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51. 发明申请

WO2014075124A1 METHODS AND COMPOSITIONS FOR THE TREATMENT AND/OR PREVENTION OF BOWEL DISORDERS 审中-公开
标题翻译：治疗和/或预防BOWEL疾病的方法和组合物
公开(公告)号：WO2014075124A1
公开(公告)日：2014-05-22
申请号：PCT/AU2012/001414
申请日：2012-11-15
申请人： VICTORIA UNIVERSITY
发明人： NURGALI, Kulmira , EDMUNDS, Lauren
IPC分类号： A61K31/06 , A61K31/05 , A61P1/00
CPC分类号： A61K31/165 , A61K31/05
摘要： The present invention relates to methods for the treatment and/or prevention of bowel disorders. The methods and compositions disclosed herein are useful in treatment and prevention of inflammatory bowel disease.
摘要翻译：本发明涉及治疗和/或预防肠病的方法。本文公开的方法和组合物可用于治疗和预防炎症性肠病。

52. 发明申请

WO2013139931A1 COMPOSITION FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES WITH PARKINSONIAN SYNDROMES 审中-公开
标题翻译：用于治疗PARKINSONIAN综合症的神经病变性疾病的组合物
公开(公告)号：WO2013139931A1
公开(公告)日：2013-09-26
申请号：PCT/EP2013/055972
申请日：2013-03-21
申请人： ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE) , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS) , UNIVERSITÉ PIERRE ET MARIE CURIE - PARIS 6 (UMPC)
发明人： CORVOL, Jean-Christophe , KLEBE, Stephan , VIDAILHET, Marie , ALEXIS, Brice , HUNOT, Stéphane
IPC分类号： A61K31/00 , A61K31/06 , A61K31/11 , A61K31/12 , A61K31/122 , A61K31/137 , A61K31/277 , A61K31/44 , A61P25/16 , A61P25/14 , A61P25/28
CPC分类号： A61K31/00 , A61K31/06 , A61K31/11 , A61K31/12 , A61K31/122 , A61K31/137 , A61K31/277 , A61K31/44
摘要： The present invention relates to a composition comprising an inhibitor of the COMT enzyme for use in the treatment of a Neurodegenerative Disease with Parkinsonian Syndromes in a subject having a COMT H allele, wherein said composition does not comprise L-Dopa.
摘要翻译：本发明涉及一种组合物，其包含用于治疗具有COMTH等位基因的受试者中具有帕金森综合征的神经变性疾病的COMT酶抑制剂，其中所述组合物不包含L-多巴。

53. 发明申请

WO2013071089A1 OPIOID ANALGESICS AND 3-HYDROXYACETANILIDE FOR TREATING PAIN 审中-公开
标题翻译：用于治疗疼痛的OPIOID ANALGESICS和3-羟基乙酰胺
公开(公告)号：WO2013071089A1
公开(公告)日：2013-05-16
申请号：PCT/US2012/064427
申请日：2012-11-09
申请人： SLX PHARMACEUTICALS, LLC , WRAY, Jonathan
发明人： WRAY, Jonathan
IPC分类号： A61K31/06
CPC分类号： A61K31/485 , A61K31/167 , A61K2300/00
摘要： Pharmaceutical combinations of opioid analgesics and analgesics that act through non-opioid mechanisms are commonly used to provide pain relief. An example of this pharmaceutical combination is the product Vicodin™, where the opioid analgesic is hydrocodone and the non-opioid is acetaminophen. However, liver toxicity from the acetaminophen component is common. The invention provides an improvement over the opioid and acetaminophen pharmaceutical combinations for the management of pain by the concomitant administration of an opioid analgesics and the non-opioid analgesic 3-hydroxyacetanilide. This combination has been found to exhibit unexpectedly enhanced analgesic activity when dosed orally in a mammal.
摘要翻译：通过非阿片类药物作用的阿片类镇痛药和镇痛药的药物组合通常用于缓解疼痛。该药物组合的实例是产品Vicodin TM，其中阿片类镇痛剂是氢可酮，非阿片样物质是对乙酰氨基酚。然而，对乙酰氨基酚组分的肝毒性是常见的。本发明通过阿片类止痛剂和非阿片类止痛剂3-羟基乙酰替苯胺的同时给药来提供对阿片类药物和对乙酰氨基酚药物组合的改善，用于治疗疼痛。已经发现，这种组合在口服给药于哺乳动物时表现出意想不到的增强的止痛活性。

