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51. 发明申请

WO0163313A2 MR IMAGING METHOD, PHASE ERROR MEASURING METHOD AND MRI SYSTEM 审中-公开
标题翻译： MR成像方法，相位误差测量方法和MRI系统
公开(公告)号：WO0163313A2
公开(公告)日：2001-08-30
申请号：PCT/US0140187
申请日：2001-02-26
申请人： GE MED SYS GLOBAL TECH CO LLC
发明人： MIYAMOTO SHOEI
IPC分类号： G01N24/08 , A61B5/055 , G01R33/46 , G01R33/48 , G01R33/565
CPC分类号： G01R33/56518 , G01R33/56563
摘要： The present invention aims to reduce degradation in image quality due to residual magnetization. In a pulse sequence of a high-speed spin echo process, a pre-pulse is applied before an excitation pulse, and a correction pulse for correcting a phase error caused by the pre-pulse is applied before an initial inversion pulse.
摘要翻译：本发明旨在减少由剩余磁化引起的图像质量降低。在高速自旋回波处理的脉冲序列中，在激励脉冲之前施加预脉冲，并且在初始反转脉冲之前施加用于校正由预脉冲引起的相位误差的校正脉冲。

52. 发明申请

WO01020357A1 FLOW-THROUGH PROBE FOR NMR SPECTROMETERS 审中-公开
标题翻译：用于NMR光谱仪的流通探测器
公开(公告)号：WO01020357A1
公开(公告)日：2001-03-22
申请号：PCT/IL2000/000558
申请日：2000-09-12
IPC分类号： G01R33/20 , G01R33/30 , G01R33/31 , G01R33/34 , G01R33/46 , G01V3/00
CPC分类号： G01R33/31 , G01R33/34092
摘要： There is disclosed an NMR probe including a body defining an internal chamber. This chamber is adapted for supporting a vacuum and the body is of a non-magnetic material. A conduit extends through the chamber in the body. The conduit has a first portion in communication with second portions, the first portion being intermediate the second portions, with the first and second portions of non-magnetic materials with substantially equal thermal expansion coefficients. An RF coil is positioned along at least a substantial portion of the first conduit portion. It is preferred that this device also include a field or frequency lock unit in the chamber, as well as a getter, to allow for degassing in the chamber to maintain the preferred high pressure vacuum. A method of using this NMR probe for NMR analysis is also disclosed.
摘要翻译：公开了一种NMR探针，其包括限定内腔的主体。该室适于支撑真空并且本体是非磁性材料。导管延伸穿过体内的腔室。导管具有与第二部分连通的第一部分，第一部分在第二部分之间，非磁性材料的第一和第二部分具有基本相等的热膨胀系数。 RF线圈沿着第一导管部分的至少大部分被定位。优选地，该装置还包括腔室中的场或频率锁定单元以及吸气剂，以允许室中的脱气以保持优选的高压真空。还公开了使用该NMR探针进行NMR分析的方法。

53. 发明申请

WO0079569A3 METHOD FOR ANALYSING A SAMPLE OF A COMPLEX MOLECULE RELATIVELY TO A REFERENCE BATCH OF THE SAME COMPLEX MOLECULE 审中-公开
标题翻译：分析复合分子样品相对于相同复合分子的参考批次的方法
公开(公告)号：WO0079569A3
公开(公告)日：2001-03-15
申请号：PCT/FR0001712
申请日：2000-06-21
申请人： EUROFINS SCIENT , MARTIN GERARD , MARTIN GILLES
发明人： MARTIN GERARD , MARTIN GILLES
IPC分类号： G01R33/44 , G01R33/46 , H01J49/04 , H01J49/42 , B01D59/44 , G01N30/72
CPC分类号： G01R33/4625 , G01N24/085 , H01J49/04 , Y10T436/143333 , Y10T436/144444 , Y10T436/24 , Y10T436/25
摘要： The invention concerns a method for analysing a sample of a complex molecule relatively to a reference batch of the same complex molecule. Said method is characterised in that it consists in breaking up the complex molecule into at least two molecular sub-entities; in determining, on the basis of the atomic sites of said products of the breakup involved in the breakup reactions, the isotope(s) to be analysed; and in establishing, for at least part of the breakup products, their isotopic profile; and in comparing the isotopic profile of the products of the breakup with the isotopic profile of the raw material(s) previously indexed and/or with the isotopic profile of the reference complex molecule subjected to the same breakup reactions. The invention is useful for detecting counterfeiting in manufacturing processes.
摘要翻译：本发明涉及相对于相同复合分子的参考批次分析复合分子的样品的方法。所述方法的特征在于其将复合分子分解成至少两个分子子实体; 在基于分解反应中涉及的分解的所述产物的原子位置的基础上，确定待分析的同位素; 并为至少部分分解产品确定其同位素特征; 并且将分解产物的同位素分布与先前指数的原料的同位素分布和/或与进行相同的分解反应的参考复合分子的同位素分布进行比较。本发明可用于在制造过程中检测伪造品。

