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51. 发明申请

WO1993025228A1 CYTOTOXINS SPECIFIC FOR GM-CSF RECEPTOR-BEARING CELLS 审中-公开
标题翻译： GM-CSF受体轴承细胞特异性细胞因子
公开(公告)号：WO1993025228A1
公开(公告)日：1993-12-23
申请号：PCT/US1993005574
申请日：1993-06-11
申请人： WHITTIER INSTITUTE FOR DIABETES AND ENDOCRINOLOGY , LAPPI, Douglas, A. , BAIRD, J., Andrew
发明人： WHITTIER INSTITUTE FOR DIABETES AND ENDOCRINOLOGY
IPC分类号： A61K37/36
CPC分类号： C07K19/00 , A61K38/00 , C07K14/415 , C07K14/535
摘要： Conjugates containing granulocyte-macrophage colony-stimulating factor (GM-CSF) conjugated to a toxic molecule are provided. The conjugates are used for ameliorating GM-CSF-mediated or GM-CSF-associated disorders, including cancers and inflammatory disease. In a preferred embodiment, GM-CSF is chemically conjugated by disulfide bonds to the ribosome-inactivating protein saporin. The resulting conjugate is highly toxic to targeted cells.
摘要翻译：提供了含有与毒性分子缀合的粒细胞 - 巨噬细胞集落刺激因子（GM-CSF）的缀合物。缀合物用于改善GM-CSF介导的或GM-CSF相关疾病，包括癌症和炎性疾病。在优选的实施方案中，GM-CSF通过二硫键与核糖体失活的蛋白质皂草素化学偶联。所得缀合物对靶细胞具有高毒性。

52. 发明申请

WO1993025227A1 USE OF GROWTH FACTOR IGF-II 审中-公开
标题翻译：使用生长因子IGF-II
公开(公告)号：WO1993025227A1
公开(公告)日：1993-12-23
申请号：PCT/SE1993000503
申请日：1993-06-07
申请人： KABI PHARMACIA AB , GLUCKMAN, Peter, David , MELLOR, David, James
发明人： KABI PHARMACIA AB
IPC分类号： A61K37/36
CPC分类号： A61K38/30
摘要： The present invention relates to the use of IGF-II or effective analogues thereof for the manufacture of a medicament for prevention or treatment of nutritional or gastrointestinal disorders and for promoting human or animal neonatal growth. It also relates to composition comprising exogenous human or animal IGF-II or effective analogues thereof in a therapeutical effective amount together with a pharmaceutically acceptable carrier or diluent or foodstuff, preferably in admixture with articial or natural milk or colostrum.
摘要翻译：本发明涉及IGF-II或其有效类似物在制备用于预防或治疗营养或胃肠道疾病和促进人或动物新生儿生长的药物中的用途。它还涉及包含外源性人或动物IGF-II或其有效类似物的治疗有效量的组合物以及药学上可接受的载体或稀释剂或食品，优选与天然乳或初乳或初乳混合。

53. 发明申请

WO1993003758A1 PRODUCTION OF HOMOGENEOUS NEUROTROPHIC FACTOR 审中-公开
标题翻译：均质神经营养因子的产生
公开(公告)号：WO1993003758A1
公开(公告)日：1993-03-04
申请号：PCT/US1992007070
申请日：1992-08-21
申请人： SCIOS NOVA INC.
发明人： SCIOS NOVA INC. , HIGAKI, Jeffrey, N. , TISCHER, Edmund, G. , CORDELL, Barbara , THOMPSON, Stewart, A.
IPC分类号： A61K37/36
CPC分类号： C07K14/475 , A61K38/00
摘要： There are disclosed neurotrophic factors which are capable of being expressed as polypeptides lacking the microheterogeneity associated with a related native-sequence factor, CNTF. Also disclosed are DNA sequences encoding the neurotrophic factors and methods for expressing and recovering the factors as homogeneous polypeptides.
摘要翻译：已经公开了能够被表达为缺乏与相关天然序列因子CNTF相关的微不同性的多肽的神经营养因子。还公开了编码神经营养因子的DNA序列和用于表达和恢复因子作为均质多肽的方法。

54. 发明申请

WO1992008480A1 A 'beta'-TYPE TRANSFORMING GROWTH FACTOR 审中-公开
标题翻译： β-TYPE转化生长因子
公开(公告)号：WO1992008480A1
公开(公告)日：1992-05-29
申请号：PCT/US1991008606
申请日：1991-11-18
申请人： CELTRIX LABORATORIES, INC.
发明人： CELTRIX LABORATORIES, INC. , OWAGA, Yasushi , SCHMIDT, David , DASCH, James
IPC分类号： A61K37/36
CPC分类号： C07K16/22 , A61K38/00 , C07K14/495 , C07K2319/02 , Y10S930/12
摘要： A new heterodimeric form of TGF- beta is described. This 25 KD molecule is active in an in vitro assay of inhibition of epithelial cell growth. The protein may be isolated from bone. When reduced, the protein elutes in two peaks by RP-HPLC. In immunoblots, the reduced protein from the earlier eluting peak reacts predominately with antibodies directed against TGF- beta 3, while reduced protein from the later eluting peak reacts predominately with antibodies directed against TGF- beta 2. The N-terminal amino acid sequence and immunoreactivity of the native protein are consistent with a heterodimer of TGF- beta 2 and TGF- beta 3.
摘要翻译：描述了一种新的异二聚体形式的TGF-β。该25KD分子在上皮细胞生长抑制的体外测定中是有活性的。蛋白质可以从骨分离。减少时，蛋白质通过RP-HPLC在两个峰中洗脱。在免疫印迹中，来自较早洗脱峰的还原蛋白主要与针对TGF-β3的抗体反应，而来自后期洗脱峰的蛋白质主要与针对TGF-β2的抗体反应.N末端氨基酸序列和免疫反应性的天然蛋白质与TGF-β2和TGF-β3的异源二聚体一致。