54. 发明申请

WO2010004256A1 CONTROLLED RELEASE TREATMENT OF DEPRESSION 审中-公开
标题翻译：控制释放治疗
公开(公告)号：WO2010004256A1
公开(公告)日：2010-01-14
申请号：PCT/GB2009/001515
申请日：2009-06-17
申请人： E-THERAPEUTICS PLC , YOUNG, Malcolm, Philip , IDOWU, Olusola, Clement , MCKEOWN, Philip
发明人： YOUNG, Malcolm, Philip , IDOWU, Olusola, Clement , MCKEOWN, Philip
IPC分类号： A61K31/05 , A61K31/055 , A61K31/06 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/194 , A61K31/29 , A61K31/343 , A61K31/415 , A61K31/485 , A61K31/5415 , A61K31/616 , A61P25/24
CPC分类号： A61K9/286 , A61K31/05 , A61K31/055 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/194 , A61K31/343 , A61K31/415 , A61K31/473 , A61K31/5415 , A61K31/555 , A61K31/612
摘要： There is described a pharmaceutical composition for controlled release of an active compound wherein the active compound is selected from the group comprising tramadol, resveratrol, acetaminophen, xorphanol, cinfenoac, furcloprofen, bismuth subsalicylate, enofelast, triflusal, ketorfanol, indriline, furofenac, cizolirtine, dacemazine, demelverine, and fenethazine, and derivatives and/or combinations thereof for the treatment or alleviation of depression. More particularly, there is described an abuse resistant pharmaceutical composition for the treatment of, inter alia , depression and controlled release pharmaceutical compositions of related thereto.
摘要翻译：描述了活性化合物的控制释放的药物组合物，其中活性化合物选自曲马多，白藜芦醇，对乙酰氨基酚，对羟基苯甲酸，菲诺酸，氟氯洛芬，亚水杨酸铋，烯诺酮，三氟乙酸，酮醇，吲哚，糠醛，茜素，达米星，甲氧韦林和芬西嗪，以及其用于治疗或缓解抑郁症的衍生物和/或组合。更具体地，描述了用于治疗特别是与其有关的抑郁症和控制释放药物组合物的滥用药物组合物。

55. 发明申请

WO2009090063A1 STEROID SAPOGENIN, ANDROSTANE AND TRITERPENOID SAPOGENIN DERIVATIVES FOR THE TREATMENT AND PREVENTION OF INFECTIOUS DISEASES 审中-公开
标题翻译：用于治疗和预防感染性疾病的STEROID青蒿素，安地尔和三磷酸肌球蛋白衍生物
公开(公告)号：WO2009090063A1
公开(公告)日：2009-07-23
申请号：PCT/EP2009/000216
申请日：2009-01-15
申请人： JADO TECHNOLOGIES GMBH , TECHNISCHE UNIVERSITÄT DRESDEN , KNÖLKER, Hans-Joachim , AGARWAL, Sameer , SCHLECHTINGEN, Georg , BRAXMEIER, Tobias , SCHROEDER, Cornelia , JENNINGS, Gary
发明人： KNÖLKER, Hans-Joachim , AGARWAL, Sameer , SCHLECHTINGEN, Georg , BRAXMEIER, Tobias , SCHROEDER, Cornelia , JENNINGS, Gary
IPC分类号： A61K31/56 , A61K31/568 , A61K31/575 , A61K31/58 , A61P31/04 , A61K31/06 , A61P31/08 , A61P31/12 , A61P31/16 , A61P31/18 , A61P31/22
CPC分类号： A61K31/58 , A61K31/56 , A61K31/568 , A61K31/575 , Y02A50/463
摘要： The present invention relates to steroid sapogenin, androstane and triterpenoid sapogenin derived amines or ammonium derivatives in the medical intervention of infectious diseases, in particular diseases caused by a virus or a bacterium, including drug-resistant strains.
摘要翻译：本发明涉及在感染性疾病的医学干预中，类固醇皂苷元，雄甾烷和三萜皂苷苷衍生的胺或铵衍生物，特别是由病毒或细菌（包括耐药菌株）引起的疾病。

56. 发明申请

WO2008034346A1 用于治疗肿瘤的组合物和方法审中-公开
公开(公告)号：WO2008034346A1
公开(公告)日：2008-03-27
申请号：PCT/CN2007/002671
申请日：2007-09-07
申请人：于保法
发明人：于保法
IPC分类号： A61K33/24 , A61K31/06 , A61K31/04 , A61K31/185 , A61K31/32 , A61K31/21 , A61K31/53 , A61K38/38 , A61P35/00
CPC分类号： A61K47/48084 , A61K31/04 , A61K31/06 , A61K31/185 , A61K31/21 , A61K31/32 , A61K31/53 , A61K33/24 , A61K36/00 , A61K38/00 , A61K45/06 , A61K47/548 , Y02A50/471 , A61K2300/00
摘要： The present invention provides a composition for treating tumor, comprising reductant-oxidant, targeting vector, anticancer drugs and hapten. The present invention also provides the method of the composition for treating vegetation, tumor and cancer.

