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51. 发明申请

WO0207742A9 BACTERIOPHAGE HAVING MULTIPLE HOST RANGE 审中-公开
标题翻译：具有多个主机范围的细菌
公开(公告)号：WO0207742A9
公开(公告)日：2002-04-18
申请号：PCT/US0123390
申请日：2001-07-25
申请人： US GOV HEALTH & HUMAN SERV , MERRIL CARL R , DASSLER KG ADI , SCHOLL DEAL
发明人： MERRIL CARL R , ADHYA SANKAR , SCHOLL DEAL
IPC分类号： A61K35/76 , A61P31/04 , C12N7/01 , A61K35/74
CPC分类号： A61K35/76 , C12N2795/14232 , Y10S435/948
摘要： The present invention discloses compositions and methods for the prophylaxis and treatment of bacterial infections by the use of polyvalent bacteriophage having multiple host range.
摘要翻译：本发明公开了通过使用具有多个宿主范围的多价噬菌体预防和治疗细菌感染的组合物和方法。

52. 发明申请

WO9909410A9 RAPID ASSAY FOR SIMULTANEOUS DETECTION AND DIFFERENTIATION OF ANTIBODIES TO HIV 审中-公开
标题翻译：快速测定HIV同时检测和分化抗体
公开(公告)号：WO9909410A9
公开(公告)日：1999-05-14
申请号：PCT/US9816506
申请日：1998-08-07
申请人： ABBOTT LAB
发明人： VALLARI ANADRUZELA S , HACKETT JOHN R JR , HICKMAN ROBERT K , VARITEK VINCENT A JR , NECKLAWS ELIZABETH C , GOLDEN ALAN M , BRENNAN CATHERINE A , DEVARE SUSHIL G
IPC分类号： C12Q1/68 , G01N33/543 , G01N33/569 , G01N33/48
CPC分类号： G01N33/56988 , G01N33/54386 , Y10S435/948 , Y10S435/974 , Y10S435/975 , Y10S530/826
摘要： A method of performing a rapid assay for the simultaneous detection and differentiation of the analytes HIV-1 group M, HIV-1 group O and HIV-2 utilizing a sequence specific polypeptide of each analyte as capture reagents. An analytical device also is provided for performing the method which includes these capture reagents. Also provided is a test kit which includes the analytical device which further can include a positive and negative control.
摘要翻译：使用每种分析物的序列特异性多肽作为捕获试剂，对分析物HIV-1组M，HIV-1组O和HIV-2同时进行检测和分化的快速检测方法。还提供了用于执行包括这些捕获试剂的方法的分析装置。还提供了包括分析装置的测试套件，该分析装置还可以包括正面和负面的对照。

53. 发明申请

WO99021880A2 PLANT BRANCHED-CHAIN AMINO ACID BIOSYNTHETIC ENZYMES 审中-公开
标题翻译：植物分支链氨基酸生物合成酶
公开(公告)号：WO99021880A2
公开(公告)日：1999-05-06
申请号：PCT/US1998/022081
申请日：1998-10-20
IPC分类号： C12N9/10 , C12N9/88 , C12N15/82 , C07K14/00
CPC分类号： C12N15/8251 , C12N9/1096 , C12N9/88 , Y10S435/948
摘要： This invention relates to an isolated nucleic acid fragment encoding a branched-chain biosynthetic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of the branched-chain biosynthetic enzyme, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the branched-chain biosynthetic enzyme in a transformed host cell.
摘要翻译：本发明涉及编码支链生物合成酶的分离的核酸片段。本发明还涉及在正义或反义方向上构建编码全部或部分支链生物合成酶的嵌合基因，其中嵌合基因的表达导致支链生物合成酶水平的改变转化的宿主细胞。

54. 发明申请

WO98050069A1 RECOMBINANT FELINE HERPESVIRUS COMPRISING A FOREIGN DNA INSERTED INTO A FELINE HERPESVIRUS GENOME 审中-公开
标题翻译：包含外来DNA的重组蛋白病毒
公开(公告)号：WO98050069A1
公开(公告)日：1998-11-12
申请号：PCT/US1998/009346
申请日：1998-05-07
IPC分类号： A61K39/00 , C12N15/869 , A61K39/12 , A61K39/245 , A61K39/265 , A61K39/27 , A61K39/38 , C12N7/04
CPC分类号： C12N15/86 , A61K39/00 , C12N2710/16743 , Y10S435/948
摘要： This invention provides a recombinant feline herpesvirus comprising a foreign DNA inserted into a feline herpesvirus genome, wherein the foreign DNA is inserted into a region of the genome which corresponds to the 3.0 kb EcoRI - SalI fragment within a SalI A fragment of the feline herpesvirus genome, the 9.5 kb SalI H fragment of the feline herpesvirus genome, or the 1.73 kb SalI N fragment of the feline herpesvirus genome and is capable of being expressed in a host cell into which the virus is introduced. Further this invention provides a recombinant feline herpesvirus comprising a feline herpesvirus genome, wherein the feline herpesvirus genome contains a deletion in a SacII site within the 3.0 kb EcoRI - SalI fragment of the SalI A fragment of the feline herpesvirus genome, the 9.5 kb SalI H fragment of the feline herpesvirus genome, or the 1.73 kb SalI N fragment of the feline herpesvirus genome. Lastly, this invention provides vaccines and methods of immunization of animals infected with feline herpesvirus.
摘要翻译：本发明提供了重组猫疱疹病毒，其包含插入猫疱疹病毒基因组的外源DNA，其中外源DNA被插入到与猫疱疹病毒基因组的SalI A片段内的3.0kb EcoRI-SalI片段相对应的基因组区域，猫疱疹病毒基因组的9.5kb SalI H片段或猫疱疹病毒基因组的1.73kb SalI N片段，并且能够在引入病毒的宿主细胞中表达。此外，本发明提供了包含猫疱疹病毒基因组的重组猫疱疹病毒，其中猫疱疹病毒基因组在猫疱疹病毒基因组SalI A片段的3.0kb EcoRI-SalI片段中的SacII位点中含有缺失，9.5kb SalI H 猫疱疹病毒基因组的片段或猫疱疹病毒基因组的1.73kb SalI N片段。最后，本发明提供疫苗和感染猫疱疹病毒的动物的免疫方法。