54. 发明申请

WO0010036A9 A METHOD AND APPARATUS FOR DIFFERENTIATING OIL BASED MUD FILTRATE FROM CONNATE OIL 审中-公开
标题翻译：用于从基础油中分离油基过滤器的方法和装置
公开(公告)号：WO0010036A9
公开(公告)日：2000-07-27
申请号：PCT/US9918597
申请日：1999-08-16
申请人： NUMAR CORP
发明人： PRAMMER MANFRED G
IPC分类号： G01R33/44 , G01R33/46 , G01V3/00
CPC分类号： G01R33/44 , G01R33/4625
摘要： A method and apparatus for processing nuclear magnetic resonance information (76) to differentiate between oil based mud filtrate (OBM), and connate oils, during subsurface exploration. An NMR experiment is performed on a sample (70) of formation fluid, and the resulting data is processed to differentiate the relaxation parameters (80) characteristic of OBMs and those characteristic of connate oils. A simple arithmetic difference (84) between relaxation times calculated for successive samples may be followed by a distribution analysis performed in either the time domain or relaxation spectrum domain (86, 94).
摘要翻译：一种用于在地下勘探期间处理核磁共振信息（76）以区分油基泥浆滤液（OBM）和合成油的方法和装置。对地层流体的样品（70）进行NMR实验，并对所得数据进行处理以区分OBM特征的松弛参数（80）和合成油的特征。对于连续样本计算的松弛时间之间的简单算术差（84）可以在时域或弛豫频域中进行分布分析（86,94）。

55. 发明申请

WO99052564A1 METHOD 审中-公开
标题翻译：方法
公开(公告)号：WO99052564A1
公开(公告)日：1999-10-21
申请号：PCT/GB1999/001097
申请日：1999-04-09
IPC分类号： A61K49/18 , G01R33/46 , A61K49/00 , G01R33/58 , G01N24/08
CPC分类号： A61K49/105 , A61K49/1806 , A61K49/1863 , G01R33/46
摘要： This invention relates to a method of measuring magnetic properties of water-insoluble particulate materials, in particular particulate magnetic resonance (mr) contrast agents. The method comprises disposing said sedimentable agent in a flowable aqueous solution of a polyalkyleneoxide-based matrix forming agent, optionally cooling the resulting dispersion to form a non-flowable aqueous dispersion of said sedimentable agent, measuring a magnetic property of said dispersion, and if desired calculating from the measured magnetic property a magnetic property of said agent or said dispersion. The method is useful in mr imaging applications.
摘要翻译：本发明涉及一种测量水不溶性颗粒材料，特别是颗粒磁共振（mr）造影剂的磁性能的方法。该方法包括将所述可沉降剂置于可流动的聚亚烷基氧化物基质形成剂的水溶液中，任选地冷却所得分散体以形成所述可沉降试剂的不可流动的水性分散体，测量所述分散体的磁性，以及如果需要从所测量的磁性能计算所述试剂或所述分散体的磁性。该方法在mr成像应用中非常有用。