55. 发明申请

WO1992003155A1 PRODUCT CONTAINING GROWTH FACTOR AND GLUTAMINE AND USE OF GROWTH FACTOR FOR THE TREATMENT OF INTESTINAL MUCOSA 审中-公开
标题翻译：含有生长因子和谷氨酰胺的产品以及生长因子用于治疗肠胃粘膜炎
公开(公告)号：WO1992003155A1
公开(公告)日：1992-03-05
申请号：PCT/SE1991000558
申请日：1991-08-22
申请人： KABI PHARMACIA AB , KIHLBERG, Reinhold , LINDGREN, Svante, Bengt , SANDBERG, Lars, Göran
发明人： KABI PHARMACIA AB
IPC分类号： A61K37/36
CPC分类号： A61K38/25 , A61K31/198 , A61K38/27 , A61K38/30 , A61K2300/00
摘要： This invention relates to a product containing a) glutamine or derivative or analogue thereof, b) short- or medium-chain fatty acid and c) a growth factor or analogue thereof for simultaneous, separate or sequential use having anabolic effects and useful for the treatment or prevention of malfunction or disease of the intestinal mucosa. The growth factor is GH, GRF, IGF-1 or IGF-2 and preferably IGF-1. The invention also relates to the use of GH, GRF, IGF-1 or IGF-2 for the manufacture of a medicament for the treatment or prevention of malfunction or disease of the intestinal mucosa.
摘要翻译：本发明涉及含有a）谷氨酰胺或其衍生物或类似物的产品，b）短链或中链脂肪酸和c）同时，分开或顺序使用具有合成代谢作用并可用于治疗的生长因子或其类似物或预防肠粘膜的功能障碍或疾病。生长因子是GH，GRF，IGF-1或IGF-2，优选IGF-1。本发明还涉及GH，GRF，IGF-1或IGF-2在制备用于治疗或预防肠粘膜功能障碍或疾病的药物中的用途。

56. 发明申请

WO1992003154A1 PRODUCT AND USE OF IT FOR THE TREATMENT OF CATABOLIC STATES COMPRISING AUTHENTIC IGF-1 AND HYPOCALORIC AMOUNT OF NUTRITIENTS 审中-公开
标题翻译：产品及其用途，用于处理包含认可IGF-1和营养成分的超临界量的试剂盒
公开(公告)号：WO1992003154A1
公开(公告)日：1992-03-05
申请号：PCT/SE1991000557
申请日：1991-08-22
申请人： KABI PHARMACIA AB , FRYKLUND, Linda , GLUCKMAN, Peter , SKOTTNER, Anna
发明人： KABI PHARMACIA AB
IPC分类号： A61K37/36
CPC分类号： A61K38/30 , A61K31/7004 , A61K31/195 , A61K31/20 , A61K2300/00
摘要： A method and a product for the treatment or prevention of a catabolic state in a patient where the patient is treated with authentic IGF-1 and a hypocaloric amount of nutrient, for example intravenously.
摘要翻译：用于治疗或预防患者中的分解代谢状态的方法和产品，其中患者用真正的IGF-1和低热量的营养物进行治疗，例如静脉内。

57. 发明申请

WO1992002247A1 METHOD FOR TREATING CORNEAL ENDOTHELIAL WOUNDS 审中-公开
标题翻译：治疗角膜内膜损伤的方法
公开(公告)号：WO1992002247A1
公开(公告)日：1992-02-20
申请号：PCT/US1991005454
申请日：1991-08-01
申请人： CHIRON OPHTHALMICS, INC.
发明人： CHIRON OPHTHALMICS, INC. , SHIMIZU, Robert, W. , SCHULTZ, Gregory, S.
IPC分类号： A61K37/36
CPC分类号： A61L26/0066 , A61K38/1841 , A61L2300/414 , Y10S514/912 , Y10S514/961 , Y10S514/97
摘要： A method for treating corneal endothelial wounds comprises administering TFG- alpha to the region of the wound in an amount sufficient to promote the healing of endothelial cells.
摘要翻译：用于治疗角膜内皮创伤的方法包括以足以促进内皮细胞愈合的量给伤口区域的TFG-α。