55. 发明申请

WO1996038474A2 DIAGNOSIS OF, AND VACCINATION AGAINST, A POSITIVE STRANDED RNA VIRUS USING AN ISOLATED, UNPROCESSED POLYPEPTIDE 审中-公开
标题翻译：使用分离的，不受约束的多肽进行诊断和接种疫苗，使用阳性的有条纹RNA病毒
公开(公告)号：WO1996038474A2
公开(公告)日：1996-12-05
申请号：PCT/US1996008112
申请日：1996-05-31
申请人： BIONOVA CORPORATION , LIAO, Jaw-Ching , WANG, Cheng-nan
发明人： BIONOVA CORPORATION
IPC分类号： C07K14/18
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2770/24222 , C12Q1/707 , G01N33/5767 , Y10S435/81 , Y10S435/948
摘要： The unprocessed polyprotein initially translated from the genome of a positive-stranded RNA virus contains epitopic configurations that are not retained in the processed proteins. The structural protein region, in particular, loses an epitopic configuration upon processing at the cleavage site between the genomic region encoding the core protein and the genomic region encoding the protein adjacent the core protein, such as the envelope protein in HCV. Compositions, methods and assays relating to the diagnosis and detection of the presence of the positive-stranded RNA virus, or antibodies to the positive-stranded RNA virus, in a sample. Compositions and methods for the induction of immune responses in, and vaccination of, an animal. Combination of the unprocessed core region with a non-structural protein (such as an NS5 or an unprocessed NS3-NS4 fusion from HCV).
摘要翻译：最初从正链RNA病毒基因组翻译的未加工的多蛋白含有未保留在加工的蛋白质中的表位构型。特别是，在编码核心蛋白质的基因组区域和编码与核心蛋白质相邻的蛋白质的基因组区域（例如HCV中的包膜蛋白）之间的切割位点处理时，结构蛋白质区域特别失去了表位构型。与样品中正链RNA病毒的存在或正链RNA病毒的抗体的诊断和检测有关的组合物，方法和测定。用于诱导动物免疫应答和免疫接种的组合物和方法。未加工的核心区域与非结构蛋白（例如NS5或来自HCV的未处理的NS3-NS4融合体）的组合。

56. 发明申请

WO1996004020A1 INFECTIOUS HIV-2 STRAINS AND NON-HUMAN PRIMATES INFECTED THEREWITH 审中-公开
标题翻译：感染HIV-2菌株和非人类初步感染
公开(公告)号：WO1996004020A1
公开(公告)日：1996-02-15
申请号：PCT/US1995009822
申请日：1995-08-02
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LEVY, Jay, A.
IPC分类号： A61K49/00
CPC分类号： A61K49/0004 , A01K67/027 , C12N2740/16011 , Y10S435/948 , Y10S435/974
摘要： Strains of HIV-2 capable of infecting humans and non-human primates such as baboons and causing an immune system disease are disclosed. The HIV-2 strain are used to infect non-human primates which infected primates present symptoms of a disease of the immune system and are used to test drugs, e.g., anti-virals and/or vaccines for their ability to treat and/or prevent lentiviral infections such as HIV infections. Useful strains are HIV-2UC2, HIV-2UC12 and HIV-2UC14 and preferred non-human primates are baboons.
摘要翻译：公开了能够感染人类和非人类灵长类动物例如狒狒并引起免疫系统疾病的HIV-2菌株。 HIV-2菌株用于感染感染灵长类动物的非人灵长类动物，其呈现免疫系统疾病的症状，并且用于测试药物，例如抗病毒剂和/或疫苗以治疗和/或预防的能力慢病毒感染如艾滋病毒感染。有用的菌株是HIV-2UC2，HIV-2UC12和HIV-2UC14，优选的非人灵长类是狒狒。