56. 发明申请

WO9932897A3 NMR APPARATUS AND METHOD FOR NON-INVASIVE IN VIVO TESTING OF A PATIENT'S BODY FLUID GLUCOSE LEVELS 审中-公开
标题翻译：核磁共振装置和患者体内液体葡萄糖水平检测非侵入性的方法
公开(公告)号：WO9932897A3
公开(公告)日：1999-09-10
申请号：PCT/US9827478
申请日：1998-12-23
申请人： AMERICAN BIOTECHNOLOGY WORKGRO
发明人： ANDERSON MARVIN H , SCHLEICH THOMAS W , JOHN BOBAN K , SCHOOLERY JAMES N
IPC分类号： G01N24/08 , A61B5/055 , G01R33/383 , G01R33/3873 , G01R33/46
CPC分类号： G01R33/383
摘要： A magnet assembly (10) for a small scale NMR spectroscopy apparatus suitable for laboratory or home use, comprising two permanent magnets (11) facing one another, a tapered pole cap (12) on each of the two facing surfaces of the permanent magnets, and a plurality of radially polarized annular canceling magnets (18) disposed about the permanent magnets and pole caps. The design and position of the radially polarized canceling magnets reduces leakage of the magnetic field, to maintain the magnetic field strength and homogeneity within the test region, without a disadvantageous increase in the size, weight and cost of the NMR apparatus. Also provided is a method for in vivo measurement of glucose concentration in a patient's body fluid using NMR spectroscopy. The method comprises spectral editing, e.g. double quantum filtering to isolate scalar coupled resonances of glucose.
摘要翻译：一种用于适用于实验室或家庭使用的小型NMR光谱仪的磁体组件（10），包括彼此面对的两个永磁体（11），在永磁体的两个相对表面中的每一个上的锥形极盖（12）以及围绕永磁体和极帽设置的多个径向极化的环形取消磁体（18）。径向偏振消除磁体的设计和位置减小磁场的泄漏，以保持测试区域内的磁场强度和均匀性，而不增加NMR装置的尺寸，重量和成本。还提供了使用NMR光谱法体内测量患者体液中葡萄糖浓度的方法。该方法包括光谱编辑，例如双量子滤波来分离葡萄糖的标量耦合共振。

57. 发明申请

WO99031523A1 METHOD AND DEVICE FOR MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：用于磁共振成像的方法和装置
公开(公告)号：WO99031523A1
公开(公告)日：1999-06-24
申请号：PCT/IB1998/001898
申请日：1998-11-30
IPC分类号： A61B5/055 , G01R33/46 , G01R33/48 , G01R33/563
CPC分类号： G01R33/446 , G01R33/56341
摘要： The invention relates to a method for determining an image of a portion of a body by means of magnetic resonance (MR), which method comprises a step for rotating a magnetization of spins in a selected portion of the body by generating an RF pulse in a selected slice. The RF pulse comprises a concatenation of a selective first RF pulse and a second selective RF pulse.
摘要翻译：本发明涉及一种用于通过磁共振（MR）来确定身体部分的图像的方法，该方法包括通过在身体的选定部分中产生RF脉冲来旋转身体的选定部分中的旋转的磁化的步骤选择切片。 RF脉冲包括选择性第一RF脉冲和第二选择性RF脉冲的级联。

58. 发明申请

WO99031522A1 MAGNETIC RESONANCE METHOD AND DEVICE FOR DETERMINING A PERFUSION IMAGE 审中-公开
标题翻译：用于确定灌注图像的磁共振方法和装置
公开(公告)号：WO99031522A1
公开(公告)日：1999-06-24
申请号：PCT/IB1998/001897
申请日：1998-11-30
IPC分类号： A61B5/055 , G01R33/46 , G01R33/48 , G01R33/563
CPC分类号： G01R33/446 , G01R33/56341
摘要： The invention relates to a magnetic resonance method for determining a perfusion image of a portion, which method comprises the following steps: generation of a control pulse sequence in a first portion of the body and measurement of a control data set by generation of an MR-image sequence for imaging of a third portion of the body, generation of a labelling pulse sequence in a second portion of the body wherein a fluid flows towards the third portion, and measurement of the labelled data set by generation of the MR-image sequence for imaging the third portion of the body, and reconstruction of the perfusion image of the fluid in a mass of the third portion of the body from a combination of the control data set and the labelled data set. In order to reduce the geometric restrictions and compensate magnetic transfer effects, the labelling pulse sequence comprises a first selective RF pulse and a second RF pulse, the control pulse sequence comprises the first selective RF pulse and a third RF pulse, a phase of the second RF pulse being opposite to that of the third RF pulse.
摘要翻译：本发明涉及一种用于确定部分的灌注图像的磁共振方法，该方法包括以下步骤：在身体的第一部分中产生控制脉冲序列，并通过生成MR- 用于对身体的第三部分进行成像的图像序列，在身体的第二部分中产生标记脉冲序列，其中流体朝向第三部分流动，以及通过生成MR图像序列来测量标记数据集，成像身体的第三部分，以及从控制数据集合和标记数据集合的组合中重建身体第三部分的质量的流体的灌注图像。为了减少几何限制并补偿磁转移效应，标记脉冲序列包括第一选择性RF脉冲和第二RF脉冲，所述控制脉冲序列包括第一选择性RF脉冲和第三RF脉冲，第二RF相位 RF脉冲与第三RF脉冲的RF脉冲相反。