57. 发明申请

WO2007118329A1 METHODS AND AGENTS FOR TREATING TUBERCULOSIS 审中-公开
标题翻译：治疗结核病的方法和药剂
公开(公告)号：WO2007118329A1
公开(公告)日：2007-10-25
申请号：PCT/CA2007/000648
申请日：2007-04-17
申请人： THE UNIVERSITY OF BRITISH COLUMBIA , QUEEN'S UNIVERSITY , ELTIS, Lindsay , SNIECKUS, Victor
发明人： ELTIS, Lindsay , SNIECKUS, Victor
IPC分类号： C07C49/747 , A61K31/05 , A61K31/055 , A61K31/06 , A61K31/122 , A61K31/19 , A61K31/192 , A61K31/5685 , A61P31/04 , A61P31/06 , C07C205/26 , C07C39/24 , C07C39/367 , C07C59/90 , G01N33/50
CPC分类号： C07C205/26 , A61K31/05 , A61K31/055 , A61K31/06 , A61K31/122 , A61K31/19 , A61K31/192 , A61K31/5685 , C07C39/245 , C07C39/367 , C07C49/747 , C07C59/90 , G01N33/56922 , G01N2500/02
摘要： The present invention relates to the treatment of tuberculosis (mycobacterial infections) by the use of KshAB complex inhibitors, or a KstD molecule, or a HsaAB complex, or a HsaC molecule, or a HsaD molecule. The application also includes a method for identifying an inhibitor or modulator of the previously mentioned molecules and complexes.
摘要翻译：本发明涉及通过使用KshAB复合抑制剂或KstD分子或HsaAB复合物或HsaC分子或HsaD分子治疗结核病（分枝杆菌感染）。该应用还包括鉴定前述分子和复合物的抑制剂或调节剂的方法。

58. 发明申请

WO2004041256A3 SAFE CHEMICAL UNCOUPLERS FOR THE TREATMENT OF OBESITY 审中-公开
标题翻译：治疗肥胖的安全化学联合疗法
公开(公告)号：WO2004041256A3
公开(公告)日：2004-09-02
申请号：PCT/DK0300742
申请日：2003-10-31
申请人： NOVO NORDISK AS
发明人： HANSEN BIRGIT SEHESTED , TULLIN SOEREN , HANSEN THOMAS KRUSE , COLDING-JOERGENSEN MORTEN
IPC分类号： A61K31/166 , A61K31/17 , A61K31/19 , A61K31/216 , A61K31/40 , A61K31/404 , C07D213/70 , C07D277/32 , C07D295/192 , C07D295/26 , C07D307/28 , C07D307/38 , C07D311/16 , C07D333/34 , A61K31/04 , A61K31/06 , C07C205/12 , C12N5/00 , C12Q1/00 , G01N33/50
CPC分类号： C07D213/70 , A61K31/166 , A61K31/17 , A61K31/19 , A61K31/216 , A61K31/40 , A61K31/404 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/32 , C07D295/192 , C07D295/26 , C07D307/28 , C07D307/38 , C07D311/16 , C07D333/34
摘要： This invention relates to chemical uncouplers with a broader safety window making the use of them in treating obesity and, consequently, in the treatment of obesity related dis-eases and conditions such as atherosclerosis, hypertension, diabetes, especially type 2 dia-betes (NIDDM (non-insulin dependent diabetes mellitus)), impaired glucose tolerance, dyslip-idemia, coronary heart disease, gallbladder disease, osteoarthritis and various types of can-cer such as endometrial, breast, prostate and colon cancers and the risk for premature death as well as other conditions, such as diseases and disorders, which conditions are improved by an increase in mitochondrial respiration, more attractive.
摘要翻译：本发明涉及具有更宽安全窗口的化学解偶联剂，使其用于治疗肥胖症，并因此用于治疗与肥胖有关的疾病和病症，如动脉粥样硬化，高血压，糖尿病，特别是2型糖尿病（NIDDM （非胰岛素依赖型糖尿病）），葡萄糖耐量降低，血脂异常，冠心病，胆囊疾病，骨关节炎和各种类型的癌症，如子宫内膜癌，乳腺癌，前列腺癌和结肠癌以及过早死亡的风险以及其他条件，如疾病和病症，这些条件通过增加线粒体呼吸而得到改善，更具吸引力。