57. 发明申请

WO1995035368A1 EXTRACTION OF HETEROLOGOUS INSOLUBLE PROTEINS FROM BACTERIA 审中-公开
标题翻译：从细菌中提取异种不育蛋白
公开(公告)号：WO1995035368A1
公开(公告)日：1995-12-28
申请号：PCT/US1995007129
申请日：1995-06-19
申请人： SCHERING CORPORATION
发明人： SCHERING CORPORATION , ALROY, Yair , ZHU, Jingdong , CONDON, Russell
IPC分类号： C12N15/10
CPC分类号： C12P21/02 , C07K14/5428 , C12N15/70 , Y10S435/948 , Y10S530/825
摘要： An insoluble mammalian protein is extracted from transformed bacteria expressing the mammalian protein while avoiding irreversible insolubilization of bacterial host proteins by homogenizing the fermentation broth, centrifuging the homogenized broth and removing the supernatant liquid from the inclusion body containing pellet. In another embodiment, the pH of the homogenized broth is adjusted to 2.0 prior to centrifugation. The acidified broth is then centrifuged, and the pellet is resuspended in buffer, homogenized again, and the inclusion body is isolated by centrifugation.
摘要翻译：从表达哺乳动物蛋白质的转化细菌中提取不溶性哺乳动物蛋白质，同时通过均化发酵肉汤，离心匀浆肉汤并从含有颗粒的包含体中除去上清液，同时避免细菌宿主蛋白的不可逆不溶解。在另一个实施方案中，在离心之前将均化肉汤的pH调节至2.0。然后将酸化的肉汤离心，将沉淀重新悬浮于缓冲液中，再次匀浆，通过离心分离包涵体。

58. 发明申请

WO1995034686A1 ISOLATION AND DIAGNOSIS OF CORONAVIRUSES 审中-公开
标题翻译：冠状病毒的分离和诊断
公开(公告)号：WO1995034686A1
公开(公告)日：1995-12-21
申请号：PCT/US1995007493
申请日：1995-06-12
申请人： BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
发明人： BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE , STORZ, Johannes
IPC分类号： C12Q01/70
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2770/20021 , C12N2770/20022 , C12Q1/70 , G01N33/5091 , G01N33/56983 , Y10S435/948
摘要： Coronaviruses can be a significant factor in bovine shipping fever. A new human rectal tumor cell line, HRT-18G, is suitable as a host cell line for the propagation of these bovine respiratory coronavirus-shipping fever viruses, and also is well suited for the propagation of other bovine coronaviruses.
摘要翻译：冠状病毒可能是牛出血热的重要因素。新的人直肠肿瘤细胞系HRT-18G适合作为这些牛呼吸道冠状病毒 - 寄生热病毒繁殖的宿主细胞系，也适用于其他牛冠状病毒的繁殖。

59. 发明申请

WO1990013631A1 BACTERIOPHAGE PREVENTION AND CONTROL OF HARMFUL PLANT BACTERIA 审中-公开
标题翻译：有害植物细菌的预防和控制
公开(公告)号：WO1990013631A1
公开(公告)日：1990-11-15
申请号：PCT/US1989001864
申请日：1989-05-03
申请人： JACKSON, Le Roy, E.
IPC分类号： C12N07/00
CPC分类号： A01N63/00 , Y10S47/09 , Y10S47/10 , Y10S435/948
摘要： For preventing or controlling bacterial harm to plants, as by disease or ice nucleation, a bacteriophage composition of matter containing one or more viral h mutants specific to a mutant of the bacteria concerned is produced and applied to seed, soil or soil supplements, plants, or plant materials that have been exposed to or are contaminated with or infected by bacterial disease, or to growing plants subject to ice nucleation or other bacterial harm. The invention is concerned with the composition and with the method of producing and using same.

60. 发明申请

WO1989010376A1 MONOCLONAL ANTIBODY FOR COLORECTAL CARCINOMA 审中-公开
标题翻译：用于色素性癌症的单克隆抗体
公开(公告)号：WO1989010376A1
公开(公告)日：1989-11-02
申请号：PCT/US1989001667
申请日：1989-04-19
申请人： NEW ENGLAND DEACONESS HOSPITAL CORPORATION , MALLORY INSTITUTE OF PATHOLOGY FOUNDATION
发明人： NEW ENGLAND DEACONESS HOSPITAL CORPORATION , MALLORY INSTITUTE OF PATHOLOGY FOUNDATION , SALEM, Ronald, R. , THOMAS, Peter , ZAMCHECK, Norman , STEELE, Glenn, D., Jr.
IPC分类号： C07K15/04
CPC分类号： C07K16/3046 , Y10S435/948 , Y10S530/808 , Y10S530/809
摘要： A monoclonal antibody raised to colorectal carcinoma, and a hybridoma which elicits the antibody, have been produced. This antibody, ND4 has been discovered to react with a new tumor marker, a glycoprotein of approximately 160 kD found on the surface of undifferentiated colorectal carcinoma cells; it does not cross-react with other known tumor markers. It is useful for detecting and monitoring colorectal carcinoma.

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