58. 发明申请

WO1992000095A1 HISTIDINE SUBSTITUTED GROWTH HORMONE RELEASING FACTOR ANALOGS 审中-公开
标题翻译： HISTIDIN取代生长激素释放因子模拟
公开(公告)号：WO1992000095A1
公开(公告)日：1992-01-09
申请号：PCT/US1991004606
申请日：1991-06-27
申请人： HOFFMANN-LA ROCHE INC.
发明人： HOFFMANN-LA ROCHE INC. , FELIX, Arthur, Martin , HEIMER, Edgar, Philip
IPC分类号： A61K37/36
CPC分类号： C07K14/60 , A61K38/00
摘要： Novel growth hormone releasing factor analogs are presented having formula (I), wherein R1 is His, 3-MeHis, desNH2His, Tyr, or desNH2Tyr; R2 is Val, Leu, or Ile; R3 is Ala; R4 is Met, Leu, Ile, or Nle; R5 is Ser or Asn; R6 is an amino acid residue sequence selected from Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu or fragments thereof where the fragment is reduced in number by one to fifteen amino acid residues from the amino acid residue which carries the substituent X; and X is either OH or NH2, and the pharmaceutically acceptable acid or base addition salts thereof. The novel growth hormone releasing factor analogs demonstrate enhanced potency for the released growth hormone, have enhanced enzymatic stability, and can be administered to a subject having a deficiency of growth hormone or for improvement of growth performance in livestock.
摘要翻译：呈现新型生长激素释放因子类似物具有式（I），其中R 1是His，3-MeHis，desNH 2 His，Tyr或desNH 2 Tyr; R2是Val，Leu或Ile; R3是Ala; R4是Met，Leu，Ile或Nle; R5是Ser或Asn; R6是选自Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu或其片段数目减少的片段的氨基酸残基序列来自携带取代基X的氨基酸残基的1至15个氨基酸残基; 并且X是OH或NH 2，以及其药学上可接受的酸或碱加成盐。新生长激素释放因子类似物表现出增强的释放的生长激素的效力，具有增强的酶稳定性，并且可以施用于具有生长激素缺乏或用于改善家畜生长性能的受试者。

59. 发明申请

WO1991007982A1 TREATMENT OF HSV 审中-公开
标题翻译：治疗HSV
公开(公告)号：WO1991007982A1
公开(公告)日：1991-06-13
申请号：PCT/US1990006962
申请日：1990-11-29
申请人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES , CORNELL RESEARCH FOUNDATION, INC. , BAIRD, Jacques, Andrew, Cloutier , HAJJAR, David, Phillip
发明人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES , CORNELL RESEARCH FOUNDATION, INC.
IPC分类号： A61K37/36
CPC分类号： A61K38/16 , A61K31/185 , C07K14/503
摘要： Basic fibroblast growth factor, a 146 amino acid residue polypeptide, analogs thereof, a lectin, suramin, protamine and/or a shortened fragment of either bFGF or of an analog thereof is used to prevent the spread of HSV-1. It has been found that topical application of an effective amount of such an agent prevents HSV uptake and/or infection in cells that are otherwise targets for such virus. One group of preferred agents are peptides which include the decapeptide sequence of a mammalian bFGF(106-115), e.g., bovine bFGF(106-115), examples of such preferred peptides include bovine bFGF(103-120)-NH2 and human bFGF(103-120)-NH2.
摘要翻译：使用碱性成纤维细胞生长因子，146个氨基酸残基多肽，其类似物，凝血素，苏拉明，鱼精蛋白和/或bFGF或其类似物的缩短片段来防止HSV-1的扩散。已经发现，有效量的这种药剂的局部施用可以防止另外针对这种病毒的细胞中的HSV摄取和/或感染。一组优选的试剂是包括哺乳动物bFGF（106-115）的十肽序列（例如牛bFGF（106-115））的肽，这些优选的肽的实例包括牛bFGF（103-120）-NH2和人bFGF （103-120）-NH 2。

60. 发明申请

WO1991003253A1 TREATMENT OF INSULIN-RESISTANT DIABETES 审中-公开
标题翻译：胰岛素抵抗糖尿病的治疗
公开(公告)号：WO1991003253A1
公开(公告)日：1991-03-21
申请号：PCT/GB1990001399
申请日：1990-09-10
申请人： GREATER GLASGOW HEALTH BOARD , McCUISH, Angus, Carstairs
发明人： GREATER GLASGOW HEALTH BOARD
IPC分类号： A61K37/36
CPC分类号： A61K38/30 , A61K2300/00
摘要： Insulin-like growth factor (IGF) is used for treatment of type A insulin-resistant diabetes by reduction of glucose levels. The treatment is applicable to Mendenhall's Syndrome, Werner Syndrome, leprechaunism, lipoatrophic diabetes, and other lipoatrophies.
摘要翻译：胰岛素样生长因子（IGF）用于通过降低葡萄糖水平来治疗A型胰岛素抵抗型糖尿病。该治疗适用于门多特综合征，维纳综合征，妖精症，脂肪营养性糖尿病和其他脂肪萎缩症。

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