59. 发明申请

WO02094316A3 METHOD OF PREPARING ALUMINIUM-HYDROXIDE GEL 审中-公开
标题翻译：制备氢氧化铝凝胶的方法
公开(公告)号：WO02094316A3
公开(公告)日：2003-05-15
申请号：PCT/IB0202870
申请日：2002-05-21
申请人： BARTELING SIMON JOHANNES
发明人： BARTELING SIMON JOHANNES
IPC分类号： A61K9/00 , A61K39/39 , A61K47/02 , A61K31/06
CPC分类号： A61K47/02 , A61K39/39 , A61K2039/55505
摘要： This invention provides a method of preparing a vaccine including the steps of providing an antigen preparing an aluminium-hydroxide gel AH-gel and mixing the antigen with the AH-gel to form an AH-gel-antigen complex. This invention further provides a method of preparing aluminium-hydroxide gel AH-gel including the steps of providing Al¿2?O¿3? in particulate form dissolving the Al¿2?O¿3? particles in an alkali and neutralising the alkali with an acid. Further included in the invention are vaccines and AH-gel prepared according to the methods of the invention.
摘要翻译：本发明提供一种制备疫苗的方法，包括以下步骤：提供制备氢氧化铝凝胶AH凝胶的抗原，并将抗原与AH凝胶混合以形成AH-凝胶 - 抗原复合物。本发明还提供一种制备氢氧化铝凝胶AH凝胶的方法，包括以下步骤：提供Al 2 O 3 以颗粒形式溶解Al 2 O 3 在碱中的颗粒并用酸中和碱。本发明还包括根据本发明方法制备的疫苗和AH-凝胶。

60. 发明申请

WO0008495A3 ANTIPROLIFERATIVE NAPHTHOQUINONES, DERIVATIVES, COMPOSITIONS, AND USES THEREOF 审中-公开
标题翻译：抗增殖性萘酚醌，衍生物，组合物及其用途
公开(公告)号：WO0008495A3
公开(公告)日：2000-05-25
申请号：PCT/US9917863
申请日：1999-08-06
申请人： UNIV PITTSBURGH
发明人： CARR BRIAN I , WILCOX CRAIG S , KERNS JEFFREY K
IPC分类号： A61P35/00 , C07C43/225 , C07C46/00 , C07C46/02 , C07C50/24 , C07C205/46 , C07C233/33 , C07C323/22 , C07C50/12 , A61K31/05 , A61K31/055 , A61K31/06 , A61K31/10 , A61K31/122 , C07C50/14 , C07C205/25 , C07C205/26 , C07C323/21
CPC分类号： C07C323/22 , C07C43/225 , C07C46/00 , C07C46/02 , C07C50/24 , C07C205/46 , C07C233/33
摘要： The present invention provides a compound selected from the group consisting of (I), (II), and (III), wherein R and R are the same or different and are each H, C1-C3 alkyl, phosphate, or C1-C3 alkyl carboxylate; R and R are the same or different and are each H, a halogen, A-Z, S-Z, S-A-Z, N(B)-Z, N(B)-A-Z, O-Z, or O-A-Z, wherein: A is a C1-C20 linear or branched saturated or unsaturated alkyl, haloalkyl, arylalkyl, cycloalkylalkyl, heterocycloalkyl, hydroxyalkyl, alkoxyalkyl, thioalkyl, carboxyalkyl, carboalkoxyalkyl, carboxyaminoalkyl, a 5- to 6-membered ring carbohydrate or the corresponding acyclic analog thereof, peptidyl, or aminoalkyl diradical; B is H or C1-C6 alkyl; Z is H, aryl, heterocyclic, or a heteroatom-containing functional group; and R -R are the same or different and are each H, a halogen, heterocyclic, Z as defined above, A-Z as defined above, or heteroatom-containing functional group, provided that R -R are not all H, useful as cellular growth inhibitors.
摘要翻译：本发明提供选自（I），（II）和（III）的化合物，其中R 1和R 4相同或不同并且各自为H，C 1 -C 3烷基，磷酸酯或羧酸C1-C3烷基酯; R 2和R 3相同或不同并且各自为H，卤素，AZ，SZ，SAZ，N（B）-Z，N（B）-AZ，OZ或OAZ，其中：A C 1 -C 20直链或支链饱和或不饱和烷基，卤代烷基，芳基烷基，环烷基烷基，杂环烷基，羟基烷基，烷氧基烷基，硫代烷基，羧基烷基，羰基烷氧基烷基，羧基氨基烷基，5-6元环碳水化合物或其相应的无环类似物，，或氨基烷基二基; B是H或C 1 -C 6烷基; Z是H，芳基，杂环或含杂原子的官能团; 和R 5 -R 8相同或不同，并且各自为H，卤素，如上定义的杂环，Z，如上定义的AZ或含杂原子的官能团，条件是R 5 -R 8不全为H，可用作细胞生长抑制剂。

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