59. 发明申请

WO99002707A1 FUSION PROTEINS COMPRISING COILED-COIL STRUCTURES 审中-公开
标题翻译：包裹线圈结构的融合蛋白
公开(公告)号：WO99002707A1
公开(公告)日：1999-01-21
申请号：PCT/GB1998/002040
申请日：1998-07-10
IPC分类号： G01R33/24 , C07K14/47 , C07K16/00 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/62 , C12R1/19 , G01R33/46
CPC分类号： C12N15/62 , C07K14/4703 , C07K2319/00 , C07K2319/21 , C07K2319/50 , C07K2319/73
摘要： The invention relates to a fusion protein comprising a) a first region capable of forming a coiled-coil structure; and b) a second region not naturally associated with the first region comprising a polypeptide sequence of interest. The fusion protein of the invention is applicable to the production of very small polypeptides in transformed host cells.
摘要翻译：本发明涉及一种融合蛋白，其包含：a）能够形成盘绕线圈结构的第一区域; 和b）不包含感兴趣的多肽序列的与天然不相关的第一区域的第二区域。本发明的融合蛋白适用于在转化的宿主细胞中生产非常小的多肽。

60. 发明申请

WO1997026549A1 USING NEURAL NETWORK AND PARTIAL LEAST SQUARE REGRESSION TECHNIQUES IN OBTAINING MEASUREMENTS OF ONE OR MORE POLYMER PROPERTIES WITH AN ON-LINE NMR SYSTEM 审中-公开
标题翻译：使用神经网络和部分最小二乘回归技术获得一个或多个聚合物性质与在线NMR系统的测量
公开(公告)号：WO1997026549A1
公开(公告)日：1997-07-24
申请号：PCT/US1996020792
申请日：1996-12-30
申请人： AUBURN INTERNATIONAL, INC.
发明人： AUBURN INTERNATIONAL, INC. , SMITH, Thomas, B. , DAY, David, R. , ROY, Ajoy, K. , TANZER, Christian, I.
IPC分类号： G01R33/46
CPC分类号： G01N24/085 , G01N24/082 , G01R33/389 , G01R33/4625
摘要： An on-line nuclear magnetic resonance (NMR) system, and related methods, are useful for predicting one or more properties of interest of a polymer. In one embodiment, a neural network is used to develop a model which correlates process variables in addition to manipulated NMR output to predict a polymer property of interest. In another embodiment, a partial least square regression technique is used to develop a model of enhanced accuracy. Either the neural network technique or the partial least square regression technique may be used in conjunction with a described multi-model or best-model-selection scheme according to the invention. The polymer can be a plastic such as polyethylene, polypropylene, or polystyrene, or a rubber such as ethylene propylene rubber.
摘要翻译：在线核磁共振（NMR）系统和相关方法可用于预测聚合物的一种或多种感兴趣的性质。在一个实施例中，使用神经网络来开发除了操纵的NMR输出之外关联过程变量以预测感兴趣的聚合物性质的模型。在另一个实施例中，使用偏最小二乘回归技术来开发增强精度的模型。神经网络技术或偏最小二乘回归技术可以与根据本发明的所描述的多模型或最佳模型选择方案结合使用。聚合物可以是诸如聚乙烯，聚丙烯或聚苯乙烯之类的塑料，或橡胶如乙丙橡胶。

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