCH is allocated in the region while CQICH is rejected (406). As the substitute to the rejected CQICH, the CRS utility may use current uplink channel quality information in combination with the corresponding HARQ ACK transmission to estimate (407) a downlink channel quality for the subscriber. Upon receiving the HARQ ACK information, the CRS utility updates (409) the subscriber(s) uplink channel quality information. The CRS utility also may activate or de-activate the uplink control region sharing.
摘要翻译：一种用于向HARQ ACKCH和CQICH两者分配上行链路控制区域（201）以便最大化通信网络中的数据传输的上行链路带宽的方法和系统。控制区域调度（CRS）实用程序（110）相对于CQICH向HARQ ACKCH分配（402）较高优先级。当同一帧（200）中相同区域（201）中的用户（101-103）都要分配HARQ ACKCH和CQICH两者时，HARQQCH被分配在该区域，而CQICH被拒绝（406）。作为拒绝的CQICH的替代品，CRS实用程序可以使用当前的上行链路信道质量信息与相应的HARQ ACK传输相结合来估计（407）用户的下行链路信道质量。在接收到HARQ ACK信息时，CRS实用程序更新（409）订户上行链路信道质量信息。 CRS实用程序还可以激活或去激活上行链路控制区域共享。

70. 发明申请

WO2009032827A2 ELECTROPORATIVE FLOW CYTOMETRY 审中-公开
标题翻译：电子流量计
公开(公告)号：WO2009032827A2
公开(公告)日：2009-03-12
申请号：PCT/US2008075088
申请日：2008-09-03
申请人： PURDUE RESEARCH FOUNDATION , LU CHANG , WANG JUN , BAO NING , GEAHLEN ROBERT L
发明人： LU CHANG , WANG JUN , BAO NING , GEAHLEN ROBERT L
IPC分类号： G01N21/65 , G01N21/05 , G01N33/48
CPC分类号： G01N33/5005 , G01N15/147 , G01N15/1484 , G01N33/574
摘要： Novel devices and methods are provided, which include electroporative flow cytometry, where electroporation is combined with flow cytometry. The devices and methods can be used for the detection a variety of cellular features, including protein translocation, and for monitoring biomechanics at single cell level. Using the novel devices methods it is possible to observe the release of proteins such as intracellular kinases out of the cells during electroporation. Using the novel devices methods it is possible to study cytoskeleton dynamics and deformability at a single ceil level, and to correlate these to diseases such as cancers.
摘要翻译：提供了新的装置和方法，其中包括电穿孔流式细胞术，其中电穿孔与流式细胞术结合。该装置和方法可用于检测各种细胞特征，包括蛋白质易位，以及用于监测单细胞水平的生物力学。使用新颖的器件方法，可以观察电穿孔期间蛋白质如细胞内激酶的释放。使用新颖的器件方法，可以在单个细胞水平上研究细胞骨架动力学和变形性，并将其与诸如癌症的疾病相关联。

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